Local Supercoil-Stabilized DNA Structure

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

Genomic sequencing.

1984 • 8,343 citations

Encyclopedia of polymer science and engineering

1985 • 5,821 citations

Principles of Nucleic Acid Structure

2008 • 4,570 citations

Encyclopedia of polymer science and engineering

1987 • 4,209 citations

Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis

1984 • 2,847 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

Molecular structure of a left-handed double helical DNA fragment at atomic resolution

1979 • 2,057 citations

A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system

1981 • 1,991 citations

Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis

1988 • 1,734 citations

DNA TOPOISOMERASES

1985 • 1,524 citations

HELIX FORMATION BY GUANYLIC ACID

1962 • 1,478 citations

Structure of a B-DNA dodecamer: conformation and dynamics.

1981 • 1,394 citations

Simple sequences are ubiquitous repetitive components of eukaryotic genomes

1984 • 1,389 citations

Sequence-Specific Cleavage of Double Helical DNA by Triple Helix Formation

1987 • 1,275 citations

Salt-induced co-operative conformational change of a synthetic DNA: Equilibrium and kinetic studies with poly(dG-dC)

1972 • 1,213 citations

Monovalent cation-induced structure of telomeric DNA: The G-quartet model

1989 • 1,202 citations

THE CHEMISTRY AND BIOLOGY OF LEFT-HANDED Z-DNA

1984 • 1,149 citations

DNA bending at adenine · thymine tracts

1986 • 1,032 citations

The structure of an oligo(dA)·oligo(dT) tract and its biological implications

1987 • 975 citations

Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops

1989 • 939 citations

FORMATION OF A THREE-STRANDED POLYNUCLEOTIDE MOLECULE

1957 • 900 citations

Structure of a B-DNA dodecamer

1981 • 891 citations

Studying single living cells and chromosomes by confocal Raman microspectroscopy

1990 • 879 citations

Purification and Further Properties of Single‐Strand‐Specific Nuclease from Aspergillus oryzae

1973 • 862 citations

Crystal structure analysis of a complete turn of B-DNA

1980 • 844 citations

A sodium-potassium switch in the formation of four-stranded G4-DNA

1990 • 789 citations

Specific regulation of gene expression by antisense, sense and antigene nucleic acids

1990 • 769 citations

The Writhing Number of a Space Curve

1971 • 754 citations

PSORALENS AS PHOTOACTIVE PROBES OF NUCLEIC ACID STRUCTURE AND FUNCTION: ORGANIC CHEMISTRY, PHOTOCHEMISTRY, AND BIOCHEMISTRY

1985 • 749 citations

Metals and DNA: Molecular Left-Handed Complements

1986 • 744 citations

Transcription generates positively and negatively supercoiled domains in the template

1988 • 742 citations

Site-Specific Oligonucleotide Binding Represses Transcription of the Human c- myc Gene in Vitro

1988 • 707 citations

THE MOLECULAR STRUCTURE OF CENTROMERES AND TELOMERES

1984 • 693 citations

Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine·guanine base pairs

1987 • 675 citations

A bifurcated hydrogen-bonded conformation in the d(A.T) base pairs of the DNA dodecamer d(CGCAAATTTGCG) and its complex with distamycin.

1987 • 671 citations

Self-Linking and the Gauss Integral in Higher Dimensions

1969 • 667 citations

Reactivity of cytosine and thymine in single-base-pair mismatches with hydroxylamine and osmium tetroxide and its application to the study of mutations.

1988 • 636 citations

On the structure of the folded chromosome of Escherichia coli

1972 • 635 citations

The interaction of closed circular DNA with intercalative dyes

1968 • 627 citations

Regulation of intracellular pH in eukaryotic cells

1988 • 618 citations

DNA topology and its biological effects

1991 • 612 citations

Folding of the DNA double helix in chromatin-like structures from simian virus 40.

1975 • 597 citations

Specific Recognition of Cruciform DNA by Nuclear Protein HMG1

1989 • 596 citations

Bent helical structure in kinetoplast DNA

1982 • 595 citations

Osmium tetraoxide cis hydroxylation of unsaturated substrates

1980 • 576 citations

Mechanics of sequence-dependent stacking of bases in B-DNA

1982 • 571 citations

The pitch of chromatin DNA is reflected in its nucleotide sequence.

1980 • 565 citations

The twisted circular form of polyoma viral DNA.

1965 • 551 citations

Cruciform structures in supercoiled DNA

1981 • 545 citations

The chemistry and biology of unusual DNA structures adopted by oligopurine · oligopyrimidine sequences

1988 • 543 citations

Physical and chemical characterization of two- and three-stranded adenine-thymine and adenine-uracil homopolymer complexes

1966 • 535 citations

Contacts between Escherichia coli RNA polymerase and an early promoter of phage T7.

1980 • 524 citations

Basic Principles in Nucleic Acid Chemistry

1974 • 523 citations

The inverted repeat as a recognizable structural feature in supercoiled DNA molecules.

1980 • 519 citations

SEQUENCE-DIRECTED CURVATURE OF DNA

1990 • 490 citations

Ordered water structure around a B-DNA dodecamer

1983 • 482 citations

The structure of the holliday junction, and its resolution

1988 • 476 citations

Eucaryotic DNA: Organization of the genome for replication

1978 • 476 citations

Nature of the open state in long polynucleotide double helices: possibility of soliton excitations.

1980 • 464 citations

A nuclease specific for heat-denatured DNA isolated from a product of Aspergillus oryzae

1966 • 457 citations

Transcription factors that activate the Ultrabithorax promoter in developmentally staged extracts

1988 • 454 citations

Left-handed Z-DNA is induced by supercoiling in physiological ionic conditions

1982 • 439 citations

Intrinsically bent DNA.

1990 • 428 citations

Inhibition of DNA Binding Proteins by Oligonucleotide-Directed Triple Helix Formation

1989 • 416 citations

Chemical probes for higher-order structure in RNA.

1980 • 415 citations

DNA H form requires a homopurine–homopyrimidine mirror repeat

1987 • 404 citations

Four-Stranded Nucleic Acid Structures 25 Years Later: From Guanosine Gels to Telomer DNA

1990 • 404 citations

Mathematical Methods for DNA Sequences.

1990 • 395 citations

Structure of plectonemically supercoiled DNA

1990 • 391 citations

Effects of Some Chemical Mutagens and Carcinogens on Nucleic Acids

1966 • 370 citations

Structures for the polynucleotide complexes Poly(dA)·Poly(dT) and Poly (dT)·Poly(dA)·Poly(dT)

1975 • 369 citations

DNA supercoiling and prokaryotic transcription

1989 • 359 citations

Transcription-driven supercoiling of DNA: Direct biochemical evidence from in vitro studies

1989 • 357 citations

Synthetic curved DNA sequences can act as transcriptional activators in Escherichia coli.

1989 • 356 citations

Antibodies to left-handed Z-DNA bind to interband regions of Drosophila polytene chromosomes

1981 • 350 citations

DNA CONFORMATION AND PROTEIN BINDING

1989 • 343 citations

Determination of Three-Dimensional Structures of Proteins and Nucleic Acids in Solution by Nuclear Magnetic Resonance Spectroscop

1989 • 342 citations

X-ray fiber diffraction and model-building study of polyguanylic acid and polyinosinic acid

1975 • 339 citations

Facile transition of poly[d(TG)·d(CA)] into a left-handed helix in physiological conditions

1983 • 335 citations

Physical and Topological Properties of Circular DNA

1966 • 335 citations

Fluorescence energy transfer shows that the four-way DNA junction is a right-handed cross of antiparallel molecules

1989 • 334 citations

STRAND SEPARATION AND SPECIFIC RECOMBINATION IN DEOXYRIBONUCLEIC ACIDS: PHYSICAL CHEMICAL STUDIES

1960 • 330 citations

Flipping of cloned d(pCpG)n.d(pCpG)n DNA sequences from right- to left-handed helical structure by salt, Co(III), or negative supercoiling.

1982 • 321 citations

Advances in electrophoresis

1988 • 317 citations

STRUCTURE AND REACTIONS OF CLOSED DUPLEX DNA

1978 • 316 citations

Magnesium ion-dependent triple-helix structure formed by homopurine-homopyrimidine sequences in supercoiled plasmid DNA.

1988 • 315 citations

Unusual DNA structures.

1988 • 309 citations

Specificity of the three-stranded complex formation between double-stranded DNA and single-stranded RNA containing repeating nucleotide sequences

1968 • 308 citations

Early and late helix-coil transitions in closed circular DNA the number of superhelical turns in polyoma DNA

1968 • 304 citations

EUKARYOTIC DNA REPLICATION

1986 • 298 citations

Use of site-specific recombination as a probe of DNA structure and metabolism in vivo

1987 • 297 citations

STRUCTURE AND DYNAMICS OF WATER SURROUNDING BIOMOLECULES

1987 • 296 citations

KMnO4 as a probe for lac promoter DNA melting and mechanism in vivo

1989 • 294 citations

THE CYCLIC HELIX AND CYCLIC COIL FORMS OF POLYOMA VIRAL DNA

1963 • 294 citations

Poly(pyrimidine) poly(purine) synthetic DNAs containing 5-methylcytosine form stable triplexes at neutral pH

1984 • 290 citations

Helix-random coil transitions in DNA homopolymer pairs

1964 • 289 citations

Structural specificities of five commonly used DNA nucleases

1984 • 286 citations

The MerR heavy metal receptor mediates positive activation in a topologically novel transcription complex

1989 • 286 citations

Chemical probes of DNA conformation: detection of Z-DNA at nucleotide resolution

1985 • 286 citations

Negatively supercoiled plasmids contain left-handed Z-DNA segments as detected by specific antibody binding

1982 • 285 citations

Water: An Integral Part of Nucleic Acid Structure

1988 • 280 citations

Topology and Formation of Triple-Stranded H-DNA

1989 • 279 citations

The Folded Genome of Escherichia coli Isolated in a Protein-DNA-RNA Complex

1971 • 278 citations

Unusual DNA Structures

2011 • 277 citations

Left-handed DNA in restriction fragments and a recombinant plasmid

1981 • 277 citations

Iron(II) EDTA Used to Measure the Helical Twist Along Any DNA Molecule

1985 • 274 citations

Single Strands, Triple Strands, and Kinks in H-DNA

1988 • 269 citations

Variation of the average rotation angle of the DNA helix and the superhelical turns of covalently closed cyclic λ DNA

1969 • 263 citations

Measurement of protein‐DNA interaction parameters by electrophoresis mobility shift assay

1989 • 262 citations

SYNTHESIS AND USE OF SYNTHETIC OLIGONUCLEOTIDES

1984 • 260 citations

Sequence dependence of the curvature of DNA: a test of the phasing hypothesis

1985 • 259 citations

Functional replacement of a protein-induced bend in a DNA recombination site

1989 • 259 citations

DNA supercoiling promotes formation of a bent repression loop in lac DNA

1987 • 252 citations

VIRUS-CELL INTERACTION WITH A TUMOR-PRODUCING VIRUS

1960 • 250 citations

DNA Supercoiling and Its Effects on DNA Structure and Function

1983 • 243 citations

On the sequence determinants and flexibility of the kinetoplast DNA fragment with abnormal gel electrophoretic mobilities

1985 • 240 citations

Comparative inhibition of rabbit globin mRNA translation by modified antisense oligodeoxynucleotides

1989 • 238 citations

Triple-strand formation in the homopurine:homopyrimidine DNA oligonucleotides d(G-A)4 and d(T-C)4

1989 • 237 citations

Curved DN

1985 • 236 citations

Temperature-gradient gel electrophoresis

1987 • 236 citations

Definitions and nomenclature of nucleic acid structure parameters.

1989 • 235 citations

Cruciform structures in palindromic DNA are favored by DNA supercoiling

1982 • 235 citations

The DNA unwinding element: a novel, cis-acting component that facilitates opening of the Escherichia coli replication origin.

1989 • 233 citations

A structural basis for S1 nuclease sensitivity of double-stranded DNA

1985 • 232 citations

Crystal lattice packing is important in determining the bend of a DNA dodecamer containing an adenine tract.

1989 • 231 citations

Thermodynamic properties of superhelical DNAs

1975 • 229 citations

Charge and Field Effects in Biosystems—2

1990 • 228 citations

Parallel Stranded DNA

1988 • 228 citations

STRAND SEPARATION AND SPECIFIC RECOMBINATION IN DEOXYRIBONUCLEIC ACIDS: BIOLOGICAL STUDIES

1960 • 227 citations

Visualization of the bent helix in kinetoplast DNA by electron microscopy

1986 • 226 citations

Sequence-dependent variation in the conformation of DNA

1981 • 220 citations

Stabilization of Z DNA in Vivo by Localized Supercoiling

1989 • 220 citations

Temperature‐Gradient gel electrophoresis of nucleic acids: Analysis of conformational transitions, sequence variations, and protein‐nucleic acid interactions

1989 • 219 citations

Structures of Homopurine-homopyrimidine Tract in Superhelical DNA

1986 • 218 citations

Left-Handed DNA in Vivo

1987 • 214 citations

d(TG)_n·d(CA)_nsequences upstream of the rat prolactin gene form Z-DNA and inhibit gene transcription

1990 • 214 citations

Heteronomous DNA

1983 • 213 citations

Cruciform formation in a negatively supercoiled DNA may be kinetically forbidden under physiological conditions

1983 • 212 citations

Sequence-Determined DNA Separations

1984 • 210 citations

UV-induced formation of pyrimidine dimers in nucleosome core DNA is strongly modulated with a period of 10.3 bases.

1987 • 209 citations

Chromatin and core particles formed from the inner histones and synthetic polydeoxyribonucleotides of defined sequence

1979 • 208 citations

Potential genetic functions of tandem repeated DNA sequence blocks in the human genome are based on a highly conserved ?chromatin folding code?

1990 • 207 citations

Poly(dA)ṁpoly(dT) is a B-type double helix with a distinctively narrow minor groove

1987 • 203 citations

Sequence-specific artificial photo-induced endonucleases based on triple helix-forming oligonucleotides

1990 • 200 citations

Drosophila Nuclear Proteins Bind to Regions of Alternating C and T Residues in Gene Promoters

1989 • 200 citations

Site-Specific Cleavage of a Yeast Chromosome by Oligonucleotide-Directed Triple-Helix Formation

1990 • 198 citations

NMR studies of DNA (R+)n.cntdot.(Y-)n.cntdot.(Y+)n triple helixes in solution: imino and amino proton markers of T.cntdot.A.cntdot.T and C.cntdot.G.cntdot.C+ base-triple formation

1989 • 198 citations

The Transition Between B-DNA and Z-DNA

1987 • 198 citations

Model for DNA and Protein Interactions and the Function of the Operator

1966 • 197 citations

An Endonuclease from Neurospora crassa Specific for Polynucleotides Lacking an Ordered Structure

1965 • 197 citations

Pulsed-Field Gel Electrophoresis of Very Large DNA Molecules

1988 • 196 citations

Complexes formed by (pyrimidine)_n·(purine)_nDNAs on lowering the pH are three-stranded

1979 • 195 citations

Direct Observation of Native DNA Structures with the Scanning Tunneling Microscope

1989 • 194 citations

The ease of DNA unwinding as a determinant of initiation at yeast replication origins

1988 • 193 citations

Models of triple-stranded polynucleotides with optimised stereochemistry

1976 • 190 citations

The Three-Dimensional Structure of DNA

1982 • 187 citations

Facile cruciform formation by an (A-T)34 sequence from a Xenopus globin gene

1985 • 186 citations

DNA double helical fragment at atomic resolution

1978 • 186 citations

Antibodies to DN

1986 • 186 citations

Synthetic Polynucleotides

1967 • 184 citations

The tetramer d(CpGpCpG) crystallizes as a left-handed double helix.

1980 • 181 citations

Use of light for footprinting DNA in vivo

1984 • 181 citations

Tris(tetramethylphenanthroline)ruthenium(II): a chiral probe that cleaves A-DNA conformations.

1988 • 181 citations

Left-handed DNA: from Synthetic Polymers to Chromosomes

1983 • 181 citations

Evidence from base-pair kinetics for two types of adenine tract structures in solution: their relation to DNA curvature

1988 • 179 citations

Mapping functional regions of transcription factor TFIIIA.

1988 • 178 citations

The contrasting structures of mismatched DNA sequences containing looped-out bases (bulges) and multiple mismatches (bubbles)

1989 • 176 citations

Chemical probing of homopurine-homopyrimidine mirror repeats in supercoiled DNA

1988 • 175 citations

DNA Gyrase and DNA Supercoiling

1979 • 175 citations

The S1-sensitive Form of D(C-T) _n ⋅d(A-G) _n : Chemical Evidence for a Three-Stranded Structure in Plasmids

1988 • 174 citations

Comparative inhibition of chloramphenicol acetyltransferase gene expression by antisense oligonucleotide analogues having alkyl phosphotriester, methylphosphonate and phosphorothioate linkages

1987 • 173 citations

Gel electrophoretic analysis of the geometry of a DNA four-way junction

1987 • 173 citations

Nucleosome cores reconstituted from poly (dA-dT) and the octamer of histones

1979 • 172 citations

Association of an S1 nuclease-sensitive structure with short direct repeats 5′ of Drosophila heat shock genes

1983 • 171 citations

Diethyl pyrocarbonate: a chemical probe for secondary structure in negatively supercoiled DNA.

1985 • 169 citations

NMR studies of triple-strand formation from the homopurine-homopyrimidine deoxyribonucleotides d(GA)4 and d(TC)4

1989 • 169 citations

Triple helix formation by oligopurine-oligopyrimidine DNA fragments

1990 • 167 citations

Base-specific reactions useful for DNA sequencing: methylene blue – sensitized photooxidation of guanine and osmium tetraoxide modification of thymine

1978 • 166 citations

Superhelical torsion in cellular DNA responds directly to environmental and genetic factors.

1990 • 166 citations

Stable DNA unwinding, not "breathing," accounts for single-strand-specific nuclease hypersensitivity of specific A+T-rich sequences.

1988 • 165 citations

New findings in methane-utilizing bacteria highlight their importance in the biosphere and their commercial potential

1980 • 165 citations

Direct visualization of supercoiled DNA molecules in solution.

1990 • 160 citations

Unwinding of double-stranded DNA helix by dehydration.

1981 • 160 citations

Transcriptional block caused by a negative supercoiling induced structural change in an alternating CG sequence

1985 • 160 citations

(dC-dA)n.(dG-dT)n sequences have evolutionarily conserved chromosomal locations in Drosophila with implications for roles in chromosome structure and function.

1987 • 158 citations

Characterization of genomic poly(dT-dG).poly(dC-dA) sequences: structure, organization, and conformation.

1984 • 157 citations

Influence of DNA sequence on the formation of non-B right-handed helices in oligopurine.oligopyrimidine inserts in plasmids.

1988 • 157 citations

Denaturation and Renaturation of Deoxyribonucleic Acid12

1963 • 157 citations

The P22 bacteriophage DNA molecule

1968 • 156 citations

On loopfolding in nucleic acid hairpin-type structures²⁹

1986 • 150 citations

Formation of a stable triplex from a single DNA strand

1990 • 150 citations

Pulsed field gel electrophoresis: a technique for fractionating large DNA molecules

1986 • 149 citations

Structural analysis of the (dA)10.2(dT)10 triple helix.

1990 • 147 citations

A stable complex between homopyrimidine oligomers and the homologous regions of duplex DNAs

1988 • 146 citations

A pH-dependent Structural Transition in the Homopurine-homopyrimidine Tract in Superhelical DNA

1985 • 145 citations

The selective degradation of pyrimidines in nucleic acids by permanganate oxidation

1967 • 135 citations

Torsional stress stabilizes extended base unpairing in suppressor sites flanking immunoglobulin heavy chain enhancer

1990 • 135 citations

Site-specific inhibition ofEcoRI restriction/modification enzymes by a DNA triple helix

1990 • 135 citations

CHEMICAL NUCLEASES: NEW REAGENTS IN MOLECULAR BIOLOGY

1990 • 135 citations

A premelting conformational transition in poly(dA)-poly(dT) coupled to daunomycin binding

1989 • 134 citations

Scanning Tunneling Microscopy of recA-DNA Complexes Coated with a Conducting Film

1988 • 134 citations

DNA bending induced by cruciform formation

1985 • 133 citations

Physical Studies of the Molecular Structure of Deoxyribose Nucleic Acid and Nucleoprotein

1956 • 133 citations

Inhibition of restriction endonuclease cleavage via triple helix formation by homopyrimidine oligonucleotides

1989 • 133 citations

Computer simulation of DNA supercoiling

1991 • 132 citations

DNA supercoiling changes the spacing requirement of two lac operators for DNA loop formation with lac repressor.

1988 • 132 citations

The effect of the base sequence on the fine structure of the DNA double helix

1986 • 132 citations

Effects of base sequence on the loop folding in DNA hairpins

1989 • 131 citations

Hairpin formation in synthetic oligonucleotides

1985 • 130 citations

Transition of a cloned d(AT)n-d(AT)n tract to a cruciformin vivo

1985 • 130 citations

Telomeres: Do the ends justify the means?

1984 • 130 citations

The stereochemistry of a four-way DNA junction: a theoretical study

1990 • 129 citations

Intramolecular DNA triplexes, bent DNA and DNA unwinding elements in the initiation region of an amplified dihydrofolate reductase replicon

1990 • 129 citations

Chemical and photochemical probing of DNA complexes

1990 • 128 citations

Determination of Base Sequence in Nucleic Acids with the Electron Microscope. V. The Thymine-Specific Reactions of Osmium Tetroxide with Deoxyribonucleic Acid and Its Components^*

1966 • 127 citations

Homologous pairing of DNA molecules by ustilago rec1 protein is promoted by sequences of Z-DNA

1986 • 126 citations

Possible structures of homopurine-homopyrimidine S1-hypersensitive sites

1984 • 125 citations

Statistical mechanics of supercoils and the torsional stiffness of the DNA double helix

1979 • 123 citations

Slow cruciform transitions in palindromic DNA.

1983 • 122 citations

Complex Formation between Polycytidylic Acid and Guanine Oligonucleotides

1964 • 122 citations

Perfect palindromic lac operator DNA sequence exists as a stable cruciform structure in supercoiled DNA in vitro but not in vivo.

1983 • 122 citations

The IN-VIVO Occurrence of Z DNA

1983 • 122 citations

Oligo(alpha-deoxynucleotide)s covalently linked to intercalating agents: differential binding to ribo- and deoxyribopolynucleotides and stability towards nuclease digestion.

1987 • 121 citations

The supercoil-stabilised cruciform of ColE1 is hyper-reactive to osmium tetroxide.

1984 • 120 citations

Formation of the triple-stranded polynucleotide helix, poly(A.A.U).

1987 • 119 citations

Laser cross-linking of nucleic acids to proteins. Methodology and first applications to the phage T4 DNA replication system.

1986 • 119 citations

A sequence conserved in both the chicken and mouse alpha 2(I) collagen promoter contains sites sensitive to S1 nuclease.

1984 • 118 citations

Oligonucleotide structure: a decade of results from single crystal X-ray diffraction studies

1989 • 118 citations

Sequence context effects on 8-methoxypsoralen photobinding to defined DNA fragments

1987 • 117 citations

An unusually long poly(purine)-poly(pyrimidine) sequence is located upstream from the human thyroglobulin gene

1985 • 116 citations

Anomalous structure and properties of poly (dA)·poly(dT). Computer simulation of the polynucleotide structure with the spine of hydration in the minor groove

1987 • 115 citations

Duplex-hairpin transitions in DNA: NMR studies on CGCGTATACGCG

1985 • 115 citations

Cross-Linking of Proteins to Nucleic Acids by Ultraviolet Light

1980 • 115 citations

The gene for rat atrial natriuretic factor.

1985 • 113 citations

(A-T)_ntracts embedded in random sequence DNA — formation of a structure which is chemically reactive and torsionally deformable

1986 • 113 citations

Positively supercoiled DNA in a virus-like particle of an archaebacterium

1986 • 112 citations

A monoclonal antibody to triplex DNA binds to eucaryotic chromosomes

1987 • 111 citations

Spectroscopic and calorimetric investigation on the DNA triplex formed by d(CTCTTCTTTCTTTTCTTTCTTCTC) and d(GAGAAGAAAGA) at acidic pH

1990 • 111 citations

Infrared demonstration of two- and three-strand helix formation between poly C and guanosine mononucleotides and oligonucleotides

1964 • 110 citations

Acid shock proteins of Escherichia coli

1990 • 110 citations

G-DNA: a twice-folded DNA structure adopted by single-stranded oligo(dG) and its implications for telomeres.

1990 • 110 citations

In vivo consequences of plasmid topology

1981 • 109 citations

Detection of an altered DNA conformation at specific sites in chromatin and supercoiled DNA.

1983 • 109 citations

Abundance and degree of dispersion of genomic d(GA) n ·d(TC) n sequences

1988 • 109 citations

Electrochemical behaviour of biological macromolecules

1986 • 108 citations

Diethyl Pyrocarbonate in Nucleic Acid Research

1976 • 108 citations

Selective degradation of thymidine and thymine deoxynucleotides

1966 • 106 citations

The Role of Cyclic Nucleic Acid Adducts in Carcinogenesis and Mutagenesis

1987 • 106 citations

A native cruciform DNA structure probed in bacteria by recombinant T7 endonuclease.

1987 • 105 citations

Interaction of a protein from rat liver nuclei with cruciform DNA.

1988 • 105 citations

Calculation of the twist and the writhe for representative models of DNA

1986 • 104 citations

A dominant influence of flanking sequences on a local structural transition in DNA

1986 • 104 citations

Self-assembled 5'-guanosine monophosphate, nuclear magnetic resonance evidence for a regular, ordered structure and slow chemical exchange

1975 • 103 citations

Raman spectra of single crystals of r(GCG)d(CGC) and d(CCCCGGGG) as models for A DNA, their structure transitions in aqueous solution, and comparison with double-helical poly(dG).cntdot.poly(dC)

1986 • 103 citations

Thymine dimer formation as a probe of the path of DNA in and between nucleosomes in intact chromatin.

1989 • 102 citations

Structural polymorphism of homopurine-homopyrimidine sequences: the secondary DNA structure adopted by a d(GA.CT)22 sequence in the presence of zinc ions.

1989 • 102 citations

Crystal structure of Z-DNA without an alternating purine-pyrimidine sequence.

1985 • 102 citations

Unusual helical packing in crystals of DNA bearing a mutation hot spot

1989 • 102 citations

Physical Studies of Protein-DNA Complexes by Footprinting

1989 • 101 citations

Highly selective chemical modification of cruciform loops by diethyl pyrocarbonate

1986 • 100 citations

The double helix: a personal view

1974 • 99 citations

A Computer Graphics Study of Sequence-Directed Bending in DNA

1983 • 98 citations

Action of single-strand specific nucleases on model DNA heteroduplexes of defined size and sequence

1977 • 98 citations

Phasing of protein-induced DNA bends in a recombination complex

1989 • 98 citations

Non-B right-handed DNA conformations of homopurine.homopyrimidine sequences in the murine immunoglobulin C alpha switch region.

1988 • 97 citations

Sequence-targeted Cleavage of single- and Double-stranded DNA by Oligothymidylates Covalently Linked to 1,10-Phenanthroline

1989 • 97 citations

The kinetic properties of cruciform extrusion are determined by DNA base-sequence

1985 • 95 citations

An E. coli Promoter That Regulates Transcription by DNA Superhelix-Induced Cruciform Extrusion

1988 • 95 citations

Acis-acting transcription element of the c-mycgene can assume an H-DNA conformation

1989 • 94 citations

Crystal structure analysis of an A-DNA fragment at 1.8 Å resolution: d(GCCCGGGC)

1987 • 93 citations

Sequence-dependent S1 nuclease hypersensitivity of a heteronomous DNA duplex.

1986 • 93 citations

Chiral probe for A-form helixes of DNA and RNA: tris(tetramethylphenanthroline)ruthenium(II)

1986 • 92 citations

DNA methylation can enhance or induce DNA curvature.

1987 • 92 citations

The three-way DNA junction is a Y-shaped molecule in which there is no helix-helix stacking.

1990 • 91 citations

Construction and analysis of monomobile DNA junctions

1988 • 91 citations

The B- to Z-DNA equilibrium in vivo is perturbed by biological processes.

1988 • 90 citations

An lmproved method for photofootprinting yeast genesin vivousing Taq polymerase

1989 • 89 citations

A Z-like form of poly(dA-dC).poly(dC-bT) in sotation?

1982 • 88 citations

Mung Bean Nuclease I

1970 • 88 citations

Sequence-Dependent Kinks Induced in Curved DNA

1990 • 88 citations

Poly(dG).poly(dC) at neutral and alkaline pH: the formation of triple stranded poly(dG).poly(dG). poly(dC)

1978 • 88 citations

The level of Z-DNA in metabolically active, permeabilized mammalian cell nuclei is regulated by torsional strain.

1989 • 87 citations

Z-DNA-forming sequences are spontaneous deletion hot spots.

1989 • 87 citations

Further analysis of the altered secondary structure of superhelical DNA. Sensitivity to methylmercuric hydroxide a chemical probe for unpaired bases

1973 • 87 citations

Identification of homologous pairing and strand-exchange activity from a human tumor cell line based on Z-DNA affinity chromatography.

1988 • 87 citations

Protonated Polynucleotide Structures

1968 • 87 citations

Unusual DNA structures in the adenovirus genome.

1986 • 87 citations

Parallel stranded duplex DNA

1988 • 86 citations

Sequence-targeted chemical modifications of nucleic acids by complementary oligonucleotides covalently linked to porphyrins

1987 • 86 citations

Structure of the deoxytetranucleotide d‐pApTpApT and a sequence‐dependent model for poly(dA‐dT)

1982 • 86 citations

Supercoiling and integration host factor change the DNA conformation and alter the flow of convergent transcription in phage Mu

1989 • 86 citations

Dependence of Z-DNA antibody binding to polytene chromosomes on acid fixation and DNA torsional strain

1983 • 85 citations

DNA structural dynamics: longitudinal breathing as a possible mechanism for the B ⇄ Z transition

1983 • 85 citations

Evolutionary selection for perfect hairpin structures in viral DNAs

1982 • 84 citations

X-ray structure of a DNA hairpin molecule

1988 • 84 citations

Altered DNA conformations detected by mung bean nuclease occur in promoter and terminator regions of supercoiled pBR322 DNA

1985 • 83 citations

Unusual DNA Structures

1988 • 83 citations

Further studies on telestability in DNA. The synthesis and characterization of the duplex block polymers d(C20A10) - d(T10G20) and d(C20A15) - d(T15G20).

1975 • 83 citations

Cruciform transitions in DNA.

1984 • 81 citations

α-DNA-V. Parallel annealing, handedness and conformation of the duplex of the unnatural α-hexadeoxyribonucleotide α-[d(CpApTpGpCpG)] with its β-complement β-[d(GpTpApCpGpC)] deduced from high field¹H-NMR

1987 • 81 citations

The segment inversion site of herpes simplex virus type 1 adopts a novel DNA structure.

1987 • 81 citations

Determination of nanogram quantities of osmium-labeled nucleic acids by stripping (inverse) voltammetry

1983 • 80 citations

DNA supercoiling in vivo

1988 • 80 citations

Premelting Changes in DNA Conformation

1976 • 79 citations

Influence of cation size and charge on the extrusion of a salt-dependent cruciform

1987 • 78 citations

Photofootprint of nucleosome core DNA in intact chromatin having different structural states

1988 • 78 citations

Can the double helix be parallel?

1986 • 78 citations

Chemical determinants of DNA bending at adenine-thymine tracts

1987 • 77 citations

Hierarchy of binding sites for chromosomal proteins HMG 1 and 2 in supercoiled deoxyribonucleic acid

1985 • 77 citations

Molecular Structure of DNA by Scanning Tunneling Microscopy

1989 • 77 citations

Diethyl pyrocarbonate: a chemical probe for DNA cruciforms

1986 • 76 citations

Influence of the sequence-dependent flexure of DNA on transcription inE.coli

1989 • 76 citations

Acid shock proteins ofEscherichia coli

1990 • 76 citations

Z-DNA Forms Without an Alternating Purine-Pyrimidine Sequence in Solution

1985 • 76 citations

Isolation of Z-DNA binding proteins from SV40 minichromosomes: evidence for binding to the viral control region

1985 • 75 citations

Immunological detection of left-handed Z DNA in isolated polytene chromosomes. Effects of ionic strength, pH, temperature and topological stress.

1984 • 75 citations

Evidence of cruciform structures in superhelical DNA provided by two‐dimensional gel electrophoresis

1983 • 75 citations

Generation of Left-handed Z-DNA in Solution and Visualization in Polytene Chromosomes by Immunofluorescence

1983 • 75 citations

Left-handed Z-DNA in bands of acid-fixed polytene chromosomes.

1983 • 75 citations

The DNA sequence of the human .beta.-globin region is strongly biased in favor of long strings of contiguous purine or pyrimidine residues

1987 • 73 citations

NMR analysis of DNA junctions: imino proton NMR studies of individual arms and intact junction

1985 • 73 citations

Structural perturbation in supercoiled DNA: hypersensitivity to modification by a single-strand-selective chemical reagent conferred by inverted repeat sequences

1983 • 73 citations

Detection in vivo of protein-DNA interactions within the lac operon of Escherichia coli

1985 • 73 citations

The structures of polyinosinic acid

1973 • 72 citations

Site-specific OsO4 modification of the B-Z junctions formed at the (dA-dC)32 region in supercoiled DNA.

1986 • 72 citations

Thermodynamics of the ColE1 cruciform

1984 • 72 citations

Left-handed Z-DNA and intramolecular triplex formation at the site of an unequal sister chromatid exchange.

1990 • 72 citations

The P22 bacteriophage DNA molecule

1968 • 72 citations

Right- and left-handed helixes of poly[d(A-T)].cntdot.poly[d(A-T)] investigated by infrared spectroscopy

1986 • 71 citations

DNA Secondary Structures: Helices, Wrinkles, and Junctions

1983 • 71 citations

Reaction of diethyl pyrocarbonate with nucleic acid components. Bases and nucleosides derived from guanine, cytosine, and uracil

1973 • 71 citations

Intramolecular DNA Triplexes in Supercoiled Plasmids

1989 • 71 citations

E. coli single strand binding protein: a new look at helix-destabilizing proteins.

1988 • 69 citations

A Structural Transition in d(AT)_n·d(AT)_nInserts within Superhelical DNA

1985 • 69 citations

Recognition Mechanisms of DNA-Specific Enzymes

1976 • 69 citations

Molecular mechanics model of supercoiled DNA

1989 • 69 citations

The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron.

1987 • 68 citations

Distribution of Polypyrimidine · Polypurine Segments in DNA from Diverse Organisms

1979 • 67 citations

Z-DNA in the rat somatostatin gene.

1985 • 66 citations

Immunofluorescent staining of mammalian nuclei and chromosomes with a monoclonal antibody to triplex DNA

1988 • 66 citations

Coexistence of A- and B-form DNA in a single crystal lattice

1989 • 66 citations

Protection against UV-induced pyrimidine dimerization in DNA by triplex formation

1990 • 66 citations

Nonrandom Distribution of Long Mono- and Dinucleotide Repeats in Drosophila Chromosomes: Correlations with Dosage Compensation, Heterochromatin, and Recombination

1989 • 66 citations

Polarographic behaviour of native and denatured deoxyribonucleic acids

1966 • 66 citations

Distortions induced in double-stranded oligonucleotides by the binding of cis- or trans-diammine-dichloroplatinum(ll) to the d(GTG) sequence

1990 • 65 citations

An unusual DMA structure detected in a telomeric sequence under superhelical stress and at low pH

1989 • 65 citations

Isolation and characterization of the Tn3 resolvase synaptic intermediate.

1988 • 65 citations

Single base mismatches in DNA long- and short-range structure probed by analysis of axis trajectory and local chemical reactivity

1989 • 64 citations

Chloroacetaldehyde-treated ribo- and deoxyribopolynucleotides. 1. Reaction products

1982 • 64 citations

Immunoassay of Carcinogen Modified DNA

1984 • 64 citations

Complementary-Addressed (Sequence-Specific) Modification of Nucleic Acids

1985 • 64 citations

Promoter search by Escherichia coli RNA polymerase on a circular DNA template.

1987 • 64 citations

The structure of cruciforms in supercoiled DNA: probing the single-stranded character of nucleotide bases with bisulphite.

1986 • 63 citations

Polymorphism of Natural DNA

1972 • 62 citations

Conversion of a helix-turn-helix motif sequence-specific DNA binding protein into a site-specific DNA cleavage agent.

1990 • 62 citations

POSSIBLE SEPARATION OF INTERTWINED NUCLEIC ACID CHAINS BY TRANSFER-TWIST

1955 • 62 citations

Z-DNA in transcriptionally active chromosomes.

1987 • 62 citations

Intramolecular DNA Triplexes in Supercoiled Plasmids

1989 • 61 citations

Locations and contexts of sequences that hybridize to poly(dG-dT).(dC-dA) in mammalian ribosomal DNAs and two X-linked genes

1988 • 61 citations

High-resolution analysis of lac transcription complexes inside cells

1986 • 61 citations

CD of six different conformational rearrangements of poly[(d(A-G)·d(C-T)] induced by low pH

1988 • 61 citations

The hydrogen-bonding structure in parallel-stranded duplex DNA is reverse Watson-Crick

1991 • 61 citations

Chemical reactivity of matched cytosine and thymine bases near mismatched and unmatched bases in a heteroduplex between DNA strands with multiple differences

1989 • 60 citations

Human homologs of TU transposon sequences: polypurine/polypyrimidine sequence elements that can alter DNA conformation in vitro and in vivo.

1986 • 60 citations

Yeast regulatory sequences preferentially adopt a non-B conformation in supercoiled DNA

1987 • 60 citations

Analysis of RNA structures by temperature-gradient gel electrophoresis: viroid replication and processing

1988 • 60 citations

Physicochemical properties of nucleosides 3. Gel formation by 8‐bromoguanosine

1969 • 60 citations

Osmium-induced alteration in DNA structure.

1984 • 59 citations

Physico-chemical properties of nucleosides

1971 • 59 citations

THE DENATURATION AND THE RENATURATION OF THE DNA OF POLYOMA VIRUS

1963 • 59 citations

(dT-dC)n and (dG-dA)n tracts arrest single stranded DNA replicationin vitro

1989 • 58 citations

Detection of intercalation‐induced changes in DNA structure by reaction with diethyl pyrocarbonate or potassium permanganate Evidence against the induction of Hoogsteen base pairing by echinomycin

1988 • 58 citations

DNA-sequence and metal-ion specificity of the formation of^*H-DNA

1990 • 58 citations

Comparative properties of DNA, RNA, and hybrid homopolymer pairs.

1965 • 58 citations

Recognition of the Structural Distortions at the Junctions Between B and Z Segments in Negatively Supercoiled DNA by Osmium Tetroxide

1985 • 58 citations

The influence of exocyclic substituents of purine bases on DNA curvature.

1987 • 58 citations

-Kinked DNA--a Structure That Gives Rise to Drug Intercalation and DNA Breathing--and Its Wider Significance in Determining the Premelting and Melting Behavior of DNA

1983 • 57 citations

Triplex DNA in plasmids and chromosomes

1989 • 57 citations

Effect of length, supercoiling, and pH on intramolecular triplex formation. Multiple conformers at pur.pyr mirror repeats.

1990 • 57 citations

Nucleic Acids and Molecular Biology

1995 • 56 citations

Molecular microscopy of labeled polynucleotides: Stability of osmium atoms

1977 • 56 citations

Deoxyribonucleic acid structure in human diploid fibroblasts stimulated to proliferate.

1977 • 56 citations

Correlation between the conformation of Escherichia coli −10 hexamer sequences and promoter strength: use of orthophenanthroline cuprous complex as a structural index.

1988 • 56 citations

Telomere G-strand structure and function analyzed by chemical protection, base analog substitution, and utilization by telomerase in vitro

1990 • 55 citations

DNA curvature in native and modified EcoRI recognition sites and possible influence upon the endonuclease cleavage reaction

1988 • 55 citations

Chemical footprinting of the interaction between left-handed Z-DNA and anti-Z-DNA antibodies by diethylpyrocarbonate carbethoxylation

1986 • 55 citations

The anomalous gel migration of a stable cruciform: temperature and salt dependence, and some comparisons with curved DNA

1987 • 54 citations

Left-Handed Z-DNA and Genetic Recombination

1989 • 54 citations

Relative stability of parallel- and anti-parallel-stranded duplex DNA

1988 • 54 citations

Salt effects on internal motions of superhelical and linear pUC8 DNA

1987 • 54 citations

A Protein-Protein Interaction Is Essential for Stable Complex Formation on a 5 S RNA Gene

1989 • 54 citations

Site specificity of psoralen-DNA interstrand cross-linking determined by nuclease Bal31 digestion

1986 • 53 citations

Location of B- and Z-DNA in the chromosomes of a primitive eukaryote dinoflagellate.

1990 • 53 citations

Configurational and dynamic properties of different length superhelical DNAs measured by dynamic light scattering

1989 • 53 citations

Helix-coil transition of parallel-stranded DNA. Thermodynamics of hairpin and linear duplex oligonucleotides

1989 • 53 citations

Salt-induced conformational changes of poly(dA-dT)

1980 • 53 citations

444 — Electrochemical analysis of polynucleotides

1981 • 53 citations

Oscillographic polarography of deoxyribonucleic acid degradation products

1961 • 52 citations

Theoretical study of cruciform states in superhelical DNAs

1982 • 52 citations

The role of DNA sequence in the formation of Z-DNA versus cruciforms in plasmids.

1988 • 52 citations

A two-state conformational equilibrium for alternating (A-T)n sequences in negatively supercoiled DNA

1987 • 52 citations

Structural variation in d(CTCTAGAG). Implications for protein-DNA interactions

1989 • 52 citations

Nonrandom distribution of long mono- and dinucleotide repeats in Drosophila chromosomes: correlations with dosage compensation, heterochromatin, and recombination.

1989 • 51 citations

Molecular cloning and sequence of the concatemer junction from vaccinia virus replicative DNA

1988 • 51 citations

Osmium tetroxide: a new probe for site-specific distortions in supercoiled DNAs

1984 • 51 citations

Superhelical DNA

1980 • 50 citations

Mung bean nuclease cleavage of a dA + dT-rich sequence or an inverted repeat sequence in supercoiled PM2 DNA depends on ionic environment

1984 • 50 citations

Bacterial chromatin: A new twist to an old story

1986 • 50 citations

Polynucléotides protonés. VII. Transitions thermiques entre differents complexes de l'acide polyinosinique et de l'acide polycytidylique en milieu acide

1969 • 50 citations

B→A Transitions within a 5 S Ribosomal RNA Gene Are Highly Sequence-specific

1989 • 50 citations

Z‐DNA and other non‐B‐DNA structures are reversed to B‐DNA by interaction with netropsin

1983 • 50 citations

Chemical probing of the homopurine·homopyrimidine tract in supercoiled DNA at single‐nucleotide resolution

1988 • 49 citations

Polypurine DNAs and RNAs form secondary structures which may be tetra-stranded

1980 • 49 citations

Neutron and light-scattering studies of DNA gyrase and its complex with DNA

1990 • 49 citations

Sequence Signals in Eukaryotic Up-stream Region

1990 • 49 citations

A molecular model for gene repression.

1966 • 48 citations

Conformation of DNA modified at a d(GG) or a d(AG) site by the antitumor drug cis-diamminedichloroplatinum(II)

1989 • 48 citations

Methylation of cytosine in the 5-position alters the structural and energetic properties of the supercoil-induced Z-helix and B-Z junctions

1988 • 48 citations

Antibodies Specific for Modified Nucleosides: An Immunochemical Approach for the Isolation and Characterization of Nucleic Acids

1980 • 48 citations

Chemical probing of conformation in large RNA molecules

1984 • 48 citations

Temperatare dependence of the gel electrophoretic mobility of superhelical DNA

1985 • 47 citations

B-Z DNA junctions contain few, if any, nonpaired bases at physiological superhelical densities.

1985 • 47 citations

Monoclonal antibodies to cruciform DNA structures

1987 • 47 citations

The role of sequence in the stabilization of left-handed DNA helices in vitro and in vivo

1988 • 47 citations

G-strings at chromosome ends

1988 • 47 citations

Rh(DIP)₃³⁺: a shape-selective metal complex which targets cruciforms

1988 • 47 citations

Pulsed field electrophoresis in contour‐clamped homogeneous electric fields for the resolution of DNA by size or topology

1989 • 47 citations

4 Primer on the Topology and Geometry of DNA Supercoiling

1990 • 47 citations

The conformation of a B-DNA decamer is mainly determined by its sequence and not by crystal environment.

1991 • 47 citations

Raman spectroscopy of Z-form poly[d(A-T)].cntdot.poly[d(A-T)]

1988 • 47 citations

Change of conformation and internal dynamics of supercoiled DNA upon binding of Escherichia coli single-strand binding protein

1985 • 46 citations

Localized chemical hyperreactivity in supercoiled DNA. Evidence for base unpairing in sequences that induce low-salt cruciform extrusion

1989 • 46 citations

Site of unequal sister chromatid exchange contains a potential Z-DNA-forming tract.

1988 • 46 citations

Changes in site specificity of single-strand-specific endonucleases on supercoiled PM2 DNA with temperature and ionic environment

1984 • 46 citations

Z Form of Poly d(A-T) · Poly d(A-T) in Solution Studied by CD and UV Spectroscopies

1987 • 46 citations

Recent aspects of the photochemistry of nucleic acids and related model compounds

1985 • 46 citations

A left-handed (Z) conformation of poly(dA-dC).poly(dG-dT) induced by polyamines

1986 • 46 citations

Unusual conformational effect exerted by Z-DNA upon its neighboring sequences.

1987 • 45 citations

Left-handed Z-DNA

1985 • 45 citations

The reaction of osmium tetroxide-pyridine complexes with nucleic acid components

1971 • 45 citations

Structure of (dG)_n· (dC)_nUnder Superhelical Stress and Acid pH

1987 • 45 citations

Cytosine methylation enhances Z-DNA formation in vivo

1990 • 45 citations

Pyrimidine 5-methyl groups influence the magnitude of DNA curvature

1990 • 45 citations

A parallel right-handed duplex of the hexamer d(TpTpTpTpTpT) with phosphate triester linkages

1987 • 45 citations

Effect of base composition at the center of inverted repeated DNA sequences on cruciform transitions in DNA.

1988 • 44 citations

Mapping using gene encyclopaedias

1987 • 44 citations

Poly(dC?dA/dG?dT) repeats in the Drosophila genome: a key function for dosage compensation and position effects?

1987 • 44 citations

Reaction conditions affect the specificity of bromoacetaidehyde as a probe for DNA cruciforms and B—Z junctions

1987 • 44 citations

Tetracycline promoter mutations decrease non-B DNA structural transitions, negative linking differences and deletions in recombinant plasmids in Escherichia coli

1989 • 44 citations

Multiple non-B-DNA conformations of polypurine.cntdot.polypyrimidine sequences in plasmids

1990 • 44 citations

Characteristics of Z-DNA helices formed by imperfect (purine-pyrimidine) sequences in plasmids.

1988 • 43 citations

Temperature-dependent CD and NMR studies on a synthetic oligonucleotide containing a B-Z junction at high salt

1989 • 43 citations

Anti-DNA antibodies: problems in their study and interpretation.

1986 • 43 citations

Magnesium-dependent supercoiling-induced transition in (dG)_n·(dC)_nstretches and formation of a new G-structure by (dG)_nstrand

1989 • 43 citations

Spectroscopic properties and helical stabilities of 25-nt parallel-stranded linear DNA duplexes

1989 • 42 citations

Cationic metal-specific structures adopted by the poly(dG) region and the direct repeats in the chicken adult β^Aglobin gene promoter

1989 • 42 citations

Protonated polynucleotides structures - 22.CD study of the acid-base titration of poly(dG).poly(dC)

1978 • 42 citations

Sequence-specific chemical modification of double-stranded DNA with alkylating oligodeoxyribonucleotide derivatives

1988 • 42 citations

Unusual Sequence Element Found at the End of an Amplicon

1987 • 41 citations

Protonated triplex DNA in E. coli cells as detected by chemical probing

1990 • 41 citations

CHEMICAL REACTIONS OF POLYNUCLEOTIDES AND NUCLEIC ACIDS

1974 • 41 citations

Base methylation and local DNA helix stability

1989 • 41 citations

Parallel DNA: generation of a duplex between two Drosophila sequences in vitro

1989 • 40 citations

Nucleotide sequence of the 3′ half of AKV

1982 • 40 citations

Influence of DNA sequence and supercoiling on the process of cruciform formation

1988 • 40 citations

A Parallel Stranded Linear DNA Duplex Incorporating dG · dC Base Pairs

1990 • 40 citations

Thermodynamic parameters are sequence-dependent for the supercoil-induced B to Z transition in recombinant plasmids.

1986 • 40 citations

The dynamic distribution and quantification of DNA cruciforms in eukaryotic nuclei

1990 • 39 citations

Dynamics of superhelical DNA studied by photon correlation spectroscopy

1986 • 39 citations

Specific binding of cruciform DNA structures by a protein from human extracts

1988 • 38 citations

The tertiary sturcture of the four-way DNA junction affords protection against DNase I Cleavage

1990 • 38 citations

Immunochemical approaches to DNA structure investigation—I

1979 • 38 citations

Structure of RNA polymerase II promoters. Conformational alterations and template properties of circularized Saccharomyces cerevisiae GAL1-GAL10 divergent promoters.

1986 • 38 citations

Action of mung bean nuclease on supercoiled PM2 DNA.

1982 • 38 citations

DNA supercoiling and its effects on the structure of DNA

1984 • 38 citations

Conformational analysis of d(C3G3), a B-family duplex in solution

1989 • 37 citations

Interaction of synthetic analogs of distamycin and netropsin with nucleic acids. Does curvature of ligand play a role in distamycin-DNA interactions?

1988 • 37 citations

Fine mapping of DNA single-stranded regions using base-specific chemical probes. Study of an open complex formed between RNA polymerase and the lac UV5 promoter

1989 • 37 citations

Eukaryotic DNA diverges at a long and complex pyrimidine.purine tract that can adopt altered conformations.

1986 • 36 citations

An oligopurine sequence bias occurs in eukaryotic viruses

1988 • 36 citations

Long (dA)_n.(dT)_ntracts can form intramolecular triplexes under superhelical stress

1990 • 36 citations

Stress-induced cruciform formation in a cloned d(CATG)10 sequence.

1986 • 36 citations

Theoretical Analysis of Conformational Equilibria in Superhelical DNA

1985 • 36 citations

Genomic footprinting in mammalian cells with ultraviolet light.

1989 • 36 citations

Supercoiled DNA is interwound in liquid crystalline solutions.

1989 • 35 citations

Sugar-unspecific Mung Bean Nuclease I

1968 • 35 citations

Changes in oscillopolarographic behaviour of deoxyribonucleic acids at temperatures below denaturation temperature

1965 • 35 citations

DNA Curvature

1987 • 35 citations

Probing of DNA polymorphic structure in the cell with osmium tetroxide

1988 • 35 citations

Poly(I) helix formation. Dependence on size-specific complexing to alkali metal ions

1978 • 35 citations

The crystal and molecular structure of an osmium bispyridine adduct of thymine

1976 • 34 citations

S1 nuclease sensitivity of a double-stranded telomeric DNA sequence

1987 • 34 citations

The Structure of the Guanine-rich Polypurine: Polypyrimidine Sequence at the Right End of the Rat L1 (LINE) Element

1989 • 34 citations

Migration properties of circular DNAs using orthogonal‐field‐alternation gel electrophoresis

1989 • 34 citations

Studies of DNA‐protein interactions by gel electrophoresis

1989 • 34 citations

Long range structural communication between sequences in supercoiled DNA. Sequence dependence of contextual influence on cruciform extrusion mechanism.

1988 • 34 citations

Perturbation of DNA hairpins containing the EcoRI recognition site by hairpin loops of varying size and composition: physical (NMR and UV) and enzymatic (EcoRI) studies

1990 • 34 citations

The structure and hydration of the A-DNA fragement d(GGGTACCC) at room temperature and low temperature

1990 • 33 citations

Sequence-directed bent DNA helix is the specific binding site for Crithidia fasciculata nicking enzyme.

1987 • 32 citations

A long polypyrimidine/polypurine tract induces an altered DNA conformation on the 3' coding region of the adjacent myosin heavy chain gene

1987 • 32 citations

Hyperreactivity of B–Z junctions to 4,5′,8-trimethylpsoralen photobinding assayed by an exonuclease III/photoreversal mapping procedure

1989 • 31 citations

Tet repressor-tet operator contacts probed by operator DNA-modification interference studies

1988 • 31 citations

Preliminary spectroscopic characterization of a synthetic DNA oligomer containing a B–Z junction at high salt

1988 • 31 citations

Unusual Protonated Structure in the Homopurine · Homopyrimidine Tract of Supercoiled and Linearized Plasmids Recognized by Chemical Probes

1987 • 31 citations

DNA topoisomerases: nature's solution to the topological ramifications of the double-helix structure of DNA.

1985 • 31 citations

Transverse alternating field electrophoresis and applications to mammalian genome mapping

1989 • 30 citations

Diethylpyrocarbonate and permanganate provide evidence for an unusual DNA conformation induced by binding of the antitumour antibiotics bleomycin and phleomycin

1988 • 30 citations

Characterization of a parallel stranded DNA hairpin

1989 • 30 citations

Structural isomerization in DNA: the formation of cruciform structures in supercoiled DNA molecules

1989 • 30 citations

Environmental influences on DNA superhelicity

1987 • 30 citations

Human globin ψB₂is not a globin-related sequence

1982 • 29 citations

Supercoil-induced unusual DNA sturctures as transcriptional block

1990 • 29 citations

The Z-Conformation of Poly(dA-dT) · Poly(dA-dT) in Solution as Studied by Ultraviolet Resonance Raman Spectroscopy

1989 • 29 citations

Differences between sites of binding to DNA and strand cleavage for complexes of bleomycin with iron of cobalt

1989 • 29 citations

Immunogenic duplex nucleic acids are nuclease resistant.

1988 • 29 citations

Parallel stranded DNA with AT base pairing

1989 • 29 citations

Nonhistone protein HMG1 removes the transcriptional block caused by left-handed Z-form segment in a supercoiled DNA

1988 • 29 citations

Echinomycin-induced hypersensitivity to osmium tetroxide of DNA fragments incapable of forming Hoogsteen base pairs.

1989 • 28 citations

DNA: Sequence, Structure and Supercoiling

1984 • 28 citations

Inhibition of restriction endonuclease cleavage due to site-specific chemical modification of the B-Z junction in supercoiled DNA.

1987 • 28 citations

Multiple DNA secondary structures in perfect inverted repeat inserts in plasmids. Right-handed B-DNA, cruciforms, and left-handed Z-DNA.

1988 • 28 citations

Z form of poly d(A–C).poly d(G–T) in solution studied by Raman spectroscopy

1987 • 28 citations

A sharp structural transition in pA03 plasmid DNA caused by increased superhelix density

1982 • 28 citations

Chloroacetaldehyde reacts with Z-DNA

1988 • 27 citations

Use of the hydroxyl radical and gel electrophoresis to study DNA structure

1989 • 27 citations

Interactions of the dimethyldiazaperopyrenium dication with nucleic acids. 2. Binding to double-stranded polynucleotides

1989 • 27 citations

A Duplex of the Oligonucleotides d(GGGGGTTTTT) and d(AAAAACCCCC) Forms an A to B Conformational Junction in Concentrated Salt Solutions

1989 • 27 citations

Simple DNA sequences and dispersed repetitive elements in the vicinity of mouse immunoglobulin K light chain genes

1983 • 27 citations

Searching for potential Z-DNA in genomic Escherichia coli DNA

1987 • 27 citations

Dam methyltransferase sites located within the loop region of the oligopurine-oligopyrimidine sequences capable of forming H-DNA are undermethylatedin vivo

1990 • 27 citations

Polynucleotide—Protein Cross-Links Induced by Ultraviolet Light and Their Use for Structural Investigation of Nucleoproteins

1989 • 26 citations

Helix stability and the mechanism of cruciform extrusion in supercoiled DNA molecules

1988 • 26 citations

Osmium tetroxide recognized structural distortions at junctions between right- and left-handed DNA in a bacterial cell.

1987 • 26 citations

Energetics of the B–H transition in supercoiled DNA carrying d(CT)_x.d(AG)_xand d(C)_n.d(G)_ninserts

1989 • 26 citations

Competitive nucleosome reconstitution of polydeoxynucleotides containing oligoguanosine tracts

1989 • 26 citations

Structure- and sequence-specificity of ozone degradation of supercoiled plasmid DNA¹

1986 • 26 citations

Conformational properties of the osmium tetraoxide bispyridine ester of 1-methylthymine and a comment on the linearity of the trans OOsO group

1976 • 25 citations

Protonated polynucleotides structures - 23. The acid-base hysteresis of poly(dG).poly(dC)

1978 • 25 citations

Altered DNA conformations In the gene regulatory region of torsionaliy-stressed SV4O DNA

1986 • 25 citations

Deformational dynamics and nmr relaxation of supercoiled DNAs

1985 • 25 citations

Control of gene expression by oligonucleotides covalently linked to intercalating agents

1989 • 25 citations

Optical activity of 5′-guanylic acid gel

1965 • 25 citations

A nicking enzyme from trypanosomatids which specifically affects the topological linking of duplex DNA circles. Purification and characterization.

1986 • 24 citations

Z-DNA-binding proteins in Escherichia coli purification, generation of monoclonal antibodies and gene isolation

1988 • 24 citations

DNA bending induced by covalently bound drugs

1990 • 24 citations

A unique endonuclease from Crithidia fasciculata which recognizes a bend in the DNA helix. Specificity of the cleavage reaction.

1988 • 23 citations

Superhelical DNA with local substructures

1987 • 23 citations

Reactivity of parallel-stranded DNA to chemical modification reagents

1990 • 23 citations

Unusual DNA structure in the regulatory region of the human papovavirus JC virus

1988 • 23 citations

Deoxyribonucleic acid conformotional changes at temperatures below melting temperature

1968 • 23 citations

Through the looking glass: the discovery of supercoiled DNA

1990 • 23 citations

High-resolution footprints of the DNA-binding domain of Epstein-Barr virus nuclear antigen 1.

1989 • 23 citations

Stochastic distribution of a short region of Z-DNA within a long repeated sequence in negatively supercoiled plasmids.

1988 • 23 citations

Chemical modification of Escherichia coli RNA polymerase by diethyl pyrocarbonate: evidence of histidine requirement for enzyme activity and intrinsic zinc binding

1986 • 23 citations

Chemical modification of 3.alpha.,20.beta.-hydroxysteroid dehydrogenase with diethyl pyrocarbonate. Evidence for an essential, highly reactive, lysyl residue

1987 • 22 citations

X-ray diffraction studies of circular superhelical DNA at 300–10,000-Å resolution

1976 • 22 citations

Substrate properties of 25-nt parallel-stranded linear DNA duplexes

1989 • 22 citations

A Note on Crystal Packing and Global Helix Structure in Short A-DNA Duplexes

1991 • 22 citations

Chloroacetaldehyde-treated ribo- and deoxyribopolynucleotides. 2. Errors in transcription by different polymerases resulting from ethenocytosine and its hydrated intermediate

1982 • 22 citations

Atypical sieving of open circular DNA during pulsed field agarose gel electrophoresis

1989 • 22 citations

Slight changes in conditions influence the family of non-B-DNA conformations of the herpes simplex virus type 1 DR2 repeats

1989 • 21 citations

B-Z Junctions in Supercoiled pRW751 DNA Contain Unpaired Bases or Non-Watson-Crick Base Pairs

1987 • 21 citations

The suffix sequence is involved in processing the 3′ ends of different mRNAs in Drosophila melanogaster

1986 • 21 citations

The turn of the quadruplex?

1989 • 21 citations

Reactions of cytosine and 5-methylcytosine with osmium(VIII) reagents: Synthesis and deamination to uracil and thymine derivatives

1981 • 21 citations

The migration anomaly of DNA fragments in polyacrylamide gels allows the detection of small sequence‐specific DNA structure variations

1989 • 21 citations

Electron Microscopy of Supercoiled pEJ4 DNA Containing Homopurine · Homopyrimidine Sequences

1989 • 20 citations

Early melting of supercoiled DNA

1988 • 20 citations

Chemical Probing of the B-Z Transition in Negatively Supercoiled DNA

1988 • 20 citations

Structural changes in positively and negatively supercoiled DNA

1989 • 20 citations

Bent DNA structures associated with several origins of replication are recognized by a unique enzyme from trypanosomatids

1988 • 20 citations

Electrochemical analysis of polynucleotides

1981 • 20 citations

Structural interconversion of alternating purine-pyrimidine inverted repeats cloned in supercoiled plasmids

1988 • 20 citations

Identification of a long stretch of homopurine · homopyrimidine sequence in a cluster of retroposons in the human genome

1990 • 20 citations

Specific cleavage of kinetoplast minicircle DNA fromLeishmania tarentolaeby mung bean nuclease and identification of several additional minicircle sequence classes

1986 • 20 citations

Unusual sequence element found at the end of an amplicon.

1987 • 19 citations

Nucleoside conformations

1972 • 19 citations

Z-DNA and the Polytene Chromosome

1983 • 19 citations

[31] An endonuclease from Neurospora crassa specific for polynucleotides lacking an ordered structure

1967 • 19 citations

Supercoil‐stabilized left‐handed DNA in the plasmid (dA‐dT)₁₆ insert formed in the presence of Ni²⁺

1989 • 19 citations

Footprinting analysis of sequence-specific DNA-drug interactions

1989 • 19 citations

Correlation between polarographic reducibility and circular dichroism of DNA at submelting temperatures

1972 • 19 citations

B‐Z DNA junctions are neither highly flexible nor strongly bent

1987 • 18 citations

Yolk proteins from nematodes, chickens, and frogs bind strongly and preferentially to left-handed Z-DNA.

1988 • 18 citations

RecBC,sbcB independent, (AT)ⁿ- mediated deletion of sequences flanking aXenopus laevis βglobin gene on propagation inE. coli

1986 • 18 citations

Supercoiled induced transition to the Z-DNA conformation affects the ability of a d(CG/GC)₁₂sequence to be organized into nucleosome-cores

1987 • 18 citations

Waves of DNA supercoiling

1989 • 18 citations

High resolution psoralen mapping reveals an altered DNA helical structure in the SV40 regulatory region

1988 • 18 citations

Site-Specific Chemical Modification of B-Z Junctions in Supercoiled DNA as Detected by Nuclease SI Digestion, Inhibition of Restriction Cleavage and Nucleotide Sequencing

1988 • 17 citations

A study of the B-Z transition of the AC-rich region of the repeat unit of a satellite DNA from Cebus by means of chemical probes.

1988 • 17 citations

Flanking AT-rich tracts cause a structural distortion in Z-DNA in plasmids.

1990 • 17 citations

Carbodiimide inactivation of Escherichia coli RNA polymerase promoters on supercoiled simian virus 40 and ColE1 DNAs occurs by a one-hit process at salt concentrations in the physiological range.

1983 • 17 citations

442 — Polarography of circular DNAs

1981 • 17 citations

Structural models for non-helical DNA.

1986 • 17 citations

Energetics of the B-Z DNA Transition

1987 • 17 citations

Length dependent formation of parallel-stranded DNA in alternating AT segments

1990 • 17 citations

AAF linked to the guanine amino group: a B-Z junction

1983 • 17 citations

Detection of Z DNA binding proteins in tissue culture cells

1988 • 17 citations

The Impact of Gene Transfer Techniques in Eukaryotic Cell Biology

1984 • 17 citations

Highly recurring sequence elements identified in eukaryotic DNAs by computer analysis are often homologous to regulatory sequences or protein binding sites

1987 • 16 citations

Probing of B-Z junctions in recombinant plasmids in vitro and in the cell with different osmium tetroxide complexes.

1989 • 16 citations

Sequence Specific Recognition of Double Helical DNA. A Synthetic Approach

1988 • 16 citations

In vivo assessment of the Z-DNA-forming potential of d(CA · GT)n and d(CG · GC)n sequences cloned into SV40 minichromosomes

1989 • 16 citations

The reactions of adenine and cytosine residues in tRNA with chloroacetaldehyde

1981 • 16 citations

Complex structural behavior of oligopurine-ligopyrimidine sequence cloned within the supercoiled plasmid

1989 • 15 citations

Genomic sequencing and in vivo footprinting

1989 • 15 citations

Antibodies to DNAs chemically modified with osmium structural probes.

1989 • 14 citations

Immunoassays for carbodiimide modified DNA-detection of unpairing transitions in supercoiled ColE1 DNA

1989 • 14 citations

The obtention of simian virus 40 recombinants carrying d(CG · GC)_n, d(CA · GT)_n and d(CT · GA)_n sequences

1987 • 14 citations

Probing of DNA structure with osmium tetroxide

1989 • 14 citations

Transcription regulation in vitro by anE.colipromoter containing a DNA cruciform in the ’-35‘ region

1989 • 14 citations

Metal Complexes Which Target DNA Sites: Coupling Recognition to Reactivity

1988 • 14 citations

Effect ofin vitrotranscription on cruciform stability

1990 • 13 citations

Interaction of oligoribocytidylates with T7 DNA in neutral and acid media

1977 • 13 citations

The Extrusion of Cruciform Structures in Supercoiled DNA — Kinetics and Mechanisms

1987 • 13 citations

Hysteretic behaviour of a Z-DNA-antibody complex

1987 • 13 citations

The effect of temperature on the cross-linking of deoxyribonucleic acid strands by ultraviolet radiation

1962 • 12 citations

The 1988 Walter Hubert lecture: Artificial control of gene expression by oligodeoxynucleotides covalently linked to intercalating agents

1989 • 12 citations

The sequence-directed bent structure in kinetoplast DNA is recognized by an enzyme from Crithidia fasciculata.

1987 • 12 citations

Localization of melted regions in supercoiled DNA

1989 • 12 citations

Detection of unusual nucleic acids with monoclonal antibodies specific for triplexes, poly(ADP-ribose), DNA-RNA hybrids, and Z-DNA

1989 • 11 citations

Intracellular Oxidative Cleavage of DNA inEscherichia Coliby the Copper-1, 10-Phenanthroline Complex

1989 • 11 citations

DNA supercoiling and DNA structure

1986 • 11 citations

Effect of the methyl group on DNA bending and curvature: structure of d(GA4U4C)2 in solution

1990 • 11 citations

Osmium tetroxide, N,N,N',N'‐tetramethylethylendiamine A new probe of DNA structure in the cell

1990 • 11 citations

Insertion of d(pCpG)n · d(pCpG)n into the lacZ gene of Escherichia coli inhibits expression of β-galactosidase in vivo

1988 • 10 citations

Resolution of model Holliday junctions by yeast endonuclease: effect of DNA structure and sequence.

1989 • 10 citations

1 New Approaches to DNA in the Crystal and in Solution

1990 • 10 citations

Kinetic persistence of cruciform structures in reconstituted minichromosomes

1988 • 10 citations

Flanking AT-rich sequences may lower the activation energy of cruciform extrusion in supercoiled DNA

1989 • 10 citations

Electrophoretic behavior of d(GGAAAAAAGG)ⁿ, d(CCAAAAAACC)ⁿ, and (CCAAAAAAGG)ⁿ, and implications for a DNA bending model

1990 • 9 citations

Structure and Expression. Vol. 2. DNA and its Drug Complexes.

1989 • 9 citations

Separation of chromosomal length DNA molecules: Pneumatic apparatus for rotating gels during electrophoresis

1989 • 9 citations

Immunological detection of lesions in DNA

1985 • 9 citations

Oligo-[α]-Deoxyribonucleotides Covalently Linked to Intercalating Agents. A New Family of Sequence-Specific Nucleic Acid Reagents

1988 • 9 citations

Parallel-Stranded DNA with trans-Crick-Watson Base Pairs

1991 • 9 citations

Influence of supercoiling on DNA structure: Laser Raman spectroscopy of the plasmid pBR322

1985 • 8 citations

Site-directed chemical modification for probing DNA-protein interactions

1989 • 8 citations

Modification of ColE1 DNA with Osmium Tetroxide Generates Positively Supercoiled Molecules

1985 • 8 citations

The Complex of Poly(dG) · Poly(dC) with Arginine: Stabilization of the B Form and Transition to Multistranded Structures

1987 • 8 citations

Structure of RNA polymerase II promoters. Coordinate conformational alteration of the upstream activator of the TATA- and RNA-initiation sequences under moderate torsional stress.

1986 • 8 citations

Z-DNA: Exploring the Biological Significance

1987 • 8 citations

IR and UV Studies on Stability and Conformations of Short DNA Duplexes Containing a No-Base Residue: Coexistence of B and Z Conformations

1988 • 8 citations

Unusual DNA Structures and the Probes Used for their Detection

1988 • 8 citations

Structure and Methods, Vol. 3. DNA and RNA.

1991 • 7 citations

Osmium tetroxide probing of local DNA structure in linear and supercoiled plasmids containing curvature-inducing sequences.

1988 • 7 citations

A Stochastic Model for Helix Bending in B-DNA

1983 • 7 citations

Effect of Length, Supercoiling, and pH on Intramolecular Triplex Formation

1990 • 7 citations

Irradiation of the template with high‐intensity (pulse‐laser) ultraviolet light results in DNA‐polymerase termination events at deoxyguanosine residues

1989 • 7 citations

Sensitivity of DNA and Nucleotides to Oxidation by Permanganate and Hydrogen Peroxide

1987 • 7 citations

Polarography of circular DNAs

1981 • 6 citations

Raman spectrum of a closed‐circular DNA

1985 • 6 citations

Isolation of a DNA-Binding Protein from Deinococcus radiodurans Having an Affinity for a Z-Form Polynucleotide1

1988 • 6 citations

Properties of DNA modified with N-methyl-N-nitrosourea

1977 • 6 citations

Unusual DNA structures at the integration site of an HIV provirus

1989 • 6 citations

Raman spectroscopy of supercoiled and nicked ColE1 plasmid

1989 • 5 citations

Hairpin-loops in supercoiled DNA

1982 • 5 citations

Slipped DNA structures within the enhancer region of the moloney murine leukemia virus

1988 • 5 citations

DNA structural alterations in the SV40 enhancer region are retained in vivo

1988 • 5 citations

Intermediate range effects in DNA I: low pH/stress induced conformational changes in the vicinity of an extruded d(AT)n·d(AT)n cruciform

1988 • 5 citations

Non-Commensurate Polypurine/Polypyrimidine DNA Structures

1988 • 4 citations

Immunochemical Approaches to the Definition of Unusual Nucleic Acid Structures

1988 • 4 citations

Nuclease S1-sensitive sites on superhelical DNA molecules carrying the LTR region of Moloney murine leukemia virus

1987 • 3 citations

Flexibility of A · Pairs in Left-Handed DNA Helices

1990 • 2 citations

The Polymorphism of DNA

1976 • 2 citations

The shifting centre

1988 • 1 citations

DNA Supercoiling as a Regulator of Bacterial Gene Expression

1987 • 1 citations