Progesterone: the forgotten hormone in men?

Tietz Textbook of Clinical Chemistry

1999 • 2,653 citations

Multiple actions of steroid hormones--a focus on rapid, nongenomic effects.

2000 • 980 citations

Cloning, expression, and characterization of a membrane progestin receptor and evidence it is an intermediary in meiotic maturation of fish oocytes

2003 • 787 citations

Identification, classification, and partial characterization of genes in humans and other vertebrates homologous to a fish membrane progestin receptor

2003 • 697 citations

Evolution of vertebrate steroid receptors from an ancestral estrogen receptor by ligand exploitation and serial genome expansions

2001 • 681 citations

Resurrecting the Ancestral Steroid Receptor: Ancient Origin of Estrogen Signaling

2003 • 672 citations

Leydig Cells: Endocrine, Paracrine, and Autocrine Regulation

1994 • 613 citations

Environmental Signaling: What Embryos and Evolution Teach Us About Endocrine Disrupting Chemicals

2001 • 579 citations

Progesterone and 17 alpha-hydroxyprogesterone. Novel stimulators of calcium influx in human sperm.

1990 • 485 citations

Regulation of innate and adaptive immunity by the female sex hormones oestradiol and progesterone

2003 • 457 citations

Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it.

1992 • 442 citations

Neuroactive steroids: mechanisms of action and neuropsychopharmacological properties

2002 • 433 citations

Steroid induced exocytosis: The human sperm acrosome reaction

1989 • 413 citations

Changes in serum concentrations of conjugated and unconjugated steroids in 40- to 80-year-old men.

1994 • 387 citations

Circulating Levels of Allopregnanolone in Humans: Gender, Age, and Endocrine Influences

1998 • 371 citations

Rationale and design of the LURIC study - a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease

2001 • 344 citations

Phosphatidylinositol 4,5-bisphosphate hydrolysis in human sperm stimulated with follicular fluid or progesterone is dependent upon Ca2+ influx

1989 • 318 citations

Therapeutic administration of progesterone antagonist in a model of Charcot-Marie-Tooth disease (CMT-1A)

2003 • 303 citations

Neurosteroids: a new function in the brain

1991 • 296 citations

Cell surface-binding sites for progesterone mediate calcium uptake in human sperm.

1991 • 291 citations

Steroid hormones and neurosteroids in normal and pathological aging of the nervous system

2003 • 291 citations

Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms

2003 • 265 citations

Regulation of Leydig Cell Steroidogenic Function During Aging1

2000 • 261 citations

Allopregnanolone and progesterone decrease cell death and cognitive deficits after a contusion of the rat pre-frontal cortex

2003 • 254 citations

Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes

2003 • 245 citations

Estrogen Receptor Expression in Prostate Cancer and Premalignant Prostatic Lesions

1999 • 237 citations

Sex Steroid Hormone Receptors in Human Thymoma

2003 • 202 citations

Neurosteroids in depression: a review

2003 • 201 citations

Hormones and Breathing

2002 • 192 citations

Progesterone Protects against Necrotic Damage and Behavioral Abnormalities Caused by Traumatic Brain Injury

2002 • 180 citations

Progesterone acts at the plasma membrane of human sperm

1991 • 179 citations

Relative expression of progesterone receptors A and B in endometrioid cancers of the endometrium.

2001 • 171 citations

Progesterone-induced changes in sleep in male subjects

1997 • 161 citations

Progesterone and its derivatives dihydroprogesterone and tetrahydroprogesterone reduce myelin fiber morphological abnormalities and myelin fiber loss in the sciatic nerve of aged rats

2003 • 161 citations

Behavioral effects and anatomic correlates after brain injury: a progesterone dose–response study

2003 • 157 citations

Identification and Characterization of Functional Nongenomic Progesterone Receptors on Human Sperm Membrane1

1998 • 154 citations

Immunohistochemistry and biochemistry in detection of androgen, progesterone, and estrogen receptors in benign and malignant human prostatic tissue

1992 • 153 citations

Direct effects of progesterone and antiprogesterone on human sperm hyperactivated motility and acrosome reaction

1992 • 151 citations

Minireview: Role of Glia in Neuroendocrine Function

2003 • 150 citations

Reduced Progesterone Metabolites Protect Rat Hippocampal Neurones From Kainic Acid Excitotoxicity In Vivo

2004 • 149 citations

Improvement in Quality‐of‐Life Measures and Stimulation of Weight Gain After Treatment with Megestrol Acetate Oral Suspension in Geriatric Cachexia: Results of a Double‐Blind, Placebo‐Controlled Study

2000 • 143 citations

The FK506-Binding Immunophilin FKBP51 Is Transcriptionally Regulated by Progestin and Attenuates Progestin Responsiveness

2003 • 143 citations

Circadian Rhythm of Salivary Cortisol, 17α-Hydroxyprogesterone, and Progesterone in Healthy Children

2003 • 139 citations

Neurosteroids Enhance Spontaneous Glutamate Release in Hippocampal Neurons

2002 • 131 citations

Male Contraception

2002 • 130 citations

Seizure exacerbation associated with inhibition of progesterone metabolism

2003 • 128 citations

The Contraceptive Agent Provera Enhances GABA_AReceptor-Mediated Inhibitory Neurotransmission in the Rat Hippocampus: Evidence for Endogenous Neurosteroids?

2003 • 127 citations

Systemic progesterone administration results in a partial reversal of the age‐associated decline in CNS remyelination following toxin‐induced demyelination in male rats

2003 • 126 citations

Administration of progesterone produces mild sedative-like effects in men and women

2003 • 125 citations

Neuroprotective Effects of Progesterone on Damage Elicited by Acute Global Cerebral Ischemia in Neurons of the Caudate Nucleus

2002 • 124 citations

Correlation of plasma neurosteroid levels to the severity of negative symptoms in male patients with schizophrenia

2002 • 122 citations

Specific Progesterone Binding to a Membrane Protein and Related Nongenomic Effects on Ca2+-Fluxes in Sperm

1999 • 120 citations

The antagonism between anesthetic steroid hormones and pentamethylenetetrazol (Metrazol)

1942 • 118 citations

Opposite actions of testosterone and progesterone on UCP1 mRNA expression in cultured brown adipocytes

2002 • 114 citations

Antiandrogen Effects of Mifepristone on Coactivator and Corepressor Interactions with the Androgen Receptor

2003 • 112 citations

Direct Effects of Testosterone, 17β-Estradiol, and Progesterone on Adrenergic Regulation in Cultured Brown Adipocytes: Potential Mechanism for Gender-Dependent Thermogenesis

2003 • 110 citations

Immunoelectron microscopic localization of three key steroidogenic enzymes (cytochrome P450(scc), 3 beta-hydroxysteroid dehydrogenase and cytochrome P450(c17)) in rat adrenal cortex and gonads

2001 • 109 citations

P450c17 Deficiency in Brazilian Patients: Biochemical Diagnosis through Progesterone Levels Confirmed by CYP17 Genotyping

2003 • 107 citations

Megestrol Acetate Stimulates Weight Gain and Ventilation in Underweight COPD Patients

2002 • 104 citations

Defective calcium influx and acrosome reaction (spontaneous and progesterone-induced) in spermatozoa of infertile men with severe teratozoospermia

1994 • 102 citations

A functional polymorphism in the progesterone receptor gene is associated with an increase in breast cancer risk.

2003 • 101 citations

Signal transduction pathways in human spermatozoa

2002 • 101 citations

Induction of Adrenal Suppression by Megestrol Acetate in Patients with AIDS

1995 • 98 citations

Leydig Cell Aging: Steroidogenic Acute Regulatory Protein (StAR) and Cholesterol Side‐Chain Cleavage Enzyme

2001 • 96 citations

Progesterone Production and Actions in the Human Central Nervous System and Neurogenic Tumors

2002 • 96 citations

Estrogen Induces de novo Progesterone Synthesis in Astrocytes

2003 • 94 citations

Progress towards hormonal male contraception

2003 • 88 citations

Progesterone, progestagens and the central nervous system

2000 • 85 citations

Effects of Testosterone Replacement and/or Resistance Exercise on the Composition of Megestrol Acetate Stimulated Weight Gain in Elderly Men: A Randomized Controlled Trial

2002 • 85 citations

Glucocorticoid Receptor Antagonism by Cyproterone Acetate and RU486

2003 • 85 citations

Effect of Progesterone on Bovine Sperm Capacitation and Acrosome Reaction

2003 • 82 citations

Progesterone receptor expression in neurofibromas.

2003 • 81 citations

The Human Kidney Is a Progesterone-Metabolizing and Androgen-Producing Organ

2003 • 79 citations

Neuroactive steroids influence peripheral myelination: a promising opportunity for preventing or treating age-dependent dysfunctions of peripheral nerves

2003 • 78 citations

Progesterone receptor expression in human prostate cancer: Correlation with tumor progression

2001 • 78 citations

Basis of progesterone protection in spinal cord neurodegeneration

2002 • 77 citations

Neurosteroids Alter γ-Aminobutyric Acid Postsynaptic Currents in Gonadotropin-Releasing Hormone Neurons: A Possible Mechanism for Direct Steroidal Control

2003 • 77 citations

Decreased Responsiveness to Progesterone of Spermatozoa in Oligozoospermic Patients

1993 • 74 citations

Defective function of a nongenomic progesterone receptor as a sole sperm anomaly in infertile patients

1992 • 74 citations

Zona Pellucida and Progesterone‐Induced Ca²⁺ Signaling and Acrosome Reaction in Human Spermatozoa

2002 • 72 citations

Minireview: Neuronal Steroid Hormone Receptors: They’re Not Just for Hormones Anymore

2003 • 71 citations

Functional properties of the N-terminal region of progesterone receptors and their mechanistic relationship to structure

2003 • 70 citations

Ein Beitrag zur Respirationsphysiologie der Gravidität¹

1912 • 69 citations

Formation and effects of neuroactive steroids in the central and peripheral nervous system

2001 • 68 citations

Hypothalamo-pituitary-adrenal function in human immunodeficiency virus-infected men.

1996 • 64 citations

Use of progestins in male contraception

2003 • 63 citations

Relationship between Serum Gonadotropins and Spermatogenic Suppression in Men Undergoing Steroidal Contraceptive Treatment

2004 • 63 citations

Stimulatory Effect of Progesterone on the Expression of Steroidogenic Acute Regulatory Protein in MA-10 Leydig Cells1

2003 • 62 citations

Sex Hormone Metabolism in Prostate Cancer Cells during Transition to an Androgen-Independent State

2003 • 61 citations

Encoding of progesterone stimulus intensity by intracellular [Ca2+] ([Ca2+]i) in human spermatozoa

2003 • 60 citations

Testosterone Undecanoate Maintains Spermatogenic Suppression Induced by Cyproterone Acetate Plus Testosterone Undecanoate in Normal Men

2003 • 58 citations

Hormone receptors in non-malignant meningiomas correlate with apoptosis, cell proliferation and recurrence-free survival

2003 • 58 citations

The gastrointestinal tract as target of steroid hormone action: Quantification of steroid receptor mRNA expression (AR, ERα, ERβ and PR) in 10 bovine gastrointestinal tract compartments by kinetic RT-PCR

2003 • 55 citations

Excessive Testicular Progesterone Secretion in Aged Male Fischer 344 Rats: A Potential Cause of Age-Related Gonadotropin Suppression and Confounding Variable in Aging Studies

1992 • 54 citations

Transcriptional regulation of the mouse steroid 5alpha-reductase type II gene by progesterone in brain

2002 • 54 citations

Progesterone can participate in down-regulation of the luteinizing hormone receptor gene expression and function in cultured murine Leydig cells

1998 • 52 citations

Testosterone and Testosterone Precursors in the Spermatic Vein and in the Testicular Tissue of Old Men

1980 • 51 citations

Progesterone Action in a Murine Leydig Tumor Cell Line (mLTC-1), Possibly through a Nonclassical Receptor Type¹

2000 • 50 citations

Regulation of Expression of Male-Specific Rat Liver Microsomal 3β-Hydroxysteroid Dehydrogenase

1991 • 48 citations

Immunolocalization of oestrogen and progesterone receptors in prostatic hyperplasia and carcinoma

1996 • 47 citations

Contraceptive Steroids Influence the Hemostatic Activation State in Healthy Men

2002 • 46 citations

Progesterone induces capacitation in human spermatozoa

2009 • 46 citations

Estradiol and progesterone modify microtubule associated protein 2 content in the rat hippocampus

2002 • 46 citations

Identification of functional binding sites for progesterone in rat Leydig cell plasma membrane

1999 • 45 citations

Progesterone as a neuroactive neurosteroid, with special reference to the effect of progesterone on myelination

2000 • 45 citations

Quantitation of cytosolic and nuclear estrogen and progesterone receptor in benign, untreated, and treated malignant human prostatic tissue by radioligand binding and enzyme-immunoassays

1990 • 45 citations

The effect of ovarian hormones on antioxidant enzyme activities in the brain of male rats.

2003 • 43 citations

The expression of the RLF/INSL3 gene is reduced in Leydig cells of the aging rat testis

2002 • 43 citations

In vitro effects of progesterone and progestins on vascular cells

2003 • 42 citations

Membrane-bound Progesterone Receptor Expression in Human Aortic Endothelial Cells

2003 • 42 citations

Biosynthesis and action of neurosteroids in the cerebellar Purkinje neuron

2003 • 42 citations

Effects of chlormadinone acetate, acetazolamide and oxygen on awake and asleep gas exchange in patients with chronic obstructive pulmonary disease (COPD)

1994 • 42 citations

Effects of progesterone on human spermatozoa prepared for in‐vitro fertilization

1996 • 41 citations

The in vitro effect of levonorgestrel on the acrosome reaction of human spermatozoa from fertile men

2003 • 41 citations

Randomized Trials of Megestrol Acetate for AIDS-Associated Anorexia and Cachexia

1994 • 39 citations

Effect of Progesterone Receptor A Predominance on Breast Cancer Cell Migration into Bone Marrow Fibroblasts

2004 • 38 citations

Ontogenetic Expression of Estrogen and Progesterone Receptors in the Mouse Lung

2003 • 37 citations

Specific Progesterone Binding to a Membrane Protein and Related Nongenomic Effects on Ca2+-Fluxes in Sperm

1999 • 37 citations

Leydig cell gene expression: effects of age and caloric restriction

2003 • 36 citations

Androgen, estrogen, and progesterone receptor contents and serum hormone profiles in patients with benign hypertrophy and carcinoma of the prostate

1990 • 36 citations

Anti-glucocorticoid effects of progesterone in vivo on rat adipose tissue metabolism

2003 • 35 citations

Palliative treatment of cancer anorexia with oral suspension of megestrol acetate.

2003 • 35 citations

The effect of ovarian hormones on antioxidant enzyme activities in the brain of male rats

2003 • 34 citations

Effects of the new steroidal antiandrogen TZP‐4238 on hormone‐induced canine prostatic hyperplasia

1992 • 33 citations

Effects of neuroactive steroids on myelin of peripheral nervous system

2003 • 33 citations

Depomedroxyprogesterone Acetate for Hot Flashes

2002 • 30 citations

Progesterone regulation of reproductive function through functionally distinct progesterone receptor isoforms.

2002 • 30 citations

Apparent pregnene hydroxylation deficiency (APHD): seeking the parentage of an orphan metabolome

2003 • 30 citations

Actions of progesterone and its 5α-reduced metabolites on the major proteins of the myelin of the peripheral nervous system

2003 • 29 citations

Effects of progesterone derivatives, dihydroprogesterone and tetrahydroprogesterone, on the subependymal layer of the adult rat

2003 • 29 citations

Multiple meningiomas arising during long-term therapy with the progesterone agonist megesterol acetate

2004 • 28 citations

Cytoskeletal responsiveness to progestins is dependent on progesterone receptor A levels

2003 • 27 citations

Effect of Progesterone on Peripheral Blood Flow in Prepubertal Female Anesthetized Pigs

2001 • 26 citations

Effects of a new steroidal antiandrogen, TZP‐4238 (17 α‐acetoxy‐6‐chloro‐2‐oxa‐4, 6‐pregnadiene‐3, 20‐dione), on spontaneously developed canine benign prostatic hyperplasia

1995 • 26 citations

Molecular Mechanism of Progesterone-Induced Antiproliferation in Rat Aortic Smooth Muscle Cells

2003 • 26 citations

The endocrine pharmacology of testosterone therapy in men

2004 • 26 citations

STUDIES IN HUMAN PHYSIOLOGY

1929 • 25 citations

Renal action of progesterone: effect on calcium reabsorption

2002 • 25 citations

Finasteride inhibits the progesterone-induced spike-wave discharges in a genetic model of absence epilepsy

2003 • 24 citations

Gonadotropin‐Mediated Regulation of the Murine VEGF Expression in MA‐10 Leydig Cells

2004 • 24 citations

THE MECHANISM OF ANTIANDROGENIC ACTION OF CHLORMADINONE ACETATE

1977 • 24 citations

Assessment of Cognitive Performance after Progesterone Administration in Healthy Male Volunteers

1997 • 24 citations

Medroxyprogesterone and paraphiles: do testosterone levels matter?

1996 • 23 citations

Histological evaluation of benign prostatic hyperplasia treated by long‐term administration of chlormadinone acetate (CMA)

1994 • 23 citations

Hormonal regulation of atypical absence seizures

2004 • 23 citations

Mifepristone pretreatment overcomes resistance of prostate cancer cells to tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL).

2002 • 23 citations

Rapid, non-genomic actions of progesterone and estradiol on steady-state calcium and resting calcium influx in lens epithelial cells

2002 • 22 citations

Male contraception

2002 • 21 citations

Regulation of progesterone receptor isoforms expression by sex steroids in the rat lung

2003 • 20 citations

Stimulation of voltage-dependent calcium channels during capacitation and by progesterone in human sperm

2002 • 20 citations

Follicular-phase serum progesterone levels of nonsmoking women do not differ from the levels of nonsmoking men

1990 • 20 citations

Downregulation of androgen, estrogen and progesterone receptor genes and protein is involved in aging-related erectile dysfunction

2003 • 19 citations

Serum ionized magnesium and calcium and sex hormones in healthy young men: importance of serum progesterone level

1999 • 19 citations

Progesterone Receptor Availability in Mouse Spermatozoa During Epididymal Transit and Capacitation: Ligand Blot Detection of Progesterone‐Binding Protein

2003 • 19 citations

Combined treatment with acetazolamide and medroxyprogesterone in chronic obstructive pulmonary disease patients

2002 • 18 citations

Demonstration of progesterone receptor‐mediated gonadotrophin suppression in the human male

2003 • 18 citations

Distribution and metabolism of topically applied progesterone in a rat model

2002 • 17 citations

Influence of sexual hormone antagonists on the anticonvulsant action of conventional antiepileptic drugs against electrically- and pentylenetetrazol-induced seizures in mice

2003 • 17 citations

Localization of testosterone and 3β‐hydroxysteroid dehydrogenase/Δ⁵‐Δ⁴‐isomerase in cynomolgus monkey (Macaca fascicularis) testes

1998 • 15 citations

Progesterone increase under DHEA-substitution in males

2003 • 15 citations

High-dose progesterone infusion in healthy males: evidence against antiglucocorticoid activity of progesterone

1995 • 15 citations

Expression and Degradation of Rat Androgen Receptor Following Castration, Testosterone Replacement and Antiandrogens Administration: Analysis by Western Blot and Immunohistochemistry.

1997 • 13 citations

Effects of some steroid hormones on head-to-head association in bovine spermatozoa

1978 • 12 citations

Progesterone decreases mating and estradiol uptake in preoptic areas of male monkeys

2001 • 12 citations

Evaluation of the effect of 17αOH‐progesterone and 17β‐oestradiol on human sperm ability to fuse with oocytes: comparison and possible interference with the effect of progesterone

2003 • 11 citations

Rapid Progression of Advanced “Hormone-Resistant” Prostate Cancer During Palliative Treatment with Progestins for Cancer Cachexia

2003 • 11 citations

Progesterone Metabolism in Human Leukemic Monoblast U937 Cells.

2002 • 11 citations

Sex steroid metabolism in human gastric mucosa: 17 beta-hydroxysteroid dehydrogenase type 2 in normal, inflamed and neoplastic gastric tissues.

2003 • 10 citations

Aldosterone- and Progesterone-Membrane-Binding Proteins New Concepts of Nongenomic Steroid Action

2000 • 10 citations

Progesterone and testicular function

1999 • 8 citations

Neuroactive steroid mechanisms and GABA type A receptor subunit assembly in hypothalamic and extrahypothalamic regions

2002 • 7 citations

‘New’ active steroids and an unforeseen mechanism of action

2000 • 6 citations

Effect of norethisterone and its A-ring reduced metabolites on the acrosome reaction in porcine spermatozoa

2002 • 6 citations

Testosterone and Sexual Experience Alter Levels of Plasma Membrane Binding Sites for Progesterone in the Male Rat Brain

2003 • 5 citations

Serum progesterone levels in patients with gastric adenocarcinoma before and after gastrectomy

1998 • 3 citations

Possible effects of progesterone on human central nervous system and neurogenic tumors

2004 • 2 citations

Immunohistochemical Studies of the Effect of Chlormadinone Acetate (CMA) on Prostatic Hyperplasia.

2002 • 1 citations