Sequence-targeted chemical modifications of nucleic acids by complementary oligonucleotides covalently linked to porphyrins

Role of metals in oxygen radical reactions

1985 • 1,149 citations

Hydroxylation of deoxyguanosine at the C-8 position by ascorbic acid and other reducing agents

1984 • 941 citations

Sequence-specific cleavage of single-stranded DNA: oligodeoxynucleotide-EDTA X Fe(II).

1985 • 243 citations

Nucleic acid-binding molecules with high affinity and base sequence specificity: intercalating agents covalently linked to oligodeoxynucleotides.

1984 • 172 citations

Hemin-mediated DNA strand scission.

1983 • 167 citations

Enzymatic amplification of translation inhibition of rabbit β-globin mRNA mediated by anti-messenger oligodeoxynucleotides covalently linked to intercalating agents

1987 • 164 citations

Induction of DNA damage by porphyrin photosensitizers.

1981 • 161 citations

Nonenzymatic sequence-specific cleavage of single-stranded DNA.

1985 • 151 citations

PHOTOCLEAVAGE OF DNA IN THE PRESENCE OF SYNTHETIC WATER‐SOLUBLE PORPHYRINS

1986 • 138 citations

DNA cleavage specificity of a group of cationic metalloporphyrins

1986 • 117 citations

Targeted cleavage of polynucleotides by complementary oligonucleotides covalently linked to iron-porphyrins

1986 • 99 citations

Double helices with parallel strands are formed by nuclease-resistant oligo-[α]-deoxynucleotides and oligo-[α]-deoxynucleotides covalently linked to an intercalating agent with complementary oligo-[β]-deoxynucleotides

1987 • 79 citations

Inability of Chemically Generated Singlet Oxygen to Break the DNA Backbone

1985 • 70 citations

DAMAGES INDUCED IN NUCLEIC ACIDS BY PHOTOSENSITIZATION

1986 • 67 citations

DNA strand scission activity of metalloporphyrins

1982 • 62 citations

Deoxyribonucleic acid cleavage specificity of a series of acridine- and acodazole-iron porphyrins as functional bleomycin models

1986 • 50 citations

Functional analogues of bleomycin: DNA cleavage by bleomycin and hemin-intercalators

1986 • 27 citations

Specific Cleavages of DNA by Ascorbate in the Presence of Copper Ion or Copper Chelates

1985 • 24 citations

³¹P NMR Studies of the Binding of the Oligonucleotide (Ap)₃A to an Oligodeoxythymidylate Covalently Linked to an Acridine Derivative

1986 • 7 citations

Functional analogs of bleomycin: sequence-specific DNA cleavage with porphyrin (Fe) intercalators.

1984 • 2 citations