Inactivation of Notch1 Impairs VDJβ Rearrangement and Allows pre-TCR-Independent Survival of Early αβ Lineage Thymocytes

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

RAG-1-deficient mice have no mature B and T lymphocytes

1992 • 2,859 citations

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 • 2,618 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

A Critical Role for Dnmt1 and DNA Methylation in T Cell Development, Function, and Survival

2001 • 1,215 citations

Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages

1992 • 1,116 citations

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 • 956 citations

Specific EGF repeats of Notch mediate interactions with Delta and serrate: Implications for notch as a multifunctional receptor

1991 • 770 citations

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1995 • 519 citations

Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice

1997 • 503 citations

An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages

1996 • 488 citations

Control points in early T-cell development

1993 • 429 citations

Analysis and Expression of a Cloned Pre-T Cell Receptor Gene

1994 • 410 citations

Notch Activity Influences the αβ versus γδ T Cell Lineage Decision

1997 • 399 citations

Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene.

1995 • 393 citations

Notch 1–Deficient Common Lymphoid Precursors Adopt a B Cell Fate in the Thymus

2001 • 392 citations

Correlating Notch Signaling with Thymocyte Maturation

1998 • 350 citations

Notch1 Signaling Promotes the Maturation of CD4 and CD8 SP Thymocytes

2000 • 317 citations

Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments

1998 • 314 citations

MOLECULAR AND CELLULAR

1989 • 302 citations

Inactivation of Notch1 in immature thymocytes does not perturb CD4 or CD8 T cell development

2001 • 300 citations

Activation of Fas by FasL induces apoptosis by a mechanism that cannot be blocked by Bcl-2 or Bcl-x_L

1999 • 295 citations

Deltex1 Redirects Lymphoid Progenitors to the B Cell Lineage by Antagonizing Notch1

2002 • 251 citations

Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice.

1995 • 245 citations

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate

2000 • 244 citations

Separate elements control DJ and VDJ rearrangement in a transgenic recombination substrate.

1990 • 224 citations

Cutting Edge: Protective Effects of Notch-1 on TCR-Induced Apoptosis

1999 • 223 citations

Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway

2002 • 204 citations

Expression pattern of Notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand–receptor interactions in intrathymic T cell development

1999 • 197 citations

Subversion of the T/B Lineage Decision in the Thymus by Lunatic Fringe-Mediated Inhibition of Notch-1

2001 • 195 citations

Early Thymocyte Development Is Regulated by Modulation of E2a Protein Activity

2001 • 190 citations

Notch1 Regulates Maturation of CD4+ and CD8+ Thymocytes by Modulating TCR Signal Strength

2001 • 182 citations

Inhibition of T-cell receptor beta-chain gene rearrangement by overexpression of the non-receptor protein tyrosine kinase p56lck.

1992 • 181 citations

Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development.

1996 • 179 citations

Somatic activation of β-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development

2001 • 175 citations

Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.

1996 • 164 citations

Chromatin Remodeling by the T Cell Receptor (Tcr)-β Gene Enhancer during Early T Cell Development

2000 • 161 citations

Modulated expression of notch1 during thymocyte development

1996 • 147 citations

FADD/MORT1 regulates the pre-TCR checkpoint and can function as a tumour suppressor

2000 • 142 citations

Molecular and Cellular Events in Early Thymocyte Development 11Received for publication October 14, 1997

1998 • 137 citations

TCR beta and TCR alpha gene enhancers confer tissue- and stage-specificity on V(D)J recombination events.

1993 • 132 citations

Activated Ras signals differentiation and expansion of CD4+8+ thymocytes.

1996 • 130 citations

A Transcriptional Enhancer 3′ of C _β2 in the T Cell Receptor β Locus

1988 • 118 citations

Evidence That γδ versus αβ T Cell Fate Determination Is Initiated Independently of T Cell Receptor Signaling

2001 • 118 citations

A novel Notch ligand, Dll4, induces T-cell leukemia/lymphoma when overexpressed in mice by retroviral-mediated gene transfer

2001 • 101 citations

Differential activation of transcription versus recombination of transgenic T cell receptor beta variable region gene segments in B and T lineage cells.

1994 • 85 citations

Stepwise specification of lymphocyte developmental lineages

2000 • 81 citations

Rearrangement of IgH genes in normal thymocyte development.

1988 • 71 citations

Molecular determinants of TCR expression and selection

2001 • 57 citations

Unexpectedly late expression of intracellular CD3ϵ and TCR γδ proteins during adult thymus development

1999 • 56 citations

Helix-Loop-Helix Proteins Regulate Pre-TCR and TCR Signaling through Modulation of Rel/NF-κB Activities

2002 • 56 citations

Developmental regulation of micro-injected histone genes in sea urchin embryos

1988 • 48 citations

Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex

1999 • 28 citations

Limited effect of chromatin remodeling on Dβ-to-Jβ recombination in CD4+CD8+ thymocyte: implications for a new aspect in the regulation of TCR β gene recombination

2001 • 17 citations