Complementary-Addressed (Sequence-Specific) Modification of Nucleic Acids

Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid

1953 • 12,496 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide.

1978 • 1,668 citations

Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide.

1978 • 841 citations

Cleavage of double helical DNA by methidium-propyl-EDTA-iron(II)

1982 • 403 citations

Design of Active-Site-Directed Irreversible Enzyme Inhibitors.

1967 • 387 citations

The nucleotide and deduced amino acid sequences of the encephalomyocarditis viral polyprotein coding region

1984 • 234 citations

Nucleic acid-binding molecules with high affinity and base sequence specificity: intercalating agents covalently linked to oligodeoxynucleotides.

1984 • 172 citations

Anticellular and antiviral effects of pppA(2′p5′A)n

1980 • 164 citations

Synthesis of ribonucleosides and diribonucleoside phosphates containing 2-chloro-ethylamine and nitrogen mustard residues.

1967 • 160 citations

Increased nuclease activity in cells treated with pppA2'p5'A2'p5' A.

1979 • 155 citations

Biological Alkylating Agents

1962 • 155 citations

Design synthesis of a sequence-specific DNA cleaving molecule. (Distamycin-EDTA)iron(II)

1982 • 124 citations

Selective inhibition of Escherichia coli protein synthesis and growth by nonionic oligonucleotides complementary to the 3′ end of 16S rRNA

1981 • 108 citations

Liposomes in biological systems

1980 • 99 citations

Thiourea Reverses Cross-Links and Restores Biological Activity in DNA Treated with Dichlorodiaminoplatinum(II)

1979 • 96 citations

Relative reactivities for monofunctional nitrogen mustard alkylation of nucleic acid components

1968 • 78 citations

Optimal conditions for uptake of exogenous DNA by chinese hamster lung cells deficient in hypoxanthine-guanine phosphoribosyltransferase

1975 • 77 citations

Complementary addressed reagents carrying EDTA‐Fe(II) groups for directed cleavage of single‐stranded nucleic acids

1984 • 67 citations

Structures of the adducts formed between [Pt(dien)C1]C1 and DNAin vitro

1982 • 58 citations

Sequence-specific double-strand cleavage of DNA by bis(EDTA-distamycin.iron(II)) and EDTA-bis(distamycin).iron(II)

1983 • 56 citations

Sequence-specific crosslinking agents for nucleic acids

1978 • 38 citations

The uptake of SV40 DNA by nonpermissive cells in the presence of DEAE-dextran

1971 • 34 citations

DNA replication in Chinese hamster ovary cells made permeable to nucleotides by tween-80 treatment.

1976 • 26 citations

Complementary addressed modification of oligonucleotide d(pGpGpCpGpGpA) with platinum derivative of oligonucleotide d(pTpCpCpGpCpCpTpTpT)

1983 • 25 citations

Intracellular inactivation of specific nucleotide sequences: A general approach to the treatment of viral diseases and virally-mediated cancers

1979 • 23 citations

Uptake of polynucleotides by mammalian cells

1974 • 22 citations

Die Methylierung von Dinucleosidphosphaten mit Diazomethan

1967 • 20 citations

Gene-directed mutagenesis in bacteriophage T7 provided by polyalkylating RNAs complementary to selected DNA sites.

1980 • 19 citations

Enzymatic transfer of ATPγS thiophosphate onto the 5′‐hydroxyl of an oligonucleotide as a route to reactive oligonucleotide derivatives

1982 • 17 citations

Interaction of microbial DNA with cultured mammalian cells Binding of the donor DNA to the cell surface

1976 • 17 citations

Equations of the kinetic curves of affinity labelling of biopolymers with the reagents consumed in parallel reactions in solution

1981 • 15 citations

Exposed and buried guanosine residues in tRNA₁^Val from yeast

1972 • 15 citations

Two‐quantum selective laser scission of polyadenilic acid in the complementary complex with a dansyl derivative of oligothymidilate

1983 • 15 citations

Selective alkylation of poly(A) tracts of RNA inside the cell with the derivative of ethyl ester of oligothymidilate bearing 2‐Chloroethylamino group

1980 • 13 citations

Kinetics and mechanism of the acid-catalyzed hydrolysis of a hypermodified nucleoside wyosine and its 5′-monophosphate¹

1985 • 13 citations

[Suppression of immunoglobulin synthesis in myeloma MORS 21 cells by an alkylating oligonucleotide derivative complementary to the mRNA coding for light-chain immunoglobulin].

1984 • 11 citations

Complementary addressed modification of yeast tRNA₁^Valwith alkylating derivative of d(pC-G)-A. The positions of the alkylated nucleotides and the course of the alkylation in the complex

1977 • 11 citations

Investigation of activation of phosphate groups in mono-and oligonucleotides with mesitoyl chloride

1978 • 11 citations

Uptake of polynucleotides by intact mammalian cells

1972 • 10 citations

Sequence-specific crosslinking agents for nucleic acids: Design and functional group testing

1979 • 8 citations

Precipitation of nucleotides by calcium phosphate

1982 • 8 citations

Effects on protein synthesis of injecting synthetic polyribonucleotides into living cells

1974 • 5 citations

Nonlinear laser photomodification of macromolecules: Possibility and applications

1980 • 4 citations

[Directed action on the genome of bacteriophage T7 using a transcript of the early gene region bearing multiple alkylating groups].

1978 • 4 citations

Preparation of psoralen-cross-linked R-loops and generation of large deletions by their repair in vivo.

1982 • 4 citations

[Complementarily addressed modification of synthetic deoxyribo -oligonucleotide by an oligonucleotide derivative carrying an alkylating reagent at the 3'-terminal thiophosphate group].

1984 • 3 citations

[Addressed chemical modification of a single-stranded DNA fragment].

1983 • 3 citations

[Fast complementarily addressed alkylation of the poly(A)--sequences of mRNA by oligothymidylate derivatives in Krebs ascitic carcinoma cells].

1984 • 2 citations

Structure of DNA in metaphase chromosomes of mouse fibroblasts

1983 • 2 citations

[Specificity of nonlinear laser scission of DNA].

1983 • 1 citations