A JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

THE COLORIMETRIC DETERMINATION OF PHOSPHORUS

1925 • 19,115 citations

The language of covalent histone modifications

2000 • 8,260 citations

Molecular characterization of a peripheral receptor for cannabinoids

1993 • 4,950 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use

2006 • 1,706 citations

Enriched environments, experience-dependent plasticity and disorders of the nervous system

2006 • 1,648 citations

Sirtuins in mammals: insights into their biological function

2007 • 1,625 citations

Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol.

1979 • 1,321 citations

Multiple dopamine D4 receptor variants in the human population

1992 • 967 citations

The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs

2000 • 545 citations

A rapid and simple radioassay for tyrosine hydroxylase activity

1964 • 506 citations

Cloning of the cDNA and gene for a human D2 dopamine receptor.

1989 • 488 citations

The distribution of [3H]kainic acid binding sites in rat CNS as determined by autoradiography

1982 • 481 citations

Molecular cloning and characterization of the human A3 adenosine receptor.

1993 • 421 citations

Enriched environment promotes behavioral and morphological recovery in a mouse model for the fragile X syndrome

2005 • 299 citations

[3H]nitrendipine-labeled calcium channels discriminate inorganic calcium agonists and antagonists.

1982 • 265 citations

[3H]cytisine binding to nicotinic cholinergic receptors in brain.

1991 • 258 citations

The human brain cholecystokinin-B/gastrin receptor. Cloning and characterization.

1993 • 229 citations

Hydroxyeicosanoids Bind to and Activate the Low Affinity Leukotriene B4 Receptor, BLT2

2001 • 200 citations

Opiate receptor binding affected differentially by opiates and opioid peptides

1979 • 187 citations

Guanylate cyclase from bovine lung. A kinetic analysis of the regulation of the purified soluble enzyme by protoporphyrin IX, heme, and nitrosyl-heme.

1982 • 182 citations

Molecular Cloning of a Human, Hemicholinium-3-Sensitive Choline Transporter

2000 • 181 citations

Differential effects of environmental enrichment on behavior and learning of male and female Ts65Dn mice, a model for Down syndrome

2002 • 163 citations

Inhibitory effects of quinolone antibacterial agents on gamma-aminobutyric acid binding to receptor sites in rat brain membranes

1988 • 159 citations

Purification and properties of mitochondrial monoamine oxidase type A from human placenta.

1985 • 149 citations

Benzodiazepine receptors: Temperature dependence of [3H]flunitrazepam binding

1979 • 136 citations

Preparation of a pure monoiodo derivative of the bee venom neurotoxin apamin and its binding properties to rat brain synaptosomes.

1982 • 125 citations

Characterization of two cloned human CB1 cannabinoid receptor isoforms.

1996 • 118 citations

Characterization of the human dopamine D3 receptor expressed in transfected cell lines

1994 • 117 citations

Inhibition of Platelet MAO-B by Kava Pyrone-Enriched Extract from Piper Methysticum Forster (Kava-Kava)

1998 • 109 citations

A threonine residue in the seventh transmembrane domain of the human A1 adenosine receptor mediates specific agonist binding.

1994 • 101 citations

Effect of Inhibitors of GABA Aminotransferase on the Metabolism of GABA in Brain Tissue and Synaptosomal Fractions

1981 • 98 citations

Molecular Cloning and Expression of the Gene Encoding Human Angiotensin II Type 2 Receptor

1994 • 97 citations

Binding of [3H]clonidine to I1-imidazoline sites in bovine adrenal medullary membranes

1993 • 96 citations

(-)-[3H] desmethoxyverapamil labels multiple calcium channel modulator receptors in brain and skeletal muscle membranes: differentiation by temperature and dihydropyridines.

1986 • 92 citations

3H-batrachotoxinin-A benzoate binding to voltage-sensitive sodium channels: inhibition by the channel blockers tetrodotoxin and saxitoxin

1986 • 88 citations

Only controls: Effect of handling, sham injection, and intraperitoneal injection of saline on behavior of mice in an elevated plus-maze

1995 • 84 citations

Studies with synthetic peptide substrates derived from the neuronal protein neurogranin reveal structural determinants of potency and selectivity for protein kinase C

1993 • 75 citations

6,8-Difluoro-4-methylumbiliferyl phosphate: a fluorogenic substrate for protein tyrosine phosphatases

2004 • 71 citations

[3H]diltiazem binding to calcium channel antagonists recognition sites in rat cerebral cortex

1985 • 69 citations

Corticotropin‐releasing factor receptor type 1 from Tupaia belangeri

1998 • 65 citations

Pharmacological characterization of the human vasopressin receptor subtypes stably expressed in Chinese hamster ovary cells

1998 • 64 citations

Development and optimization of high-throughput in vitro protein phosphatase screening assays

2007 • 62 citations

Functional Characterization of Three Mutations of the Endothelin B Receptor Gene in Patients With Hirschsprung’s Disease: Evidence for Selective Loss of Gi Coupling

2001 • 59 citations

Characterization of two affinity states of adenosine A2a receptors with a new radioligand, 2-[2-(4-amino-3-[125I]iodophenyl)ethylamino]adenosine.

1995 • 51 citations

Molecular characterisation of cloned bradykinin B1 receptors from rat and human

1999 • 50 citations

Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene

1994 • 39 citations

SR146131: a new potent, orally active, and selective nonpeptide cholecystokinin subtype 1 receptor agonist. I. In vitro studies.

1999 • 33 citations

Ligand binding and functional properties of human angiotensin AT1 receptors in transiently and stably expressed CHO-K1 cells

2005 • 28 citations

Structurally Unique Inhibitors of Human Mitogen-Activated Protein Kinase Phosphatase-1 Identified in a Pyrrole Carboxamide Library

2007 • 24 citations

Antiestrogenic potency and binding characteristics of the triphenylethylene H1285 in MCF-7 human breast cancer cells.

1985 • 21 citations

Rat brain dendrotoxin receptors associated with voltage-gated potassium channels: dendrotoxin binding and receptor solubilization.

1989 • 17 citations

[6.7-Dihydroxycoumarin (Aesculetin) as a substrate for catechol-o-methyltransferase (author's transl)].

1976 • 13 citations

Resolution of high and low affinity progesterone receptors from human breast carcinoma T47D cells.

1988 • 12 citations

Daily change of cage depresses mass gain in mice.

1990 • 10 citations

Brief cortisol exposure elevates adrenal phenylethanolamine N-methyltransferase after a necessary lag period

1993 • 5 citations

p-chlorophenylalanine-reversible reduction of sigma binding sites by chronic imipramine treatment in rat brain

1992 • 2 citations