DNA supercoiling changes the spacing requirement of two lac operators for DNA loop formation with lac repressor.

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

A new method for sequencing DNA.

1977 • 7,941 citations

Equilibria and kinetics of lac repressor-operator interactions by polyacrylamide gel electrophoresis

1981 • 2,828 citations

Supercoil Sequencing: A Fast and Simple Method for Sequencing Plasmid DNA

1985 • 2,505 citations

A gel electrophoresis method for quantifying the binding of proteins to specific DNA regions: application to components of the Escherichia coli lactose operon regulatory system

1981 • 1,991 citations

Regulation of Inducible and Tissue-Specific Gene Expression

1987 • 1,640 citations

Gene regulation by proteins acting nearby and at a distance

1986 • 886 citations

The Writhing Number of a Space Curve

1971 • 754 citations

Cooperative binding of λ repressors to sites separated by integral turns of the DNA helix

1986 • 450 citations

The degree of unwinding of the DNA helix by ethidium

1974 • 440 citations

Energetics of DNA twisting

1983 • 410 citations

Torsional rigidity of DNA and length dependence of the free energy of DNA supercoiling

1984 • 397 citations

An operator at -280 base pairs that is required for repression of araBAD operon promoter: addition of DNA helical turns between the operator and promoter cyclically hinders repression.

1984 • 375 citations

Factors involved in control of tissue-specific expression of albumin gene

1987 • 367 citations

lac repressor forms loops with linear DNA carrying two suitably spaced lac operators.

1987 • 353 citations

Requirement of stereospecific alignments for initiation from the simian virus 40 early promoter

1986 • 336 citations

Multiple DNA-pRotein Interactions Governing High-Precision DNA Transactions

1986 • 302 citations

Linking numbers and nucleosomes.

1976 • 291 citations

A perfectly symmetric lac operator binds the lac repressor very tightly.

1983 • 256 citations

DNA supercoiling promotes formation of a bent repression loop in lac DNA

1987 • 252 citations

DNA Supercoiling and Its Effects on DNA Structure and Function

1983 • 243 citations

Energetics of DNA twisting

1983 • 223 citations

Upstream Operators Enhance Repression of the lac Promoter

1986 • 197 citations

The number of superhelical turns in native Virion SV40 DNA and Minicol DNA determined by the band counting method

1976 • 187 citations

Lac repressor and Lac operator

1976 • 187 citations

Facile cruciform formation by an (A-T)34 sequence from a Xenopus globin gene

1985 • 186 citations

The DNA loop model for ara repression: AraC protein occupies the proposed loop sites in vivo and repression-negative mutations lie in these same sites.

1986 • 167 citations

DNA loops induced by cooperative binding of λ repressor

1986 • 165 citations

Transcriptional block caused by a negative supercoiling induced structural change in an alternating CG sequence

1985 • 160 citations

Measurements of unwinding of lac operator by repressor

1974 • 158 citations

The interaction of the recognition helix of lac repressor with lac operator.

1987 • 151 citations

Catastrophic variation of twist and writhing of circular DNAs with constraint?

1979 • 149 citations

The interaction of recombination proteins with supercoiled DNA: Defining the role of supercoiling in lambda integrative recombination

1986 • 148 citations

Topological unwinding of strong and weak promoters by RNA polymerase

1987 • 136 citations

Supercoils in prokaryotic DNA restrained in vivo.

1980 • 133 citations

Possible ideal lac operator: Escherichia coli lac operator-like sequences from eukaryotic genomes lack the central G X C pair.

1984 • 129 citations

Statistical mechanics of supercoils and the torsional stiffness of the DNA double helix

1979 • 123 citations

All three elements of the lac pS promoter mediate its transcriptional response to DNA supercoiling

1987 • 119 citations

DNA binding characteristics of lactose repressor and the trypsin-resistant core repressor.

1980 • 118 citations

Association of DNA-bound progesterone receptors

1987 • 116 citations

Twist and writhing in short circular DNAs according to first-order elasticity

1984 • 115 citations

Communication between segments of DNA during site-specific recombination

1987 • 107 citations

Long-range cooperativity between gene regulatory sequences in a prokaryote

1987 • 106 citations

Synthetic lac operator mediates repression through lac repressor when introduced upstream and downstream from lac promoter.

1986 • 87 citations

Lac repressor - lac operator interaction. Circular dichroism study

1981 • 80 citations

Influence of sequence and distance between two operators on interaction with the lac repressor.

1987 • 79 citations

Detection in vivo of protein-DNA interactions within the lac operon of Escherichia coli

1985 • 73 citations

Transcription of Escherichia coli ara in vitro

1986 • 65 citations

Specific destruction of the second lac operator decreases repression of the lac operon in Escherichia coli fivefold

1987 • 65 citations

Construction, Isolation and Implications of Repressor‐galactosidase ·ß‐galactosidase Hybrid Molecules

1977 • 61 citations

Supercoiling facilitates lac operator-repressor-pseudooperator interactions.

1987 • 60 citations

Why should DNA loop?

1987 • 57 citations

Influence of supercoiling and sequence context on operator DNA binding with lac repressor.

1987 • 54 citations

Properties of supercoiled DNA in gel electrophoresis

1986 • 49 citations

Helical repeat of DNA in solution. The V curve method

1987 • 44 citations

Topoisomer gel retardation: detection of anti-Z-DNA antibodies bound to Z-DNA within supercoiled DNA minicircles

1988 • 40 citations

Allosteric regulation of inducer and operator binding to the lactose repressor

1986 • 36 citations

Environmental influences on DNA superhelicity

1987 • 30 citations

Direct Measurement of DNA Unwinding Angle in Specific Interaction between lac Operator and Repressor

1983 • 24 citations

Specificity and flexibility

1987 • 24 citations

Recombination by resolvase is inhibited by lac repressor simultaneously binding operators between res sites

1987 • 22 citations

Netropsin Increases the Linking Number of DNA

1983 • 19 citations