Imaging Sigma Receptors: Applications in Drug Development

The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dog.

1976 • 2,883 citations

Purification, molecular cloning, and expression of the mammalian sigma1-binding site.

1996 • 880 citations

Pitfalls in Oncologic Diagnosis with FDG PET Imaging: Physiologic and Benign Variants

1999 • 827 citations

Neurosteroids: of the nervous system, by the nervous system, for the nervous system.

1997 • 643 citations

NEUROSTEROIDS: A NOVEL FUNCTION OF THE BRAIN

1998 • 598 citations

Cocaine self-administration in dopamine-transporter knockout mice

1998 • 523 citations

Cocaine reward models: Conditioned place preference can be established in dopamine- and in serotonin-transporter knockout mice

1998 • 502 citations

Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines.

1995 • 477 citations

Anatomy of SUV

2000 • 453 citations

Triggering of Myocardial Infarction by Cocaine

1999 • 436 citations

Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus.

1995 • 426 citations

Cloning and Functional Expression of the Human Type 1 Sigma Receptor (hSigmaR1)

1996 • 409 citations

Clinical Role of FDG PET in Evaluation of Cancer Patients

2003 • 388 citations

Autoradiographic localization of sigma receptor binding sites in guinea pig and rat central nervous system with (+)3H-3-(3-hydroxyphenyl)-N-(1- propyl)piperidine

1986 • 385 citations

FDG Accumulation and Tumor Biology

1998 • 365 citations

Synthesis and evaluation of 18F-labeled choline as an oncologic tracer for positron emission tomography: initial findings in prostate cancer.

2001 • 356 citations

Pharmacological and autoradiographic discrimination of sigma and phencyclidine receptor binding sites in brain with (+)-[3H]SKF 10,047, (+)-[3H]-3-[3-hydroxyphenyl]-N-(1-propyl)piperidine and [3H]-1-[1-(2-thienyl)cyclohexyl]piperidine.

1986 • 339 citations

Value of [ ¹¹ C]choline-Positron Emission Tomography for Re-Staging Prostate Cancer: A Comparison With [ ¹⁸ F]fluorodeoxyglucose-Positron Emission Tomography

2003 • 310 citations

Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors

1996 • 296 citations

??-1 Receptor Ligands

2004 • 286 citations

The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical models.

2003 • 285 citations

Increased uptake of the apoptosis-imaging agent (99m)Tc recombinant human Annexin V in human tumors after one course of chemotherapy as a predictor of tumor response and patient prognosis.

2002 • 282 citations

Sigma1 (σ1) receptor agonists and neurosteroids attenuate β25–35-amyloid peptide-induced amnesia in mice through a common mechanism

1998 • 280 citations

Dehydroepiandrosterone Monotherapy in Midlife-Onset Major and Minor Depression

2005 • 252 citations

From tumor biology to clinical PET: A review of positron emission tomography (PET) in oncology

2001 • 252 citations

Clinically significant inaccurate localization of lesions with PET/CT: frequency in 300 patients.

2003 • 248 citations

Rapid detection of human infections with fluorine-18 fluorodeoxyglucose and positron emission tomography: preliminary results

1998 • 242 citations

Steroids, neuroactive steroids and neurosteroids in psychopathology

2004 • 239 citations

Sigma receptors: recent advances and new clinical potentials

2000 • 239 citations

Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell lines.

2002 • 238 citations

Sigma receptors: biology and therapeutic potential

2004 • 235 citations

Effective Tumor Cell Death by σ-2 Receptor Ligand Siramesine Involves Lysosomal Leakage and Oxidative Stress

2005 • 228 citations

Sigma-2 receptors as a biomarker of proliferation in solid tumours

2000 • 226 citations

The interaction between neuroactive steroids and the σ1 receptor function: behavioral consequences and therapeutic opportunities

2001 • 221 citations

Development of (18)F-fluoroethylcholine for cancer imaging with PET: synthesis, biochemistry, and prostate cancer imaging.

2002 • 212 citations

Cocaine binding at σ receptors

1988 • 208 citations

Dehydroepiandrosterone Augmentation in the Management of Negative, Depressive, and Anxiety Symptoms in Schizophrenia

2003 • 204 citations

Pharmacotherapies for Treatment of Cocaine Abuse: Preclinical Aspects

1999 • 204 citations

Neurosteroids in depression: a review

2003 • 201 citations

Binding properties of SA4503, a novel and selective σ1 receptor agonist

1996 • 186 citations

Understanding the Molecular Mechanism of Sigma-1 Receptors: Towards A Hypothesis that Sigma-1 Receptors are Intracellular Amplifiers for Signal Transduction

2003 • 182 citations

Neuroactive Neurosteroids as Endogenous Effectors for the Sigma1 (.SIGMA.1) Receptor. Pharmacological Evidence and Therapeutic Opportunities.

1999 • 181 citations

The antidepressant-like effect induced by sigma(1)-receptor agonists and neuroactive steroids in mice submitted to the forced swimming test.

2001 • 178 citations

Cocaine Increases the Endothelial Release of Immunoreactive Endothelin and Its Concentrations in Human Plasma and Urine

1998 • 174 citations

A Genome-Based Resource for Molecular Cardiovascular Medicine

1997 • 171 citations

Positron-emission tomography with [18F]fluorodeoxyglucose

2000 • 170 citations

Visualization of Prostate Cancer with 11C-Choline Positron Emission Tomography

2002 • 167 citations

18F-FDG PET evaluation of the response to therapy for lymphoma and for breast, lung, and colorectal carcinoma.

2003 • 165 citations

Exon‐Intron Structure, Analysis of Promoter Region, and Chromosomal Localization of the Human Type 1 σ Receptor Gene

1998 • 161 citations

Quantitative assessment of tumor metabolism using FDG-PET imaging

2000 • 159 citations

σ Receptors: potential medications development target for anti-cocaine agents

2003 • 159 citations

Combined 18F-FDG and 11C-methionine PET scans in patients with newly progressive metastatic prostate cancer.

2002 • 159 citations

σ-Receptors in Endocrine Organs: Identification, Characterization, and Autoradiographic Localization in Rat Pituitary, Adrenal, Testis, and Ovary

1989 • 158 citations

The Increased Accumulation of [18F]Fluorodeoxyglucose in Untreated Prostate Cancer

1999 • 154 citations

Neurosteroids Affect Spatial/Reference, Working, and Long-Term Memory of Female Rats

1995 • 154 citations

Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain

1986 • 152 citations

Sigma1 (σ1) receptor antagonists represent a new strategy against cocaine addiction and toxicity

2002 • 152 citations

Increased Diurnal Plasma Concentrations of Dehydroepiandrosterone in Depressed Patients

1998 • 146 citations

Overexpression of sigma receptors in nonneural human tumors.

1991 • 138 citations

The Role of Sigma Receptors in Depression

2005 • 137 citations

[3H]1,3-di(2-tolyl)guanidine and [3H](+)pentazocine binding sites in the rat brain: Autoradiographic visualization of the putative sigma1 and sigma2 receptor subtypes

1997 • 135 citations

Pharmacophore Identification for Sigma-1 (σ1) Receptor Binding: Application of the "Deconstruction - Reconstruction - Elaboration" Approach

2005 • 133 citations

Intratumoral distribution of tritiated-FDG in breast carcinoma: correlation between Glut-1 expression and FDG uptake.

1996 • 133 citations

Clinical profile of remoxipride ‐ a combined analysis of a comparative double‐blind multicentre trial programme

1990 • 132 citations

Uptake of positron emission tomography tracers in experimental bacterial infections: a comparative biodistribution study of radiolabeled FDG, thymidine, l -methionine, 67 Ga-citrate, and 125 I-HSA

1999 • 129 citations

Modulation of nmda and dopaminergic neurotransmissions by sigma ligands: Possible implications for the treatment of psychiatric disorders

1996 • 129 citations

Dehydroepiandrosterone sulfate attenuates dizocilpine-induced learning impairment in mice via σ1-receptors

1997 • 125 citations

Accumulation of [ 11 C]acetate in normal prostate and benign prostatic hyperplasia: comparison with prostate cancer

2002 • 125 citations

Phencyclidine and σ opiate receptors in brain: Biochemical and autoradiographical differentiation

1985 • 124 citations

σ1 Receptor subtype is involved in the relief of behavioral despair in the mouse forced swimming test

1996 • 119 citations

NE-100, a novel sigma receptor ligand: In vivo tests

1993 • 116 citations

Discovery of High-Affinity Ligands of σ₁ Receptor, ERG2, and Emopamil Binding Protein by Pharmacophore Modeling and Virtual Screening

2005 • 116 citations

Regulation of [3H]dopamine release from rat striatal slices by sigma receptor ligands.

1994 • 116 citations

Potentiation by dehydroepiandrosterone of the neuronal response to N-methyl-D-aspartate in the CA3 region of the rat dorsal hippocampus: an effect mediated via sigma receptors.

1996 • 114 citations

ProstaScint scan may enhance identification of prostate cancer recurrences after prostatectomy, radiation, or hormone therapy: analysis of 136 scans of 100 patients.

1998 • 111 citations

The modulation by neurosteroids of the scopolamine-induced learning impairment in mice involves an interaction with sigma1 (σ1) receptors

1998 • 108 citations

Multicenter ProstaScint imaging findings in 2154 patients with prostate cancer

2000 • 108 citations

Fluorine-18-Labelled Fluoropyridines: Advances in Radiopharmaceutical Design

2005 • 106 citations

Sigma receptor ligands modulate contractility, Ca++ influx and beating rate in cultured cardiac myocytes.

1994 • 106 citations

Electrophysiological effects of selective ?-receptor agonists, antagonists, and the selective phencyclidine receptor agonist MK-801 on midbrain dopamine neurons

1989 • 106 citations

In vivo evaluation of [11C]SA4503 as a PET ligand for mapping CNS sigma1 receptors

2000 • 104 citations

Involvement of sigma receptors in the behavioral effects of cocaine: evidence from novel ligands and antisense oligodeoxynucleotides

2002 • 101 citations

Role of 2-[18F]-Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) in the Early Assessment of Response to Chemotherapy in Metastatic Breast Cancer Patients

2000 • 100 citations

Neurosteroids: Molecular mechanisms of action and psychopharmacological significance

1996 • 99 citations

Sigma binding states in the brain; An emerging concept for multiple sites and their relevance for psychiatric disorders

1990 • 99 citations

Modulation by neurosteroids of the in vivo (+)-[3H]SKF-10,047 binding to ?1 receptors in the mouse forebrain

1996 • 97 citations

Neocortical epileptogenesis in vitro: studies with N-methyl-D-aspartate, phencyclidine, sigma and dextromethorphan receptor ligands.

1989 • 97 citations

Targeting sigma receptor-binding benzamides as in vivo diagnostic and therapeutic agents for human prostate tumors.

1999 • 96 citations

Neuropsychopharmacological properties of neuroactive steroids

1999 • 95 citations

Cocaine-induced seizures and lethality appear to be associated with distinct central nervous system binding sites.

1993 • 93 citations

18F-labeled radiopharmaceuticals for PET in oncology, excluding FDG

2000 • 91 citations

Differential regulation of σ and PCP receptors after chronic administration of haloperidol and phencyclidine in mice

1989 • 91 citations

Analysis of blood clearance and labeled metabolites for the estrogen receptor tracer [F-18]-16α-Fluorestradiol (FES)

1997 • 91 citations

SA4503, a novel cognitive enhancer with σ1 receptor agonist properties, facilitates NMDA receptor-dependent learning in mice

1997 • 89 citations

Sigma receptors modulate both A9 and A10 dopaminergic neurons in the rat brain: functional interaction with NMDA receptors

1990 • 88 citations

σ Binding site ligands inhibit cell proliferation in mammary and colon carcinoma cell lines and melanoma cells in culture

1995 • 88 citations

Endogenous concentrations of DHEA and DHEA-S Decrease with remission of depression in older adults

2001 • 85 citations

σ Receptor Activation Blocks Potassium Channels and Depresses Neuroexcitability in Rat Intracardiac Neurons

2005 • 83 citations

Current status of PET in breast cancer imaging, staging, and therapy

2001 • 82 citations

Sigma-2 receptors are specifically localized to lipid rafts in rat liver membranes

2004 • 82 citations

Comparison of FDG-PET with MIBI-SPECT in the Detection of Breast Cancer and Axillary Lymph Node Metastasis

2000 • 82 citations

σ Receptor-active neuroleptics are cytotoxic to C6 glioma cells in culture

1993 • 82 citations

Measurement of glucose consumption using [18F]fluorodeoxyglucose

2002 • 81 citations

Elevated Blood Levels of Dehydroepiandrosterone Sulphate Vary with Symptom Load in Posttraumatic Stress Disorder: Findings from a Longitudinal Study of Refugees in Sweden

2002 • 81 citations

Inotropic action of σ receptor ligands in isolated cardiac myocytes from adult rats

1995 • 79 citations

Utility of capromab pendetide (ProstaScint) imaging in the management of prostate cancer.

2001 • 78 citations

Selective σ receptor agonist and antagonist affect dopamine neuronal activity

1989 • 78 citations

Cocaine and σ-1 receptors modulate HIV infection, chemokine receptors, and the HPA axis in the huPBL-SCID model

2005 • 77 citations

Beneficial Effects of Acute and Repeated Administrations of σ Receptor Agonists on Behavioral Despair in Mice Exposed to Tail Suspension

1998 • 76 citations

Autoradiographic distribution of [3H](+)-pentazocine and [3H]1,3-di-o-tolylguanidine (DTG) binding sites in guinea pig brain: a comparative study

1992 • 76 citations

Motor effects of two sigma ligands mediated by nigrostriatal dopamine neurons

1989 • 75 citations

Evaluation of preoperative ProstaScint™ scans in the prediction of nodal disease

2002 • 74 citations

Ameliorating effect of SA4503, a novel σ1 receptor agonist, on memory impairments induced by cholinergic dysfunction in rats

1996 • 74 citations

The development of estrogen and progestin radiopharmaceuticals for imaging breast cancer.

1997 • 74 citations

A Perspective on the New Mechanism of Antidepressants: Neuritogenesis Through Sigma-1 Receptors

2004 • 72 citations

Stereoisomers of [3H]-N-allylnormetazocine bind to different sites in mouse brain.

1984 • 71 citations

Standardized uptake value and quantification of metabolism for breast cancer imaging with FDG and L-[1-11C]tyrosine PET.

1997 • 71 citations

Modulation by sigma ligands of N-methyl-D-aspartate-induced [3H]noradrenaline release in the rat hippocampus: G-protein dependency

1992 • 70 citations

Radioiodinated N-(2-Diethylaminoethyl)benzamide Derivatives with High Melanoma Uptake: Structure−Affinity Relationships, Metabolic Fate, and Intracellular Localization

2000 • 70 citations

PET imaging of prostate cancer with 11C-acetate.

2003 • 70 citations

SA4503, a novel cognitive enhancer, with σ1 receptor agonistic properties

1997 • 68 citations

Basal plasma dehydroepiandrosterone sulfate level: a possible predictor for response to electroconvulsive therapy in depressed psychotic inpatients

2000 • 68 citations

Development of a Tc-99m labeled sigma-2 receptor-specific ligand as a potential breast tumor imaging agent

2001 • 68 citations

Sigma receptors are highly concentrated in the rat pineal gland

1990 • 67 citations

N-alkyl substituted analogs of the σ receptor ligand BD1008 and traditional σ receptor ligands affect cocaine-induced convulsions and lethality in mice

2001 • 66 citations

Highly selective σ receptor ligands elevate inositol 1,4,5-trisphosphate production in rat cardiac myocytes

1998 • 66 citations

Metabotropic neurosteroid/sigma-receptor involved in stimulation of nociceptor endings of mice.

2001 • 65 citations

Sigma receptors are associated with cortical limbic areas in the primate brain

1992 • 65 citations

BMY 14802, a Sigma Receptor Ligand for the Treatment of Schizophrenia

1994 • 63 citations

Electrophysiological effects of BMY 14802, a new potential antipsychotic drug, on midbrain dopamine neurons in the rat: acute and chronic studies.

1988 • 62 citations

Clinical Trials with Sigma Ligands

2004 • 61 citations

Positron-emission tomographic imaging of cancer: Glucose metabolism and beyond*

2001 • 61 citations

PET imaging in breast cancer.

2001 • 59 citations

Sigma and opioid receptors in human brain tumors

1990 • 59 citations

Interactions of 16α-[18F]-fluoroestradiol (FES) with sex steroid binding protein (SBP)

1999 • 57 citations

in vivo evaluation of [18F]1-(3-fluoropropyl)-4-(4-cyanophenoxymethyl)piperidine: A Selective sigma-1 receptor radioligand for PET

1997 • 57 citations

Sigma receptors are expressed in human non-small cell lung carcinoma

1995 • 57 citations

Enhancement of acetylcholine release by SA4503, a novel sigma 1 receptor agonist, in the rat brain.

1996 • 56 citations

Phencyclidine Impairs Latent Learning in Mice Interaction between Glutamatergic Systems and Sigma1 Receptors

2001 • 55 citations

[3H]BIMU-1, a 5-hydroxytryptamine3 receptor ligand in NG-108 cells, selectively labels sigma-2 binding sites in guinea pig hippocampus.

1993 • 55 citations

Biochemical, behavioral, and electrophysiologic actions of the selective sigma receptor ligand (+)-pentazocine.

1988 • 55 citations

Activation of σ1 receptor subtype leads to neuroprotection in the rat primary neuronal cultures

1998 • 54 citations

Effects of σ1 receptor agonist SA4503 and neuroactive steroids on performance in a radial arm maze task in rats

2000 • 54 citations

DuP 734 [1-(cyclopropylmethyl)-4-(2'(4''-fluorophenyl)-2'-oxoethyl)- piperidine HBr], a sigma and 5-hydroxytryptamine2 receptor antagonist: receptor-binding, electrophysiological and neuropharmacological profiles.

1992 • 53 citations

Potential antidepressant activity of sigma ligands.

2004 • 53 citations

Antidepressant Treatment of Psychotic Major Depression: Potential Role of the σ Receptor

2005 • 53 citations

Differential involvement of the sigma₁ (σ₁) receptor in the anti‐amnesic effect of neuroactive steroids, as demonstrated using an in vivo antisense strategy in the mouse

2001 • 51 citations

Modulation of steroidal levels by adrenalectomy/castration and inhibition of neurosteroid synthesis enzymes affect σ₁ receptor‐mediated behaviour in mice

1999 • 51 citations

Prostate cancer and prostate bed SPECT imaging with ProstaScint®: Semiquantitative correlation with prostatic biopsy results

1998 • 51 citations

Preclinical evaluation of [11C]SA4503: radiation dosimetry,in vivo selectivity and PET imaging of sigma1 receptors in the cat brain

2000 • 50 citations

Halogenated 4-(Phenoxymethyl)piperidines as Potential Radiolabeled Probes for σ-1 Receptors: In Vivo Evaluation of [¹²³I]-1-(Iodopropen-2-yl)-4-[(4-cyanophenoxy)methyl]piperidine

1997 • 50 citations

Cocaine-sensitive sigma-receptor and its interaction with steroid hormones in the human placental syncytiotrophoblast and in choriocarcinoma cells.

1995 • 49 citations

Immunopharmacological profile of SR 31747: In vitro and in vivo studies on humoral and cellular responses

1994 • 49 citations

True

2000 • 48 citations

Autoradiographic distribution of sigma receptors in human neocortex, hippocampus, basal ganglia, cerebellum, pineal and pituitary glands

1991 • 48 citations

σ1 Receptors in rat striatum regulate NMDA-stimulated [3H]dopamine release via a presynaptic mechanism

1995 • 47 citations

Sigma 1 receptor subtype is involved in the facilitation of cortical dopaminergic transmission in the rat brain.

1997 • 47 citations

Synthesis and evaluation of [18F] labeled benzamides: High affinity sigma receptor ligands for PET imaging

1997 • 47 citations

Effect of SA4503, a novel σ1 receptor agonist, against glutamate neurotoxicity in cultured rat retinal neurons

1998 • 47 citations

Conformational Analysis, Pharmacophore Identification, and Comparative Molecular Field Analysis of Ligands for the Neuromodulatory .sigma.3 Receptor

1994 • 46 citations

Long-term low-dose dehydroepiandrosterone replacement therapy in aging males with partial androgen deficiency

2004 • 46 citations

Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523

2001 • 45 citations

Current hypotheses on sigma receptors and their physiological role: possible implications in psychiatry.

1993 • 44 citations

Bcl-2–related antisense therapy

2002 • 41 citations

Regional distribution and kinetics of haloperidol binding in human brain: A pet study with [¹⁸F]haloperidol

1992 • 41 citations

A placebo‐controlled clinical trial of remoxipride and chlorpromazine in newly admitted schizophrenic patients with acute exacerbation

1990 • 40 citations

PET and SPECT Exploration of Central Monoaminergic Transporters for the Development of New Drugs and Treatments in Brain Disorders

2005 • 40 citations

Expression of bcl-2 by breast cancer: a possible diagnostic application.

1996 • 39 citations

Acute and chronic administration of the selective sigma1 receptor agonist SA4503 significantly alters the activity of midbrain dopamine neurons in rats: An in vivo electrophysiological study

1999 • 39 citations

NE-100, a novel sigma receptor ligand: Effect on phencyclidine-induced behaviors in rats, dogs and monkeys

1994 • 39 citations

σ Receptor ligands (+)-SKF10,047 and SA4503 improve dizocilpine-induced spatial memory deficits in rats

1998 • 39 citations

Open clinical trial on the sigma ligand panamesine in patients with schizophrenia

1997 • 38 citations

PET Imaging in Clinical Drug Abuse Research

2005 • 38 citations

Synthesis, in vitro pharmacologic characterization, and preclinical evaluation of N-[2-(1′-piperidinyl)ethyl]-3-[125I]iodo-4-methoxybenzamide (P[125I]MBA) for imaging breast cancer

1999 • 38 citations

Synthesis, structure and quantitative structure-activity relationships of σ receptor ligands, 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazines

1997 • 37 citations

Enhanced antidepressant efficacy of σ1 receptor agonists in rats after chronic intracerebroventricular infusion of β-amyloid-(1–40) protein

2004 • 37 citations

Review of the Pharmacological and Clinical Profile of Rimcazole

2004 • 37 citations

Synthesis, In Vitro Binding, and Tissue Distribution of Radioiodinated 2-[125I]N-(N-Benzylpiperidin-4-yl)-2-Iodo Benzamide, 2-[125I]BP: A Potential σ Receptor Marker for Human Prostate Tumors

1998 • 37 citations

The value of positron emission tomography (PET) imaging in disease staging and therapy assessment

2002 • 35 citations

Lu 28-179 labels a σ2-site in rat and human brain

2002 • 35 citations

Radiosynthesis of .sigma. receptor ligands for positron emission tomography: carbon-11 and fluorine-18 labeled guanidines

1991 • 35 citations

Evidence that the σ1 receptor is not directly coupled to G proteins

2000 • 35 citations

Clinical Applications of FDG‐PET in Oncology

2002 • 35 citations

In vitro progesterone effects on 3H-dopamine release from rat corpus striatum slices obtained under different endocrine conditions

1993 • 34 citations

Efficacy and Safety of an Opiate Sigma-Receptor Antagonist (SL 82.0715) in Schizophrenic Patients with Negative Symptoms: an Open Dose-Range Study

1996 • 34 citations

N-(N-Benzylpiperidin-4-yl)-2-[18F]fluorobenzamide: A potential ligand for PET imaging of σ receptors

1997 • 34 citations

Trishomocubanes: novel σ-receptor ligands modulate amphetamine-stimulated [3H]dopamine release

2001 • 34 citations

Enhanced antidepressant effect of sigma1 (σ1) receptor agonists in β25–35-amyloid peptide-treated mice

2002 • 33 citations

The involvement of dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) in blocking the therapeutic effect of electroconvulsive shocks in an animal model of depression

2005 • 33 citations

Effect of NE-100, a novel σ receptor ligand, on phencyclidine-induced cognitive dysfunction

1994 • 33 citations

Molecular modeling of σ1 receptor ligands: a model of binding conformational and electrostatic considerations

2003 • 33 citations

Synthesis and evaluation of [¹⁸F]fluoroethyl SA4503 as a PET ligand for the sigma receptor

2002 • 33 citations

[18F]N-4′-Fluorobenzyl-4-(3-bromophenyl) acetamide for imaging the sigma receptor status of tumors: comparison with [18F]FDG and [125I]IUDR

2001 • 32 citations

Synthesis and Quantitative Structure−Activity Relationships of N-(1-Benzylpiperidin-4-yl)phenylacetamides and Related Analogues as Potent and Selective σ₁ Receptor Ligands

1998 • 32 citations

Efficacy and Safety of the Sigma Receptor Ligand EMD 57445 (Panamesine) in Patients with Schizophrenia: an Open Clinical Trial

1999 • 31 citations

Behavioral Pharmacology of σ-Ligands

2004 • 31 citations

Examination of four 123I-labeled piperidine-based sigma receptor ligands as potential melanoma imaging agents: Initial studies in mouse tumor models

1997 • 31 citations

^99mTc-Labeled σ-Receptor-Binding Complex: Synthesis, Characterization, and Specific Binding to Human Ductal Breast Carcinoma (T47D) Cells

1997 • 31 citations

Sigma receptor scintigraphy with N-[2-(1'-piperidinyl)ethyl]-3-(123)I-iodo-4-methoxybenzamide of patients with suspected primary breast cancer: first clinical results.

2002 • 30 citations

Synthesis and PET studies of fluorine-18-BMY 14802: a potential antipsychotic drug.

1993 • 30 citations

Evaluation of prostate cancer patients receiving multiple staging tests, including ProstaScint� scintiscans

2000 • 29 citations

Sigma-receptor imaging by means of I123-IDAB scintigraphy: clinical application in melanoma and non-small cell lung cancer.

1997 • 29 citations

Sigma Receptor Antagonists Inhibit Human Lens Cell Growth and Induce Pigmentation

2005 • 29 citations

Ameliorative Effect of SA4503, a Novel Cognitive Enhancer, on the Basal Forebrain Lesion-Induced Impairment of the Spatial Learning Performance in Rats

1998 • 29 citations

A double‐blind multicentre study comparing remoxipride, two and three times daily, with haloperidol in schizophrenia

1990 • 29 citations

Synthesis, in vitro validation and in vivo pharmacokinetics of [125I]N-[2-(4-Iodophenyl)Ethyl]-N-Methyl-2-(1-Piperidinyl) ethylamine: A high-affinity ligand for imaging sigma receptor positive tumors

1996 • 28 citations

Apparent desensitization of a σ receptor sub-population in neonatal rat cardiac myocytes by pre-treatment with σ receptor ligands

1996 • 28 citations

The influences of blood glucose and duration of fasting on myocardial glucose uptake of [18F]fluoro-2-deoxy-D-glucose

2002 • 28 citations

Breast cancer staging using technetium-99m sestamibi and indium-111 pentetreotide single-photon emission tomography

1997 • 28 citations

Effect of SA4503 on the electrically evoked release of3H-acetylcholine from striatal and hippocampal rat brain slices

2002 • 28 citations

Substituted Halogenated Arylsulfonamides: A New Class of σ Receptor Binding Tumor Imaging Agents

1998 • 26 citations

Synthesis and preliminary evaluation of [123I]1-(4-cyanobenzyl)-4-[[(trans-iodopropen-2-yl)oxy]-methyl]piperidine: A novel high affinity sigma receptor radioligand for SPECT

1997 • 26 citations

Structural similitudes between cytotoxic antiestrogen-binding site (AEBS) ligands and cytotoxic sigma receptor ligands. evidence for a relationship between cytotoxicity and affinity for AEBS or sigma-2 receptor but not for sigma-1 receptor

1999 • 26 citations

Does sigma receptor antagonism predict clinical antipsychotic efficacy?

1991 • 25 citations

Preclinical acute toxicity studies and rodent-based dosimetry estimates of the novel sigma-1 receptor radiotracer [18F]FPS

2003 • 25 citations

Remoxipride and haloperidol in schizophrenia: a double‐blind multicentre study.

1990 • 24 citations

Sigma ligands stimulate GTPase activity in mouse prefrontal membranes: evidence for the existence of metabotropic sigma receptor

1997 • 24 citations

DuP 734 [1-(cyclopropylmethyl)-4-(2'(4''-fluorophenyl)-2'- oxoethyl)piperidine HBr], a potential antipsychotic agent: preclinical behavioral effects.

1992 • 23 citations

Attenuation of Scopolamine-Induced and Age-Associated Memory Impairments by the Sigma and 5-Hydroxytryptamine_1A Receptor Agonist OPC-14523 (1-{3-[4-(3-chlorophenyl)-1-piperazinyl]propyl}-5-methoxy-3,4-dihydro-2[1H]-quinolinone monomethanesulfonate)

2002 • 23 citations

Progesterone in vitro increases NMDA-evoked [3H]dopamine release from striatal slices in proestrus rats

1996 • 23 citations

Synthesis and in vivo evaluation of [11C]SA6298 as a PET sigma1 receptor ligand

1999 • 23 citations

Nuclear Medicine Techniques for the Diagnosis and Therapy of Prostate Carcinoma

2001 • 23 citations

The selective σ1 receptor agonist, 1-(3,4-dimethoxyphenethyl)-4-(phenylpropyl)piperazine (SA4503), blocks the acquisition of the conditioned place preference response to (−)-nicotine in rats

2001 • 22 citations

New Molecular Targets of Breast Cancer Therapy

2002 • 22 citations

Clinical oncologic positron emission tomography: An introduction

2002 • 22 citations

Steroid Binding at σ Receptors: CNS and Immunological Implications

2007 • 22 citations

Double blind comparative study of remoxipride and haloperidol in acute schizophrenic patients

1990 • 22 citations

Autoradiographic identification and characterization of σ receptors in guinea pig brain using [3H]1(cyclopropylmethyl)-4-(2′-(4≈-fluorophenyl)-2′-oxoethyl) piperidine ([3H]DuP 734), a novel σ receptor ligand

1992 • 21 citations

Ligands for opioid and σ-receptors improve cardiac electrical stability in rat models of post-infarction cardiosclerosis and stress

1999 • 21 citations

Synthesis of (±)-[18F]BMY 14802, its enantiomers and their anatomical distributions in rodents

1993 • 19 citations

N-(n-benzylpiperidin-4-yl)-2-[18f]fluorobenzamide: a potential ligand for pet imaging of breast cancer

2000 • 19 citations

Increased binding to sigma sites of N-[1′(2-piperidinyl)ethyl)-4-[I-125]-iodobenzamide (I-125-PAB) with onset of tumor cell proliferation

1998 • 19 citations

[3H]YM-09151–2 (nemonapride), a potent radioligand for both sigma1 and sigma2 receptor subtypes

1996 • 19 citations

Reduction of IL-10 and Nitric Oxide Synthesis by SR31747A (Sigma Ligand) in RAW Murine Macrophages

2001 • 18 citations

Untitled

2001 • 18 citations

[Positron emission tomography (PET) and (F-18)-fluorodeoxyglucose in (FDG) in cancerology].

1998 • 18 citations

Sigma and Phencyclidine Receptors in the Brain-Endocrine-Immune Axis

1993 • 18 citations

Novel Sigma Binding Site Ligands as Inhibitors of Cell Proliferation in Breast Cancer

2003 • 18 citations

Putative σ3 sites in mammalian brain have histamine H1 receptor properties: evidence from ligand binding and distribution studies with the novel H1 radioligand [ ]-(−)-trans-1-phenyl-3-aminotetralin

1999 • 17 citations

Uptake of 99mTc-MIBI and 99mTc-tetrofosmin into malignant versus nonmalignant breast cell lines.

2000 • 16 citations

Dueling Enigmas: Neurosteroids and Sigma Receptors in the Limelight

2000 • 16 citations

Imaging prostate derived tumors with PET and N-(3-[18F]fluoropropyl)putrescine

1990 • 15 citations

In Vitro and In Vivo Expression of Opioid and σ Receptors in Rat C6 Glioma and Mouse N18TG2 Neuroblastoma Cells

1994 • 14 citations

Synthesis and receptor binding properties of fluoro- and iodo-substituted high-affinity .sigma.-receptor ligands: identification of potential PET and SPECT .sigma.-receptor imaging agents

1992 • 14 citations

Clinical oncological applications of Positron Emission Tomography (PET) using fluorine-18-fluoro-2-deoxy-D-glucose.

2002 • 14 citations

Microdialysis and 2-[18F]fluoro-2-deoxy-D-glucose (FDG): A study on insulin action on FDG transport, uptake and metabolism in rat muscle, liver and adipose tissue

2003 • 14 citations

Possible Involvement of a σ Receptor Subtype in the Neck Dystonia in Rats

1999 • 14 citations

Synthesis of a selective sigma receptor radioligand for SPECT: [123I]-1-(2-hydroxyethyl)-4-(4-iodophenoxymethyl)piperidine

1996 • 14 citations

A comparative molecular field analysis (CoMFA) study using semiempirical, density functional, ab initio methods and pharmacophore derivation using DISCOtech on sigma 1 ligands

2004 • 14 citations

Turnover rate and stimulus-evoked release of dopamine by progesterone and N-methyl-d-aspartic acid in rat striatum during pregnancy

1996 • 13 citations

The (11C) acetate positron emission tomography in prostatic carcinoma. New prospects in metabolic imaging

2002 • 12 citations

The value of early and double phase 99Tcm-sestamibi scintimammography in the diagnosis of breast cancer

2000 • 12 citations

[18F]Haloperidol binding in baboon brain in vivo

1996 • 12 citations

A shifting landseape: What will be next FDG in PET oncology?

2002 • 11 citations

Breast cancer imaging: The future

2001 • 10 citations

Investigation of the Use of Positron Emission Tomography for Neuroreceptor Imaging in Rabbit Eyes

2004 • 9 citations

Characterization of the sigma ligand panamesine, a potential antipsychotic, by immune response in patients with schizophrenia and by sleep-EEG changes in normal controls

1999 • 9 citations

Focus on Molecules: the Sigma-1 Receptor

2005 • 9 citations

Neuropsychopharmacological profile of remoxipride in comparison with clozapine.

1997 • 9 citations

Analysis of FDG uptake with hybrid PET using standardised uptake values

2001 • 7 citations

Positron emission tomography study of human prostatic adenocarcinoma using carbon-11 putrescine

1994 • 7 citations

Atypical neuroleptics in acute schizophrenia: a double-blind comparative study of remoxipride and haloperidol.

1990 • 7 citations

La TEP au 〚18F〛-fluoro-2-désoxyglucose dans l’imagerie des cancers gynécologiques

2001 • 6 citations

Delayed Tc-99m Citrate Scintigraphy in the Evaluation of Palpable Breast Masses

1999 • 6 citations

Identification and pharmacological characterization of SRBP-2: a novel SR31747A-binding protein.

2003 • 6 citations

Variability of insulin-stimulated myocardial glucose uptake in healthy elderly subjects

2002 • 5 citations

[Are sigma receptors implicated in ischemic injury?].

2002 • 5 citations

Current Strategies for the Development of Novel Antipsychotic Drugs

2003 • 5 citations

[Opioid system and cardiac resistance to ischemic and reperfusion injuries].

2000 • 4 citations

[Dependence of the pump function of the isolated rat heart on the functional activity of sigma receptors during reperfusion].

1999 • 3 citations

Pharmacological Effects of .SIGMA.-Receptor Ligands. Anti-amnesic effects of sigma (.SIGMA.)-receptor agonists.

1999 • 3 citations

[Uptake of FDG (2-fluoro-2-deoxy-D-glucose) as a tumor imaging agent into erythrocytes and accumulation of FDG in tumor cells].

2003 • 3 citations

Sigma1 Receptor Subtype Does Not Interact With Stereotyped Behaviors in Rats

1998 • 3 citations

[Ligands of opioid and sigma receptors and correction of cardiac electrical instability in post-infarction cardiosclerosis].

2001 • 2 citations

Combined treatment with NMDA antagonist, CGP 37849, and sigma receptor agonists, SA4503 or DTG, decreases the neuroleptic-induced catalepsy in rats.

2001 • 1 citations