The contrasting structures of mismatched DNA sequences containing looped-out bases (bulges) and multiple mismatches (bubbles)

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

A new pair of M13 vectors for selecting either DNA strand of double-digest restriction fragments

1982 • 3,041 citations

The locus of sequence-directed and protein-induced DNA bending

1984 • 1,453 citations

DNA bending at adenine · thymine tracts

1986 • 1,032 citations

Trans-complementable copy-number mutants of plasmid ColE1

1980 • 975 citations

Polymer support oligonucleotide synthesis XVIII^1.2): use ofβ-cyanoethyi-N,N-dialkylamino-/N-morpholino phosphoramidite of deoxynucleosides for the synthesis of DNA fragments simplifying deprotection and isolation of the final product

1984 • 840 citations

Reactivity of cytosine and thymine in single-base-pair mismatches with hydroxylamine and osmium tetroxide and its application to the study of mutations.

1988 • 636 citations

Bent helical structure in kinetoplast DNA

1982 • 595 citations

Cruciform structures in supercoiled DNA

1981 • 545 citations

The inverted repeat as a recognizable structural feature in supercoiled DNA molecules.

1980 • 519 citations

DNA MISMATCH CORRECTION

1987 • 427 citations

Detection of single base substitutions in total genomic DNA

1985 • 375 citations

High sequence specificity of micrococcal nuclease

1981 • 349 citations

Polynucleotide kinase exchange reaction: quantitave assay for restriction endonuclease-generated 5'-phosphoroyl termini in DNA.

1977 • 289 citations

Chemical probes of DNA conformation: detection of Z-DNA at nucleotide resolution

1985 • 286 citations

Sequence dependence of the curvature of DNA: a test of the phasing hypothesis

1985 • 259 citations

On the sequence determinants and flexibility of the kinetoplast DNA fragment with abnormal gel electrophoretic mobilities

1985 • 240 citations

A structural basis for S1 nuclease sensitivity of double-stranded DNA

1985 • 232 citations

RNA binding site of R17 coat protein

1987 • 210 citations

Model for the participation of quasi-palindromic DNA sequences in frameshift mutation.

1982 • 199 citations

Association of an S1 nuclease-sensitive structure with short direct repeats 5′ of Drosophila heat shock genes

1983 • 171 citations

Diethyl pyrocarbonate: a chemical probe for secondary structure in negatively supercoiled DNA.

1985 • 169 citations

A pH-dependent Structural Transition in the Homopurine-homopyrimidine Tract in Superhelical DNA

1985 • 145 citations

DNA bending induced by cruciform formation

1985 • 133 citations

Extra adenosine stacks into the self-complementary d(CGCAGAATTCGCG) duplex in solution

1982 • 123 citations

The supercoil-stabilised cruciform of ColE1 is hyper-reactive to osmium tetroxide.

1984 • 120 citations

(A-T)_ntracts embedded in random sequence DNA — formation of a structure which is chemically reactive and torsionally deformable

1986 • 113 citations

Deletions of bases in one strand of duplex DNA, in contrast to single-base mismatches, produce highly kinked molecules: possible relevance to the folding of single-stranded nucleic acids.

1989 • 100 citations

Highly selective chemical modification of cruciform loops by diethyl pyrocarbonate

1986 • 100 citations

The three-dimensional structure of a DNA duplex containing looped-out bases

1988 • 99 citations

Reaction of diethyl pyrocarbonate with nucleic acid components. Adenosine

1971 • 98 citations

Extrahelical adenosine stacks into right-handed DNA: solution conformation of the d(C-G-C-A-G-A-G-C-T-C-G-C-G) duplex deduced from distance geometry analysis of nuclear Overhauser effect spectra

1986 • 94 citations

Kinetics for exchange of imino protons in the d(C-G-C-G-A-A-T-T-C-G-C-G) double helix and in two similar helices that contain a G.cntdot.T base pair, d(C-G-T-G-A-A-T-T-C-G-C-G), and an extra adenine, d(C-G-C-A-G-A-A-T-T-C-G-C-G)

1982 • 92 citations

DNA bending by the bulge defect

1989 • 88 citations

Structural model for an oligonucleotide containing a bulged guanosine by NMR and energy minimization

1988 • 80 citations

Diethyl pyrocarbonate: a chemical probe for DNA cruciforms

1986 • 76 citations

Reaction of diethyl pyrocarbonate with nucleic acid components. Bases and nucleosides derived from guanine, cytosine, and uracil

1973 • 71 citations

Local destabilisation of a DNA double helix by a T–T wobble pair

1979 • 69 citations

Crystal structure of 15-mer DNA duplex containing unpaired bases

1988 • 68 citations

Structure, dynamics, and thermodynamics of mismatched DNA oligonucleotide duplexes d(CCCAGGG)2 and d(CCCTGGG)2

1987 • 68 citations

Initiation of heteroduplex-loop repair by T4-encoded endonuclease VII in vitro.

1988 • 62 citations

Pyrimidine · pyrimidine base-pair mismatches in DNA

1988 • 59 citations

Synthesis and thermal melting behavior of oligomer.polymer complexes containing defined lengths of mismatched dA·dG and dG·dG nucleotides

1977 • 51 citations

Conformational perturbation due to an extra adenosine in a self‐complementary oligodeoxynucleotide duplex

1987 • 43 citations

Fine mapping of DNA single-stranded regions using base-specific chemical probes. Study of an open complex formed between RNA polymerase and the lac UV5 promoter

1989 • 37 citations

Dynamic, Sequence-dependent DNA Structure as Exemplified by Cruciform Extrusion from Inverted Repeats in Negatively Supercoiled DNA

1983 • 32 citations

Construction of a Systematic Set of tRNA Mutants by Ligation of Synthetic Oligonucleotides into Defined Single-Stranded Gaps

1986 • 17 citations