The endocrinology of menstruation – a role for the immune system

Cloning of a novel receptor expressed in rat prostate and ovary.

1996 • 4,782 citations

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

1986 • 2,341 citations

Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.

1995 • 1,834 citations

Human Estrogen Receptor β-Gene Structure, Chromosomal Localization, and Expression Pattern1

1997 • 1,098 citations

Some immunological and endocrinological problems raised by the evolution of viviparity in verte- brates

1953 • 838 citations

Differential Transcriptional Regulation of the Two Vascular Endothelial Growth Factor Receptor Genes

1997 • 792 citations

Subgroup of Reproductive Functions of Progesterone Mediated by Progesterone Receptor-B Isoform

2000 • 693 citations

Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer.

2000 • 691 citations

Progestin Regulation of Cellular Proliferation*

1990 • 659 citations

Immunohistochemical Analysis of Human Uterine Estrogen and Progesterone Receptors Throughout the Menstrual Cycle*

1988 • 653 citations

Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin.

1994 • 584 citations

Human Estrogen Receptor -Gene Structure, Chromosomal Localization, and Expression Pattern

1997 • 576 citations

Halting angiogenesis suppresses carcinoma cell invasion

1997 • 430 citations

Vascular Endothelial Growth Factor Upregulates the Expression of Matrix Metalloproteinases in Vascular Smooth Muscle Cells

1998 • 428 citations

Interleukin-8. A corneal factor that induces neovascularization.

1992 • 385 citations

PHYSIOLOGY OF THE CORPUS LUTEUM

1929 • 351 citations

PROSTAGLANDIN E2, PROSTAGLANDIN I2 AND THE VASCULAR CHANGES OF INFLAMMATION

1979 • 343 citations

Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors.

1993 • 330 citations

Uterine leukocytes and decidualization

2000 • 324 citations

Induction of inflammatory angiogenesis by monocyte chemoattractant protein-1

1999 • 321 citations

Progesterone Receptor Regulates Decidual Prolactin Expression in Differentiating Human Endometrial Stromal Cells1

1999 • 309 citations

Human implantation : cell biology and immunology

1995 • 298 citations

Use of Immunocytochemistry of Progesterone and Estrogen Receptors for Endometrial Dating

1988 • 252 citations

IMPLANTATION, MENSTRUATION AND INFLAMMATION

1986 • 244 citations

Menstruation: induction by matrix metalloproteinases and inflammatory cells

1999 • 238 citations

Cytokine control in human endometrium

2001 • 226 citations

A Dual Mechanism Mediates Repression of NF-κB Activity by Glucocorticoids

1998 • 225 citations

Estrogen Receptor β, But Not Estrogen Receptor α, Is Present in the Vascular Endothelium of the Human and Nonhuman Primate Endometrium1

2001 • 218 citations

Levels of prostaglandins in human endometrium during the normal menstrual cycle

1974 • 216 citations

Angiogenesis, vascular endothelial growth factor and the endometrium

1998 • 216 citations

Chemokine and cyclooxygenase-2 expression in human endometrium coincides with leukocyte accumulation

1997 • 216 citations

Mifepristone (RU 486) -- A Modulator of Progestin and Glucocorticoid Action

1993 • 215 citations

Progesterone receptors in reproduction: functional impact of the A and B isoforms

2000 • 215 citations

Vascular Endothelial Growth Factor Expression in Human Endometrium Is Regulated by Hypoxia¹

2000 • 206 citations

Up-regulation of flk-1/vascular endothelial growth factor receptor 2 by its ligand in a cerebral slice culture system.

1997 • 195 citations

Immunocytochemical analysis of oestrogen receptors and progesterone receptors in the human uterus throughout the menstrual cycle and after the menopause

1992 • 190 citations

Response of tumour cells to hypoxia: role of p53 and NFkB

1998 • 181 citations

The Effect of 17β-Estradiol and Progesterone on Prostaglandin Production by Human Endometrium Maintained in Organ Culture

1980 • 174 citations

The signals and molecular pathways involved in human menstruation, a unique process of tissue destruction and remodelling

1996 • 173 citations

Prostacyclin and thromboxane in gynecology and obstetrics

1985 • 163 citations

Pregnancy Maintenance and Parturition: The Role of Prostaglandin in Manipulating the Immune and Inflammatory Response

1994 • 161 citations

Interleukin-8 Induces Proliferation of Endometrial Stromal Cells: a Potential Autocrine Growth Factor1

1998 • 155 citations

Progesterone receptor subtype B is differentially regulated in human endometrial stroma

1998 • 154 citations

Vascular Endothelial Growth Factor Expression in Human Endometrium Is Regulated by Hypoxia

2000 • 152 citations

Granulocyte chemotactic protein/interleukin-8 induces plasma leakage and neutrophil accumulation in rabbit skin.

1989 • 149 citations

Immunohistochemical localization of androgen receptor in the human endometrium, decidua, placenta and pathological conditions of the endometrium

1992 • 142 citations

Role of Inflammatory Mediators in Human Endometrium during Progesterone Withdrawal and Early Pregnancy¹

1999 • 139 citations

Serum testosterone concentrations in women throughout the menstrual cycle and following HCG administration

1974 • 136 citations

Progesterone Antagonists Increase Androgen Receptor Expression in the Rhesus Macaque and Human Endometrium1

2001 • 135 citations

The NF-kappaB pathway in human endometrium and first trimester decidua

2001 • 131 citations

Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors [published erratum appears in Mol Endocrinol 1993 Nov;7(11):1378]

1993 • 118 citations

Human endometrial matrix metalloproteinase-2, a putative menstrual proteinase. Hormonal regulation in cultured stromal cells and messenger RNA expression during the menstrual cycle.

1996 • 117 citations

The effect of RU 486 administered during the early luteal phase on bleeding pattern, hormonal parameters and endometrium

1990 • 110 citations

Matrix Metalloproteinase and Matrix Metalloproteinase Inhibitor Expression in Endometrial Stromal Cells during Progestin-Initiated Decidualization and Menstruation-Related Progestin Withdrawal**This work was supported in part by grants from the National Institutes of Health R29-HD29540–01A1 and HD-94–23 (to C.J.L.). Portions of this work were presented at the 44th Annual Meeting of the Society for Gynecologic Investigation. (Lockwood CJ, Krikun G, Hausknecht V, Wang E-Y, Ziegler D, Schatz F, …

1998 • 108 citations

A Plain-muscle Stimulant in the Menstruum

1957 • 106 citations

Role of Inflammatory Mediators in Human Endometrium during Progesterone Withdrawal and Early Pregnancy

1999 • 105 citations

Immunohistochemical localization of estradiol and progesterone receptors in human uterus throughout pregnancy: expression in endometrial blood vessels.

1994 • 104 citations

Hypoxia and cAMP Stimulate Vascular Endothelial Growth Factor (VEGF) in Human Endometrial Stromal Cells: Potential Relevance to Menstruation and Endometrial Regeneration

1999 • 99 citations

Prostaglandins and menstruation

1996 • 95 citations

The effects of mefenamic acid and norethisterone on measured menstrual blood loss.

1990 • 94 citations

A Dual Mechanism Mediates Repression of NF- B Activity by Glucocorticoids

1998 • 86 citations

Matrix Metalloproteinase Expression in Macaca mulatta Endometrium: Evidence for Zone-Specific Regulatory Tissue Gradients1

1998 • 83 citations

Immunology of human placental implantation: clinical implications of our current understanding

1997 • 82 citations

Localization of the angiotensin II and its receptor subtype expression in human endometrium and identification of a novel high-affinity angiotensin II binding site.

1995 • 75 citations

Regulation of matrix metalloproteinases in human endometrium

2000 • 74 citations

Progesterone Antagonists Increase Androgen Receptor Expression in the Rhesus Macaque and Human Endometrium

2001 • 71 citations

Interleukin-8 Induces Proliferation of Endometrial Stromal Cells: a Potential Autocrine Growth Factor

1998 • 71 citations

Progesterone Withdrawal Up-Regulates Vascular Endothelial Growth Factor Receptor Type 2 in the Superficial Zone Stroma of the Human and Macaque Endometrium: Potential Relevance to Menstruation*

2000 • 69 citations

Presence of messenger ribonucleic acid for endothelin-1, endothelin-2, and endothelin-3 in human endometrium and a change in the ratio of ETA and ETB receptor subtype across the menstrual cycle.

1992 • 68 citations

Estrogens and Progestogens in Clinical Practice

1999 • 67 citations

Effect of exogenous prostaglandin E₂ and actinomycin D on plasma leakage induced by neutrophil‐activating peptide‐1/interleukin‐8

1990 • 66 citations

Polymorphonuclear Leukocytes in the Endometrium During the Normal Menstrual Cycle

1987 • 65 citations

The effects of mifepristone (RU486) on prostaglandin dehydrogenase in decidual and chorionic tissue in early pregnancy

1993 • 61 citations

Estrogen Receptor , But Not Estrogen Receptor , Is Present in the Vascular Endothelium of the Human and Nonhuman Primate Endometrium

2001 • 60 citations

The effects of an antiprogestin, mifepristone, and an antiestrogen, tamoxifen, on endometrial 17 beta-hydroxysteroid dehydrogenase and progestin and estrogen receptors during the luteal phase of the menstrual cycle: an immunohistochemical study.

1993 • 59 citations

Immunohistochemical localization of estradiol and progesterone receptors in human uterus throughout pregnancy: expression in endometrial blood vessels

1994 • 56 citations

Perivascular location of a chemokine interleukin-8 in human endometrium: a preliminary report

1994 • 54 citations

Perivascular Interleukin-8 Messenger Ribonucleic Acid Expression in Human Endometrium Varies across the Menstrual Cycle and in Early Pregnancy Decidua¹

1999 • 51 citations

Control of Biosynthesis and Post-Transcriptional Modification of the Progesterone Receptor

1992 • 49 citations

Plasminogen activator activity during decidualization of human endometrial stromal cells is regulated by plasminogen activator inhibitor 1.

1995 • 47 citations

8 Prostaglandins, prostaglandin inhibitors and their roles in gynaecological disorders

1992 • 39 citations

The effects of post-ovulatory administration of onapristone on the development of a secretory endometrium

1996 • 39 citations

Perivascular Interleukin-8 Messenger Ribonucleic Acid Expression in Human Endometrium Varies across the Menstrual Cycle and in Early Pregnancy Decidua

1999 • 37 citations

Progesterone Withdrawal Up-Regulates Vascular Endothelial Growth Factor Receptor Type 2 in the Superficial Zone Stroma of the Human and Macaque Endometrium: Potential Relevance to Menstruation

2000 • 36 citations

Biological Mechanisms Underlying the Clinical Effects of RU 486: Modulation of Cultured Endometrial Stromal Cell Stromelysin-1 and Prolactin Expression¹

1997 • 32 citations

Oestrous and menstrual cycles

1984 • 30 citations

Presence of messenger ribonucleic acid for endothelin-1, endothelin-2, and endothelin-3 in human endometrium and a change in the ratio of ETA and ETB receptor subtype across the menstrual cycle

1992 • 30 citations

Biological Mechanisms Underlying the Clinical Effects of RU 486: Modulation of Cultured Endometrial Stromal Cell Stromelysin-1 and Prolactin Expression

1997 • 28 citations

Comparison of the patterns of androstenedione, progesterone, and estradiol during the human menstrual cycle

1974 • 27 citations

The effects of an antiprogestin, mifepristone, and an antiestrogen, tamoxifen, on endometrial 17 beta-hydroxysteroid dehydrogenase and progestin and estrogen receptors during the luteal phase of the menstrual cycle: an immunohistochemical study

1993 • 26 citations

CD40 Expression in Uterine Tissues: A Key Regulator of Cytokine Expression by Fibroblasts¹

2001 • 26 citations

Plasminogen activator activity during decidualization of human endometrial stromal cells is regulated by plasminogen activator inhibitor 1

1995 • 26 citations

Metabolism of Prostaglandins by the Nonpregnant Human Uterus*

1983 • 23 citations

CD40 Expression in Uterine Tissues: A Key Regulator of Cytokine Expression by Fibroblasts

2001 • 18 citations