Diethylpyrocarbonate and permanganate provide evidence for an unusual DNA conformation induced by binding of the antitumour antibiotics bleomycin and phleomycin

A clinical review of bleomycin—a new antineoplastic agent

1973 • 860 citations

Activated bleomycin. A transient complex of drug, iron, and oxygen that degrades DNA.

1981 • 458 citations

Chemical probes for higher-order structure in RNA.

1980 • 415 citations

ON THE MECHANISM OF ACTION OF BLEOMYCIN : SCISSION OF DNA STRANDS IN VITRO AND IN VIVO

1969 • 328 citations

Pyrimidine-specific chemical reactions useful for DNA sequencing

1980 • 326 citations

Characterization of two xenopus somatic 5S DNAs and one minor oocyte-specific 5S DNA

1980 • 305 citations

Sequence specific cleavage of DNA by the antitumor antibiotics neocarzinostatin and bleomycin.

1978 • 299 citations

A role for ferrous ion and oxygen in the degradation of DNA by bleomycin

1976 • 291 citations

Chemical probes of DNA conformation: detection of Z-DNA at nucleotide resolution

1985 • 286 citations

Interaction of bleomycin with DNA.

1978 • 250 citations

Bleomycin-specific fragmentation of double-stranded DNA

1978 • 187 citations

Increased DNA chain breakage by combined action of bleomycin and superoxide radical

1975 • 183 citations

Diethyl pyrocarbonate: a chemical probe for secondary structure in negatively supercoiled DNA.

1985 • 169 citations

The selective degradation of pyrimidines in nucleic acids by permanganate oxidation

1967 • 135 citations

Sequence-specific positioning of core histones on an 860 base-pair DNA

1987 • 134 citations

Highly selective chemical modification of cruciform loops by diethyl pyrocarbonate

1986 • 100 citations

Nucleotide sequence binding preferences of nogalamycin investigated by DNase I footprinting

1986 • 78 citations

Diethyl pyrocarbonate: a chemical probe for DNA cruciforms

1986 • 76 citations

Stoichiometry of DNA strand scission and aldehyde formation by bleomycin.

1982 • 75 citations

Effects of O2 on the reactions of activated bleomycin.

1982 • 66 citations

Hoogsteen base pairs proximal and distal to echinomycin binding sites on DNA.

1987 • 61 citations

Copper(II).bleomycin, iron(III).bleomycin, and copper(II).phleomycin: comparative study of deoxyribonucleic acid binding

1981 • 60 citations

Comparison of the sequence specificity of bleomycin cleavage in two slightly different DNA sequences

1985 • 47 citations

Induction of local denaturation in DNA in vitro by phleomycin and caffeine

1974 • 25 citations

Sequence-selective binding of phleomycin to DNA

1987 • 18 citations

Amplification of the antibiotic effects of the bleomycins, phleomycins and tallysomycins: Its dependence on the nature of the variable basic groups.

1985 • 12 citations