Non-genomic progesterone actions in female reproduction

A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

1909 • 6,516 citations

Pharmacological Reviews

2024 • 2,716 citations

THE JOURNAL OF REPRODUCTIVE MEDICINE

1999 • 2,509 citations

Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.

1995 • 1,834 citations

Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.

1990 • 1,510 citations

Prevention of Recurrent Preterm Delivery by 17 Alpha-Hydroxyprogesterone Caproate

2003 • 1,503 citations

Large-scale characterization of HeLa cell nuclear phosphoproteins

2004 • 1,377 citations

Roadmap to embryo implantation: clues from mouse models

2006 • 1,220 citations

Neurosteroids: endogenous regulators of the GABAA receptor

2005 • 1,083 citations

Molecular Cues to Implantation

2004 • 1,042 citations

Signaling Properties of Hyaluronan Receptors

2002 • 997 citations

Multiple actions of steroid hormones--a focus on rapid, nongenomic effects.

2000 • 980 citations

Crucial Step in Cholesterol Homeostasis

2002 • 945 citations

Nongenomic actions of steroid hormones

2003 • 944 citations

Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response

2006 • 939 citations

Identification of a consensus motif for retention of transmembrane proteins in the endoplasmic reticulum.

1990 • 918 citations

Physiological Action of Progesterone in Target Tissues*

1997 • 912 citations

Human Decidual Natural Killer Cells Are a Unique NK Cell Subset with Immunomodulatory Potential

2003 • 854 citations

Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes

2003 • 787 citations

Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function.

1993 • 749 citations

A proposal for the classification of sigma binding sites

1992 • 743 citations

Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites

2006 • 725 citations

Gene Expression Analysis of Endometrium Reveals Progesterone Resistance and Candidate Susceptibility Genes in Women with Endometriosis

2007 • 697 citations

Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor

2003 • 697 citations

Subgroup of Reproductive Functions of Progesterone Mediated by Progesterone Receptor-B Isoform

2000 • 693 citations

Global Gene Profiling in Human Endometrium during the Window of Implantation

2002 • 686 citations

Unequal risks for breast cancer associated with different hormone replacement therapies: results from the E3N cohort study

2007 • 616 citations

Progesterone Receptor Contains a Proline-Rich Motif that Directly Interacts with SH3 Domains and Activates c-Src Family Tyrosine Kinases

2001 • 582 citations

ProTECT: A Randomized Clinical Trial of Progesterone for Acute Traumatic Brain Injury

2006 • 578 citations

Molecular Phenotyping of Human Endometrium Distinguishes Menstrual Cycle Phases and Underlying Biological Processes in Normo-Ovulatory Women

2005 • 572 citations

Differential Gene Regulation by the Two Progesterone Receptor Isoforms in Human Breast Cancer Cells

2002 • 566 citations

Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model

2004 • 556 citations

Endocrine Regulation of Menstruation

2005 • 553 citations

Nongenomic Steroid Action: Controversies, Questions, and Answers

2003 • 553 citations

Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform

2003 • 534 citations

Decidualization of the Human Endometrium: Mechanisms, Functions, and Clinical Perspectives

2007 • 534 citations

Steroid Binding at σ Receptors Suggests a Link Between Endocrine, Nervous, and Immune Systems

1988 • 531 citations

Progesterone-regulated genes in the ovulation process: ADAMTS-1 and cathepsin L proteases

2000 • 527 citations

Uterine Glands Provide Histiotrophic Nutrition for the Human Fetus during the First Trimester of Pregnancy

2002 • 500 citations

Pulsatile Secretion of Luteinizing Hormone: Differential Suppression by Ovarian Steroids*

1980 • 489 citations

REGULATION OF SIGNAL TRANSDUCTION PATHWAYS BY ESTROGEN AND PROGESTERONE

2004 • 475 citations

Inhibition of oxytocin receptor function by direct binding of progesterone

1998 • 468 citations

Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells

2005 • 460 citations

American Heart Association Prevention Conference IV: Prevention and Rehabilitation of Stroke

1997 • 455 citations

Improved outcomes from the administration of progesterone for patients with acute severe traumatic brain injury: a randomized controlled trial

2008 • 445 citations

Cyclic AMP and progesterone receptor cross-talk in human endometrium: a decidualizing affair

2003 • 427 citations

Complete amino acid sequence of the human progesterone receptor deduced from cloned cDNA

1987 • 419 citations

Risk Factors

1997 • 396 citations

Physiological Action of Progesterone in Target Tissues

1997 • 393 citations

Parturition

2007 • 387 citations

Nongenomic Actions of Steroid Hormones in Reproductive Tissues*

1998 • 375 citations

The Opposing Transcriptional Activities of the Two Isoforms of the Human Progesterone Receptor Are Due to Differential Cofactor Binding

2000 • 375 citations

Reproductive Functions of Progesterone Receptors

2002 • 374 citations

Natural Killer Cells in Pregnancy and Recurrent Pregnancy Loss: Endocrine and Immunologic Perspectives

2004 • 373 citations

CORRELATIONS BETWEEN THE CHEMICAL STRUCTURE AND THE PHARMACOLOGICAL ACTIONS OF THE STEROIDS¹

1942 • 348 citations

Progesterone receptor membrane component 1: An integrative review

2007 • 347 citations

PAQR Proteins: A Novel Membrane Receptor Family Defined by an Ancient7-Transmembrane Pass Motif

2005 • 347 citations

Molecular Pharmacology

1971 • 339 citations

Characteristics of membrane progestin receptor alpha (mPRα) and progesterone membrane receptor component 1 (PGMRC1) and their roles in mediating rapid progestin actions

2008 • 339 citations

Convergent Pathways for Steroid Hormone- and Neurotransmitter-Induced Rat Sexual Behavior

1994 • 332 citations

Obstetrics & Gynecology

2023 • 321 citations

Progesterone Signaling in Human Myometrium through Two Novel Membrane G Protein-Coupled Receptors: Potential Role in Functional Progesterone Withdrawal at Term

2006 • 313 citations

Selective Progesterone Receptor Modulator Development and Use in the Treatment of Leiomyomata and Endometriosis

2005 • 307 citations

Prevention of Brca1 -Mediated Mammary Tumorigenesis in Mice by a Progesterone Antagonist

2006 • 305 citations

Selective progesterone receptor modulators and progesterone antagonists: mechanisms of action and clinical applications

2005 • 304 citations

Intracellular Calcium Accumulation and Responsiveness to Progesterone in Capacitating Human Spermatozoa

1991 • 304 citations

Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function

1993 • 304 citations

Promoter Hypermethylation of Progesterone Receptor Isoform B (PR-B) in Endometriosis

2006 • 298 citations

Cell surface-binding sites for progesterone mediate calcium uptake in human sperm.

1991 • 291 citations

Steroid and G Protein Binding Characteristics of the Seatrout and Human Progestin Membrane Receptor α Subtypes and Their Evolutionary Origins

2006 • 289 citations

Nuclear Receptor Coregulators and Human Disease

2007 • 289 citations

Decidual Stromal Cell Response to Paracrine Signals from the Trophoblast: Amplification of Immune and Angiogenic Modulators1

2006 • 288 citations

Ca(2+) signaling via sigma(1)-receptors: novel regulatory mechanism affecting intracellular Ca(2+) concentration.

2000 • 287 citations

Progesterone and its metabolites increase myelin basic protein expression in organotypic slice cultures of rat cerebellum

2003 • 280 citations

Up-Regulation of the Progesterone Receptor (PR)-C Isoform in Laboring Myometrium by Activation of Nuclear Factor-κB May Contribute to the Onset of Labor through Inhibition of PR Function

2005 • 280 citations

Purification and Partial Sequencing of High‐Affinity Progesterone‐Binding Site(s) from Porcine Liver Membranes

1996 • 276 citations

Decidual spiral artery remodelling begins before cellular interaction with cytotrophoblasts

1998 • 275 citations

Progesterone Receptor Plays a Major Antiinflammatory Role in Human Myometrial Cells by Antagonism of Nuclear Factor-κB Activation of Cyclooxygenase 2 Expression

2006 • 273 citations

Progesterone modulates a neuronal nicotinic acetylcholine receptor.

1992 • 272 citations

Reproductive tissue selective actions of progesterone receptors

2004 • 269 citations

A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition

2003 • 268 citations

Uterine natural killer cells: a specialized differentiation regulated by ovarian hormones

2006 • 265 citations

Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms

2003 • 265 citations

Multisite protein modification and intramolecular signaling

2004 • 260 citations

Ovulation: New factors that prepare the oocyte for fertilization

2005 • 260 citations

The Neurosteroid Allopregnanolone Promotes Proliferation of Rodent and Human Neural Progenitor Cells and Regulates Cell-Cycle Gene and Protein Expression

2005 • 251 citations

Wide genomic analysis of human endometrial receptivity: new times, new opportunities

2006 • 247 citations

Nuclear Progesterone Receptors in the Human Pregnancy Myometrium: Evidence that Parturition Involves Functional Progesterone Withdrawal Mediated by Increased Expression of Progesterone Receptor-A

2007 • 242 citations

Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling

2003 • 242 citations

Dap1/PGRMC1 Binds and Regulates Cytochrome P450 Enzymes

2007 • 226 citations

Progesterone inhibits membrane-bound adenylate cyclase in Xenopus laevis oocytes

1981 • 218 citations

Progesterone Membrane Receptor Component 1 Expression in the Immature Rat Ovary and Its Role in Mediating Progesterone’s Antiapoptotic Action

2006 • 216 citations

Thrombosis and haemostasis

2005 • 216 citations

RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism.

1994 • 214 citations

Progesterone receptor transcription and non-transcription signaling mechanisms

2003 • 211 citations

The classical progesterone receptor mediates Xenopus oocyte maturation through a nongenomic mechanism

2000 • 210 citations

The Role of Extranuclear Signaling Actions of Progesterone Receptor in Mediating Progesterone Regulation of Gene Expression and the Cell Cycle

2006 • 209 citations

Uterine junctional zone: function and disease

1995 • 207 citations

Unfolding the Action of Progesterone Receptors

2003 • 207 citations

Progesterone as an immunomodulatory molecule

2001 • 206 citations

Post-translational modifications of steroid receptors

2006 • 199 citations

A membrane-associated progesterone-binding protein, 25-Dx, is regulated by progesterone in brain regions involved in female reproductive behaviors

2000 • 195 citations

Multiplicity of Progesterone's Actions and Receptors in the Mammalian Ovary1

2006 • 195 citations

Membrane Topology and Insertion of Membrane Proteins: Search for Topogenic Signals

2000 • 194 citations

The endocrinology of menstruation – a role for the immune system

2001 • 194 citations

Differential Effects of Estradiol and Estradiol-BSA Conjugates

1999 • 193 citations

Expression of membrane progesterone receptors on human T lymphocytes and Jurkat cells and activation of G-proteins by progesterone

2007 • 192 citations

Progesterone Receptor Membrane Component-1 (PGRMC1) Is the Mediator of Progesterone’s Antiapoptotic Action in Spontaneously Immortalized Granulosa Cells As Revealed by PGRMC1 Small Interfering Ribonucleic Acid Treatment and Functional Analysis of PGRMC1 Mutations

2007 • 187 citations

Progesterone: the forgotten hormone in men?

2004 • 186 citations

Global Gene Profiling in Human Endometrium during the Window of Implantation

2002 • 186 citations

Steroid Receptor Phosphorylation: A Key Modulator of Multiple Receptor Functions

2007 • 183 citations

Ca²⁺– and Calmodulin‐Dependent Phosphorylation of Microtubule‐Associated Protein 2 and t Factor, and Inhibition of Microtubule Assembly

1983 • 180 citations

Allosteric modulations of the nicotinic acetylcholine receptor

1993 • 179 citations

Dopamine requires the unoccupied progesterone receptor to induce sexual behavior in mice.

1996 • 178 citations

Plasma Steroid-Binding Proteins

1991 • 177 citations

Inflammatory pathways in the mechanism of parturition

2007 • 176 citations

Differential Expression of FOXO1 and FOXO3a Confers Resistance to Oxidative Cell Death upon Endometrial Decidualization

2006 • 175 citations

Rapid, Nongenomic Steroid Actions: A New Age?

2000 • 174 citations

Rehabilitation

1997 • 170 citations

Immunohistochemical localization of oestrogen receptors and progesterone receptors in the human ovary throughout the menstrual cycle

1990 • 169 citations

Central Actions of Ovarian Steroids in the Feedback Regulation of Pulsatile Secretion of Luteinizing Hormone

1987 • 169 citations

Inhibition of rat sexual behavior by antisense oligonucleotides to the progesterone receptor.

1994 • 167 citations

Nongenomic Actions of Steroid Hormones in Reproductive Tissues

1998 • 164 citations

Novel Perspectives for Progesterone in Hormone Replacement Therapy, with Special Reference to the Nervous System

2007 • 164 citations

The Sigma1 Protein as a Target for the Non-genomic Effects of Neuro(active)steroids: Molecular, Physiological, and Behavioral Aspects

2006 • 162 citations

A Nongenomic Mechanism for Progesterone-mediated Immunosuppression: Inhibition of K+ Channels, Ca2+ Signaling, and Gene Expression in T Lymphocytes

1998 • 160 citations

Progesterone increases brain‐derived neuroptrophic factor expression and protects against glutamate toxicity in a mitogen‐activated protein kinase‐ and phosphoinositide‐3 kinase‐dependent manner in cerebral cortical explants

2007 • 158 citations

The Androgen and Progesterone Receptors Regulate Distinct Gene Networks and Cellular Functions in Decidualizing Endometrium

2008 • 157 citations

Mannheim Classification of Nongenomically Initiated (Rapid) Steroid Action(s)

2000 • 154 citations

[The effects of an antiprogesterone steroid in women: interruption of the menstrual cycle and of early pregnancy].

1982 • 150 citations

Making Sense of Cross-Talk between Steroid Hormone Receptors and Intracellular Signaling Pathways: Who Will Have the Last Word?

2003 • 148 citations

Death or survival – progesterone-dependent cell fate decisions in the human endometrial stroma

2006 • 148 citations

NK Cells Expressing a Progesterone Receptor Are Susceptible to Progesterone-Induced Apoptosis

2008 • 146 citations

Hormones and sexuality: effect of estrogen and progestogen.

1980 • 144 citations

Ovarian Steroids: The Good, the Bad, and the Signals that Raise Them

2006 • 142 citations

Sigma-1 Receptors Bind Cholesterol and Remodel Lipid Rafts in Breast Cancer Cell Lines

2007 • 142 citations

Human spermatozoa as a model for studying membrane receptors mediating rapid nongenomic effects of progesterone and estrogens

2004 • 142 citations

Identification and cDNA Cloning of a Novel RNA-binding Protein That Interacts with the Cyclic Nucleotide-responsive Sequence in the Type-1 Plasminogen Activator Inhibitor mRNA

2001 • 135 citations

Vascular Effects of Progesterone

2001 • 135 citations

Steroid hormone control of myometrial contractility and parturition

2007 • 135 citations

Two different molecular mechanisms underlying progesterone neuroprotection against ischemic brain damage

2008 • 135 citations

5′-Heterogeneity in Human Progesterone Receptor Transcripts Predicts a New Amino-Terminal Truncated “C”-Receptor and Unique A-Receptor Messages

1990 • 135 citations

Myometrial Progesterone Responsiveness

2007 • 132 citations

Regulated expression of putative membrane progestin receptor homologues in human endometrium and gestational tissues

2005 • 131 citations

Pregnenolone binds to microtubule-associated protein 2 and stimulates microtubule assembly

2000 • 130 citations

Immune-like mechanisms in ovulation

2008 • 129 citations

An Essential Function of the SRC-3 Coactivator in Suppression of Cytokine mRNA Translation and Inflammatory Response

2007 • 128 citations

Trafficking of nuclear receptors in living cells

2000 • 127 citations

Radiotelemetric Monitoring of Hypothalamic Gonadotropin-Releasing Hormone Pulse Generator Activity Throughout the Menstrual Cycle of the Rhesus Monkey^*

1991 • 127 citations

Mechanisms of labour—biochemical aspects

2003 • 125 citations

Heterologous expression of human mPRα, mPRβ and mPRγ in yeast confirms their ability to function as membrane progesterone receptors

2008 • 123 citations

The Classical Progesterone Receptor Associates with p42 MAPK and Is Involved in Phosphatidylinositol 3-Kinase Signaling inXenopus Oocytes

2001 • 122 citations

Progesterone receptor membrane component 1—Many tasks for a versatile protein

2007 • 121 citations

Biological Roles of Estrogen and Progesterone in Human Endometrial Carcinoma - New developments in potential endocrine therapy for endometrial cancer -

2007 • 120 citations

Specific Progesterone Binding to a Membrane Protein and Related Nongenomic Effects on Ca2+-Fluxes in Sperm

1999 • 120 citations

Lysophospholipid signaling in the function and pathology of the reproductive system

2008 • 119 citations

Multiple Trafficking Signals Regulate Kainate Receptor KA2 Subunit Surface Expression

2003 • 119 citations

Oocyte Maturation: The Coming of Age of a Germ Cell

2005 • 116 citations

Microtubule-associated protein 2 (MAP2) is a neurosteroid receptor

2006 • 115 citations

Progestin membrane receptors involved in the meiotic maturation of teleost oocytes: a review with some new findings

2002 • 115 citations

Regulation of the SUMO pathway sensitizes differentiating human endometrial stromal cells to progesterone

2006 • 114 citations

Anti-seizure effects of progesterone and 3α,5α-THP in kainic acid and perforant pathway models of epilepsy

2000 • 113 citations

Cloning and Characterization of an Ovine Intracellular Seven Transmembrane Receptor for Progesterone that Mediates Calcium Mobilization

2006 • 112 citations

Phosphorylation-Dependent Antagonism of Sumoylation Derepresses Progesterone Receptor Action in Breast Cancer Cells

2007 • 112 citations

Integration of Rapid Signaling Events with Steroid Hormone Receptor Action in Breast and Prostate Cancer

2006 • 111 citations

The Role of Xenopus Membrane Progesterone Receptor β in Mediating the Effect of Progesterone on Oocyte Maturation

2006 • 111 citations

Interpopulational differences in progesterone levels during conception and implantation in humans

2004 • 110 citations

Human Homologs of the Putative G Protein-Coupled Membrane Progestin Receptors (mPRα, β, and γ) Localize to the Endoplasmic Reticulum and Are Not Activated by Progesterone

2006 • 109 citations

Progesterone involvement in breast development and tumorigenesis—as revealed by progesterone receptor “knockout” and “knockin” mouse models

2003 • 109 citations

Differential Hormone-Dependent Phosphorylation of Progesterone Receptor A and B Forms Revealed by a Phosphoserine Site-Specific Monoclonal Antibody

2000 • 109 citations

Progesterone Regulation of Human Granulosa/Luteal Cell Viability by an RU486-Independent Mechanism

2006 • 108 citations

Progesterone Triggers a Wave of Increased Free Calcium during the Human Sperm Acrosome Reaction

1997 • 105 citations

Expression of progesterone receptor membrane component 1 and its partner serpine 1 mRNA binding protein in uterine and placental tissues of the mouse and human

2008 • 102 citations

Mifepristone (RU486) alone or in combination with a prostaglandin analogue for termination of early pregnancy: a review

1991 • 101 citations

Rationale for the Use of Histone Deacetylase Inhibitors as a Dual Therapeutic Modality in Multiple Sclerosis

2006 • 101 citations

Conservation of structure and cold-regulation of RNA-binding proteins in cyanobacteria: Probable convergent evolution with eukaryotic glycine-rich RNA-binding proteins

1999 • 100 citations

Neuroendocrine Regulation of Feminine Sexual Behavior: Lessons from Rodent Models and Thoughts About Humans

2007 • 99 citations

Cell-surface expression, progestin binding, and rapid nongenomic signaling of zebrafish membrane progestin receptors α and β in transfected cells

2006 • 99 citations

Mechanisms Underlying “Functional” Progesterone Withdrawal at Parturition

2004 • 98 citations

The uterine junctional zone

2006 • 96 citations

Uterine Glands Provide Histiotrophic Nutrition for the Human Fetus during the First Trimester of Pregnancy

2002 • 95 citations

Effects of progesterone on sperm function: mechanisms of action

2000 • 94 citations

Cross Talk Between Cyclic Nucleotides and Polyphosphoinositide Hydrolysis, Protein Kinases, and Contraction in Smooth Muscle

2001 • 94 citations

Mechanisms of Progesterone Receptor Export from Nuclei: Role of Nuclear Localization Signal, Nuclear Export Signal, and Ran Guanosine Triphosphate

1998 • 94 citations

Integration of progesterone receptor mediated rapid signaling and nuclear actions in breast cancer cell models: Role of mitogen-activated protein kinases and cell cycle regulators

2005 • 92 citations

Cloning and identification of a membrane progestin receptor in goldfish ovaries and evidence it is an intermediary in oocyte meiotic maturation

2005 • 90 citations

Progesterone Receptor Regulates Bcl-2 Gene Expression through Direct Binding to Its Promoter Region in Uterine Leiomyoma Cells

2007 • 90 citations

Biphasic Elevation of [Ca2+]i in Individual Human Spermatozoa Exposed to Progesterone

2000 • 89 citations

Assessment of the proliferative, apoptotic and cellular renovation indices of the human mammary epithelium during the follicular and luteal phases of the menstrual cycle

2005 • 88 citations

From endometrial hyperplasia to endometrial cancer: insight into the biology and possible medical preventive measures

2008 • 86 citations

Molecular Characterization of a Novel Intracellular Hyaluronan-binding Protein

2000 • 85 citations

Preovulatory effects of the progesterone antagonist mifepristone (RU486) in mice

1991 • 85 citations

Imaging Sigma Receptors: Applications in Drug Development

2006 • 85 citations

Differential Response of Progesterone Receptor Isoforms in Hormone-Dependent and -Independent Facilitation of Female Sexual Receptivity

2006 • 85 citations

The involvement of progesterone in the onset of human labour

2002 • 85 citations

Does the rat corpus luteum express the progesterone receptor gene?

1995 • 85 citations

Inhibition of Uterine Contractility by Progesterone and Progesterone Metabolites: Mediation by Progesterone and Gamma Amino Butyric AcidA Receptor Systems

1991 • 84 citations

Dopamine requires the unoccupied progesterone receptor to induce sexual behavior in mice [published erratum appears in Mol Endocrinol 1997 Apr;11(4):423]

1996 • 84 citations

Signaling mechanisms in progesterone–neurotransmitter interactions

2005 • 84 citations

Extra-Nuclear Signaling of Progesterone Receptor to Breast Cancer Cell Movement and Invasion through the Actin Cytoskeleton

2008 • 82 citations

Progesterone Mediates its Anti-Mitogenic and Anti-Apoptotic Actions in Rat Granulosa Cells Through a Progesterone-Binding Protein With Gamma Aminobutyric AcidA Receptor-Like Features1

1998 • 81 citations

Subnuclear Distribution of Progesterone Receptors A and B in Normal and Malignant Endometrium

2004 • 81 citations

Inhibition of rat sexual behavior by antisense oligonucleotides to the progesterone receptor

1994 • 81 citations

Expression and Function of PAIRBP1 Within Gonadotropin-Primed Immature Rat Ovaries: PAIRBP1 Regulation of Granulosa and Luteal Cell Viability1

2005 • 80 citations

Combined hormone replacement therapy and risk of breast cancer in a French cohort study of 3175 women

2002 • 79 citations

Evaluation of Fetal and Maternal Genetic Variation in the Progesterone Receptor Gene for Contributions to Preterm Birth

2007 • 79 citations

Cracking the coregulator codes

2008 • 77 citations

Progesterone-Induced Neuroprotection

2006 • 76 citations

Sex differences in progesterone receptor immunoreactivity in neonatal mouse brain depend on estrogen receptor α expression

2001 • 74 citations

Medroxyprogesterone Acetate Induces Cell Proliferation through Up-Regulation of Cyclin D1 Expression via Phosphatidylinositol 3-Kinase/Akt/Nuclear Factor-κB Cascade in Human Breast Cancer Cells

2005 • 73 citations

Involvement of Protein Kinase A and A Kinase Anchoring Protein in the Progesterone-Initiated Human Sperm Acrosome Reaction1

2000 • 71 citations

Evidence for the existence of a third progesterone receptor protein in human breast cancer cell line T47D.

1994 • 70 citations

The Human NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase Gene Promoter Is Controlled by Ets and Activating Protein-1 Transcription Factors and Progesterone

2000 • 70 citations

Systematic Expression Analysis and Antibody Screening Do Not Support the Existence of Naturally Occurring Progesterone Receptor (PR)-C, PR-M, or Other Truncated PR Isoforms

2008 • 69 citations

Steroid-induced perturbations of membranes and its relevance to sperm acrosome reaction

1992 • 68 citations

Localization of a putative progesterone membrane binding protein in porcine hepatocytes.

1998 • 68 citations

Mifepristone and misoprostol sequential regimen side effects, complications and safety

2006 • 66 citations

Progestin Activation of Nongenomic Pathways via Cross Talk of Progesterone Receptor with Estrogen Receptor β Induces Proliferation of Endometrial Stromal Cells

2005 • 66 citations

Expression of sigma 1 receptor in human breast cancer

2004 • 66 citations

Identification of an Endoplasmic Reticulum-Retention Motif in an Intracellular Loop of the Kainate Receptor Subunit KA2

2006 • 65 citations

Characterization of a Putative Membrane Receptor for Progesterone in Rat Granulosa Cells1

2001 • 65 citations

The effect of mifepristone on breast cell proliferation in premenopausal women evaluated through fine needle aspiration cytology

2008 • 64 citations

Non-Genomic Actions of Progesterone in the Normal and Neoplastic Mammalian Ovary

2007 • 64 citations

Regulation of platelet aggregation and adenosine triphosphate release in vitro by 17beta-estradiol and medroxyprogesterone acetate in postmenopausal women.

2000 • 64 citations

Integration of progesterone receptor action with rapid signaling events in breast cancer models

2007 • 63 citations

Identification of the rat adrenal zona fasciculata/reticularis specific protein, inner zone antigen (IZAg), as the putative membrane progesterone receptor

2001 • 63 citations

Cloning and expression of a novel, truncated, progesterone receptor

2003 • 62 citations

Role of progesterone and progestin therapy in threatened abortion and preterm labour

2007 • 62 citations

Follow-Up Examination at the Age of 15 Months of Extremely Preterm Infants after Postnatal Estradiol and Progesterone Replacement

2001 • 61 citations

Progesterone Regulates Granulosa Cell Viability Through a Protein Kinase G-Dependent Mechanism That May Involve 14-3-3σ1

2004 • 60 citations

Combined hormone replacement therapy and risk of breast cancer in a French cohort study of 3175 women

2002 • 60 citations

Interactions between progesterone and tumor necrosis factor-α in the regulation of primordial follicle assembly

2006 • 59 citations

Membrane-Initiated Events Account for Progesterone's Ability to Regulate Intracellular Free Calcium Levels and Inhibit Rat Granulosa Cell Mitosis1

2002 • 58 citations

Progesterone blocks estrogen-induced DNA synthesis through the inhibition of replication licensing

2006 • 58 citations

Regulation of Sex Differences in Progesterone Receptor Expression in the Medial Preoptic Nucleus of Postnatal Rats

2002 • 58 citations

Honey, we need to talk about the membrane progestin receptors

2008 • 58 citations

Classic and Non-classic Progesterone Receptors are both Expressed in Human Spermatozoa

2005 • 58 citations

Up-Regulation of p21- and RhoA-Activated Protein Kinases in Human Pregnant Myometrium

2000 • 58 citations

Differential Effects of Estradiol and Estradiol-BSA Conjugates

1999 • 56 citations

Pharmacokinetics of anti‐D IgG in pregnant RhD‐negative women

2003 • 56 citations

Involvement of an Unnamed Protein, RDA288, in the Mechanism through which Progesterone Mediates Its Antiapoptotic Action in Spontaneously Immortalized Granulosa Cells

2004 • 56 citations

Progesterone Increases Tissue Factor Gene Expression, Procoagulant Activity, and Invasion in the Breast Cancer Cell Line ZR-75-1

2005 • 56 citations

BJOG An International Journal of Obstetrics and Gynaecology

2015 • 56 citations

Mid-aged and aged wild-type and progestin receptor knockout (PRKO) mice demonstrate rapid progesterone and 3α,5α-THP-facilitated lordosis

2006 • 55 citations

Nongenomic effects of progesterone on human intestinal smooth muscle cells

1996 • 55 citations

Zona pellucida-induced acrosome reaction in human sperm: dependency on activation of pertussis toxin-sensitive Gi protein and extracellular calcium, and priming effect of progesterone and follicular fluid

2002 • 55 citations

Characterization of a new family of proteins that interact with the C‐terminal region of the chromatin‐remodeling factor CHD‐3¹

2002 • 54 citations

Progesterone can participate in down-regulation of the luteinizing hormone receptor gene expression and function in cultured murine Leydig cells

1998 • 52 citations

Progesterone Receptors and Neural Development: A Gap between Bench and Bedside?

2008 • 52 citations

Regulation of Vascular Tone During Pregnancy

2006 • 51 citations

Postmenopausal hormone therapy in clinical perspective

2007 • 51 citations

Expression analysis and RNA localization of PAI-RBP1 (SERBP1) in epithelial ovarian cancer: Association with tumor progression

2007 • 49 citations

Progestin-induced caveolin-1 expression mediates breast cancer cell proliferation

2006 • 49 citations

True

2000 • 48 citations

Porcine spermatozoa contain more than one membrane progesterone receptor

2004 • 47 citations

Nongenomic Inhibition of Oxytocin Binding by Progesterone in the Ovine Uterus1

2004 • 47 citations

Mannheim Classification of Nongenomically Initiated (Rapid) Steroid Action(s)

2000 • 46 citations

Non-Genomic Sex Steroid Actions in the Vascular System

2007 • 46 citations

Identification of functional binding sites for progesterone in rat Leydig cell plasma membrane

1999 • 45 citations

Progestin inhibition of cell death in human breast cancer cell lines

2006 • 45 citations

Extragenomic actions of progesterone in human sperm and progesterone metabolites in human platelets

1999 • 44 citations

Progestogens regulate endothelial actin cytoskeleton and cell movement via the actin-binding protein moesin

2008 • 42 citations

Decidual Cell‐expressed Tissue Factor in Human Pregnancy and Its Involvement in Hemostasis and Preeclampsia‐related Angiogenesis

2008 • 41 citations

Actions of progesterone on human sperm: A model of non-genomic effects of steroids

1995 • 41 citations

Progesterone Receptor as an Indicator of Sperm Function

2002 • 41 citations

Uterine contractility patterns of the outer and inner zones of the myometrium.

1974 • 40 citations

Non-Genomic Steroid Actions in Human Spermatozoa

2007 • 40 citations

Testosterone and Progesterone Rapidly Attenuate Plasma Membrane Gβγ-Mediated Signaling in Xenopus laevis Oocytes by Signaling through Classical Steroid Receptors

2006 • 39 citations

The role of progesterone in endometrial estradiol- and progesterone-receptor synthesis in women with menstrual disorders and habitual abortion

2007 • 39 citations

Putative gene loci associated with carcinogenesis and metastasis of endocervical adenocarcinomas of uterus determined by conventional and array-based CGH

2004 • 38 citations

Progesterone Potentiates IP<sub>3</sub>-Mediated Calcium Signaling Through Akt/PKB

2008 • 38 citations

Progesterone signaling in breast and endometrium

2006 • 37 citations

Specific Progesterone Binding to a Membrane Protein and Related Nongenomic Effects on Ca2+-Fluxes in Sperm

1999 • 37 citations

Genetic defects causing mitochondrial respiratory chain disorders and disease

2000 • 36 citations

Unusual steroid specificity of the cell surface progesterone receptor on human sperm.

1996 • 36 citations

Are the progestins responsible for breast cancer risk during hormone therapy in the postmenopause?

2008 • 35 citations

Progesterone Signaling in Mammary Gland Development

2008 • 34 citations

Progesterone and estradiol concentrations in nonpregnant and pregnant human myometrium. Effect of progesterone and estradiol on cyclic adenosine monophosphate-phosphodiesterase activity.

1990 • 34 citations

Progesterone-induced sphingosine kinase-1 expression in the rat uterus during pregnancy and signaling consequences

2006 • 33 citations

Hormone Receptor Patterning Plays a Critical Role in Normal Lobuloalveolar Development and Breast Cancer Progression

2003 • 33 citations

Progesterone metabolites rapidly stimulate calcium influx in human platelets by a src-dependent pathway

2008 • 31 citations

Differential Hormone-Dependent Phosphorylation of Progesterone Receptor A and B Forms Revealed by a Phosphoserine Site-Specific Monoclonal Antibody

2000 • 30 citations

The effects of a progesterone metabolite, 5β‐dihydroprogesterone, on oxytocin receptor binding in human myometrial membranes

2003 • 26 citations

Does the rat corpus luteum express the progesterone receptor gene?

1995 • 25 citations

Cooperative DNA Binding by the B-Isoform of Human Progesterone Receptor: Thermodynamic Analysis Reveals Strongly Favorable and Unfavorable Contributions to Assembly

2006 • 24 citations

Midtrimester abortion in patients with a previous uterine scar

2003 • 23 citations

Mechanisms of Progesterone Receptor Export from Nuclei: Role of Nuclear Localization Signal, Nuclear Export Signal, and Ran Guanosine Triphosphate

1998 • 23 citations

The role of progestin receptors and the mitogen-activated protein kinase pathway in δ opioid receptor facilitation of female reproductive behaviors

2005 • 22 citations

Membrane progestin receptors α and γ in renal epithelium

2008 • 21 citations

The nuclear receptor co-repressor RIP140 controls the expression of metabolic gene networks

2006 • 21 citations

Effect of Initial Subcellular Localization of Progesterone Receptor on Import Kinetics and Transcriptional Activity

2005 • 21 citations

BRCA1 Control of Steroid Receptor Ubiquitination

2007 • 20 citations

RAPID EFFECT OF PROGESTERONE ON TRANSEPITHELIAL RESISTANCE OF HUMAN FETAL MEMBRANES: EVIDENCE FOR NON‐GENOMIC ACTION

2007 • 17 citations

Classical Xenopus laevis progesterone receptor associates to the plasma membrane through its ligand‐binding domain

2007 • 17 citations

Progesterone Maintains Basal Intracellular Adenosine Triphosphate Levels and Viability of Spontaneously Immortalized Granulosa Cells by Promoting an Interaction between 14-3-3σ and ATP Synthaseβ/Precursor through a Protein Kinase G-Dependent Mechanism

2007 • 16 citations

The Human NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase Gene Promoter Is Controlled by Ets and Activating Protein-1 Transcription Factors and Progesterone

2000 • 15 citations

Sphingosine 1-phosphate dynamically regulates myosin light chain phosphatase activity in human endothelial cells

2002 • 13 citations

Preventing Cervical Ripening: The Primary Mechanism by Which Progestational Agents Prevent Preterm Birth?

2009 • 12 citations

Follow-Up Examination at the Age of 15 Months of Extremely Preterm Infants after Postnatal Estradiol and Progesterone Replacement

2001 • 10 citations

Variations on hormone replacement therapy: An answer to the ‘one dose fits all’ Women's Health Initiative study

2007 • 9 citations

Anisomycin and verapamil influence the action of progesterone on regulation of term human myometrial contractile activity

1997 • 4 citations

CLINICAL AND EXPERIMENTAL PHARMACOLOGY & PHYSIOLOGY

1986 • 2 citations

Deleted Work

1955 • 0 citations