Progesterone as an immunomodulatory molecule

Bidirectional cytokine interactions in the maternal-fetal relationship: is successful pregnancy a TH2 phenomenon?

1993 • 2,828 citations

STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS

1985 • 1,911 citations

A Class I Antigen, HLA-G, Expressed in Human Trophoblasts

1990 • 1,417 citations

Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids

1980 • 925 citations

A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids.

1980 • 841 citations

Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production.

1995 • 676 citations

Human lymphocytes bearing T cell receptor gamma/delta are phenotypically diverse and evenly distributed throughout the lymphoid system.

1989 • 547 citations

Evidence for extrathymic changes in the T cell receptor gamma/delta repertoire.

1990 • 510 citations

Prostaglandin E2 differentially modulates cytokine secretion profiles of human T helper lymphocytes.

1993 • 491 citations

Two forms of the T-cell receptor γ protein found on peripheral blood cytotoxic T lymphocytes

1987 • 391 citations

Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2.

1994 • 374 citations

A progesterone-dependent immunomodulatory protein alters the Th1Th2 balance

1996 • 347 citations

Preconceptional natural-killer-cell activity as a predictor of miscarriage

1995 • 326 citations

Sex steroid receptors in peripheral T cells: absence of androgen receptors and restriction of estrogen receptors to OKT8-positive cells.

1983 • 308 citations

The Antiprogestin Steroid RU 486 and Human Fertility Control

1985 • 298 citations

Recognition of a Peptide Antigen by Heat Shock--reactive γδ T Lymphocytes

1990 • 291 citations

Cell populations in human early pregnancy decidua: characterization and isolation of large granular lymphocytes by flow cytometry.

1988 • 284 citations

V gamma 2V delta 2 TCR-dependent recognition of non-peptide antigens and Daudi cells analyzed by TCR gene transfer.

1995 • 276 citations

INFLUENCE OF ACETYLSALICYLIC ACID, AN INHIBITOR OF PROSTAGLANDIN SYNTHESIS, ON THE DURATION OF HUMAN GESTATION AND LABOUR

1973 • 275 citations

Prostaglandin E2 and Dexamethasone Inhibit IL-12 Receptor Expression and IL-12 Responsiveness

1998 • 213 citations

Differential Regulation of Interleukin-10 (IL-10) and IL-12 by Glucocorticoids In Vitro

1998 • 203 citations

Differential modulation of T helper type 1 (Th1) and T helper type 2 (Th2) cytokine secretion by prostaglandin E₂ critically depends on interleukin‐2

1995 • 181 citations

Infiltrating decidual natural killer cells are associated with spontaneous abortion in mice

1988 • 181 citations

Adverse effect of pregnancy on melanoma. A reappraisal

1976 • 175 citations

Human Vγ9‐Vδ2 cells are stimulated in a crossreactive fashion by a variety of phosphorylated metabolites

1995 • 168 citations

Oestrogen and Human T Lymphocytes: Presence of Specific Receptors in the T‐Suppressor/Cytotoxic Subset

1988 • 164 citations

The Mechanism of the Inhibitory Effect of Progesterone on Lymphocyte Cytotoxicity: I. Progesterone‐Treated Lymphocytes Release a Substance Inhibiting Cytotoxicity and Prostaglandin Synthesis

1985 • 163 citations

The Immunological Pregnancy Protective Effect of Progesterone Is Manifested via Controlling Cytokine Production

1996 • 163 citations

HLA-Related Control of Spontaneous and Antibody-Dependent Cell-Mediated Cytotoxic Activity in Humans

1976 • 161 citations

A Nongenomic Mechanism for Progesterone-mediated Immunosuppression: Inhibition of K+ Channels, Ca2+ Signaling, and Gene Expression in T Lymphocytes

1998 • 160 citations

Modulation of the natural killer cell activity in pregnant mice alters the spontaneous abortion rate

1987 • 150 citations

Immunosuppression by sex steroid hormones. The effect upon PHA- and PPD-stimulated lymphocytes.

1977 • 148 citations

Immunoregulatory effects of a suppressor factor from healthy pregnant women's lymphocytes after progesterone induction

1989 • 142 citations

The rabbit progesterone receptor. Evidence for a single steroid-binding subunit and characterization of receptor mRNA.

1984 • 140 citations

Reactivity of lymphocytes to a progesterone receptor-specific monoclonal antibody

1990 • 137 citations

Evaluation of oestrogen and progesterone receptor expression in uterine mucosal lymphocytes

1996 • 136 citations

Pharmacological Profile of RU 486 in Animals

1985 • 136 citations

PGE2-mediated immunosuppression by first trimester human decidual cells blocks activation of maternal leukocytes in the decidua with potential anti-trophoblast activity

1989 • 134 citations

A Murine Model of Preterm Labor: Inflammatory Mediators Regulate the Production of Prostaglandin E2 and Interleukin-6 by Murine Decidua

1993 • 131 citations

Progesterone‐Induced Blocking Factor Inhibits Degranulation of Natural Killer Cells

1999 • 128 citations

Gamma delta T cells can recognize nonclassical MHC in the absence of conventional antigenic peptides.

1994 • 122 citations

Hormonal Regulation of Immunoglobulins: Influence of Estradiol on Immunoglobulins A and G in the Rat Uterus*

1980 • 118 citations

Cell populations in the human early pregnancy decidua: natural killer activity and response to interleukin-2 of CD56-positive large granular lymphocytes.

1990 • 114 citations

Recognition of trophoblasts by gamma delta T cells.

1994 • 112 citations

Immunomorphologic Studies of Human Decidua - Associated Lymphoid Cells in Normal Early Pregnancy

1995 • 112 citations

Characterization of murine decidual natural killer (NK) cells and their relevance to the success of pregnancy

1985 • 110 citations

Phenotypic and functional studies of leukocytes in human endometrium and endometriosis

1998 • 109 citations

The Role of γ/δ T Cells in Progesterone‐Mediated Immunomodulation During Pregnancy: A Review

1999 • 103 citations

The Antiabortive Effect of Progesterone-Induced Blocking Factor in Mice Is Manifested by Modulating NK Activity

1997 • 103 citations

Maternal anti-placental reactivity in natural, immunologically-mediated fetal resorptions.

1994 • 102 citations

Activation of uterine intraepithelial γδ T cell receptor‐positive lymphocytes during pregnancy

1993 • 98 citations

Immunomorphologic studies of human decidua-associated lymphoid cells in normal early pregnancy.

1994 • 97 citations

Cytokine Production by Lymphocytes in Pregnancy

1997 • 96 citations

Gamma delta T cells of human early pregnancy decidua: evidence for local proliferation, phenotypic heterogeneity, and extrathymic differentiation.

1997 • 95 citations

The Expression of a Progesterone‐Induced Immunomodulatory Protein in Pregnancy Lymphocytes

1995 • 94 citations

Normal murine and porcine embryos recruit NK cells to the uterus

1988 • 94 citations

The Role of γ/δ T Cell Receptor Positive Cells in Pregnancy

1999 • 92 citations

Decidual Natural Killer Cytotoxicity Decreased in Normal Pregnancy but Not in Anembryonic Pregnancy and Recurrent Spontaneous Abortion

1995 • 84 citations

Lymphocytic progesterone receptors in normal and pathological human pregnancy

1989 • 83 citations

Progesterone and Non‐specific Immunologic Mechanisms in Pregnancy

1997 • 82 citations

MECHANISM OF INHIBITION OF PROSTAGLANDIN BIOSYNTHESIS BY HYDROCORTISONE IN RAT LEUCOCYTES

1979 • 78 citations

Reproductive Immunology 1989

1990 • 78 citations

Endometrial leucocytes: expression of steroid hormone receptors.

1998 • 78 citations

Sex hormones and dexamethasone modulate interleukin-5 gene expression in T lymphocytes

1993 • 76 citations

Inhibitory effect of progesterone and 20α-hydroxypregn-4-en-3-one on the phytohemagglutinin-induced transformation of human lymphocytes

1977 • 75 citations

The suppressive effect of progesterone on lymphocyte cytotoxicity: unique progesterone sensitivity of pregnancy lymphocytes

1985 • 73 citations

Differential expression of the class I MHC genes in the embryo and placenta during midgestational development in the mouse.

1989 • 72 citations

Placental Expression of HLA Class I Genes

1996 • 69 citations

Pregnant mice are not primed but can be primed to fetal alloantigens.

1979 • 67 citations

The role of gamma/delta T-cell receptor-positive cells in pregnancy: part II.

1999 • 66 citations

Synchronous Expansion of Intermediate TCR Cells in the Liver and Uterus during Pregnancy

1995 • 66 citations

Immunologic factors contributing to the initiation of labor—Lymphocyte reactivity in term labor and threatened preterm delivery

1986 • 61 citations

The release of PGF2α and PGE2 from separated cells of human endometrium and decidua

1988 • 61 citations

Varicella pneumonia in pregnancy

1968 • 58 citations

Estrogen and progesterone receptors in some human myeloma cell lines and murine hybridomas

1988 • 55 citations

Progesterone facilitates Implantation of Xenogenic Cultured Cells in Hamster Uterus

1972 • 55 citations

Progesterone Induced Blocking Factor Seen in Pregnancy Lymphocytes Soon After Implantation

1996 • 55 citations

Interleukin-1β-stimulated PGE2 production from early first trimester human decidual cells is inhibited by dexamethasone and progesterone

1995 • 55 citations

Suppression of murine allogeneic cell interactions by sex hormones

1979 • 54 citations

Early Recognition of Pregnancy by the Maternal Immune System

1998 • 54 citations

ADVERSE EFFECT OF PREGNANCY ON MELANOMA

1976 • 53 citations

HLA Class I Expression on the Materno‐Fetal Interface

1997 • 51 citations

Enhancement of the Expression of Progesterone Receptor on Progesterone‐Treated Lymphocytes After Immunotherapy in Unexplained Recurrent Spontaneous Abortion

1996 • 49 citations

The Fetal Thymus of Guinea Pig as an Estrogen Target Organ*

1982 • 49 citations

The potentiating effect of pregnancy on humoral immune responses of mice

1991 • 49 citations

Recognition of MHC TL Gene Products by γδ T Cells

1991 • 49 citations

Immunosuppressive effect of serum progesterone during pregnancy depends on the progesterone binding capacity of the lymphocytes

1983 • 49 citations

The Role of γ/δ T‐Cell Receptor‐Positive Cells in Pregnancy: Part II

1999 • 48 citations

The Effect of a Progesterone‐Induced Immunologic Blocking Factor on NK‐Mediated Resorption

1990 • 47 citations

Estradiol induced alterations of the immune system— I. Enhancement of IgM production

1985 • 45 citations

Phenotypic characterization of normal human placental mononuclear cells

1993 • 44 citations

Progesterone receptors in lymphocytes of liver-transplanted and transfused patients

1989 • 42 citations

An analysis of the uterine lymphocyte-derived hybridoma cell line GWM 1–2 for expression of receptors for estrogen, progesterone and interleukin 2

1996 • 39 citations

A single human cell expresses all messenger ribonucleic acids: the arrow of time in a cell

1998 • 38 citations

Dynamics of Eosinophils in the Uterus after Oestrogen Administration

1976 • 37 citations

Lymphocyte‐Derived Progesterone‐Induced Blocking Factor Corrects Resorption in a Murine Abortion System

1990 • 34 citations

Increased Expression of Cell Surface Markers on Endometrial γδ T‐Cell Receptor⁺ Intraepithelial Lymphocytes Induced by the Local Presence of the Sheep Conceptus

1997 • 32 citations

A progesterone-induced blocking factor corrects high resorption rates in mice treated with antiprogesterone

1990 • 31 citations

Reproductive Immunology

1999 • 31 citations

Progesterone receptor in chicken bursa of Fabricius and thymus: evidence for expression in B-lymphocytes

1998 • 29 citations

Progesterone Suppression of Pregnancy Lymphocytes Is not Mediated by Glucocorticoid Effect

1990 • 27 citations

Possible mediators in endotoxin-induced abortion

1990 • 22 citations

A high-affinity, low-capacity receptor for estradiol in normal and anemic mouse spleen cytosols

1977 • 21 citations

Cyclooxygenase is involved in the effects of progesterone-induced blocking factor on the production of interleukin 12

2000 • 18 citations

Tuberculin Reaction in Tuberculosis during Pregnancy1

2019 • 17 citations

Familial Malignant Melanoma of the Female Genitalia

1979 • 17 citations

The effect of prostaglandins and indomethacin on cytotoxic T-lymphocytes and their precursors

1989 • 15 citations

Modulation of human lymphocyte response to phytohemagglutinin by antineoplastic prostaglandins

1992 • 14 citations

Murine Pregnancies Predisposed to Spontaneous Resorption Show Alterations in the Concentrations of Leukotriene B4 and Prostaglandin E21

1992 • 13 citations

Influence of treatment with prostaglandin synthesis inhibitor or progesterone on cytotoxic activity and progesterone binding capacity of lymphocytes during pregnancy

1983 • 12 citations

Familial Malignant Melanoma of the Female Genitalia

1979 • 9 citations

Prolonged gestation does not extend survival of uterine Natural Killer lymphocytes in mice deleted in the receptor for prostaglandin F2α

2000 • 8 citations

Relationships of prostaglandin levels and natural killer (NK) cell cytotoxicity of mononuclear cells in cord blood.

1984 • 7 citations

Effect of Antiprogestin ZK 98.734 on the Ovarian Cycle, Early Pregnancy, and on its Binding to Progesterone Receptors in the Myometrium of Marmoset Callithrix Jacchus

1988 • 7 citations

Influence of the oral administration of micronized progesterone on plasma and tissue levels of steroids in human pregnancy.

1985 • 7 citations

Interaction of progesterone- and cytokine-mediated immunomodulatory mechanisms in favor of successful gestation

1995 • 6 citations

The Nature and Possible Functions of MHC Antigens on the Surface of Human Trophoblast

1999 • 6 citations

Deleted Work

1955 • 0 citations