The IN-VIVO Occurrence of Z DNA

Why genes in pieces?

1978 • 2,256 citations

Molecular structure of a left-handed double helical DNA fragment at atomic resolution

1979 • 2,057 citations

Salt-induced co-operative conformational change of a synthetic DNA: Equilibrium and kinetic studies with poly(dG-dC)

1972 • 1,213 citations

DNA gyrase: an enzyme that introduces superhelical turns into DNA.

1976 • 1,175 citations

Human fetal gγ- and Aγ-globin genes: Complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes

1980 • 947 citations

Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC).

1981 • 873 citations

Mechanism of action of nalidixic acid: Purification of Escherichia coli nalA gene product and its relationship to DNA gyrase and a novel nicking-closing enzyme

1977 • 777 citations

A novel repeated element with Z-DNA-forming potential is widely found in evolutionarily diverse eukaryotic genomes.

1982 • 759 citations

Folding of the DNA double helix in chromatin-like structures from simian virus 40.

1975 • 597 citations

Conformational fluctuations of DNA helix.

1975 • 562 citations

Left-handed DNA helices

1980 • 519 citations

High-salt d(CpGpCpG), a left-handed Z′ DNA double helix

1980 • 493 citations

Helical repeat of DNA in solution.

1979 • 481 citations

E. coli DNA binding protein HU forms nucleosome-like structure with circular double-stranded DNA

1979 • 459 citations

Left-handed Z-DNA is induced by supercoiling in physiological ionic conditions

1982 • 439 citations

Antibodies to left-handed Z-DNA bind to interband regions of Drosophila polytene chromosomes

1981 • 350 citations

Facile transition of poly[d(TG)·d(CA)] into a left-handed helix in physiological conditions

1983 • 335 citations

Antibody diversity: Somatic hypermutation of rearranged VH genes

1981 • 334 citations

Flipping of cloned d(pCpG)n.d(pCpG)n DNA sequences from right- to left-handed helical structure by salt, Co(III), or negative supercoiling.

1982 • 321 citations

Mechanism of the Antitumour Effect of Interferon in Mice

1972 • 317 citations

The complete sequence of a chromosomal mouse α-globin gene reveals elements conserved throughout vertebrate evolution

1979 • 317 citations

STRUCTURE AND REACTIONS OF CLOSED DUPLEX DNA

1978 • 316 citations

Potential Z-DNA forming sequences are highly dispersed in the human genome

1982 • 316 citations

The sequence (dC-dA)n X (dG-dT)n forms left-handed Z-DNA in negatively supercoiled plasmids.

1983 • 314 citations

Do genes-in-pieces imply proteins-in-pieces?

1978 • 287 citations

Negatively supercoiled plasmids contain left-handed Z-DNA segments as detected by specific antibody binding

1982 • 285 citations

The problems of eukaryotic and prokaryotic DNA packaging and in vivo conformation posed by superhelix density heterogeneity

1977 • 233 citations

Superhelical Escherichia coli DNA: Relaxation by coumermycin

1978 • 203 citations

Mapping of Heavy Chain Genes for Mouse Immunoglobulins M and D

1980 • 188 citations

Z* DNA, the left-handed helical form of poly[d(G-C)] in MgCl2-ethanol, is biologically active.

1982 • 155 citations

MOLECULAR ASPECTS OF GENETIC EXCHANGE AND GENE CONVERSION

1974 • 154 citations

Mn2+ and other transition metals at low concentration induce the right-to-left helical transformation of poly[d(G-C)].

1982 • 145 citations

Induction of the Z conformation in poly(dG-dC).poly(dG-dC) by binding of N-2-acetylaminofluorene to guanine residues.

1981 • 143 citations

Organization and complete sequence of identical embryonic and plasmacytoma kappa V-region genes.

1980 • 138 citations

Supercoils in prokaryotic DNA restrained in vivo.

1980 • 133 citations

Conformational flexibility of junctions between contiguous B- and Z-DNAs in supercoiled plasmids.

1983 • 113 citations

Isolation of Drosophila proteins that bind selectively to left-handed Z-DNA.

1982 • 113 citations

In vivo consequences of plasmid topology

1981 • 109 citations

Left-handed DNA. Cloning, characterization, and instability of inserts containing different lengths of (dC-dG) in Escherichia coli.

1982 • 98 citations

Spectroscopic studies on acetylaminofluorene-modified (dT-dG)n . (dC-dA)n suggest a left-handed conformation.

1982 • 89 citations

Generation of Left-handed Z-DNA in Solution and Visualization in Polytene Chromosomes by Immunofluorescence

1983 • 75 citations

A condensed form of (dG-dC)n.cntdot.(dG-dC)n as an intermediate between the B- and Z- conformations induced by sodium acetate

1983 • 52 citations

dnaG (primase)-dependent origins of DNA replication. Nucleotide sequences of the negative strand initiation sites of bacteriophages St-1, phi K, and alpha 3.

1979 • 43 citations

A method for the purification ofE. coli plasmid DNA by homogeneous lysis and polyethylene glycol precipitation

1983 • 35 citations

The expanding Earth

1981 • 6 citations