The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

The Pathogenesis of Insulin-Dependent Diabetes Mellitus

1994 • 1,077 citations

Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

1997 • 806 citations

Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus

1995 • 749 citations

A Polymorphic Locus Near the Human Insulin Gene Is Associated with Insulin-dependent Diabetes Melliitus

1984 • 744 citations

The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences

1982 • 524 citations

Positive and Negative Thymocyte Selection Induced by Different Concentrations of a Single Peptide

1994 • 497 citations

The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription

1995 • 383 citations

Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility

1991 • 378 citations

Molecular Cloning and Identification of a Receptor-Type Protein Tyrosine Phosphatase, IA-2, from Human Insulinoma

1994 • 317 citations

Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases.

1994 • 308 citations

HUMAN TYPE 1 DIABETES AND THE INSULIN GENE: Principles of Mapping Polygenes

1996 • 291 citations

Susceptibility to insulin dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR

1993 • 271 citations

Transgenic Expression of Mouse Proinsulin II Prevents Diabetes in Nonobese Diabetic Mice

1997 • 248 citations

Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen.

1993 • 236 citations

Functional Polymorphism in the Parental Imprinting of the Human IGF2R Gene

1993 • 228 citations

T-cell tolerance toward a transgenic beta-cell antigen and transcription of endogenous pancreatic genes in thymus.

1994 • 223 citations

Promoter-specific imprinting of the human insulin-like growth factor-II gene

1994 • 222 citations

IDDM2-VNTR-encoded Susceptibility to Type 1 Diabetes: Dominant Protection and Parental Transmission of Alleles of the Insulin Gene-linked Minisatellite Locus

1996 • 165 citations

Insulin II gene expression in rat central nervous system

1993 • 132 citations

Imprinted and Genotype-specific Expression of Genes at theIDDM2Locus in Pancreas and Leucocytes

1996 • 115 citations

Regulation of insulin gene expression by the IDDM associated, insulin locus haplotype

1995 • 106 citations

Insulin Gene Region-Encoded Susceptibility to IDDM Maps Upstream of the Insulin Gene

1995 • 91 citations

Localization of a Type I Diabetes Susceptibility Locus to the Variable Tandem Repeat Region Flanking the Insulin Gene

1993 • 86 citations

Characterization of Insulin Autoantibodies in Relatives of Patients With Type I Diabetes

1993 • 74 citations

Evidence of IgG Autoantibodies Against Human Proinsulin in Patients With IDDM Before Insulin Treatment

1988 • 73 citations

The Search for IDDM Susceptibility Genes: The Next Generation

1996 • 71 citations

Escape of Thymocytes and Mature T Cells from Clonal Deletion Due to Limiting Tolerogen Expression Levels

1994 • 57 citations

The Paternally Inherited Insulin Gene B Allele (1,428 FokI site) Confers Protection from Insulin-dependent Diabetes in Families

1994 • 41 citations

Parental imprinting effect at the INS-IGF2 diabetes susceptibility locus

1995 • 37 citations

ICA69 is expressed equally in the human endocrine and exocrine pancreas

1996 • 33 citations

Experimental autoimmune insulitis. Induction by T lymphocytes specific for a peptide of proinsulin.

1995 • 31 citations

Paternally TransmittedIDDM2Influences Diabetes Susceptibility Despite Biallelic Expression of the Insulin Gene in Human Pancreas

1996 • 25 citations

Autoantibodies to Insulin and to Proinsulin in Type 1 Diabetic Patients and in At-Risk Probands Differentiate Only Little between Both Antigens

1995 • 20 citations