The Role of Extranuclear Signaling Actions of Progesterone Receptor in Mediating Progesterone Regulation of Gene Expression and the Cell Cycle

Effects of Conjugated Equine Estrogen in Postmenopausal Women With Hysterectomy

2004 • 4,391 citations

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

Nuclear Receptors and Lipid Physiology: Opening the X-Files

2001 • 2,040 citations

Influence of Estrogen Plus Progestin on Breast Cancer and Mammography in Healthy Postmenopausal Women

2003 • 1,839 citations

Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B.

1990 • 1,510 citations

Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice

1994 • 982 citations

Specific protection against breast cancers by cyclin D1 ablation

2001 • 930 citations

Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes

2003 • 787 citations

Cyclins and cancer

1991 • 701 citations

Subgroup of Reproductive Functions of Progesterone Mediated by Progesterone Receptor-B Isoform

2000 • 693 citations

Expression and amplification of cyclin genes in human breast cancer.

1993 • 667 citations

Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor

1998 • 618 citations

Progesterone Receptor Contains a Proline-Rich Motif that Directly Interacts with SH3 Domains and Activates c-Src Family Tyrosine Kinases

2001 • 582 citations

Differential Gene Regulation by the Two Progesterone Receptor Isoforms in Human Breast Cancer Cells

2002 • 566 citations

Characterization of sgk, a Novel Member of the Serine/Threonine Protein Kinase Gene Family Which Is Transcriptionally Induced by Glucocorticoids and Serum

1993 • 537 citations

Defective mammary gland morphogenesis in mice lacking the progesterone receptor B isoform

2003 • 534 citations

Poliovirus RNA synthesis utilizes an RNP complex formed around the 5′-end of viral RNA.

1993 • 493 citations

REGULATION OF SIGNAL TRANSDUCTION PATHWAYS BY ESTROGEN AND PROGESTERONE

2004 • 475 citations

A paracrine role for the epithelial progesterone receptor in mammary gland development

1998 • 452 citations

The Steroid Receptor Coactivator-1 Contains Multiple Receptor Interacting and Activation Domains That Cooperatively Enhance the Activation Function 1 (AF1) and AF2 Domains of Steroid Receptors

1998 • 421 citations

Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum.

1993 • 415 citations

Cyclin D1 in Breast Cancer Pathogenesis

2005 • 395 citations

FRAP reveals that mobility of oestrogen receptor-α is ligand- and proteasome-dependent

2000 • 390 citations

Estrogen induction of the cyclin D1 promoter: Involvement of a cAMP response-like element

1999 • 358 citations

17beta-Estradiol induces cyclin D1 gene transcription, p36D1-p34cdk4 complex activation and p105Rb phosphorylation during mitogenic stimulation of G(1)-arrested human breast cancer cells.

1996 • 344 citations

High-Mobility Group Chromatin Proteins 1 and 2 Functionally Interact with Steroid Hormone Receptors To Enhance Their DNA Binding In Vitro and Transcriptional Activity in Mammalian Cells

1998 • 338 citations

The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene.

1999 • 337 citations

Hormone Replacement Therapy with Estrogen or Estrogen plus Medroxyprogesterone Acetate Is Associated with Increased Epithelial Proliferation in the Normal Postmenopausal Breast1

1999 • 334 citations

Progesterone Signaling in Human Myometrium through Two Novel Membrane G Protein-Coupled Receptors: Potential Role in Functional Progesterone Withdrawal at Term

2006 • 313 citations

Nucleocytoplasmic shuttling of the progesterone receptor.

1991 • 296 citations

Biphasic Regulation of Breast Cancer Cell Growth by Progesterone: Role of the Cyclin-Dependent Kinase Inhibitors, p21 and p27Kip1

1997 • 271 citations

Reproductive phenotypes of the progesterone receptor null mutant mouse

1996 • 260 citations

Non-transcriptional action of oestradiol and progestin triggers DNA synthesis

1999 • 252 citations

Progestins Both Stimulate and Inhibit Breast Cancer Cell Cycle Progression while Increasing Expression of Transforming Growth Factor α, Epidermal Growth Factor Receptor, c-fos, and c-myc Genes

1991 • 218 citations

Two Domains of the Progesterone Receptor Interact with the Estrogen Receptor and Are Required for Progesterone Activation of the c-Src/Erk Pathway in Mammalian Cells

2003 • 216 citations

New T47D breast cancer cell lines for the independent study of progesterone B- and A-receptors: only antiprogestin-occupied B-receptors are switched to transcriptional agonists by cAMP.

1994 • 214 citations

Breast Cancer Patients with Progesterone Receptor PR-A-Rich Tumors Have Poorer Disease-Free Survival Rates

2004 • 211 citations

Unfolding the Action of Progesterone Receptors

2003 • 207 citations

Transgenic mice carrying an imbalance in the native ratio of A to B forms of progesterone receptor exhibit developmental abnormalities in mammary glands

1998 • 203 citations

Estrogen Regulation of Cyclin D1 Gene Expression in ZR-75 Breast Cancer Cells Involves Multiple Enhancer Elements

2001 • 200 citations

Murine mammary gland carcinogenesis is critically dependent on progesterone receptor function.

1999 • 190 citations

Progestins both stimulate and inhibit breast cancer cell cycle progression while increasing expression of transforming growth factor alpha, epidermal growth factor receptor, c-fos, and c-myc genes.

1991 • 172 citations

Estrogen Receptor-mediated Activation of the Serum Response Element in MCF-7 Cells through MAPK-dependent Phosphorylation of Elk-1

2001 • 158 citations

Estrogens and Progesterone Promote Persistent CCND1 Gene Activation during G₁ by Inducing Transcriptional Derepression via c-Jun/c-Fos/Estrogen Receptor (Progesterone Receptor) Complex Assembly to a Distal Regulatory Element and Recruitment of Cyclin D1 to Its Own Gene Promoter

2004 • 156 citations

The activities of cyclin D1 that drive tumorigenesis

2004 • 149 citations

Differential Localization and Activity of the A- and B-Forms of the Human Progesterone Receptor Using Green Fluorescent Protein Chimeras

1999 • 149 citations

Re-expression of estrogen receptor alpha in estrogen receptor alpha-negative MCF-7 cells restores both estrogen and insulin-like growth factor-mediated signaling and growth.

2001 • 148 citations

Identification of Murine Uterine Genes Regulated in a Ligand-Dependent Manner by the Progesterone Receptor

2005 • 147 citations

Progesterone Receptors Induce Cell Cycle Progression via Activation of Mitogen-Activated Protein Kinases

2004 • 147 citations

Steroid Receptors and Cell Cycle in Normal Mammary Epithelium

2004 • 144 citations

Hormonal control of alveolar development and its implications for breast carcinogenesis.

2002 • 138 citations

Progestins Induce Transcriptional Activation of Signal Transducer and Activator of Transcription 3 (Stat3) via a Jak- and Src-Dependent Mechanism in Breast Cancer Cells

2005 • 129 citations

Mechanisms of Cyclin-Dependent Kinase Inactivation by Progestins

1998 • 126 citations

Estrogen and progestin regulation of cell cycle progression.

1998 • 117 citations

Requirements for estrogen receptor α membrane localization and function

2005 • 115 citations

Ligand-Specific Dynamics of the Progesterone Receptor in Living Cells and during Chromatin Remodeling In Vitro

2005 • 111 citations

Glucocorticoids stimulate humansgk1gene expression by activation of a GRE in its 5′-flanking region

2002 • 110 citations

Progesterone, in Addition to Estrogen, Induces Cyclin D1 Expression in the Murine Mammary Epithelial Cell, in Vivo*

1997 • 100 citations

Germ‐line mutations in BRCA1 or BRCA2 in the normal breast are associated with altered expression of estrogen‐responsive proteins and the predominance of progesterone receptor A

2004 • 90 citations

Comparison of different antibodies for detection of progesterone receptor in breast cancer

2002 • 84 citations

Impaired Mammary Gland Development in Cyl-1−/− Mice during Pregnancy and Lactation Is Epithelial Cell Autonomous

1999 • 82 citations

Irreversible loss of the oestrogen receptor in T47D breast cancer cells following prolonged oestrogen deprivation

1996 • 82 citations

Revealing Progesterone's Role in Uterine and Mammary Gland Biology: Insights from the Mouse

2005 • 80 citations

Medroxyprogesterone Acetate Induces Cell Proliferation through Up-Regulation of Cyclin D1 Expression via Phosphatidylinositol 3-Kinase/Akt/Nuclear Factor-κB Cascade in Human Breast Cancer Cells

2005 • 73 citations

Cooperation of p27^Kip1 and p18^INK4c in Progestin-Mediated Cell Cycle Arrest in T-47D Breast Cancer Cells

2000 • 69 citations

Progestin Effects on Long-Term Growth, Death, and Bcl-xL in Breast Cancer Cells

2000 • 64 citations

A specific role for cyclin D1 in mammary gland development.

1997 • 62 citations

Progesterone Induces Focal Adhesion in Breast Cancer Cells MDA-MB-231 Transfected with Progesterone Receptor Complementary DNA

2000 • 61 citations

Interactions between progestins and heregulin (HRG) signaling pathways: HRG acts as mediator of progestins proliferative effects in mouse mammary adenocarcinomas

1999 • 56 citations

Progesterone receptor interacting coregulatory proteins and cross talk with cell signaling pathways

2002 • 53 citations

Apoptosis inhibition mediated by medroxyprogesterone acetate treatment of breast cancer cell lines

2001 • 41 citations

Biphasic effect of medroxyprogesterone-acetate (MPA) treatment on proliferation and cyclin D1 gene transcription in T47D breast cancer cells

2000 • 25 citations

Hormone Replacement Therapy With Estrogen or Estrogen Plus Medroxyprogesterone Acetate Is Associated With Increased Epithelial Proliferation in the Normal Postmenopausal Breast

2000 • 6 citations