Endogenous neurosteroids regulate GABAA receptors through two discrete transmembrane sites

SWISS-MODEL: an automated protein homology-modeling server

2003 • 5,370 citations

Molecular basis of agonism and antagonism in the oestrogen receptor

1997 • 3,285 citations

Steroid Hormone Metabolites Are Barbiturate-Like Modulators of the GABA Receptor

1986 • 2,194 citations

Structure and gating mechanism of the acetylcholine receptor pore

2003 • 1,261 citations

Neurosteroids: endogenous regulators of the GABAA receptor

2005 • 1,083 citations

Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain.

1991 • 943 citations

Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by δ subunit-containing GABA _A receptors

2003 • 785 citations

Structure-activity relationships for steroid interaction with the gamma-aminobutyric acidA receptor complex.

1987 • 601 citations

Formation and plasticity of GABAergic synapses: physiological mechanisms and pathophysiological implications

2003 • 325 citations

Neurosteroid Biosynthesis in the Human Brain and Its Clinical Implications

2003 • 190 citations

The effects of inhibitors of GABAergic transmission and stress on brain and plasma allopregnanolone concentrations

1997 • 184 citations

Neurosteroid Prolongs GABA_AChannel Deactivation by Altering Kinetics of Desensitized States

1997 • 173 citations

Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain

2000 • 168 citations

Neuroactive Steroids are Altered in Schizophrenia and Bipolar Disorder: Relevance to Pathophysiology and Therapeutics

2005 • 158 citations

Ethanol regulation of γ-aminobutyric acidA receptors: genomic and nongenomic mechanisms

2004 • 156 citations

Neurosteroid Access to the GABA_AReceptor

2005 • 152 citations

Pathogenesis in Menstrual Cycle‐Linked CNS Disorders

2003 • 143 citations

The Contraceptive Agent Provera Enhances GABA_AReceptor-Mediated Inhibitory Neurotransmission in the Rat Hippocampus: Evidence for Endogenous Neurosteroids?

2003 • 127 citations

Is there a physiological role for the neurosteroid THDOC in stress-sensitive conditions?

2003 • 120 citations

γ-Aminobutyric Acid Increases the Water Accessibility of M3 Membrane-Spanning Segment Residues in γ-Aminobutyric Acid Type A Receptors

1999 • 94 citations

Cloning and functional expression of a Drosophila gamma-aminobutyric acid receptor.

1994 • 85 citations

The role of pregnane neurosteroids in ethanol withdrawal: behavioral genetic approaches

2004 • 81 citations

Channel Gating of the Glycine Receptor Changes Accessibility to Residues Implicated in Receptor Potentiation by Alcohols and Anesthetics

2004 • 61 citations

Neurosteroids act on the GABAA receptor at sites on the N-terminal side of the middle of TM2

1998 • 60 citations

Neuroactive steroids as modulators of depression and anxiety

2005 • 54 citations

Functional and Structural Analysis of the GABAA Receptor α1 Subunit during Channel Gating and Alcohol Modulation

2004 • 45 citations

Comparative modeling of a GABAA alpha1 receptor using three crystal structures as templates

2004 • 43 citations

Sites of positive allosteric modulation by neurosteroids on ionotropic γ‐aminobutyric acid receptor subunits

2004 • 35 citations