Distinct Signals Mediate Maturation and Allelic Exclusion in Lymphocyte Progenitors

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow.

1991 • 1,622 citations

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

1988 • 1,562 citations

Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic Lineages

1994 • 1,506 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

Activation of Raf as a Result of Recruitment to the Plasma Membrane

1994 • 979 citations

Profound block in thymocyte development in mice lacking p56lck

1992 • 965 citations

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1995 • 726 citations

Sequential Interactions of the TCR with Two Distinct Cytoplasmic Tyrosine Kinases

1994 • 711 citations

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

1995 • 710 citations

Pleiotropic effects of a null mutation in the c-fos proto-oncogene

1992 • 643 citations

Syk tyrosine kinase required for mouse viability and B-cell development

1995 • 632 citations

pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells

1992 • 574 citations

Essential Role of LAT in T Cell Development

1999 • 537 citations

Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn

1992 • 514 citations

BLNK

1998 • 501 citations

LAT Is Required for TCR-Mediated Activation of PLCγ1 and the Ras Pathway

1998 • 486 citations

Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice

1995 • 475 citations

Characterization of the B Lymphocyte Populations in Lyn-Deficient Mice and the Role of Lyn in Signal Initiation and Down-Regulation

1997 • 451 citations

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice.

1994 • 426 citations

Uncoupling of Nonreceptor Tyrosine Kinases from PLC-γ1 in an SLP-76-Deficient T Cell

1998 • 412 citations

Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development

1998 • 405 citations

Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes

1993 • 403 citations

Selective requirement for MAP kinase activation in thymocyte differentiation

1995 • 398 citations

A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture.

1993 • 393 citations

Double-strand signal sequence breaks in V(D)J recombination are blunt, 5'-phosphorylated, RAG-dependent, and cell cycle regulated.

1993 • 381 citations

STRUCTURE AND FUNCTION OF THE PRE-T CELL RECEPTOR

1997 • 362 citations

Impaired Viability and Profound Block in Thymocyte Development in Mice Lacking the Adaptor Protein SLP-76

1998 • 360 citations

Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function.

1995 • 355 citations

The Ets-1 Transcription Factor Is Required for the Development of Natural Killer Cells in Mice

1998 • 351 citations

Developmentally Controlled Expression of Immunoglobulin V _H Genes

1985 • 349 citations

Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene

1995 • 313 citations

A dominant-negative transgene defines a role for p56lck in thymopoiesis.

1993 • 306 citations

Defective trophoblast function in mice with a targeted mutation of Ets2

1998 • 299 citations

Inhibition of Mitogen-Activated Protein Kinase Kinase Blocks T Cell Proliferation But Does Not Induce or Prevent Anergy

1998 • 298 citations

αβ T Cell Development Is Abolished in Mice Lacking Both Lck and Fyn Protein Tyrosine Kinases

1996 • 294 citations

Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription.

1991 • 289 citations

IL-2 receptor α chain (CD25JAC) expression defines a crucial stage in pre-B cell development

1994 • 284 citations

The RAG1 and RAG2 Proteins Establish the 12/23 Rule in V(D)J Recombination

1996 • 281 citations

Involvement of p21ras distinguishes positive and negative selection in thymocytes.

1995 • 278 citations

PU.1 Functions in a Cell-Autonomous Manner to Control the Differentiation of Multipotential Lymphoid–Myeloid Progenitors

1997 • 276 citations

Changes in the VH Gene Repertoire of Developing Precursor B Lymphocytes in Mouse Bone Marrow Mediated by the Pre-B Cell Receptor

1997 • 253 citations

The Syk family of protein tyrosine kinases in T‐cell activation and development

1998 • 251 citations

Defective thymocyte proliferation and IL-2 production in transgenic mice expressing a dominant-negative form of CREB

1996 • 249 citations

Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII.

1994 • 218 citations

The Influence of the MAPK Pathway on T Cell Lineage Commitment

1997 • 217 citations

The MAP Kinase Pathway Controls Differentiation from Double-Negative to Double-Positive Thymocyte

1996 • 213 citations

Fyn Can Partially Substitute for Lck in T Lymphocyte Development

1996 • 213 citations

Regulation of V(D)J Recombination Activator Protein RAG-2 by Phosphorylation

1993 • 209 citations

A Conserved Degradation Signal Regulates RAG-2 Accumulation during Cell Division and Links V(D)J Recombination to the Cell Cycle

1996 • 199 citations

Influence of immunoglobulin heavy- and light-chain expression on B-cell differentiation.

1994 • 189 citations

Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck.

1992 • 181 citations

Surrogate Light Chain Expression Is Required to Establish Immunoglobulin Heavy Chain Allelic Exclusion during Early B Cell Development

1996 • 174 citations

Thymic tumorigenesis induced by overexpression of p56lck.

1991 • 172 citations

A transgenic immunoglobulin Mu gene prevents rearrangement of endogenous genes

1985 • 169 citations

The Syk and ZAP-70 SH2-containing tyrosine kinases are implicated in pre-T cell receptor signaling

1997 • 159 citations

An activated Ick transgene promotes thymocyte development in rag-1 mutant mice

1994 • 157 citations

Control of B cell development by Ras-mediated activation of Raf

1997 • 152 citations

Essential Role of the Pre-T Cell Receptor in Allelic Exclusion of the T Cell Receptor β Locus

1997 • 146 citations

Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain

1989 • 140 citations

Regulation of c-myc expression by Ras/Raf signalling

1998 • 134 citations

Activated Ras signals differentiation and expansion of CD4+8+ thymocytes.

1996 • 130 citations

Surface expression of the beta T cell receptor (TCR) chain in the absence of other TCR or CD3 proteins on immature T cells.

1991 • 121 citations

Delayed thymocyte development induced by augmented expression of p56lck.

1991 • 117 citations

Surrogate Light Chain in B Cell Development

1996 • 110 citations

Induction of c-myc transcription by the v-Abl tyrosine kinase requires Ras, Raf1, and cyclin-dependent kinases.

1997 • 108 citations

Restoration of Thymopoiesis in pTα−/− Mice by Anti-CD3ε Antibody Treatment or with Transgenes Encoding Activated Lck or Tailless pTα

1997 • 106 citations

The pre-T cell receptor (TCR) complex is functionally coupled to the TCR-zeta subunit.

1995 • 98 citations

The cytoplasmic domains of immunoglobulin (Ig) alpha and Ig beta can independently induce the precursor B cell transition and allelic exclusion.

1995 • 94 citations

Constitutive tyrosine phosphorylation of the T-cell receptor (TCR) zeta subunit: regulation of TCR-associated protein tyrosine kinase activity by TCR zeta.

1993 • 91 citations

Raf regulates positive selection

1996 • 90 citations

Activated Ras Signals Developmental Progression of Recombinase-activating Gene (RAG)-deficient Pro-B Lymphocytes

1999 • 82 citations

The Cell Cycle and V(D)J Recombination

1996 • 59 citations

IL-2 receptor α chain expression during early B lymphocyte differentiation

1994 • 50 citations

Somatic generation of immune diversity

1988 • 46 citations

Constitutive Tyrosine Phosphorylation of the T-Cell Receptor (TCR) ζ Subunit: Regulation of TCR-Associated Protein Tyrosine Kinase Activity by TCR ζ

1993 • 36 citations

p56lck Signals for Regulating Thymocyte Development Can Be Distinguished by Their Dependency on Rho Function

1998 • 33 citations

A cell cycle analysis of growth-related genes expressed during T lymphocyte maturation.

1990 • 32 citations

Regulation of BCR- and PKC/Ca2+-mediated activation of the Raf1/MEK/MAPK pathway by protein-tyrosine kinase and -tyrosine phosphatase activities

1996 • 27 citations

A role for c-myc in the regulation of thymocyte differentiation and possibly positive selection.

1996 • 25 citations

B-lymphocyte-lineage Cells from Early Precursors to Ig-secreting Plasma Cells: Targets of Regulation by the myc/mad/max Families of Genes?

1997 • 17 citations

Signal transduction pathways regulating the development of αβ T cells

1998 • 6 citations