Non-Genomic Steroid Actions in Human Spermatozoa

Estrogen Receptor Null Mice: What Have We Learned and Where Will They Lead Us?

1999 • 1,965 citations

Population study of causes, treatment, and outcome of infertility.

1985 • 1,120 citations

Timing of Sexual Intercourse in Relation to Ovulation — Effects on the Probability of Conception, Survival of the Pregnancy, and Sex of the Baby

1995 • 1,103 citations

Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility.

1996 • 827 citations

Identification of a Testicular Odorant Receptor Mediating Human Sperm Chemotaxis

2003 • 736 citations

Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor

2003 • 697 citations

The ‘Capacitation’ of the Mammalian Sperm

1952 • 690 citations

Atomic structure of progesterone complexed with its receptor

1998 • 654 citations

Assisted reproductive technology

2019 • 520 citations

Progesterone and 17 alpha-hydroxyprogesterone. Novel stimulators of calcium influx in human sperm.

1990 • 485 citations

Sperm guidance in mammals — an unpaved road to the egg

2006 • 476 citations

Phosphoproteome Analysis of Capacitated Human Sperm

2003 • 473 citations

Steroid induced exocytosis: The human sperm acrosome reaction

1989 • 413 citations

International Union of Pharmacology. XLIX. Nomenclature and Structure-Function Relationships of Transient Receptor Potential Channels

2005 • 389 citations

Nongenomic Actions of Steroid Hormones in Reproductive Tissues*

1998 • 375 citations

Mammalian sperm translate nuclear-encoded proteins by mitochondrial-type ribosomes

2006 • 347 citations

Penetration, Adhesion, and Fusion in Mammalian Sperm-Egg Interaction

2002 • 329 citations

Exocytosis in spermatozoa in response to progesterone and zona pellucida

1994 • 328 citations

Fertility of mammalian spermatozoa: its development and relativity

1994 • 326 citations

Phosphatidylinositol 4,5-bisphosphate hydrolysis in human sperm stimulated with follicular fluid or progesterone is dependent upon Ca2+ influx

1989 • 318 citations

Intracellular Calcium Accumulation and Responsiveness to Progesterone in Capacitating Human Spermatozoa

1991 • 304 citations

Regulation of sperm function by reactive oxygen species

2004 • 299 citations

Cell surface-binding sites for progesterone mediate calcium uptake in human sperm.

1991 • 291 citations

Assisted reproductive technology in Europe, 2003. Results generated from European registers by ESHRE

2007 • 281 citations

Purification and Partial Sequencing of High‐Affinity Progesterone‐Binding Site(s) from Porcine Liver Membranes

1996 • 276 citations

Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm.

1995 • 272 citations

Hyperactivated Motility of Bull Sperm Is Triggered at the Axoneme by Ca2+ and Not cAMP

2002 • 249 citations

Characterization of the Intracellular Calcium Store at the Base of the Sperm Flagellum That Regulates Hyperactivated Motility1

2003 • 238 citations

An adhesion-associated agonist from the zona pellucida activates G protein-promoted elevations of internal Ca2+ and pH that mediate mammalian sperm acrosomal exocytosis

1989 • 238 citations

Ca²⁺Entry through Store-operated Channels in Mouse Sperm Is Initiated by Egg ZP3 and Drives the Acrosome Reaction

2000 • 225 citations

Activation of voltage-dependent calcium channels of mammalian sperm is required for zona pellucida-induced acrosomal exocytosis

1992 • 224 citations

An Inositol 1,4,5-Trisphosphate Receptor-Gated Intracellular Ca2+ Store Is Involved in Regulating Sperm Hyperactivated Motility1

2001 • 222 citations

Membrane‐Initiated Steroid Actions and theProteins that Mediate Them

1999 • 214 citations

Full-Length cDNA Sequence of a Progesterone Membrane-Binding Protein from Porcine Vascular Smooth Muscle Cells

1996 • 210 citations

Progesterone at the picomolar range is a chemoattractant for mammalian spermatozoa

2006 • 194 citations

Short Communication

1998 • 188 citations

Stimulation of Human Spermatozoa with Progesterone Gradients to Simulate Approach to the Oocyte

2004 • 187 citations

Biological basis for human capacitation

2005 • 187 citations

Sperm motility in the presence of boundaries*

1995 • 185 citations

Human Sperm Plasma Membrane Progesterone Receptor(s) and the Acrosome Reaction1

1996 • 184 citations

On the epididymis and its role in the development of the fertile ejaculate.

1995 • 182 citations

Estrogen Receptor (ER)α and ERβ Are Both Expressed in Human Ejaculated Spermatozoa: Evidence of Their Direct Interaction with Phosphatidylinositol-3-OH Kinase/Akt Pathway

2004 • 179 citations

Identification and Characterization of a Novel Functional Estrogen Receptor on Human Sperm Membrane That Interferes with Progesterone Effects

1999 • 171 citations

17 -Estradiol and environmental estrogens significantly affect mammalian sperm function

2003 • 166 citations

The Sigma1 Protein as a Target for the Non-genomic Effects of Neuro(active)steroids: Molecular, Physiological, and Behavioral Aspects

2006 • 162 citations

Evidence Suggesting Involvement of a Unique Human Sperm Steroid Receptor/Cl- Channel Complex in the Progesterone-Initiated Acrosome Reaction

1993 • 161 citations

Carbohydrates mediate the adherence of hamster sperm to oviductal epithelium

1995 • 159 citations

Phospholipase Cδ4 is required for Ca2+ mobilization essential for acrosome reaction in sperm

2003 • 155 citations

Identification and Characterization of Functional Nongenomic Progesterone Receptors on Human Sperm Membrane1

1998 • 154 citations

Particulate Adenylate Cyclase Plays a Key Role in Human Sperm Olfactory Receptor-mediated Chemotaxis

2004 • 152 citations

Human spermatozoa as a model for studying membrane receptors mediating rapid nongenomic effects of progesterone and estrogens

2004 • 142 citations

The Cysteine-rich Secretory Protein Domain of Tpx-1 Is Related to Ion Channel Toxins and Regulates Ryanodine Receptor Ca2+ Signaling

2005 • 141 citations

The state of the union: the cell biology of fertilization

2002 • 140 citations

Physiology: Sperm numbers and distribution within the human Fallopian tube around ovulation

1993 • 138 citations

Cracking the egg: increased complexity in the zona pellucida

2005 • 131 citations

The Intraacrosomal Calcium Pool Plays a Direct Role in Acrosomal Exocytosis

2002 • 126 citations

The Meaning of Sperm Capacitation A Historical Perspective

1984 • 125 citations

Isolation and characterization of a novel gene induced by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in rat liver

1996 • 122 citations

Evidence that a GABAA-Like Receptor is Involved in Progesterone-Induced Acrosomal Exocytosis in Mouse Spermatozoa1

1995 • 122 citations

Specific Progesterone Binding to a Membrane Protein and Related Nongenomic Effects on Ca2+-Fluxes in Sperm

1999 • 120 citations

Regulators of sperm function

1996 • 117 citations

Intracellular events and signaling pathways involved in sperm acquisition of fertilizing capacity and acrosome reaction

2000 • 115 citations

The acrosomal vesicle of mouse sperm is a calcium store

2004 • 111 citations

Human Homologs of the Putative G Protein-Coupled Membrane Progestin Receptors (mPRα, β, and γ) Localize to the Endoplasmic Reticulum and Are Not Activated by Progesterone

2006 • 109 citations

Human Ejaculated Spermatozoa Contain Active P450 Aromatase

2002 • 109 citations

Ion fluxes through the progesterone-activated channel of the sperm plasma membrane

1993 • 107 citations

SNARE Complex Assembly Is Required for Human Sperm Acrosome Reaction

2002 • 105 citations

Andrology: The interaction in vitro of human spermatozoa with epithelial cells from the human uterine (Fallopian) tube

1995 • 105 citations

Intracellular calcium increase and acrosome reaction in response to progesterone in human spermatozoa are correlated with in-vitro fertilization

1995 • 105 citations

Progesterone Triggers a Wave of Increased Free Calcium during the Human Sperm Acrosome Reaction

1997 • 105 citations

Andrology: Two functional assays of sperm responsiveness to progesterone and their predictive values in in-vitro fertilization

1996 • 104 citations

Progesterone and RU486: opposing effects on human sperm.

1994 • 102 citations

The Fallopian tubes in domestic mammals: how vital is their physiological activity?

2005 • 98 citations

Differential release of soluble and matrix components: evidence for intermediate states of secretion during spontaneous acrosomal exocytosis in mouse sperm☆

2003 • 97 citations

Calcium-induced Acrosomal Exocytosis Requires cAMP Acting through a Protein Kinase A-independent, Epac-mediated Pathway

2006 • 94 citations

Sequence of ejaculation affects the spermatozoon as a carrier and its message

2003 • 90 citations

Biphasic Elevation of [Ca2+]i in Individual Human Spermatozoa Exposed to Progesterone

2000 • 89 citations

Progesterone-Mediated Calcium Influx and Acrosome Reaction of Human Spermatozoa: Pharmacological Investigation of T-Type Calcium Channels1

1999 • 88 citations

Greater numbers of human spermatozoa associate with endosalpingeal cells derived from the isthmus compared with those from the ampulla

1997 • 85 citations

Sperm protein “DE” mediates gamete fusion through an evolutionarily conserved site of the CRISP family

2006 • 84 citations

Estrogens and epididymal function

2001 • 84 citations

Progesterone stimulates p42 extracellular signal-regulated kinase (p42erk) in human spermatozoa

1998 • 83 citations

Steroid levels in ovarian follicular fluid related to follicle size and health status during the normal menstrual cycle in women

1986 • 82 citations

Metabolic Changes in Human Spermatozoa Related to Capacitation

1972 • 82 citations

Ligands induce conformational changes in the carboxyl-terminus of progesterone receptors which are detected by a site-directed antipeptide monoclonal antibody.

1992 • 81 citations

Progesterone Mediates its Anti-Mitogenic and Anti-Apoptotic Actions in Rat Granulosa Cells Through a Progesterone-Binding Protein With Gamma Aminobutyric AcidA Receptor-Like Features1

1998 • 81 citations

Progesterone-Mediated Efflux of Cytosolic Chloride During the Human Sperm Acrosome Reaction

1995 • 81 citations

Expression and Function of PAIRBP1 Within Gonadotropin-Primed Immature Rat Ovaries: PAIRBP1 Regulation of Granulosa and Luteal Cell Viability1

2005 • 80 citations

Hpr6.6 protein mediates cell death from oxidative damage in MCF‐7 human breast cancer cells

2003 • 77 citations

Co-localization of the inositol 1,4,5-trisphosphate receptor and calreticulin in the equatorial segment and in membrane bounded vesicles in the cytoplasmic droplet of human spermatozoa

2001 • 76 citations

The neoglycoprotein mannosebovine serum albumin, but not progesterone, activates T-type calcium channels in human spermatozoa

1999 • 76 citations

Tyrosine kinase inhibition reduces the plateau phase of the calcium increase in response to progesterone in human sperm

1995 • 73 citations

Fusion of prostasomes to human spermatozoa stimulates the acrosome reaction

2003 • 68 citations

Assessment of Different Sperm Quality Parameters to Predict in vitro Fertility of Bulls

2002 • 68 citations

The extragenomic action of progesterone on human spermatozoa: evidence for a ubiquitous response that is rapidly down-regulated.

1996 • 66 citations

Identification of Rat Cysteine-Rich Secretory Protein 4 (Crisp4) as the Ortholog to Human CRISP1 and Mouse Crisp4

2006 • 66 citations

Patterns of [Ca2+]i mobilization and cell response in human spermatozoa exposed to progesterone

2006 • 61 citations

Encoding of progesterone stimulus intensity by intracellular [Ca2+] ([Ca2+]i) in human spermatozoa

2003 • 60 citations

Requirement of protein tyrosine kinase and phosphatase activities for human sperm exocytosis

2003 • 60 citations

Roles of glycodelin in modulating sperm function

2006 • 60 citations

Dual regulation of the T‐type Ca²⁺ current by serum albumin and β‐estradiol in mammalian spermatogenic cells

2000 • 59 citations

A novel functional estrogen receptor on human sperm membrane interferes with progesterone effects

2000 • 58 citations

Classic and Non-classic Progesterone Receptors are both Expressed in Human Spermatozoa

2005 • 58 citations

Involvement of an Unnamed Protein, RDA288, in the Mechanism through which Progesterone Mediates Its Antiapoptotic Action in Spontaneously Immortalized Granulosa Cells

2004 • 56 citations

Zona pellucida-induced acrosome reaction in human sperm: dependency on activation of pertussis toxin-sensitive Gi protein and extracellular calcium, and priming effect of progesterone and follicular fluid

2002 • 55 citations

Fertilization and early embryology: Sperm interaction with human oviductal cells in vitro

1996 • 55 citations

Effect of intracellular pH on depolarization-evoked calcium influx in human sperm

2004 • 54 citations

Development of a novel home sperm test

2005 • 54 citations

Fertilization and early embrology: A sequential analysis of the effect of progesterone on specific sperm functions crucial to fertilization in vitro in infertile patients*

1994 • 52 citations

Slow calcium oscillations in human spermatozoa

2004 • 51 citations

γ-Aminobutyric acid (GABA) a and b receptors mediate the stimulatory effects of GABA on the human sperm acrosome reaction: interaction with progesterone

1999 • 49 citations

Porcine spermatozoa contain more than one membrane progesterone receptor

2004 • 47 citations

The Effect of Steroid Hormones on Motility and Selective Migration of X- and Y-Bearing Human Spermatozoa

1976 • 46 citations

Progesterone initiation of the human sperm acrosome reaction: the obligatory increase in intracellular calcium is independent of the chloride requirement

1994 • 44 citations

Regulation of mammalian sperm capacitation by endogenous molecules

2006 • 43 citations

Nifedipine reveals the existence of two discrete components of the progesterone-induced [Ca2+]i transient in human spermatozoa

2003 • 43 citations

Binding of 17-β-estradiol to the outer surface and nucleus of human spermatozoa

1979 • 41 citations

Are high-affinity progesterone binding site(s) from porcine liver microsomes members of the σ receptor family?

1998 • 40 citations

Stimulation of the zona-free hamster ova penetration efficiency by human spermatozoa after 17β-estradiol treatment

1983 • 39 citations

Implication of cAMP during porcine sperm capacitation and protein tyrosine phosphorylation

2004 • 39 citations

Differential Nuclear Localization of the Cancer/Testis-Associated Protein, SPAN-X/CTp11, in Transfected Cells and in 50% of Human Spermatozoa1

2001 • 38 citations

Aromatase and oestrogens in human male germ cells

2005 • 37 citations

Andrology: Classification of male factor infertility relevant to in-vitro fertilization insemination strategies using mannose ligands, acrosome status and anti-cytoskeletal antibodies

1996 • 36 citations

The Effect of Steroids on the in Vitro Migration of Washed Human Spermatozoa in Modified Tyrode’S Solution or in Fasting Human Blood Serum

1979 • 36 citations

Protein kinase C-mediated phosphorylation of the two polybasic regions of synaptotagmin VI regulates their function in acrosomal exocytosis

2005 • 36 citations

Unusual steroid specificity of the cell surface progesterone receptor on human sperm.

1996 • 36 citations

Intracellular calcium measurements in individual human sperm demonstrate that the majority can respond to progesterone

1995 • 35 citations

Progesterone induces activation in Octopus vulgaris spermatozoa

2001 • 30 citations

Simultaneous activation of PLA2 and PLC are required to promote acrosomal reaction stimulated by progesterone via G‐proteins

2004 • 29 citations

The metabolism and motility of human spermatozoa in the presence of steroid hormones and synthetic progestagens

1978 • 29 citations

Caprine sperm acrosome reaction: promotion by progesterone and homologous zona pellucida

2000 • 27 citations

Preovulatory follicular fluid steroid levels in stimulated and unstimulated cycles triggered with human chorionic gonadotropin

1991 • 26 citations

Andrology: Undetectable expression of genomic progesterone receptor in human spermatozoa

1995 • 25 citations

POTASSIUM INCREASES INTRACELLULAR CALCIUM SIMULATING PROGESTERONE ACTION IN HUMAN SPERM

2000 • 22 citations

Nitric oxide and fusion with prostasomes increase cytosolic calcium in progesterone-stimulated sperm

2002 • 21 citations

Doses of levonorgestrel comparable to that delivered by the levonorgestrel-releasing intrauterine system can modify the in vitro expression of zona binding sites of human spermatozoa

2005 • 21 citations

Comparative concentrations of steroid hormones and proteins in human peri-ovulatory peritoneal and follicular fluids

2006 • 20 citations

An Experimental Analysis of Female Sterility in the Rabbit

1952 • 17 citations

Epididymal genomics and the search for a male contraceptive

2006 • 16 citations

INFLUENCE OF PROGESTERONE AND GABA A RECEPTOR ON CALCIUM MOBILIZATION DURING HUMAN SPERM ACROSOME REACTION

1999 • 16 citations

Steroidal Sigma Receptor Ligands Affect Signaling Pathways in Human Spermatozoa1

2000 • 14 citations

Sperm binding to the human zona pellucida and calcium influx in response to GnRH and progesterone

2002 • 14 citations

Effects of progesterone on human spermatozoa: clinical implications.

1999 • 8 citations