Notch Signaling: Cell Fate Control and Signal Integration in Development

Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia

1996 • 1,951 citations

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1998 • 1,600 citations

Signalling downstream of activated mammalian Notch

1995 • 1,375 citations

Notch Signaling

1995 • 1,282 citations

Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

1997 • 1,239 citations

Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats

1985 • 1,063 citations

The choice of cell fate in the epidermis of Drosophila

1991 • 736 citations

Nuclear Access and Action of Notch In Vivo

1998 • 730 citations

The Notch1 receptor is cleaved constitutively by a furin-like convertase

1998 • 720 citations

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.

1996 • 717 citations

Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila

1990 • 675 citations

Control of Daughter Cell Fates during Asymmetric Division: Interaction of Numb and Notch

1996 • 656 citations

Intracellular Cleavage of Notch Leads to a Heterodimeric Receptor on the Plasma Membrane

1997 • 615 citations

Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity.

1995 • 594 citations

Fringe modulates Notch–ligand interactions

1997 • 578 citations

Groucho is required for Drosophila neurogenesis, segmentation, and sex determination and interacts directly with hairy-related bHLH proteins

1994 • 560 citations

The suppressor of hairless protein participates in notch receptor signaling

1994 • 547 citations

LIN-12/Notch signaling: lessons from worms and flies

1998 • 545 citations

Kuzbanian Controls Proteolytic Processing of Notch and Mediates Lateral Inhibition during Drosophila and Vertebrate Neurogenesis

1997 • 516 citations

On the phenotype and development of mutants of early neurogenesis inDrosophila melanogaster

1983 • 493 citations

numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos

1989 • 493 citations

The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD

1994 • 483 citations

Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jκ/Su(H)

1995 • 476 citations

Notch is required for successive cell decisions in the developing Drosophila retina.

1989 • 473 citations

Intrinsic activity of the lin-12 and Notch intracellular domains in vivo

1993 • 466 citations

Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors.

1986 • 427 citations

Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor

1993 • 424 citations

Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.

1993 • 421 citations

Processing of the Notch Ligand Delta by the Metalloprotease Kuzbanian

1999 • 413 citations

The function and regulation of cut expression on the wing margin of Drosophila: Notch, Wingless and a dominant negative role for Delta and Serrate

1997 • 407 citations

Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing

1995 • 392 citations

Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway

1996 • 372 citations

Metalloprotease-Disintegrins: Links to Cell Adhesion and Cleavage of TNFα and Notch

1997 • 363 citations

Alterations in Notch signaling in neoplastic lesions of the human cervix.

1995 • 355 citations

Correlating Notch Signaling with Thymocyte Maturation

1998 • 350 citations

The WRPW Motif of the Hairy-Related Basic Helix-Loop-Helix Repressor Proteins Acts as a 4-Amino-Acid Transcription Repression and Protein-Protein Interaction Domain

1996 • 344 citations

KUZ, a Conserved Metalloprotease-Disintegrin Protein with Two Roles in Drosophila Neurogenesis

1996 • 331 citations

Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila

1996 • 331 citations

Delta-1 Activation of Notch-1 Signaling Results in HES-1 Transactivation

1998 • 328 citations

The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells

1998 • 328 citations

Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation.

1996 • 316 citations

The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage.

1996 • 313 citations

An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye

1993 • 307 citations

Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: implications for notch function.

1991 • 297 citations

THE LIN-12/Notch SIGNALING PATHWAY AND ITS REGULATION

1997 • 292 citations

Cell proliferation control by Notch signaling in Drosophila development

1998 • 269 citations

Delta-Notch Signaling and Drosophila Cell Fate Choice

1994 • 268 citations

Wingless and Notch regulate cell-cycle arrest in the developing Drosophila wing

1998 • 263 citations

Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc

1997 • 261 citations

Notch Inhibition of E47 Supports the Existence of a Novel Signaling Pathway

1998 • 261 citations

A hierarchy of cross-regulation involving Notch, wingless, vestigial and cut organizes the dorsal/ventral axis of the Drosophila wing

1996 • 260 citations

Cell recognition, signal induction, and symmetrical gene activation at the dorsal-ventral boundary of the developing drosophila wing

1995 • 257 citations

A dorsal/ventral boundary established by Notch controls growth and polarity in the Drosophila eye

1998 • 254 citations

Organization of wing formation and induction of a wing-patterning gene at the dorsal/ventral compartment boundary

1994 • 254 citations

The function of the neurogenic genes during epithelial development in the Drosophila embryo

1992 • 248 citations

Cell autonomy of lin-12 function in a cell fate decision in C. elegans

1989 • 241 citations

Chromosomal Deficiencies and the Embryonic Development of Drosophila Melanogaster

1937 • 235 citations

Asymmetric Notch activation specifies photoreceptors R3 and R4 and planar polarity in the Drosophila eye

1999 • 224 citations

Notch signalling mediates segmentation of the Drosophila leg

1998 • 223 citations

Cutting Edge: Protective Effects of Notch-1 on TCR-Induced Apoptosis

1999 • 223 citations

Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos

1998 • 217 citations

Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway

1994 • 209 citations

Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis

1997 • 207 citations

Notch regulates wingless expression and is not required for reception of the paracrine wingless signal during wing margin neurogenesis in Drosophila

1995 • 199 citations

Notch signalling inDrosophila: three ways to use a pathway

1998 • 195 citations

Indirect evidence for Delta-dependent intracellular processing of Notch in Drosophila embryos

1998 • 193 citations

Human deltex is a conserved regulator of Notch signalling

1998 • 189 citations

The Genetics of Embryogenesis in Drosophila

1970 • 180 citations

Maggot's hair and bug's eye: Role of cell interactions and intrinsic factors in cell fate specification

1995 • 180 citations

Notch is required for wingless signaling in the epidermis of Drosophila

1994 • 179 citations

Cis-interactions between Delta and Notch modulate neurogenic signalling in Drosophila

1998 • 177 citations

Notch Signaling in Vertebrate Development and Disease

1997 • 170 citations

HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3

1998 • 165 citations

A Role for Abl in Notch Signaling

1998 • 161 citations

Inhibition of the DNA-binding activity of Drosophila suppressor of hairless and of its human homolog, KBF2/RBP-J kappa, by direct protein-protein interaction with Drosophila hairless.

1994 • 160 citations

SUP-17, a Caenorhabditis elegans ADAM protein related to Drosophila KUZBANIAN, and its role in LIN-12/NOTCH signalling

1997 • 155 citations

Lateral inhibition mediated by the Drosophila neurogenic gene delta is enhanced by proneural proteins.

1994 • 154 citations

The metalloprotease-disintegrin Kuzbanian participates in Notch activation during growth and patterning of Drosophila imaginal discs

1997 • 152 citations

The Groucho/Transducin-like Enhancer of split Transcriptional Repressors Interact with the Genetically Defined Amino-terminal Silencing Domain of Histone H3

1997 • 149 citations

Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signalling

1996 • 148 citations

The effects of certain X‐chromosome deficiencies on the embryonic development of Drosophila melanogaster

1940 • 148 citations

T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells.

1996 • 136 citations

The Notch Locus and the Cell Biology of Neuroblast Segregation

1991 • 131 citations

Identification and localization of a sea urchin Notch homologue: insights into vegetal plate regionalization and Notch receptor regulation

1997 • 127 citations

Notch Receptors, Partners and Regulators: From Conserved Domains to Powerful Functions

1998 • 125 citations

bHLH proteins encoded by theEnhancer of split complex ofDrosophila negatively interfere with transcriptional activation mediated by proneural genes

1994 • 113 citations

Drosophila eye development: Notch and Delta amplify a neurogenic pattern conferred on the morphogenetic furrow by scabrous

1995 • 110 citations

Notch-1 inhibits apoptosis in murine erythroleukemia cells and is necessary for differentiation induced by hybrid polar compounds

1999 • 108 citations

Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements

1997 • 105 citations

Complex Proteolytic Processing Acts on Delta, a Transmembrane Ligand for Notch, duringDrosophilaDevelopment

1998 • 103 citations

Notch signaling: direct or what?

1998 • 101 citations

Delta and Serrate are redundant Notch ligands required for asymmetric cell divisions within the Drosophila sensory organ lineage

1998 • 97 citations

Involvement of Notch-1 in mammalian retinal neurogenesis: association of Notch-1 activity with both immature and terminally differentiated cells

1995 • 96 citations

Scalloped wings Is the Lucilia cuprina Notch Homologue and a Candidate for the Modifier of Fitness and Asymmetry of Diazinon Resistance

1996 • 96 citations

Analysis of Dominant Enhancers and Suppressors of Activated Notch in Drosophila

1996 • 90 citations

Modulation of wingless signaling by Notch in Drosophila

1994 • 81 citations

Transcriptional regulation of Notch and Delta: requirement for neuroblast segregation in Drosophila

1997 • 80 citations

Asymmetric Expression of Notch/Delta/Serrate Is Associated with the Anterior–Posterior Axis of Feather Buds

1997 • 71 citations

Serrate expression can functionally replace Delta activity during neuroblast segregation in the Drosophila embryo

1995 • 71 citations

Boundary Formation in Drosophila Wing: Notch Activity Attenuated by the POU Protein Nubbin

1998 • 64 citations

Evidence for Physical and Functional Association Between EMB-5 and LIN-12 in Caenorhabditis elegans

1996 • 52 citations

Asymmetry – where evolutionary and developmental genetics meet

1996 • 41 citations

Interactions between Wingless and Notch during the assignment of cell fates in Drosophila.

1998 • 21 citations

GP300SCA Is Not a High Affinity Notch Ligand

1996 • 11 citations

Molecular characterization of the Notch homologue from the Australian sheep blowfly, Lucilia cuprina

1998 • 10 citations

Deleted Work

1955 • 0 citations