Chemical and photochemical probing of DNA complexes

Genomic sequencing.

1984 • 8,343 citations

A new method for sequencing DNA.

1977 • 7,941 citations

LXXIII.—Oxidation of tartaric acid in presence of iron

1894 • 2,887 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

The catalytic decomposition of hydrogen peroxide by iron salts

1934 • 2,483 citations

DNAase footprinting a simple method for the detection of protein-DNA binding specificity

1978 • 2,092 citations

Genetical Implications of the Structure of Deoxyribonucleic Acid

1953 • 2,087 citations

PROTEIN-DNA RECOGNITION

1984 • 1,649 citations

Oxidation of tartaric acid in presence of iron

1894 • 1,515 citations

Genetical Implications of the Structure of Deoxyribonucleic Acid

2017 • 1,338 citations

Structure of Chromatin

1977 • 1,276 citations

Sequence-Specific Cleavage of Double Helical DNA by Triple Helix Formation

1987 • 1,275 citations

Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region

1985 • 1,244 citations

The Molecular Basis of Antibiotic Action

1981 • 1,237 citations

THE CHEMISTRY AND BIOLOGY OF LEFT-HANDED Z-DNA

1984 • 1,149 citations

Structural aspects of platinum anticancer drug interactions with DNA

1987 • 927 citations

E. coli RNA polymerase interacts homologously with two different promoters

1980 • 911 citations

Mechanisms of bleomycin-induced DNA degradation

1987 • 869 citations

Crystal structure analysis of a complete turn of B-DNA

1980 • 844 citations

Design of Sequence-Specific DNA-Binding Molecules

1986 • 840 citations

[41] Modification of histidyl residues in proteins by diethylpyrocarbonate

1977 • 813 citations

FURTHER STUDIES ON THE ALKYLATION OF NUCLEIC ACIDS AND THEIR CONSTITUENT NUCLEOTIDES

1963 • 801 citations

lac repressor-operator interaction

1970 • 791 citations

PSORALENS AS PHOTOACTIVE PROBES OF NUCLEIC ACID STRUCTURE AND FUNCTION: ORGANIC CHEMISTRY, PHOTOCHEMISTRY, AND BIOCHEMISTRY

1985 • 749 citations

Metals and DNA: Molecular Left-Handed Complements

1986 • 744 citations

Reactivity of cytosine and thymine in single-base-pair mismatches with hydroxylamine and osmium tetroxide and its application to the study of mutations.

1988 • 636 citations

Mapping proteinDNA interactions in vivo with formaldehyde: Evidence that histone H4 is retained on a highly transcribed gene

1988 • 619 citations

Nuclease activity of 1,10-phenanthroline-copper ion

1986 • 602 citations

Contacts between Escherichia coli RNA polymerase and an early promoter of phage T7.

1980 • 524 citations

Hydroxyl radical "footprinting": high-resolution information about DNA-protein contacts and application to lambda repressor and Cro protein.

1986 • 518 citations

Oxygen-dependent cleavage of DNA by the 1,10-phenanthroline . cuprous complex. Inhibition of Escherichia coli DNA polymerase I.

1979 • 515 citations

Structure of the Lambda Complex at 2.5 Å Resolution: Details of the Repressor-Operator Interactions

1988 • 500 citations

Cleavage of DNA with methidiumpropyl-EDTA-iron(II): reaction conditions and product analyses

1984 • 477 citations

Two protein-binding sites in chromatin implicated in the activation of heat-shock genes

1984 • 474 citations

DNA structural variations in the E. coli tyrT promoter

1984 • 448 citations

Formaldehyde-mediated DNA-protein crosslinking: a probe for in vivo chromatin structures.

1985 • 440 citations

Oligodeoxynucleotides as inhibitors of gene expression: a review.

1988 • 419 citations

DNA H form requires a homopurine–homopyrimidine mirror repeat

1987 • 404 citations

Cleavage of double helical DNA by methidium-propyl-EDTA-iron(II)

1982 • 403 citations

Torsional tension in the DNA double helix measured with trimethylpsoralen in living E. coli cells: Analogous measurements in insect and human cells

1980 • 394 citations

Effects of Some Chemical Mutagens and Carcinogens on Nucleic Acids

1966 • 370 citations

Genomic footprinting reveals cell type-specific DNA binding of ubiquitous factors

1987 • 356 citations

Cell-type-specific contacts to immunoglobulin enhancers in nuclei

1985 • 341 citations

Structure of replicating simian virus 40 minichromosomes

1986 • 340 citations

In vivo protein–DNA interactions in a glucocorticoid response element require the presence of the hormone

1986 • 328 citations

Pyrimidine-specific chemical reactions useful for DNA sequencing

1980 • 326 citations

[33] Hydroxyl radical footprinting: A high-resolution method for mapping protein-DNA contacts

1987 • 322 citations

The unusual conformation adopted by the adenine tracts in kinetoplast DNA

1987 • 321 citations

The photochemistry of the uranyl ion

1974 • 321 citations

Physical Analysis of Transcription Preinitiation Complex Assembly on a Class II Gene Promoter

1988 • 320 citations

Footprinting DNA-protein complexes in situ following gel retardation assays using 1,10-phenanthroline-copper ion: Escherichia coli RNA polymerase-lac promoter complexes

1987 • 312 citations

KMnO4 as a probe for lac promoter DNA melting and mechanism in vivo

1989 • 294 citations

The MerR heavy metal receptor mediates positive activation in a topologically novel transcription complex

1989 • 286 citations

Chemical probes of DNA conformation: detection of Z-DNA at nucleotide resolution

1985 • 286 citations

Structural specificities of five commonly used DNA nucleases

1984 • 286 citations

The chemistry of activated bleomycin

1986 • 282 citations

An exonuclease protection assay reveals heat-shock element and TATA box DNA-binding proteins in crude nuclear extracts

1985 • 280 citations

Iron(II) EDTA Used to Measure the Helical Twist Along Any DNA Molecule

1985 • 274 citations

Porphyrin—Nucleic Acid Interactions: A Review

1989 • 257 citations

Topography of simian virus 40 A protein-DNA complexes: arrangement of pentanucleotide interaction sites at the origin of replication

1983 • 253 citations

DNA supercoiling promotes formation of a bent repression loop in lac DNA

1987 • 252 citations

Detecting protein-DNA interactions in vivo: distribution of RNA polymerase on specific bacterial genes.

1984 • 250 citations

Sites and structure of gamma radiation-induced DNA strand breaks.

1982 • 249 citations

Sequence-specific cleavage of single-stranded DNA: oligodeoxynucleotide-EDTA X Fe(II).

1985 • 243 citations

Tumor necrosis factor alpha induces proteins that bind specifically to kappa B-like enhancer elements and regulate interleukin 2 receptor alpha-chain gene expression in primary human T lymphocytes.

1989 • 230 citations

In vivo interactions of RNA polymerase II with genes of Drosophila melanogaster.

1985 • 229 citations

The integration host factor of Escherichia coli binds to bent DNA at the origin of replication of the plasmid pSC101

1987 • 228 citations

Molecular recognition of B-DNA by Hoechst 33258

1985 • 227 citations

Echinomycin Binding Sites on DNA

1984 • 218 citations

Chromomycin, mithramycin, and olivomycin binding sites on heterogeneous DNA. Footprinting with methidiumpropyl-EDTA.cntdot.iron(II)

1983 • 218 citations

Sequence-specific binding and photocrosslinking of alpha and beta oligodeoxynucleotides to the major groove of DNA via triple-helix formation.

1988 • 216 citations

Topoisomerase I interacts with transcribed regions in Drosophila cells

1986 • 210 citations

UV-induced formation of pyrimidine dimers in nucleosome core DNA is strongly modulated with a period of 10.3 bases.

1987 • 209 citations

Interaction of RNA polymerase with lacUV5 promoter DNA during mRNA initiation and elongation

1985 • 207 citations

Differential gene activation by glucocorticoids and progestins through the hormone regulatory element of mouse mammary tumor virus

1988 • 205 citations

A Holliday recombination intermediate is twofold symmetric.

1988 • 201 citations

Specific interaction between a transcription factor and the upstream element of the adenovirus-2 major late promoter.

1985 • 195 citations

Polyfunctional DNA intercalating agents

1986 • 190 citations

The Three-Dimensional Structure of DNA

1982 • 187 citations

Facile cruciform formation by an (A-T)34 sequence from a Xenopus globin gene

1985 • 186 citations

Tris(tetramethylphenanthroline)ruthenium(II): a chiral probe that cleaves A-DNA conformations.

1988 • 181 citations

RNA polymerase unwinds an 11-base pair segment of a phage T7 promoter

1979 • 181 citations

Use of light for footprinting DNA in vivo

1984 • 181 citations

Sequence-specific binding of echinomycin to DNA: evidence for conformational changes affecting flanking sequences

1984 • 178 citations

Mapping functional regions of transcription factor TFIIIA.

1988 • 178 citations

DNA-binding site of lac repressor probed by dimethylsulfate methylation of lac operator

1979 • 177 citations

Nuclear and cytoplasmic genes controlling synthesis of variant mitochondrial polypeptides in male-sterile maize

1980 • 177 citations

Constitutive and metal-inducible protein:DNA interactions at the mouse metallothionein I promoter examined by in vivo and in vitro footprinting.

1988 • 176 citations

The Photochemistry and Photobiology of Furocoumarins (Psoralens)

1984 • 176 citations

Methidiumpropyl-EDTA-Fe(II) and DNase I footprinting report different small molecule binding site sizes on DNA

1983 • 175 citations

Chemical probing of homopurine-homopyrimidine mirror repeats in supercoiled DNA

1988 • 175 citations

Cross-Linking of DNA in Situ as a Probe for Chromatin Structure

1976 • 175 citations

Nuclease activity of 1,10-phenanthroline-copper ion. Conformational analysis and footprinting of the lac operon

1985 • 173 citations

The mechanism of iron EDTA catalyzed superoxide dismutation

1983 • 171 citations

Missing contact probing of DNA-protein interactions.

1987 • 170 citations

Diethyl pyrocarbonate: a chemical probe for secondary structure in negatively supercoiled DNA.

1985 • 169 citations

Contactpoint analysis of the HeLa nuclear factor I recognition site reveals symmetrical binding at one side of the DNA helix.

1987 • 168 citations

Structural and Sequence-Dependent Aspects of Drug Intercalation Into Nucleic Acid

1984 • 167 citations

Base-specific reactions useful for DNA sequencing: methylene blue – sensitized photooxidation of guanine and osmium tetraoxide modification of thymine

1978 • 166 citations

An amino-terminal fragment of lac repressor binds specifically to lac operator

1978 • 164 citations

Mapping of single-stranded regions in duplex DNA at the sequence level: single-strand-specific cytosine methylation in RNA polymerase-promoter complexes.

1983 • 164 citations

Interactions of the RNA polymerase of bacteriophage T7 with its promoter during binding and initiation of transcription.

1986 • 160 citations

Structural details of an adenine tract that does not cause DNA to bend

1988 • 159 citations

Nuclease activity of 1,10-phenanthroline-copper: sequence-specific targeting.

1986 • 158 citations

Binding of the herpes simplex virus immediate-early gene product ICP4 to its own transcription start site

1987 • 158 citations

Mapping of the sites of protection on a 5 S RNA gene by the Xenopus transcription factor IIIA

1986 • 158 citations

The molecular topography of rna polymerase-promoter interaction

1979 • 153 citations

Contacts between Escherichia coli RNA polymerase and a lac operon promoter.

1978 • 148 citations

Thermodynamic parameters governing interaction of EcoRI endonuclease with specific and nonspecific DNA sequences.

1983 • 147 citations

Light-induced cleavage of DNA by metal complexes

1986 • 147 citations

Metal-activated hydrolytic cleavage of DNA

1987 • 146 citations

Definitions and Nomenclature of Nucleic Acid Structure Parameters

1989 • 145 citations

Use of exonuclease III to determine the site of stable lesions in defined sequences of DNA: the cyclobutane pyrimidine dimer and cis and trans dichlorodiammine platinum II examples

1981 • 144 citations

Nuclease activity of 1,10-phenanthroline-copper ion. Chemistry of deoxyribose oxidation

1987 • 143 citations

Regulatory functions of the λ repressor reside in the amino-terminal domain

1979 • 143 citations

Cross-linking of DNA with trimethylpsoralen is a probe for chromatin structure

1977 • 143 citations

Damage by Visible Light to the Acridine Orange-DNA Complex

1961 • 142 citations

Protein-DNA Interactions in Vivo Upstream of a Cell Cycle-Regulated Human H4 Histone Gene

1987 • 139 citations

Site-Specific DNA Binding of Nuclear Factor I: Analyses of Cellular Binding Sites

1985 • 138 citations

Topological unwinding of strong and weak promoters by RNA polymerase

1987 • 136 citations

Contacts between the lac repressor and the thymines in the lac operator.

1977 • 132 citations

Essential contact residues within SV40 large T antigen binding sites I and II identified by alkylation-interference

1984 • 131 citations

Control of expression of the Tn10-encoded tetracycline resistance operon II. Interaction of RNA polymerase and TET repressor with the tet operon regulatory region

1984 • 127 citations

Determination of Base Sequence in Nucleic Acids with the Electron Microscope. V. The Thymine-Specific Reactions of Osmium Tetroxide with Deoxyribonucleic Acid and Its Components^*

1966 • 127 citations

Changes in the DNA structure of the lac UV5 promoter during formation of an open complex with Escherichia coli RNA polymerase

1985 • 125 citations

Primary organization of nucleosome core particle of chromatin: sequence of histone arrangement along DNA.

1978 • 124 citations

A highly basic histone H4 domain bound to the sharply bent region of nucleosomal DNA

1988 • 123 citations

The photoaddition of trimethylpsoralen to Drosophila melanogaster nuclei: a probe for chromatin substructure

1977 • 123 citations

Psoralen-crosslinking of DNA as a probe for the structure of active nucleolar chromatin

1984 • 120 citations

The supercoil-stabilised cruciform of ColE1 is hyper-reactive to osmium tetroxide.

1984 • 120 citations

Enhancer-origin interaction in plasmid R6K involves a DNA loop mediated by initiator protein

1988 • 119 citations

Laser cross-linking of nucleic acids to proteins. Methodology and first applications to the phage T4 DNA replication system.

1986 • 119 citations

EFFICIENT FORMATION OF A CROSSLINKABLE HMT MONOADDUCT AT THE Kpn I RECOGNITION SITE

1984 • 118 citations

Adenine specific DNA chemical sequencing reaction

1987 • 118 citations

Photofootprinting in vivo detects transcription-dependent changes in yeast TATA boxes

1987 • 117 citations

DNA cleavage specificity of a group of cationic metalloporphyrins

1986 • 117 citations

Sequence context effects on 8-methoxypsoralen photobinding to defined DNA fragments

1987 • 117 citations

Bacteriophage λ protein cII binds promoters on the opposite face of the DNA helix from RNA polymerase

1983 • 116 citations

Cross-Linking of Proteins to Nucleic Acids by Ultraviolet Light

1980 • 115 citations

Photochemical Attachment of lac Repressor to Bromodeoxyuridine-Substituted lac Operator by Ultraviolet Radiation

1974 • 114 citations

Formation of cytosine glycol and 5,6-dihydroxycytosine in deoxyribonucleic acid on treatment with osmium tetroxide

1986 • 113 citations

(A-T)_ntracts embedded in random sequence DNA — formation of a structure which is chemically reactive and torsionally deformable

1986 • 113 citations

Evidence for kinks in DNA folding in the nucleosome

1987 • 113 citations

UV irradiation of nucleic acids: formation, purification and solution conformational analysis of the ‘6-4 lesion’ of dTpdT

1985 • 112 citations

In vivo DNA-binding properties of a yeast transcription activator protein.

1987 • 112 citations

Interaction of psoralen-derivatized oligodeoxyribonucleoside methylphosphonates with single-stranded DNA

1988 • 109 citations

Identification and purification of a Drosophila protein that binds to the terminal 31-base-pair inverted repeats of the P transposable element.

1988 • 109 citations

The γδ resolvase induces an unusual DNA structure at the recombinational crossover point

1987 • 107 citations

Double strand cleavage of genomic DNA at a single site by triple helix formation

1988 • 106 citations

Topography of simian virus 40 A protein-DNA complexes: arrangement of protein bound to the origin of replication

1983 • 104 citations

T4 DNA polymerase (3′–5′) exonuclease, an enzyme for the detection and quantitation of stable DNA lesions: the ultraviolet light example

1985 • 104 citations

Use of an 125I-labelled DNA ligand to probe DNA structure

1983 • 104 citations

Reaction of nucleosome DNA with dimethyl sulfate.

1979 • 103 citations

Physical Studies of Protein-DNA Complexes by Footprinting

1989 • 101 citations

Sequence dependence for bypass of thymine glycols in DNA by DNA polymerase I

1986 • 101 citations

NMR studies of echinomycin bisintercalation complexes with d(A1-C2-G3-T4) and d(T1-C2-G3-A4) duplexes in aqueous solution: sequence-dependent formation of Hoogsteen A1.cntdot.T4 and Watson-Crick T1.cntdot.A4 base pairs flanking the bisintercalation site

1988 • 100 citations

Studies of the functional topography of Escherichia coli RNA polymerase

1989 • 100 citations

Cleavage of chromatin with methidiumpropyl-EDTA . iron(II).

1983 • 100 citations

Highly selective chemical modification of cruciform loops by diethyl pyrocarbonate

1986 • 100 citations

Interaction of int protein with specific sites on λ att DNA

1979 • 98 citations

Positive regulation of the Escherichia coli l-rhamnose operon is mediated by the products of tandemly repeated regulatory genes

1987 • 97 citations

Investigations into the sequence-selective binding of mithramycin and related ligands to DNA

1985 • 96 citations

Distamycins inhibit the binding of OTF-1 and NFE-1 transfactors to their conserved DNA elements

1989 • 94 citations

The missing nucleoside experiment: a new technique to study recognition of DNA by protein

1989 • 94 citations

DNA sequence specificity of the pyrrolo[1,4]benzodiazepine antitumor antibiotics. Methidiumpropyl-EDTA-iron(II) footprinting analysis of DNA binding sites for anthramycin and related drugs

1986 • 94 citations

Sequence-specific scission of RNA by 1,10-phenanthroline-copper linked to deoxyoligonucleotides

1988 • 92 citations

Topography of the interaction of recA protein with single-stranded deoxyoligonucleotides.

1986 • 92 citations

Interactions of T7 RNA polymerase with T7 late promoters measured by footprinting with methidiumpropyl-EDTA-iron(II)

1987 • 92 citations

Chiral probe for A-form helixes of DNA and RNA: tris(tetramethylphenanthroline)ruthenium(II)

1986 • 92 citations

Interaction of T7 RNA polymerase with DNA in an elongation complex arrested at a specific psoralen adduct site.

1988 • 92 citations

Comparison of the structures of Cro and λ repressor proteins from bacteriophage λ

1983 • 91 citations

Nucleosomal Instability and Induction of New Upstream Protein-DNA Associations Accompany Activation of Four Small Heat Shock Protein Genes in Drosophila melanogaster

1986 • 90 citations

cis-Diamminedichloroplatinum(II) binds in a unique manner to oligo(dG).oligo(dC) sequences in DNA - a new assay using exonuclease III

1981 • 90 citations

An lmproved method for photofootprinting yeast genesin vivousing Taq polymerase

1989 • 89 citations

Binding and bending of the lambda replication origin by the phage O protein.

1985 • 87 citations

Sequence-targeted chemical modifications of nucleic acids by complementary oligonucleotides covalently linked to porphyrins

1987 • 86 citations

Tissue-specific and steroid-dependent interaction of transcription factors with the oestrogen-inducible apoVLDL II promoter in vivo.

1988 • 86 citations

Chemical ‘snapshots’ of DNA: using the hydroxyl radical to study the structure of DNA and DNA-protein complexes

1987 • 85 citations

Co-ordinate control of synthesis of mitochondrial and non-mitochondrial hemoproteins: a binding site for the HAP1 (CYP1) protein in the UAS region of the yeast catalase T gene (CTT1).

1988 • 85 citations

Chromosomes and chromatin

1988 • 83 citations

Promoter recognition by Escherichia coli RNA polymerase

1988 • 82 citations

Synthesis and biological properties of 5-azido-2'-deoxyuridine 5'-triphosphate, a photoactive nucleotide suitable for making light-sensitive DNA

1987 • 81 citations

Structural basis of protein-nucleic acid interactions

1987 • 79 citations

Structure of in-vivo transcribing chromatin as studied in simian virus 40 minichromosomes

1986 • 78 citations

Photofootprint of nucleosome core DNA in intact chromatin having different structural states

1988 • 78 citations

Nucleotide sequence binding preferences of nogalamycin investigated by DNase I footprinting

1986 • 78 citations

Identification of proteins and protein domains that contact DNA within adenovirus nucleoprotein cores by ultraviolet light crosslinking of oligonucleotides 32P-labelled in vivo

1986 • 77 citations

DNA-binding properties of an adenovirus 289R E1A protein.

1988 • 77 citations

PSORALEN PHOTOCHEMISTRY

1981 • 77 citations

Diethyl pyrocarbonate: a chemical probe for DNA cruciforms

1986 • 76 citations

Photochemical cross-linking studies on the interaction of Escherichia coli RNA polymerase with T7 DNA

1978 • 76 citations

Primary organization of nucleosomes

1985 • 76 citations

Unstable Hoogsteen base pairs adjacent to echinomycin binding sites within a DNA duplex.

1989 • 76 citations

Sequence-specific double-strand cleavage of DNA by penta-N-methylpyrrolecarboxamide-EDTA X Fe(II).

1983 • 76 citations

Histone-histone interactions within chromatin. Crosslinking studies using ultraviolet light

1976 • 75 citations

Eukaryotic RNA polymerase I promoter binding is directed by protein contacts with transcription initiation factor and is DNA sequence-independent

1987 • 74 citations

Distamycin and Penta-N-Methylpyrrolecarboxamide Binding Sites on Native DNA A Comparison of Methidiumproyl-EDTA-Fe(II) Footprinting and DNA Affinity Cleaving

1984 • 74 citations

Detection in vivo of protein-DNA interactions within the lac operon of Escherichia coli

1985 • 73 citations

Active site labeling of the RNA polymerases A, B, and C from yeast.

1987 • 72 citations

Thermodynamics of the ColE1 cruciform

1984 • 72 citations

Site-specific OsO4 modification of the B-Z junctions formed at the (dA-dC)32 region in supercoiled DNA.

1986 • 72 citations

trp repressor arms contribute binding energy without occupying unique locations on DNA

1989 • 71 citations

Photochemical crosslinking of bacteriophage T4 single‐stranded DNA‐binding protein (gp32) to oligo‐p(dT)₈: Identification of phenylalanine‐183 as the site of crosslinking

1988 • 71 citations

Reaction of diethyl pyrocarbonate with nucleic acid components. Bases and nucleosides derived from guanine, cytosine, and uracil

1973 • 71 citations

Sequence specificity of DNA cleavage by bis(1,10-phenanthroline)copper(I)

1988 • 71 citations

Psoralen-crosslinked secondary structure map of single-stranded virus DNA.

1976 • 70 citations

Electron microscopy of DNA crosslinked with trimethylpsoralen: test of the secondary structure of eukaryotic inverted repeat sequences.

1976 • 70 citations

DNA-binding properties and characterization of human transcription factor TFIIIC2.

1987 • 70 citations

Use of whole-cell fixation to visualize replicating and maturing simian virus 40: identification of new viral gene product.

1981 • 70 citations

DNA strand scission by naturally occurring 5-alkylresorcinols

1988 • 69 citations

Cooperativity in A-tract structure and the bending properties of composite TnAn blocks

1989 • 69 citations

Topography of interaction of Escherichia coli RNA polymerase subunits with lac UV5 promoter

1981 • 68 citations

Identification of proteins interacting with the enhancer of human U2 small nuclear RNA genes

1987 • 68 citations

Interaction of Escherichia coli RNA polymerase with DNA in an elongation complex arrested at a specific psoralen crosslink site

1988 • 68 citations

Three sequence-specific DNA-protein complexes are formed with the same promoter element essential for expression of the rat somatostatin gene.

1988 • 67 citations

Complementary addressed reagents carrying EDTA‐Fe(II) groups for directed cleavage of single‐stranded nucleic acids

1984 • 67 citations

The chemistry of activated bleomycin

1990 • 66 citations

An unusual DMA structure detected in a telomeric sequence under superhelical stress and at low pH

1989 • 65 citations

Echinomycin and distamycin induce rotation of nucleosome core DNA

1986 • 65 citations

Complementary-Addressed (Sequence-Specific) Modification of Nucleic Acids

1985 • 64 citations

Chemical aspects of UV-induced crosslinking of proteins to nucleic acids. Photoreactions with lysine and tryptophan

1985 • 64 citations

Site-specific DNA binding of nuclear factor I: analyses of cellular binding sites.

1985 • 64 citations

Promoter search by Escherichia coli RNA polymerase on a circular DNA template.

1987 • 64 citations

Molecular mechanism of promoter selection in gene transcription. II. Kinetic evidence for promoter search by a one-dimensional diffusion of RNA polymerase molecule along the DNA template.

1982 • 63 citations

Uranyl salts as photochemical agents for cleavage of DNA and probing of protein‐DNA contacts

1988 • 62 citations

Genomic sequencing and in vivo footprinting of an expression-specific DNase I-hypersensitive site of avian vitellogenin II promoter reveal a demethylation of a mCpG and a change in specific interactions of proteins with DNA.

1988 • 62 citations

Hoogsteen base pairs proximal and distal to echinomycin binding sites on DNA.

1987 • 61 citations

Chemical reactivity of matched cytosine and thymine bases near mismatched and unmatched bases in a heteroduplex between DNA strands with multiple differences

1989 • 60 citations

Sequence-specific recognition of B DNA by bis(EDTA-distamycin)fumaramide

1985 • 60 citations

Solution hybridization of crosslinkable DNA oligonucleotides to bacteriophage M13 DNA

1987 • 60 citations

Cationic porphyrins as probes of DNA structure

1986 • 60 citations

A pre-B cell nuclear protein that specifically interacts with the immunoglobulin V-J recombination sequences

1987 • 58 citations

Probing co-operative DNA-binding in vivo

1988 • 58 citations

Detection of intercalation‐induced changes in DNA structure by reaction with diethyl pyrocarbonate or potassium permanganate Evidence against the induction of Hoogsteen base pairing by echinomycin

1988 • 58 citations

Sequence-targeted photosensitized reactions in nucleic acids by oligo-.alpha.-deoxynucleotides and oligo-.beta.-deoxynucleotides covalently linked to proflavin

1988 • 58 citations

Photofootprinting of drug‐binding sites‐on DNA using diazo‐ and azido‐9‐aminoacridine derivatives

1989 • 57 citations

Hydroxyl radical footprinting of the sequence‐selective binding of netropsin and distamycin to DNA

1987 • 56 citations

Correlation between the conformation of Escherichia coli −10 hexamer sequences and promoter strength: use of orthophenanthroline cuprous complex as a structural index.

1988 • 56 citations

Induction by torsional stress of an altered DNA conformation 5' upstream of the gene for a high mobility group protein from trout and specific binding to flanking sequences by the gene product HMG-T

1988 • 55 citations

Diethyl pyrocarbonate can detect a modified DNA structure induced by the binding of quinoxaline antibioties

1988 • 55 citations

Chemical footprinting of the interaction between left-handed Z-DNA and anti-Z-DNA antibodies by diethylpyrocarbonate carbethoxylation

1986 • 55 citations

Sequence-specific interaction between the replication initiator protein of plasmid pT181 and its origin of replication.

1986 • 55 citations

Site specificity of psoralen-DNA interstrand cross-linking determined by nuclease Bal31 digestion

1986 • 53 citations

Interaction of the bovine papillomavirus type 1 E2 transcriptional control protein with the viral enhancer: purification of the DNA-binding domain and analysis of its contact points with DNA

1988 • 53 citations

Chemical probes reveal no evidence of Hoogsteen base pairing in complexes formed between echinomycin and DNA in solution

1988 • 53 citations

DNA intercalators induce specific release of HMG 14, HMG 17 and other DNA-binding proteins from chicken erythrocyte chromatin.

1985 • 53 citations

"Ultraviolet footprinting" accurately maps sequence-specific contacts and DNA kinking in the EcoRI endonuclease-DNA complex.

1988 • 53 citations

A two-state conformational equilibrium for alternating (A-T)n sequences in negatively supercoiled DNA

1987 • 52 citations

Protein—DNA crosslinking in reconstituted nucleohistone, nuclei and whole cells by picosecond UV laser irradiation

1988 • 51 citations

Ethylation interference and X-ray crystallography identify similar interactions between 434 repressor and operator

1985 • 51 citations

Osmium tetroxide: a new probe for site-specific distortions in supercoiled DNAs

1984 • 51 citations

Sites of contact between λ operators and λ repressor

1977 • 51 citations

Contacts between the LexA repressor-or its DNA-binding domain-and the backbone of the recA operator DNA.

1988 • 50 citations

Nucleosomes structure and its dynamic transitions

1980 • 50 citations

Tests of spool models for DNA packaging in phage lambda

1983 • 50 citations

Comparison of the open complexes formed by RNA polymerase at the Escherichia coli lac UV5 promoter

1987 • 49 citations

Nucleosomal instability and induction of new upstream protein-DNA associations accompany activation of four small heat shock protein genes in Drosophila melanogaster.

1986 • 49 citations

The accessibility of DNA to dimethylsulfate in complexes with recA protein.

1987 • 48 citations

Primary organization of nucleosomal core particles is invariable in repressed and active nuclei from animal, plant and yeast cells

1985 • 46 citations

Recent aspects of the photochemistry of nucleic acids and related model compounds

1985 • 46 citations

Laser crosslinking ofE.coliRNA polymerase and T7 DNA

1982 • 46 citations

Localized chemical hyperreactivity in supercoiled DNA. Evidence for base unpairing in sequences that induce low-salt cruciform extrusion

1989 • 46 citations

Unusual conformational effect exerted by Z-DNA upon its neighboring sequences.

1987 • 45 citations

Chromatin structure of the ribosomal RNA genes of Tetrahymena thermophila as analyzed by trimethylpsoralen crosslinking in vivo

1980 • 45 citations

Thymine dimer formation in DNA between 25°C and 100°C

1967 • 44 citations

Reduced 4,5',8-trimethylpsoralen cross-linking of left-handed Z-DNA stabilized by DNA supercoiling

1987 • 44 citations

RNA polymerase makes important contacts upstream from base pair −49 at the Escherichia coli galactose operon P1 promoter

1987 • 44 citations

Orientation of nucleosomes and linker DNA in calf thymus chromatin determined by photochemical dichroism

1984 • 44 citations

Visualization of the movement of the Escherichia coli RNA polymerase along the Lac UV5 promoter during the initiation of the transcription

1986 • 43 citations

Sequence specificity of 125I-labelled Hoechst 33258 damage in six closely related DNA sequences

1988 • 43 citations

Characteristics of Z-DNA helices formed by imperfect (purine-pyrimidine) sequences in plasmids.

1988 • 43 citations

Cationic metal-specific structures adopted by the poly(dG) region and the direct repeats in the chicken adult β^Aglobin gene promoter

1989 • 42 citations

Photosensitization of cobalt bleomycin

1986 • 42 citations

Photochemical cleavage of DNA by nitrobenzamides linked to 9-aminoacridine

1988 • 42 citations

Interaction of cellular factors related to the Jun oncoprotein with the promoter of a replication-dependent hamster histone H3.2 gene.

1989 • 42 citations

Photochemical coupling of 5-bromouracil (BU) to a peptide linkage. A model for BU-DNA protein photocrosslinking

1987 • 41 citations

Modification of adenine and cytosine derivatives with bromoacetaldehyde.

1980 • 41 citations

Uranyl mediated photofootprinting reveals strongE.coliRNA polymerase-DNA backbone contacts in the +10 region of theDeoP1 promoter open complex

1989 • 41 citations

A Proton Magnetic Resonance Study of the Ultraviolet Photoproduct of d(TpT) in Aqueous Solution

1975 • 41 citations

Bacteriophage T7 late promoters with point mutations: quantitative footprinting andin vivoexpression

1988 • 40 citations

Structure of the extrachromosomal ribosomal RNA chromatin of Physarum polycephalum

1987 • 40 citations

Identification of interacting amino acids at the histone 2A-2B binding site

1979 • 38 citations

Probing the structure of gal operator-repressor complexes. Conformation change in DNA.

1987 • 38 citations

Protein-binding site at the immunoglobulin mu membrane polyadenylylation signal: possible role in transcription termination.

1987 • 38 citations

The 43 residue DNA binding domain of γδ resolvase binds adjacent major and minor grooves of DNA

1989 • 37 citations

Interaction of synthetic analogs of distamycin and netropsin with nucleic acids. Does curvature of ligand play a role in distamycin-DNA interactions?

1988 • 37 citations

Fine mapping of DNA single-stranded regions using base-specific chemical probes. Study of an open complex formed between RNA polymerase and the lac UV5 promoter

1989 • 37 citations

DNA-protein interactions in the Drosophila melanogaster mitochondrial genome as deduced from trimethylpsoralen crosslinking patterns.

1980 • 37 citations

Adenosine-guanosine preferential photocleavage of DNA by azido-benzoyl- and diazocyclopenta-dienylcarbonyloxy derivatives of 9-aminoacridine

1988 • 37 citations

Higher-order structure of chromatin: evidence from photochemically detected linear dichroism

1986 • 36 citations

Mapping of sequences with 2-fold symmetry on the simian virus 40 genome: a photochemical crosslinking approach.

1977 • 36 citations

In vivo homologous recombination intermediates of yeast mitochondrial DNA analyzed by electron microscopy

1986 • 36 citations

A model for hormone receptor binding to the mouse mammary tumour virus regulatory element bared on hydroxyl radical footprinting

1988 • 35 citations

Probing of DNA polymorphic structure in the cell with osmium tetroxide

1988 • 35 citations

Photochemical cleavage of DNA by 2,7-diazapyrenium cations

1986 • 35 citations

Molecular mechanism of promoter selection in gene transcription. I. Development of a rapid mixing-photocrosslinking technique to study the kinetics of Escherichia coli RNA polymerase binding to T7 DNA.

1982 • 35 citations

In vivofootprinting of the estrogen-inducible vitellogenin II gene from chicken

1988 • 34 citations

DNA binding by the bacteriophage SPO1-encoded type II DNA-binding protein, transcription factor 1. Formation of nested complexes at a selective binding site.

1986 • 34 citations

Protein—DNA cross-linking

1984 • 34 citations

Differential crosslinking of histones and non-histones in nuclei by cis-Pt(II)

1983 • 34 citations

Photochemical crosslinking of lac repressor to nonoperator 5-bromouracil-substituted DNA

1984 • 33 citations

Histone-DNA interactions within chromatin. Isolation of histones from DNA-histone adducts induced in nuclei by UV light

1978 • 33 citations

DNA strand specificity in promoter recognition by RNA polymerase

1980 • 32 citations

DNA : protein interactions and gene regulation

1987 • 32 citations

Testing models of the arrangement of DNA inside bacteriophage λ by crosslinking the packaged DNA

1982 • 32 citations

Chemical footprinting of 5S RNA chromatin in embryos of Drosophila melanogaster.

1984 • 32 citations

Protein factor(s) binding independently to two different regions of the adenovirus 2 major late promoter

1986 • 32 citations

Psoralen-crosslinking of soluble and of H1-depleted soluble rat liver chromatin

1984 • 32 citations

The method of crosslinking histones to DNA partly depurinated at neutral pH

1981 • 31 citations

The mechanism of loading of the FLP recombinase onto its DNA target sequence

1988 • 31 citations

The basis of chromatin fiber assembly within chromosomes studied by histone-DNA crosslinking followed by trypsin digestion

1980 • 31 citations

Unusual Protonated Structure in the Homopurine · Homopyrimidine Tract of Supercoiled and Linearized Plasmids Recognized by Chemical Probes

1987 • 31 citations

DNA-Protein Interactions in Nucleosomes and in Chromatin

1979 • 31 citations

Hyperreactivity of B–Z junctions to 4,5′,8-trimethylpsoralen photobinding assayed by an exonuclease III/photoreversal mapping procedure

1989 • 31 citations

Tet repressor-tet operator contacts probed by operator DNA-modification interference studies

1988 • 31 citations

A distinct octamer-binding protein present in malignant melanoma cells

1988 • 31 citations

DNA interaction and nucleotide sequence cleavage of copper-streptonigrin

1984 • 30 citations

Diethylpyrocarbonate and permanganate provide evidence for an unusual DNA conformation induced by binding of the antitumour antibiotics bleomycin and phleomycin

1988 • 30 citations

Relaxation of chromatin structure by ethidium bromide binding: determined by viscometry and histone dissociation studies

1976 • 30 citations

Selective visualization of gene structure with ultraviolet light.

1988 • 30 citations

Specific sequence-specific recognition of right-handed double-helical DNA by (2S,3S)- and (2R,3R)-dihydroxybis(netropsin)succinamide

1986 • 30 citations

Differences between sites of binding to DNA and strand cleavage for complexes of bleomycin with iron of cobalt

1989 • 29 citations

Events during eucaryotic rRNA transcription initiation and elongation: conversion from the closed to the open promoter complex requires nucleotide substrates.

1988 • 29 citations

The binding of catabolite activator protein and RNA polymerase to the Escherichia coli galactose and lactose promoters probed by alkylation interference studies.

1986 • 28 citations

Ester der Pyrokohlensäure

1938 • 28 citations

Echinomycin-induced hypersensitivity to osmium tetroxide of DNA fragments incapable of forming Hoogsteen base pairs.

1989 • 28 citations

Contacts between Escherichia coli RNA polymerase and thymines in the lac UV5 promoter.

1979 • 28 citations

Demonstration of specific high affinity binding sites in plasmid DNA by photoaffinity labeling with an ethidium analog.

1982 • 27 citations

Photo-induced nicking of deoxyribonucleic acid by ruthenium(II)-bleomycin in the presence of air

1985 • 27 citations

Osmium tetroxide recognized structural distortions at junctions between right- and left-handed DNA in a bacterial cell.

1987 • 26 citations

Distribution of the core histones H_2AH_2B, H₃and H₄during cell replication

1982 • 25 citations

Psoralen-cross-linking study of the organization of intracellular adenovirus nucleoprotein complexes

1988 • 25 citations

In vivo "photofootprint" changes at sequences between the yeast GAL1 upstream activating sequence and "TATA" element require activated GAL4 protein but not a functional TATA element.

1988 • 25 citations

RNA polymerase induces DNA bending at yeast mitochondria] promoters

1988 • 25 citations

Reagents for photoaffinity labeling. I. Photobinding efficiency of aryl azido-, diazocyclopentadienyl-and ethyl diazomalonyl-derivatives of 9-aminoacridine

1983 • 24 citations

Histones H3 and H4 interact with the ends of nucleosome DNA.

1976 • 24 citations

Crosslinking of chromosomal proteins to DNA in HeLa cells by UV, gamma radiation and some antitumor drugs

1983 • 23 citations

Hybridization selection of covalent nucleic acid-protein complexes. 2. Cross-linking of proteins to specific Escherichia coli mRNAs and DNA sequences by formaldehyde treatment of intact cells.

1985 • 23 citations

Footprinting of DNA secondary structure by high‐intensity (laser) ultraviolet irradiation

1985 • 22 citations

Footprinting studies on the interactions of nogalamycin, arugomycin, decilorubicin and viriplanin with DNA.

1988 • 22 citations

Accessibility of ribosomal genes to trimethyl psoralen in nuclei of Physarum polycephalum.

1982 • 21 citations

B-Z Junctions in Supercoiled pRW751 DNA Contain Unpaired Bases or Non-Watson-Crick Base Pairs

1987 • 21 citations

Conformational DNA transition in thein vitrotorsionally strained chickenβ-globin 5′ region

1986 • 20 citations

Analysis of the psoralen-crosslinking pattern in chromatin DNA by exonuclease digestion

1988 • 20 citations

Comparison of the interactions of the adenovinis type 2 major core protein and its precursor with DNA

1986 • 20 citations

Photoaffinity labeling of Escherichia coli RNA polymerase/poly[d(A-T)] transcription complexes by nascent RNA

1988 • 19 citations

Crosslinking of DNA to nuclear lamina proteins by UV irradiation in vivo

1987 • 19 citations

In situ photochemical crosslinking of HeLa cell mitochondrial DNA by a psoralen derivative reveals a protected region near the origin of replication

1981 • 19 citations

Analysis of the effects of antibiotics on the structure of nucleosome core particles determined by DNAase I cleavage

1987 • 19 citations

Supercoil‐stabilized left‐handed DNA in the plasmid (dA‐dT)₁₆ insert formed in the presence of Ni²⁺

1989 • 19 citations

High resolution psoralen mapping reveals an altered DNA helical structure in the SV40 regulatory region

1988 • 18 citations

Photoaffinity Labeling of Chromatin

1982 • 18 citations

Photocleavage of DNA and photofootprinting of E.coli RNA polymerase bound to promoter DNA by azido-9-acridinylamines

1988 • 18 citations

A study of the B-Z transition of the AC-rich region of the repeat unit of a satellite DNA from Cebus by means of chemical probes.

1988 • 17 citations

Psoralen photofootprinting of protein‐binding sites on DNA

1988 • 17 citations

9-(4-Nitrobenzamidopolymethylene)aminoacridines and their photochemical cleavage of DNA

1987 • 16 citations

DNA strand scission and apurinic sites induced by photoactivated aflatoxins.

1988 • 15 citations

Photochemical cross-linking of protein and DNA in chromatin. Synthesis and application of a photosensitive cleavable derivative of 9-aminoacridine with two photoprobes connected through a disulphide-containing linker

1984 • 15 citations

Hybridization selection of nucleic acid-protein complexes. 1. Detection of proteins cross-linked to specific mRNAs and DNA sequences by irradiation of intact Escherichia coli cells with ultraviolet light.

1985 • 15 citations

Electron microscopy of AD5 replicating molecules after in vivo photocrosslinking with trioxsalen

1981 • 15 citations

Subunit topography of RNA polymerase (E. coli) in the complex with DNA

1978 • 15 citations

Complex structural behavior of oligopurine-ligopyrimidine sequence cloned within the supercoiled plasmid

1989 • 15 citations

Interstrand crosslinks due to 4,5′,8-trimethylpsoralen and near ultraviolet light in specific sequences of animal DNA

1988 • 15 citations

On the use of ultraviolet light to study protein-DNA crosslinking.

1976 • 14 citations

Diethyl pyrocarbonate reaction with the lactose repressor protein affects both inducer and DNA binding

1988 • 14 citations

Studies on the arrangement of DNA inside viruses using a breakable bis-psoralen crosslinker

1987 • 13 citations

Chromatin dynamics. Fast and slow modes of nucleosome movement revealed through psoralen binding and repair

1985 • 13 citations

Nonenzymatic sequence-specific methyl transfer to single-stranded DNA.

1988 • 12 citations

Localization of melted regions in supercoiled DNA

1989 • 12 citations

Photoaffinity labeling of chromatin using a tritiated (azidoaryl)bis(acridinyl)spermidine photoprobe

1985 • 12 citations

Photoaffinity labelling of submitochondrial membranes with the 3-azido analogue of 9-amino-3-chloro-7-methoxyacridine

1985 • 11 citations

lac operator DNA modification in the presence of proteolytic fragments of the repressor protein

1984 • 11 citations

A rapid mixing-photocrosslinking technique to study the dynamics of nucleic acid-protein interactions

1983 • 10 citations

Photochemical crosslinking of transcription complexes with psoralen. I. Covalent attachment of in vitro SV4O nascent RNA to its double-stranded DNA template

1978 • 10 citations

Azide photoaffinity analogs for acridine dye binding sites

1981 • 10 citations

DNA conformational variations in the in vitro torsionally strained Ig ϰ light chain gene localize on consensus sequences

1988 • 10 citations

Termini generated at the site of the DNA breakage mediated by photoexcited promazines

1986 • 10 citations

NMR study of the effect of sugar-phosphate backbone ethylation on the stability and conformation of DNA double helix

1987 • 10 citations

The structure of nucleosomal core particles within transcribed and repressed gene regions

1988 • 9 citations

Stepwise unfolding of chromatin by urea

1985 • 9 citations

A specific and efficient photoreaction betweenE.coliRNA polymerase and T₊₁in thelacUV5 ordeoPI promoter

1988 • 9 citations

In vivo photoreaction of a chiral cobalt complex: DNA cleavage by Co(DIP)33+ in mammalian cells

1988 • 8 citations

Identification of sequence-specific DNA-binding factors by label transfer: application to the adenovirus-2 major late promoter

1988 • 8 citations

Contact site of histones 2A and 2B in chromatin and in solution

1985 • 8 citations

ON THE DNA BENDING BY PSORALEN INTERSTRAND CROSSLINKING. A GEL ELECTROPHORETIC STUDY

1988 • 8 citations

Photochemical crosslinking of protein and DNA in chromatin

1985 • 7 citations

The use of ultraviolet Light in the fractionation of chromatin containing unsubstituted and bromodeoxyuridine-substituted DNA

1979 • 7 citations

Osmium tetroxide probing of local DNA structure in linear and supercoiled plasmids containing curvature-inducing sequences.

1988 • 7 citations

Sensitivity of DNA and Nucleotides to Oxidation by Permanganate and Hydrogen Peroxide

1987 • 7 citations

Perturbation of lac operator DNA modification by tryptic core protein from lac repressor.

1983 • 6 citations

Supercoil-induced Z-DNA formation within 5′-end of chicken myb proto-oncogene

1989 • 6 citations

Differential binding of nonhistone chromosomal proteins to the putative mouse origin of replication

1983 • 5 citations

DNA structural alterations in the SV40 enhancer region are retained in vivo

1988 • 5 citations

The use of Psoralen-Photocrosslinking for the Analysis of the Chromatin Structure during Transcription

1989 • 5 citations

Specific protection of nucleotides in the lac operator from DMS methylation and DNase I nicking by crude bacterial cell extracts

1982 • 5 citations

Photonucleases

1989 • 3 citations

ChemInform Abstract: AZIDE PHOTOAFFINITY ANALOGS FOR ACRIDINE DYE BINDING SITES

1981 • 3 citations

Studies of the Binding and Biological Actions of Ethidium

1989 • 2 citations

A method for detecting protein-DNA interactions at sites of chromatin replication

1987 • 2 citations

[Determination of C-terminal groups of vegetable proteins by a thiohydantoin method].

1960 • 1 citations

[Os4O4 reacts primarily with -10 and -35 sites of Escherichia coli lacUV5-promoter].

1987 • 1 citations

Quantitative photoaffinity labeling of Escherichia coli RNA polymerase transcription complexes by nascent RNA

1989 • 1 citations

Structural features of the DNA template required for transcription in vitro by yeast RNA polymerase B (II)

1986 • 1 citations