BRCA1 Control of Steroid Receptor Ubiquitination

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription

2000 • 1,658 citations

Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

1997 • 1,466 citations

Ubiquitin: structures, functions, mechanisms

2004 • 1,308 citations

Brca1 Controls Homology-Directed DNA Repair

1999 • 1,205 citations

Cyclic, Proteasome-Mediated Turnover of Unliganded and Liganded ERα on Responsive Promoters Is an Integral Feature of Estrogen Signaling

2003 • 718 citations

Breast Cancer Risk After Bilateral Prophylactic Oophorectomy in BRCA1 Mutation Carriers

1999 • 674 citations

The RING Heterodimer BRCA1-BARD1 Is a Ubiquitin Ligase Inactivated by a Breast Cancer-derived Mutation

2001 • 623 citations

Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiPl

1997 • 509 citations

BRCA1 Inhibition of Estrogen Receptor Signaling in Transfected Cells

1999 • 494 citations

BRCA1 is a component of the RNA polymerase II holoenzyme

1997 • 450 citations

Evidence for a transcriptional activation function of BRCA1 C-terminal region

1996 • 443 citations

Direct Acetylation of the Estrogen Receptor α Hinge Region by p300 Regulates Transactivation and Hormone Sensitivity

2001 • 347 citations

Prevention of Brca1 -Mediated Mammary Tumorigenesis in Mice by a Progesterone Antagonist

2006 • 305 citations

BRCA1-Dependent Ubiquitination of γ-Tubulin Regulates Centrosome Number

2004 • 287 citations

BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP

2006 • 276 citations

Role of direct interaction in BRCA1 inhibition of estrogen receptor activity

2001 • 265 citations

Sumoylation of the Estrogen Receptor α Hinge Region Regulates Its Transcriptional Activity

2005 • 222 citations

Autoubiquitination of the BRCA1·BARD1 RING Ubiquitin Ligase

2002 • 218 citations

BRCA1 mediates ligand-independent transcriptional repression of the estrogen receptor

2001 • 212 citations

Estrogen receptor α is a putative substrate for the BRCA1 ubiquitin ligase

2007 • 170 citations

BRCA1/BARD1 Ubiquitinate Phosphorylated RNA Polymerase II

2005 • 148 citations

BRCA1/BARD1 inhibition of mRNA 3′ processing involves targeted degradation of RNA polymerase II

2005 • 145 citations

Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts.

2002 • 133 citations

Centrosomal Microtubule Nucleation Activity Is Inhibited by BRCA1-Dependent Ubiquitination

2005 • 118 citations

BRCA1 participates in DNA decatenation

2005 • 109 citations

Activation of Transcription in Vitro by the BRCA1 Carboxyl-terminal Domain

1999 • 83 citations

BRCA1 Ubiquitinates RPB8 in Response to DNA Damage

2007 • 48 citations

A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase

2007 • 47 citations

Direct Stimulation of Transcription Initiation by BRCA1 Requires Both Its Amino and Carboxyl Termini

2006 • 13 citations