Butylated Hydroxyanisole and Its Metabolitetert-Butylhydroquinone Differentially Regulate Mitogen-activated Protein Kinases

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

The stress-activated protein kinase subfamily of c-Jun kinases

1994 • 2,616 citations

Requirement for Generation of H ₂ O ₂ for Platelet-Derived Growth Factor Signal Transduction

1995 • 2,505 citations

The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases

1995 • 2,441 citations

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

1995 • 2,238 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

1993 • 1,902 citations

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis

1996 • 1,784 citations

How MAP Kinases Are Regulated

1995 • 1,742 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

1993 • 1,236 citations

Activation of Mitogen-activated Protein Kinase by H2O2

1996 • 1,202 citations

A Divergence in the MAP Kinase Regulatory Network Defined by MEK Kinase and Raf

1993 • 1,086 citations

Ultraviolet Light and Osmotic Stress: Activation of the JNK Cascade Through Multiple Growth Factor and Cytokine Receptors

1996 • 1,046 citations

Parallel signal processing among mammalian MAPKs

1995 • 1,015 citations

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1994 • 1,005 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

The Role of c-Jun N-terminal Kinase (JNK) in Apoptosis Induced by Ultraviolet C and γ Radiation

1996 • 881 citations

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling.

1993 • 705 citations

Radioprotectors and anticarcinogens

1983 • 613 citations

Carcinogenicity of Butylated Hydroxyanisole in F344 Rats<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref><xref ref-type="fn" rid="fn4">4</xref>

1983 • 574 citations

Activation of ternary complex factor Elk-1 by MAP kinases.

1993 • 561 citations

Persistent Activation of c-Jun N-terminal Kinase 1 (JNK1) in γ Radiation-induced Apoptosis

1996 • 460 citations

Elevation of hepatic glutathione S-transferase activities and protection against mutagenic metabolites of benzo(a)pyrene by dietary antioxidants.

1978 • 338 citations

Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun.

1994 • 296 citations

Regulation of Ras-mediated signalling: more than one way to skin a cat

1995 • 292 citations

Antioxidant response element

1994 • 245 citations

Synthetic antioxidants: Biochemical actions and interference with radiation, toxic compounds, chemical mutagens and chemical carcinogens

1984 • 233 citations

Electrophile and antioxidant regulation of enzymes that detoxify carcinogens.

1995 • 230 citations

Inhibitory effects of phenolic compounds on benzo(a)pyrene-induced neoplasia.

1980 • 224 citations

Differential activation of ERK, JNK/SAPK and P3/CSBP/RK map kinase family members during the cellular response to arsenite

1996 • 211 citations

SOS Phosphorylation and Disassociation of the Grb2-SOS Complex by the ERK and JNK Signaling Pathways

1996 • 180 citations

Arachidonic acid activates c-jun N-terminal kinase through NADPH oxidase in rabbit proximal tubular epithelial cells

1997 • 177 citations

Participation of Reactive Oxygen Species in the Lysophosphatidic Acid-stimulated Mitogen-activated Protein Kinase Kinase Activation Pathway

1995 • 176 citations

Inhibition of Growth Factor-induced Protein Synthesis by a Selective MEK Inhibitor in Aortic Smooth Muscle Cells

1996 • 170 citations

Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways. Evidence of a role for early tyrosine phosphorylation.

1994 • 167 citations

Phenethyl isothiocyanate, a natural chemopreventive agent, activates c-Jun N-terminal kinase 1.

1996 • 110 citations

Adriamycin activates c-jun N-terminal kinase in human leukemia cells: a relevance to apoptosis

1996 • 104 citations

Comparative effects of butylated hydroxyanisole on hepatic in vivo DNA binding and in vitro biotransformation of aflatoxin B1 in the rat and mouse

1987 • 102 citations

p120 GAP Modulates Ras Activation of Jun Kinases and Transformation

1997 • 97 citations

Generation and recycling of radicals from phenolic antioxidants

1990 • 92 citations

Cytotoxicity of butylated hydroxyanisole and butylated hydroxytoluene in isolated rat hepatocytes

1988 • 92 citations

Butylated hydroxyanisole in perspective

1991 • 91 citations

Metabolic activation of phenol by human myeloperoxidase and horseradish peroxidase.

1986 • 89 citations

Enhancement of liver microsome epoxide hydratase activity in rodents by treatment with 2(3)-tert-butyl-4-hydroxyanisole.

1978 • 83 citations

Glutathione and ascorbate reduction of the acetaminophen radical formed by peroxidase. Detection of the glutathione disulfide radical anion and the ascorbyl radical.

1990 • 78 citations

Butylated hydroxyanisole-stimulated NADPH oxidase activity in rat liver microsomal fractions.

1983 • 68 citations

Ascorbate Is the Primary Reductant of the Phenoxyl Radical of Etoposide in the Presence of Thiols both in Cell Homogenates and in Model Systems

1994 • 66 citations

A carcinogenesis reversibility study of the effects of butylated hydroxyanisole on the forestomach and urinary bladder in male fischer 344 rats

1988 • 61 citations

Production of reactive oxygen species due to metabolic activation of butylated hydroxyanisole

1989 • 61 citations

THE SIGNIFICANCE OF INDUCED FORESTOMACH TUMORS

1990 • 56 citations

BHA study in pigs

1986 • 56 citations

Food Additives Metabolism, Fate of Butylated Hydroxyanisole in Man and Dog

1962 • 54 citations

The peroxidase-dependent activation of butylated hydroxyanisole and butylated hydroxytoluene (BHT) to reactive intermediates

1989 • 51 citations

Glutathione conjugates of tert-butyl-hydroquinone, a metabolite of the urinary tract tumor promoter 3-tert-butyl-hydroxyanisole, are toxic to kidney and bladder.

1996 • 50 citations

In vitro metabolism of 3-t-butyl-4-hydroxyanisole and its irreversible binding to proteins

1983 • 49 citations

Effect of synthetic antioxidants on hydrogen peroxide formation, oxyferro cytochrome P-450 concentration and oxygen consumption in liver microsomes☆

1985 • 43 citations

An 85-day study of butylated hydroxyanisole in the cynomolgus monkey

1985 • 40 citations

Oxygen radical formation during prostaglandin H synthase-mediated biotransformation of butylated hydroxyanisole

1993 • 34 citations

Effects of simultaneous treatment with various chemicals on BHA-induced development of rat forestomatch hyperplasia - complete inhibition by diethylmaletate in a 5-week feeding study

1987 • 28 citations

Metabolism of 3-tert-butyl-4-hydroxyanisole by horseradish peroxidase and hydrogen peroxide.

1992 • 26 citations

Induction of oxidative DNA damage and enhancement of cell proliferation in human lymphocytes in vitro by butylated hydroxyanisole

1995 • 24 citations

Tracking the use of antioxidants through industry surveys

1986 • 21 citations

Evaluation of genotoxicity of tert.-butylhydroquinone in an hepatocyte-mediated assay with V79 Chinese hamster lung cells and in strain D7 of Saccharomyces cerevisiae

1992 • 16 citations

Elevation of conjugation capacity in isolated hepatocytes from BHA-treated mice

1982 • 14 citations

Initiating activity of 3-tert-butyl-4-hydroxyanisole (3-BHA) and its metabolites in two-stage transformation of BALB/3T3 cells

1990 • 12 citations

Butylated hydroxyanisole-induced alterations parameters in rat forestomach in relation to cytochrome P-450-mediated metabolism

1989 • 12 citations

Effects of butylated hydroxyanisole on arachidonic acid and linoleic acid metabolism in relation to gastrointestinal cell proliferation in the rat

1992 • 7 citations