Transcriptional block caused by a negative supercoiling induced structural change in an alternating CG sequence

The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers

1982 • 6,153 citations

Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids

1977 • 3,019 citations

REGULATORY SEQUENCES INVOLVED IN THE PROMOTION AND TERMINATION OF RNA TRANSCRIPTION

1979 • 2,730 citations

Gene organization and primary structure of a ribosomal RNA operon from Escherichia coli

1981 • 1,732 citations

THE CHEMISTRY AND BIOLOGY OF LEFT-HANDED Z-DNA

1984 • 1,149 citations

DNA Topoisomerases

1981 • 977 citations

E. coli RNA polymerase interacts homologously with two different promoters

1980 • 911 citations

Visualization of Nucleolar Genes

1969 • 865 citations

Vectors bearing a hybrid trp-lac promoter useful for regulated expression of cloned genes in Escherichia coli

1983 • 810 citations

Novobiocin and coumermycin inhibit DNA supercoiling catalyzed by DNA gyrase.

1976 • 719 citations

DNA Gyrase and the Supercoiling of DNA

1980 • 713 citations

Active chromatin

1982 • 549 citations

Negatively supercoiled simian virus 40 DNA contains Z-DNA segments within transcriptional enhancer sequences

1983 • 474 citations

An altered DNA conformation detected by S1 nuclease occurs at specific regions in active chick globin chromatin

1982 • 448 citations

Left-handed Z-DNA is induced by supercoiling in physiological ionic conditions

1982 • 439 citations

Chromatin assembly in Xenopus oocytes: In vivo studies

1984 • 404 citations

Torsional tension in the DNA double helix measured with trimethylpsoralen in living E. coli cells: Analogous measurements in insect and human cells

1980 • 394 citations

Visualization of Bacterial Genes in Action

1970 • 385 citations

Antibodies to left-handed Z-DNA bind to interband regions of Drosophila polytene chromosomes

1981 • 350 citations

Energetics of B-to-Z transition in DNA.

1983 • 335 citations

Facile transition of poly[d(TG)·d(CA)] into a left-handed helix in physiological conditions

1983 • 335 citations

Flipping of cloned d(pCpG)n.d(pCpG)n DNA sequences from right- to left-handed helical structure by salt, Co(III), or negative supercoiling.

1982 • 321 citations

The sequence (dC-dA)n X (dG-dT)n forms left-handed Z-DNA in negatively supercoiled plasmids.

1983 • 314 citations

A topological model for transcription based on unwinding angle analysis of E. coli RNA polymerase binary, initiation and ternary complexes

1982 • 264 citations

DNA Supercoiling and Its Effects on DNA Structure and Function

1983 • 243 citations

Cruciform structures in palindromic DNA are favored by DNA supercoiling

1982 • 235 citations

Chromatin assembly in Xenopus oocytes: In vitro studies

1984 • 230 citations

Thermodynamic properties of superhelical DNAs

1975 • 229 citations

Transcription of DNA injected into Xenopus oocytes is influenced by template topology

1983 • 219 citations

Conformation of promoter DNA: Fine mapping of S1-hypersensitive sites

1983 • 216 citations

Cruciform formation in a negatively supercoiled DNA may be kinetically forbidden under physiological conditions

1983 • 212 citations

Transcription of the early region of bacteriophage T7: Selective initiation with dinucleotides

1973 • 209 citations

Superhelical Escherichia coli DNA: Relaxation by coumermycin

1978 • 203 citations

Promoters: Structure and function

1983 • 186 citations

Chromatin Structure and Gene Activity: The Role of Nonhistone Chromosomal Protein

1982 • 184 citations

RNA polymerase unwinds an 11-base pair segment of a phage T7 promoter

1979 • 181 citations

DNA Gyrase and DNA Supercoiling

1979 • 175 citations

A general method for maximizing the expression of a cloned gene.

1979 • 173 citations

Termination of transcription in E. coli

1983 • 167 citations

Mapping of single-stranded regions in duplex DNA at the sequence level: single-strand-specific cytosine methylation in RNA polymerase-promoter complexes.

1983 • 164 citations

Positively supercoiled plasmid DNA is produced by treatment ofEscherichia coliwith DNA gyrase inhibitors

1983 • 163 citations

Isolation and characterisation of a strain carrying a conditional lethal mutation in the cou gene of Escherichia coli K12

1979 • 157 citations

Z* DNA, the left-handed helical form of poly[d(G-C)] in MgCl2-ethanol, is biologically active.

1982 • 155 citations

Angular Alteration of the DNA Helix by E. coli RNA Polymerase

1972 • 145 citations

Elastic torsional strain in DNA within a fraction of SV40 minichromosomes: relation to transcriptionally active chromatin.

1982 • 134 citations

Supercoils in prokaryotic DNA restrained in vivo.

1980 • 133 citations

Slow cruciform transitions in palindromic DNA.

1983 • 122 citations

Perfect palindromic lac operator DNA sequence exists as a stable cruciform structure in supercoiled DNA in vitro but not in vivo.

1983 • 122 citations

Relationship between superhelical density and cruciform formation in plasmid pVH51.

1982 • 88 citations

Dependence of Z-DNA antibody binding to polytene chromosomes on acid fixation and DNA torsional strain

1983 • 85 citations

Determination of nucleotide sequences at promotor regions by the use of dinucleotides

1971 • 76 citations

Left-handed Z-DNA in bands of acid-fixed polytene chromosomes.

1983 • 75 citations

Sites Required for Position-Effect Regulation of Mating-type Information in Yeast

1983 • 64 citations

DNA supercoiling and its effects on the structure of DNA

1984 • 38 citations

Escherichia coli RNA polymerase-rifampicin complexes bound at promoter sites block RNA chain elongation by Escherichia coli/RNA polymerase and T7-specific RNA polymerase

1978 • 37 citations

Comparative transcription of right- and left-handed poly[d(G-C)] by wheat germ RNA polymerase II.

1983 • 36 citations

Effect of template conversion from the B to the Z conformation on RNA polymerase activity

1984 • 34 citations