Oligo-[α]-Deoxyribonucleotides Covalently Linked to Intercalating Agents. A New Family of Sequence-Specific Nucleic Acid Reagents

Predicting DNA duplex stability from the base sequence.

1986 • 1,800 citations

Improved free-energy parameters for predictions of RNA duplex stability.

1986 • 1,472 citations

NUCLEOSIDE PHOSPHOROTHIOATES

1985 • 830 citations

Nuclease activity of 1,10-phenanthroline-copper ion

1986 • 602 citations

Physical and chemical characterization of two- and three-stranded adenine-thymine and adenine-uracil homopolymer complexes

1966 • 535 citations

Nucleosides and Nucleotides

1973 • 492 citations

Sequence-specific recognition, photocrosslinking and cleavage of the DNA double helix by an oligo-(α]-thymidylate covalently linked to an azidoproflavine derivative

1987 • 488 citations

THE ROLE OF ANTISENSE RNA IN GENE REGULATION

1986 • 456 citations

Specific antiviral activity of a poly(L-lysine)-conjugated oligodeoxyribonucleotide sequence complementary to vesicular stomatitis virus N protein mRNA initiation site.

1987 • 329 citations

The use of single-stranded DNA and RNase H to promote quantitative ‘hybrid arrest of translation’ of mRNA/DNA hybrids in reticulocyte lysate cell-free translations

1986 • 245 citations

Sequence-specific cleavage of single-stranded DNA: oligodeoxynucleotide-EDTA X Fe(II).

1985 • 243 citations

Sequence-specific binding and photocrosslinking of alpha and beta oligodeoxynucleotides to the major groove of DNA via triple-helix formation.

1988 • 216 citations

Conjugation of methotrexate to poly(L-lysine) increases drug transport and overcomes drug resistance in cultured cells

1978 • 200 citations

Complexes formed by (pyrimidine)_n·(purine)_nDNAs on lowering the pH are three-stranded

1979 • 195 citations

Comparative inhibition of chloramphenicol acetyltransferase gene expression by antisense oligonucleotide analogues having alkyl phosphotriester, methylphosphonate and phosphorothioate linkages

1987 • 173 citations

Nucleic acid-binding molecules with high affinity and base sequence specificity: intercalating agents covalently linked to oligodeoxynucleotides.

1984 • 172 citations

Enzymatic amplification of translation inhibition of rabbit β-globin mRNA mediated by anti-messenger oligodeoxynucleotides covalently linked to intercalating agents

1987 • 164 citations

Nuclease activity of 1,10-phenanthroline-copper: sequence-specific targeting.

1986 • 158 citations

Nonenzymatic sequence-specific cleavage of single-stranded DNA.

1985 • 151 citations

Inhibition of vesicular stomatitis virus protein synthesis and infection by sequence-specific oligodeoxyribonucleoside methylphosphonates

1986 • 151 citations

Rate of degradation of [α]- and [β]-oligodeoxynucleotides inXenopusoocytes. Implications for anti-messenger strategies

1987 • 143 citations

Nuclease activity of 1,10-phenanthroline-copper ion. Chemistry of deoxyribose oxidation

1987 • 143 citations

Translation arrest by oligodeoxynucleotides complementary to mRNA coding sequences yields polypeptides of predetermined length

1986 • 142 citations

Methyl phosphotriesters in alkylated DNA are repaired by the Ada regulatory protein ofE. coli

1985 • 139 citations

Selective inhibition of the cytopathic effect of type A influenza viruses by oligodeoxynucleotides covalently linked to an intercalating agent

1987 • 131 citations

Α-DNA II. Synthesis of unnatural Α-anomeric oligodeoxyribonucleotides containing the four usual bases and study of their substrate activities for nucleases

1987 • 130 citations

Oligo(alpha-deoxynucleotide)s covalently linked to intercalating agents: differential binding to ribo- and deoxyribopolynucleotides and stability towards nuclease digestion.

1987 • 121 citations

α-DNA VI: comparative study of α- and β-anomeric oligodeoxyribonucleotides in hybridization to mRNA and in cell free translation inhibition

1987 • 121 citations

Control of ribonucleic acid function by oligonucleoside methylphosphonates

1985 • 115 citations

Inhibition of rabbit globin mRNA translation by sequence-specific oligodeoxyribonucleotides

1985 • 115 citations

Mechanisms of the reactions of some copper complexes in the presence of DNA with superoxide, hydrogen peroxide, and molecular oxygen

1986 • 112 citations

Oligodeoxynucleotides covalently linked to intercalating dyes as base sequence-specific ligands. Influence of dye attachment site.

1984 • 107 citations

Specific inhibition of mRNA translation by complementary oligonucleotides covalently linked to intercalating agents.

1986 • 107 citations

Solid-phase synthesis of oligodeoxyribonucleoside methylphosphonates

1986 • 102 citations

Targeted cleavage of polynucleotides by complementary oligonucleotides covalently linked to iron-porphyrins

1986 • 99 citations

α-DNA I. Synthesis, characterization by high field¹H-NMR, and base-pairing properties of the unnatural hexadeoxyribonudeotide α-[d(CpCpTpTpCpC)] with its complement β-[d(GpGpApApGpG)]

1986 • 98 citations

Oligodeoxynucleotides covalently linked to intercalating agents: a new class of gene regulatory substances

1985 • 88 citations

An acridine-linked oligodeoxynucleotide targeted to the common 5' end of trypanosome mRNAs kills cultured parasites

1987 • 87 citations

Sequence-targeted chemical modifications of nucleic acids by complementary oligonucleotides covalently linked to porphyrins

1987 • 86 citations

α-DNA-V. Parallel annealing, handedness and conformation of the duplex of the unnatural α-hexadeoxyribonucleotide α-[d(CpApTpGpCpG)] with its β-complement β-[d(GpTpApCpGpC)] deduced from high field¹H-NMR

1987 • 81 citations

Double helices with parallel strands are formed by nuclease-resistant oligo-[α]-deoxynucleotides and oligo-[α]-deoxynucleotides covalently linked to an intercalating agent with complementary oligo-[β]-deoxynucleotides

1987 • 79 citations

Model Studies for the Direct Effect of High-energy Irradiation on DNA. Mechanism of Strand Break Formation Induced by Laser Photoionization of Poly U in Aqueous Solution

1985 • 75 citations

Mechanisms of the dismutation of superoxide catalyzed by the copper(II) phenanthroline complex and of the oxidation of the copper(I) phenanthroline complex by oxygen in aqueous solution

1983 • 70 citations

Complementary addressed reagents carrying EDTA‐Fe(II) groups for directed cleavage of single‐stranded nucleic acids

1984 • 67 citations

Complementary-Addressed (Sequence-Specific) Modification of Nucleic Acids

1985 • 64 citations

Synthetic nucleosides and nucleotides. XXI. On the synthesis and biological evaluations of 2'-deoxy-.ALPHA.-D-ribofuranosyl nucleosides and nucleotides.

1984 • 63 citations

Oligo-[α]-deoxynucleotides covalently linked to an intercalating agent. Double helices with parallel strands are formed with complementary oligo-[β]-deoxynucleotides

1987 • 63 citations

Sequence-targeted photosensitized reactions in nucleic acids by oligo-.alpha.-deoxynucleotides and oligo-.beta.-deoxynucleotides covalently linked to proflavin

1988 • 58 citations

Periodic cleavage of poly(dA) by oligothymidylates covalently linked to the 1,10-phenanthroline-copper complex

1988 • 55 citations

Sequence-targeted cleavage of nucleic acids by oligo-[.alpha.]thymidylate-phenanthroline conjugates: parallel and antiparallel double helices are formed with DNA and RNA, respectively

1988 • 54 citations

Anti-messenger oligodeoxynucleotides: specific inhibition of rabbit β-globin synthesis in wheat germ extracts and Xenopus oocytes

1986 • 52 citations

Activation of ribonuclease L by (2'-5')(A)4-poly(L)-lysine) conjugates in intact cells

1986 • 50 citations

Nucleosides and nucleotides. Part 5. The stereochemistry of oligonucleotides consisting of 2′-deoxy-α-d-ribosides, a study withDreiding stereomodels

1973 • 42 citations

Nucleosides and Nucleotides. Part 7. Four dithymidine monophosphates with different anomeric configurations, their synthesis and behaviour towards phosphodiesterases

1974 • 38 citations

Oligothymidylate analogs having stereoregular, alternating methylphosphonate/phosphodiester backbones as primers for DNA polymerase

1982 • 37 citations

Proton and phosphorus nuclear magnetic resonance studies of an oligothymidylate covalently linked to an acridine derivative and of its binding to complementary sequences

1985 • 33 citations

Oligothymidylates Substitubs en Position 3’ Par un Derive De L'Acridine

1986 • 32 citations

Synthesis and structural studies of a self-complementary decadeoxynucleotide d(AATTGCAATT) I. - Synthesis and chemical characterization of the decanucleotide

1981 • 31 citations

α-DNA IV: α-anomeric and β-anomeric tetrathymidylates covalently linked to intercalating oxazolopyridocarbazole. Synthesis, physicochemical properties and poly (rA) binding

1987 • 30 citations

2D-NMR studies of the unnatural duplex α-d(TCTAAAC)-β-d(AGATTTG)

1987 • 29 citations

Nucleosides and Nucleotides

2023 • 29 citations

Nucleic acid components and their analogues. CLIV. Nucleoside and nucleotide derivatives of α-uridine, 2'-deoxy-α-uridine and 2'-deoxy-α-cytidine, and their affinity towards nucleolytic enzymes

1973 • 26 citations

Nuclear magnetic resonance studies of complex formation between the oligonucleotide d(TATC) covalently linked to an acridine derivative and its complementary sequence d(GATA)

1986 • 19 citations

Oligothymidylates Substitues Par Un Derive De L'Acridine en Position 5′, A La Fois En Position 5′ et 3′ Ou Sur Un Phosphate Internucleotidique

1988 • 19 citations

Nonionic Oligonucleotide Analogs as New Tools for Studies on the Structure and Function of Nucleic Acids Inside Living Cells

1983 • 14 citations

Oligothymidylates Comportant La Structure Alternee Alkylphosphotriester-Phosphodiester Et Lies De Facon Covalente A Un Agent Intercalant

1986 • 13 citations

Conformations of Duplex Structures Formed by Oligodeoxynucleotides Covalently Linked to the Intercalator 2-Methoxy-6-Chloro-9-Aminoacridine

1987 • 11 citations

Chemical synthesis of natural and modified oligodeoxynucleotides

1985 • 11 citations

Specific Gene Regulation by Oligodeoxynucleotides Covalently Linked to Intercalating Agents

1987 • 10 citations

PHOSPHOAMMONIUM, REACTIF DE PHOSPHORYLATION EN SYNTHESE OLIGONUCLEOTIDIQUE

1983 • 4 citations

Deleted Work

1955 • 0 citations