From endometrial hyperplasia to endometrial cancer: insight into the biology and possible medical preventive measures

Two pathogenetic types of endometrial carcinoma

1983 • 2,309 citations

Treatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis

1993 • 1,739 citations

The behavior of endometrial hyperplasia. A long-term study of “untreated” hyperplasia in 170 patients

1985 • 1,243 citations

Obesity, endogenous hormones, and endometrial cancer risk: a synthetic review.

2002 • 1,002 citations

Source of Estrogen Production in Postmenopausal Women1

1973 • 961 citations

Overexpression of Cyclooxygenase-2 Is Sufficient to Induce Tumorigenesis in Transgenic Mice

2001 • 809 citations

Estrogen production and action

2001 • 764 citations

Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies.

1997 • 689 citations

Effects of Hormone Replacement Therapy on Endometrial Histology in Postmenopausal Women

1996 • 568 citations

Aromatase expression in endometriosis.

1996 • 520 citations

Effect of obesity on conversion of plasma androstenedione to estrone in postmenopausal women with and without endometrial cancer

1978 • 438 citations

Plasma Precursors of Estrogen. II. Correlation of the Extent of Conversion of Plasma Androstenedione to Estrone with Age¹

1974 • 436 citations

Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE2 via cyclic AMP, leading to activation of promoter II of the CYP19 (aromatase) gene.

1996 • 418 citations

Uterine papillary serous carcinoma (UPSC): a single institution review of 129 cases

2003 • 343 citations

Origin of Estrogen in Normal Men and in Women with Testicular Feminization*

1979 • 323 citations

Clinicopathologic review of 118 granulosa and 82 theca cell tumors.

1980 • 273 citations

Reproducibility of the Diagnosis of Endometrial Hyperplasia, Atypical Hyperplasia, and Well-Differentiated Carcinoma

1998 • 253 citations

Reproducibility of the diagnosis of atypical endometrial hyperplasia

2006 • 252 citations

Low-Dose Esterified Estrogen Therapy

1997 • 226 citations

Stimulation of Aromatase P450 Promoter (II) Activity in Endometriosis and Its Inhibition in Endometrium Are Regulated by Competitive Binding of Steroidogenic Factor-1 and Chicken Ovalbumin Upstream Promoter Transcription Factor to the Same cis-Acting Element

1999 • 200 citations

Low-dose esterified estrogen therapy: effects on bone, plasma estradiol concentrations, endometrium, and lipid levels. Estratab/Osteoporosis Study Group

1997 • 186 citations

Estrogen biosynthesis in endometriosis: molecular basis and clinical relevance

2000 • 168 citations

Blaustein's Pathology of the Female Genital Tract, 5th ed

2002 • 151 citations

Aromatase and COX-2 expression in human breast cancers

2001 • 146 citations

Racial differences in the overexpression of epidermal growth factor type II receptor (HER2/neu): A major prognostic indicator in uterine serous papillary cancer

2005 • 135 citations

Cyclooxygenase‐2 expression in endometrial carcinoma

2002 • 115 citations

Proliferative endometrial response to theca-granulosa cell tumors

1971 • 105 citations

CYP19 (aromatase cytochrome P450) gene expression in human malignant endometrial tumors.

1994 • 104 citations

Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells

2002 • 93 citations

Risk of Endometrial Cancer in Relation to Use of Low-Dose, Unopposed Estrogens

1998 • 85 citations

Coordinate Regulation of the Production and Signaling of Retinoic Acid by Estrogen in the Human Endometrium

2003 • 72 citations

Up-regulation of Cyclooxygenase-2 Expression and Prostaglandin Synthesis in Endometrial Stromal Cells by Malignant Endometrial Epithelial Cells

2002 • 62 citations

The ATAC (‘Arimidex’, Tamoxifen, Alone or in Combination) adjuvant breast cancer trial: first results of the endometrial sub-protocol following 2 years of treatment

2005 • 60 citations

Third generation aromatase inhibitors may prevent endometrial growth and reverse tamoxifen-induced uterine changes in postmenopausal breast cancer patients

2004 • 57 citations

Identification of a Novel Estrogen-Regulated Gene, EIG121, Induced by Hormone Replacement Therapy and Differentially Expressed in Type I and Type II Endometrial Cancer

2005 • 53 citations

Expression of cyclooxygenase-2 in cervical, endometrial, and ovarian malignancies

2003 • 52 citations

P53 codon 72 polymorphism and correlation with ovarian and endometrial cancer in Greek women

2004 • 51 citations

Aromatase inhibitor anastrozole for treating endometrial hyperplasia in obese postmenopausal women

2004 • 49 citations

Anastrozole versus tamoxifen treatment in postmenopausal women with endocrine-responsive breast cancer and tamoxifen-induced endometrial pathology.

2006 • 39 citations

COX-2 inhibition in clinical cancer prevention.

2001 • 37 citations

The expression of cyclooxygenase-1 and -2 in proliferative endometrium and endometrial adenocarcinoma

2002 • 32 citations

Prospective endometrial assessment of breast cancer patients treated with third generation aromatase inhibitors

2006 • 23 citations

Induction of cyclooxygenase-2 in human endometrial stromal cells by malignant endometrial epithelial cells: evidence for the involvement of extracellularly regulated kinases and CCAAT/enhancer binding proteins

2003 • 19 citations

Comparison of endometrial carcinoma coexisting with and without endometrial hyperplasia.

2000 • 16 citations

Expression of cyclooxygenase-2 in endometrial adenocarcinoma.

2005 • 14 citations