DNA MISMATCH REPAIR AND GENETIC INSTABILITY

The Genome Sequence of Drosophila melanogaster

2000 • 5,882 citations

Comprehensive Identification of Cell Cycle–regulated Genes of the YeastSaccharomyces cerevisiaeby Microarray Hybridization

1998 • 4,811 citations

DNA Repair and Mutagenesis

2006 • 4,725 citations

Multiple Pathways of Recombination Induced by Double-Strand Breaks in Saccharomyces cerevisiae

1999 • 2,095 citations

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1998 • 1,852 citations

MISMATCH REPAIR IN REPLICATION FIDELITY, GENETIC RECOMBINATION, AND CANCER BIOLOGY

1996 • 1,485 citations

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

2000 • 1,236 citations

DNA EXCISION REPAIR

1996 • 1,127 citations

Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair

1993 • 1,076 citations

Evolution of high mutation rates in experimental populations of E. coli

1997 • 909 citations

Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability.

1998 • 855 citations

High Mutation Frequencies Among Escherichia coli and Salmonella Pathogens

1996 • 836 citations

Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over

1996 • 800 citations

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

1995 • 785 citations

The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants

1989 • 728 citations

Biallelic inactivation of hMLH 1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers

1998 • 629 citations

Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair.

1996 • 576 citations

Requirement for PCNA in DNA Mismatch Repair at a Step Preceding DNA Resynthesis

1996 • 569 citations

DNA Mismatch Correction in a Defined System

1989 • 551 citations

Meiotic Pachytene Arrest in MLH1-Deficient Mice

1996 • 549 citations

hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

1996 • 541 citations

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

1995 • 536 citations

MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas

1998 • 498 citations

Different base/base mismatches are corrected with different efficiencies by the methyl-directed DNA mismatch-repair system of E. coli

1984 • 468 citations

The role of DNA mismatch repair in drug resistance

1998 • 459 citations

Mammalian DNA Mismatch Repair

1999 • 451 citations

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

1993 • 445 citations

A Novel Mutation Avoidance Mechanism Dependent on S. cerevisiae RAD27 Is Distinct from DNA Mismatch Repair

1997 • 434 citations

Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.

1996 • 422 citations

Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines.

1990 • 408 citations

RECOMBINATION IN YEAST

1971 • 405 citations

Isolation of MutSβ from Human Cells and Comparison of the Mismatch Repair Specificities of MutSβ and MutSα

1998 • 405 citations

Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.

1995 • 403 citations

Transformation of MutL by ATP Binding and Hydrolysis

1999 • 400 citations

MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair.

1995 • 391 citations

Identification and characterization of Saccharomyces cerevisiae EXO1 , a gene encoding an exonuclease that interacts with MSH2

1997 • 382 citations

Mammalian MutS homologue 5 is required for chromosome pairing in meiosis

1999 • 382 citations

Microsatellite Instability in Yeast: Dependence on Repeat Unit Size and DNA Mismatch Repair Genes

1997 • 381 citations

Removal of Nonhomologous DNA Ends in Double-Strand Break Recombination: the Role of the Yeast Ultraviolet Repair Gene RAD1

1992 • 375 citations

Crystal Structure and ATPase Activity of MutL

1998 • 374 citations

hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability.

1999 • 374 citations

Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction

1994 • 371 citations

Hypermethylation of the hMLH1 gene promoter in human gastric cancers with microsatellite instability.

1999 • 369 citations

hMSH2–hMSH6 Forms a Hydrolysis-Independent Sliding Clamp on Mismatched DNA

1999 • 368 citations

hMutSβ, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA

1996 • 363 citations

Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint.

1995 • 362 citations

High frequencies of short frameshifts in poly-CA/TG tandem repeats borne by bacteriophage M13 inEscherichia coliK-12

1987 • 362 citations

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

1993 • 361 citations

Mutation in the Mismatch Repair Gene Msh6 Causes Cancer Susceptibility

1997 • 359 citations

Heteroduplex repair in extracts of human HeLa cells

1991 • 355 citations

Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions.

1992 • 353 citations

Hot Spot Focusing of Somatic Hypermutation in MSH2-Deficient Mice Suggests Two Stages of Mutational Targeting

1998 • 352 citations

Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DMA mismatch repair

1998 • 351 citations

Proliferation of mutators in A cell population

1997 • 342 citations

Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer

1994 • 329 citations

APC mutations in colorectal tumors with mismatch repair deficiency.

1996 • 329 citations

MutS mediates heteroduplex loop formation by a translocation mechanism

1997 • 325 citations

MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability

2000 • 323 citations

MLH1 Promoter Methylation and Gene Silencing is the Primary Cause of Microsatellite Instability in Sporadic Endometrial Cancers

1999 • 316 citations

Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents

1999 • 314 citations

Hypermutability of Homonucleotide Runs in Mismatch Repair and DNA Polymerase Proofreading Yeast Mutants

1997 • 313 citations

Initiation of methyl-directed mismatch repair.

1992 • 313 citations

The mismatch repair system contributes to meiotic sterility in an interspecific yeast hybrid.

1996 • 308 citations

Molecular keys to speciation: DNA polymorphism and the control of genetic exchange in enterobacteria

1997 • 308 citations

Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination

1997 • 305 citations

Base selection, proofreading, and mismatch repair during DNA replication in Escherichia coli.

1993 • 300 citations

Functional specificity of MutL homologs in yeast: Evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction

1999 • 291 citations

Spectra of spontaneous mutations in Escherichia coli strains defective in mismatch correction: the nature of in vivo DNA replication errors.

1987 • 291 citations

Transcription-Coupled Repair Deficiency and Mutations in Human Mismatch Repair Genes

1996 • 289 citations

The Saccharomyces cerevisiae MLH 3 gene functions in MSH3-dependent suppression of frameshift mutations

1998 • 275 citations

Involvement of the Mismatch Repair System in Temozolomide-Induced Apoptosis

1998 • 275 citations

Specific Cleavage of Model Recombination and Repair Intermediates by the Yeast Rad1-Rad10 DNA Endonuclease

1994 • 265 citations

MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1

1999 • 253 citations

Heteroduplex deoxyribonucleic acid base mismatch repair in bacteria

1986 • 252 citations

Mismatch repair proteins MutS and MutL inhibit RecA-catalyzed strand transfer between diverged DNAs.

1994 • 251 citations

Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosis.

1997 • 243 citations

Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiae.

1994 • 236 citations

MSH2 and MSH6 Are Required for Removal of Adenine Misincorporated Opposite 8-Oxo-Guanine in S. cerevisiae

1999 • 230 citations

Dual roles for DNA sequence identity and the mismatch repair system in the regulation of mitotic crossing-over in yeast

1997 • 230 citations

Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction

1993 • 224 citations

Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene.

1994 • 222 citations

MEIOTIC GENE CONVERSION MUTANTS IN SACCHAROMYCES CEREVISIAE. I. ISOLATION AND CHARACTERIZATION OF pms1-1 AND pms1-2

1985 • 220 citations

Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation

1999 • 219 citations

Crossing Over During Caenorhabditis elegans Meiosis Requires a Conserved MutS-Based Pathway That Is Partially Dispensable in Budding Yeast

1999 • 219 citations

ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair

1998 • 218 citations

Reduced Isotype Switching in Splenic B Cells from Mice Deficient in Mismatch Repair Enzymes

1999 • 218 citations

RAD1 and RAD10, but Not Other Excision Repair Genes, Are Required for Double-Strand Break-Induced Recombination in Saccharomyces cerevisiae

1995 • 217 citations

Repair of DNA heteroduplexes containing small heterologous sequences in Escherichia coli.

1992 • 215 citations

Mismatch correction at O6-methylguanine residues in E. coli DNA

1982 • 215 citations

HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions

1999 • 212 citations

A set of lacZ mutations in Escherichia coli that allow rapid detection of specific frameshift mutations.

1990 • 211 citations

Mismatch repair deficiency associated with overexpression of the MSH3 gene

1998 • 210 citations

A Mutational Analysis of the Yeast Proliferating Cell Nuclear Antigen Indicates Distinct Roles in DNA Replication and DNA Repair

1995 • 209 citations

Methyl-directed mismatch repair is bidirectional

1993 • 208 citations

The 3′→5′ Exonucleases of DNA Polymerases δ and ɛ and the 5′→3′ Exonuclease Exo1 Have Major Roles in Postreplication Mutation Avoidance in Saccharomyces cerevisiae

1999 • 205 citations

Barriers to Genetic Exchange between Bacterial Species: Streptococcus pneumoniae Transformation

2000 • 204 citations

A Role for Exonuclease I from S. pombe in Mutation Avoidance and Mismatch Correction

1995 • 202 citations

Evidence for Involvement of Yeast Proliferating Cell Nuclear Antigen in DNA Mismatch Repair

1996 • 200 citations

Spontaneous mutation in the Escherichia coli lacI gene.

1991 • 200 citations

The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin

1996 • 198 citations

The Consequences of Growth of a Mutator Strain of Escherichia coli as Measured by Loss of Function Among Multiple Gene Targets and Loss of Fitness

2000 • 196 citations

Requirement of the Yeast RTH1 5′ to 3′ Exonuclease for the Stability of Simple Repetitive DNA

1995 • 195 citations

Cloning and nucleotide sequence of DNA mismatch repair gene PMS1 from Saccharomyces cerevisiae: homology of PMS1 to procaryotic MutL and HexB

1989 • 193 citations

Nucleotide-promoted Release of hMutSα from Heteroduplex DNA Is Consistent with an ATP-dependent Translocation Mechanism

1998 • 190 citations

Requirement of the Yeast MSH3 and MSH6 Genes for MSH2-dependent Genomic Stability

1996 • 187 citations

Mutator Phenotypes Conferred by MLH1Overexpression and by Heterozygosity for mlh1Mutations

1999 • 186 citations

Increased Hypermutation at G and C Nucleotides in Immunoglobulin Variable Genes from Mice Deficient in the MSH2 Mismatch Repair Protein

1998 • 183 citations

Identification of hMutLβ, a Heterodimer of hMLH1 and hPMS1

1999 • 183 citations

hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage

1999 • 181 citations

The Mismatch Repair System Reduces Meiotic Homeologous Recombination and Stimulates Recombination-Dependent Chromosome Loss

1996 • 178 citations

Mismatch repair, molecular switches, and signal transduction

1998 • 176 citations

Products of DNA mismatch repair genes mutS and mutL are required for transcription-coupled nucleotide-excision repair of the lactose operon in Escherichia coli.

1996 • 174 citations

hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalpha

1998 • 173 citations

The Drosophila meiotic recombination gene mei-9 encodes a homologue of the yeast excision repair protein Rad1.

1995 • 170 citations

The Role of the Mismatch Repair Machinery in Regulating Mitotic and Meiotic Recombination Between Diverged Sequences in Yeast

1999 • 168 citations

The Escherichia coliMutL Protein Physically Interacts with MutH and Stimulates the MutH-associated Endonuclease Activity

1999 • 168 citations

The Saccharomyces cerevisiae Msh2 and Msh6 Proteins Form a Complex That Specifically Binds to Duplex Oligonucleotides Containing Mismatched DNA Base Pairs

1996 • 168 citations

MutS and MutL Activate DNA Helicase II in a Mismatch-dependent Manner

1998 • 164 citations

Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3

1996 • 163 citations

DHFR/MSH3 amplification in methotrexate-resistant cells alters the hMutSα/hMutSβ ratio and reduces the efficiency of base–base mismatch repair

1997 • 162 citations

Mismatch Repair Co-opted by Hypermutation

1998 • 159 citations

Human exonuclease I interacts with the mismatch repair protein hMSH2.

1998 • 159 citations

Functional analysis of human MLH1 mutations in Saccharomyces cerevisiae

1998 • 157 citations

Evidence for a physical interaction between the Escherichia coli methyl-directed mismatch repair proteins MutL and UvrD

1998 • 154 citations

Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2

1997 • 153 citations

Functional Overlap in Mismatch Repair by Human MSH3 and MSH6

1998 • 152 citations

Purification and characterization of MSH1, a yeast mitochondrial protein that binds to DNA mismatches.

1994 • 152 citations

Repair of defined single base-pair mismatches in Escherichia coli

1985 • 149 citations

Mismatch-, MutS-, MutL-, and Helicase II-dependent Unwinding from the Single-strand Break of an Incised Heteroduplex

1998 • 149 citations

Repair of DNA loops involves DNA-mismatch and nucleotide-excision repair proteins

1997 • 146 citations

Control of large chromosomal duplications in Escherichia coli by the mismatch repair system.

1991 • 140 citations

Mismatch Repair Deficiency Interferes with the Accumulation of Mutations in Chronically Stimulated B Cells and Not with the Hypermutation Process

1998 • 139 citations

Different mutator phenotypes in Mlh1 - versus Pms2 -deficient mice

1999 • 138 citations

Interactions of Human hMSH2 with hMSH3 and hMSH2 with hMSH6: Examination of Mutations Found in Hereditary Nonpolyposis Colorectal Cancer

1998 • 137 citations

Involvement of the DNA mismatch repair system in antineoplastic drug resistance

1999 • 133 citations

Mismatch Repair Processing of Carcinogen-DNA Adducts Triggers Apoptosis

1999 • 132 citations

Requirement of Mismatch Repair Genes MSH2 and MSH3 in the RAD1-RAD10 Pathway of Mitotic Recombination in Saccharomyces cerevisiae

1996 • 131 citations

Genetic and Biochemical Analysis of Msh2p-Msh6p: Role of ATP Hydrolysis and Msh2p-Msh6p Subunit Interactions in Mismatch Base Pair Recognition

1997 • 129 citations

Arabidopsis MutS Homologs—AtMSH2, AtMSH3, AtMSH6, and a Novel AtMSH7—Form Three Distinct Protein Heterodimers with Different Specificities for Mismatched DNA

2000 • 128 citations

Dominant negative mutator mutations in the mutS gene of Escherichia coli

1994 • 127 citations

Conserved Properties between Functionally Distinct MutS Homologs in Yeast

1997 • 126 citations

Analysis of a gene conversion gradient at the HIS4 locus in Saccharomyces cerevisiae.

1992 • 126 citations

ATP-dependent Assembly of a Ternary Complex Consisting of a DNA Mismatch and the Yeast MSH2-MSH6 and MLH1-PMS1 Protein Complexes

1998 • 126 citations

Biochemical Characterization of the Interaction between the Saccharomyces cerevisiae MSH2-MSH6 Complex and Mispaired Bases in DNA

1999 • 126 citations

Functional Domains of the Saccharomyces cerevisiae Mlh1p and Pms1p DNA Mismatch Repair Proteins and Their Relevance to Human Hereditary Nonpolyposis Colorectal Cancer-Associated Mutations

1997 • 123 citations

Hypermutation in Pathogenic Bacteria

1999 • 122 citations

Physical interaction between components of DNA mismatch repair and nucleotide excision repair

1998 • 121 citations

Hypermutation of Immunoglobulin Genes in Memory B Cells of DNA Repair–deficient Mice

1998 • 116 citations

Regulation of Mitotic Homeologous Recombination in Yeast: Functions of Mismatch Repair and Nucleotide Excision Repair Genes

2000 • 115 citations

Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast

2000 • 114 citations

Mismatch Repair Proteins Regulate Heteroduplex Formation during Mitotic Recombination in Yeast

1998 • 110 citations

Frameshift Intermediates in Homopolymer Runs Are Removed Efficiently by Yeast Mismatch Repair Proteins

1997 • 108 citations

hMSH5: a human MutS homologue that forms a novel heterodimer with hMSH4 and is expressed during spermatogenesis.

1999 • 108 citations

The Effect of Mismatch Repair and Heteroduplex Formation on Sexual Isolation in Bacillus

1998 • 106 citations

The Saccharomyces cerevisiae Msh2 protein specifically binds to duplex oligonucleotides containing mismatched DNA base pairs and insertions.

1995 • 106 citations

Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2

1998 • 105 citations

The Escherichia coli MutL protein stimulates binding of Vsr and MutS to heteroduplex DNA

1998 • 104 citations

Dissociation of Mismatch Recognition and ATPase Activity by hMSH2-hMSH3

1999 • 103 citations

MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2

1996 • 101 citations

Photocross-linking of the NH2-terminal Region of Taq MutS Protein to the Major Groove of a Heteroduplex DNA

1997 • 100 citations

Evolutionary origin, diversification and specialization of eukaryotic MutS homolog mismatch repair proteins

2000 • 99 citations

Homologous Recombination between thetufGenes ofSalmonella typhimurium

1996 • 98 citations

Saccharomyces cerevisiae pol30 (Proliferating Cell Nuclear Antigen) Mutations Impair Replication Fidelity and Mismatch Repair

1999 • 98 citations

Dependence on RAD52 and RAD1 for anticancer drug resistance mediated by inactivation of mismatch repair genes

1999 • 98 citations

Cloning and Expression Analysis of a Meiosis-Specific MutS Homolog: The HumanMSH4Gene

1997 • 98 citations

A Naturally Occurring hPMS2 Mutation Can Confer a Dominant Negative Mutator Phenotype

1998 • 98 citations

Mutator phenotypes of yeast strains heterozygous for mutations in the MSH 2 gene

1999 • 97 citations

A Mutation in the MSH6 Subunit of the Saccharomyces cerevisiae MSH2-MSH6 Complex Disrupts Mismatch Recognition

1999 • 95 citations

Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting

1997 • 95 citations

Saccharomyces cerevisiae MSH2, a mispaired base recognition protein, also recognizes Holliday junctions in DNA

1997 • 94 citations

Homology Search and Choice of Homologous Partner during Mitotic Recombination

1999 • 93 citations

DNA Mismatch Repair in Plants (An Arabidopsis thaliana Gene That Predicts a Protein Belonging to the MSH2 Subfamily of Eukaryotic MutS Homologs)

1997 • 91 citations

Barriers to recombination between closely related bacteria: MutS and RecBCD inhibit recombination between Salmonella typhimurium and Salmonella typhi

1997 • 91 citations

The Saccharomyces cerevisiae Msh2 Mismatch Repair Protein Localizes to Recombination Intermediates In Vivo

2000 • 91 citations

Effect of base pair mismatches on recombination via the RecBCD pathway

1989 • 91 citations

Saccharomyces cerevisiaeMsh2p and Msh6p ATPase Activities Are Both Required during Mismatch Repair

1998 • 90 citations

Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype

1996 • 90 citations

The role of mismatch repair in the prevention of base pair mutations in Saccharomyces cerevisiae

1998 • 88 citations

Analysis of microsatellite mutations in the mitochondrial DNA of Saccharomyces cerevisiae

2000 • 87 citations

Mutation, recombination, and incipient speciation of bacteria in the laboratory

1999 • 86 citations

Mismatch repair proteins and mitotic genome stability

2000 • 82 citations

Enhancement of MSH2–MSH3-mediated mismatch recognition by the yeast MLH1–PMS1 complex

1997 • 82 citations

Severe Attenuation of the B Cell Immune Response in Msh2-deficient Mice

1999 • 81 citations

Differential involvement of the human mismatch repair proteins, hMLH1 and hMSH2, in transcription-coupled repair.

1997 • 80 citations

Mechanism and Control of Interspecies Recombination in Escherichia coli. I. Mismatch Repair, Methylation, Recombination and Replication Functions

1998 • 78 citations

Involvement of nucleotide-excision repair in msh2 pms1-independent mismatch repair

1999 • 75 citations

Gene targeting by linear duplex DNA frequently occurs by assimilation of a single strand that is subject to preferential mismatch correction

1997 • 70 citations

Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice

1997 • 67 citations

Novel dominant mutations in Saccharomyces cerevisiae MSH6

2000 • 67 citations

Methyl-directed repair of frameshift mutations in heteroduplex DNA.

1986 • 65 citations

'Saccharomyces cerevisiae MSH2/6 Complex Interacts with Holliday Junctions and Facilitates Their Cleavage by Phage Resolution Enzymes

1999 • 64 citations

Multiple Heterologies Increase Mitotic Double-Strand Break-Induced Allelic Gene Conversion Tract Lengths in Yeast

1999 • 63 citations

Four mismatch repair paralogues coexist in Arabidopsis thaliana: AtMSH2, AtMSH3, AtMSH6-1 and AtMSH6-2

1999 • 61 citations

Recombination Is Essential for Viability of an Escherichia coli dam (DNA Adenine Methyltransferase) Mutant

2000 • 59 citations

Sequence Composition and Context Effects on the Generation and Repair of Frameshift Intermediates in Mononucleotide Runs in Saccharomyces cerevisiae

2000 • 59 citations

The Prevention of Repeat-Associated Deletions in Saccharomyces cerevisiae by Mismatch Repair Depends on Size and Origin of Deletions

1996 • 59 citations

Functional analysis of human MutS and MutS complexes in yeast

1999 • 59 citations

Cloning and Characterization of the Human andCaenorhabditis elegansHomologs of theSaccharomyces cerevisiae MSH5Gene

1998 • 59 citations

Influence of DNA Sequence Identity on Efficiency of Targeted Gene Replacement

1997 • 57 citations

Separation-of-Function Mutations in Saccharomyces cerevisiae MSH2 That Confer Mismatch Repair Defects but Do Not Affect Nonhomologous-Tail Removal during Recombination

1999 • 56 citations

Isolation and characterization of AtMLH1, a MutL homologue from Arabidopsis thaliana

1999 • 55 citations

Cloning, Structural Characterization, and Chromosomal Localization of the Human Orthologue ofSaccharomyces cerevisiaeMSH5 Gene

1998 • 55 citations

Deletion Mutation Analysis of the mutS Gene inEscherichia coli

1999 • 55 citations

Microsatellite instability in Drosophila spellchecker1 (MutS homolog) mutants

1999 • 54 citations

Removal of Frameshift Intermediates by Mismatch Repair Proteins in Saccharomyces cerevisiae

1999 • 54 citations

Spectra of spontaneous mutations at the hprt locus in colorectal carcinoma cell lines defective in mismatch repair

1997 • 53 citations

Role of MutS ATPase Activity in MutS,L-dependent Block of in Vitro Strand Transfer

1998 • 53 citations

Theswi4⁺gene ofSchizosaccharomyces pombeencodes a homologue of mismatch repair enzymes

1992 • 52 citations

The msh2 Gene of Schizosaccharomyces pombe Is Involved in Mismatch Repair, Mating-Type Switching, and Meiotic Chromosome Organization

1999 • 50 citations

Marker effects of G to C transversions on intragenic recombination and mismatch repair in Schizosaccharomyces pombe.

1993 • 49 citations

GENETIC ANALYSIS OF BACTERIOPHAGE-ENCODED COCHAPERONINS

2000 • 47 citations

Mismatch Repair Systems in Saccharomyces cerevisiae

2003 • 45 citations

Characterization of the Repeat-Tract Instability and Mutator Phenotypes Conferred by a Tn3 Insertion in RFC1, the Large Subunit of the Yeast Clamp Loader

1999 • 45 citations

Mismatch Repair Mutants in Yeast Are Not Defective in Transcription-Coupled DNA Repair of UV-Induced DNA Damage

1996 • 45 citations

RETRACTED: Requirement for DNA mismatch repair proteins in the transcription-coupled repair of thymine glycols in Saccharomyces cerevisiae

1998 • 44 citations

Tosca:ADrosophilaGene Encoding a Nuclease Specifically Expressed in the Female Germline

1996 • 43 citations

Increased somatic recombination in methylation tolerant human cells with defective DNA mismatch repair

1998 • 40 citations

Saccharomyces cerevisiae exonuclease-1 plays a role in UV resistance that is distinct from nucleotide excision repair

1998 • 38 citations

Overexpression of vsr in Escherichia coli is mutagenic

1996 • 37 citations

Tumors of DNA mismatch repair-deficient hosts exhibit dramatic increases in genomic instability

1998 • 36 citations

Highly Mismatched Molecules Resembling Recombination Intermediates Efficiently Transform Mismatch Repair Proficient Escherichia coli

1997 • 34 citations

Stabilization of the intermediate in frameshift mutation

1999 • 33 citations

The Yeast HSM3 Gene Acts in One of the Mismatch Repair Pathways

1998 • 32 citations

A tester system for detecting each of the six base-pair substitutions in Saccharomyces cerevisiae by selecting for an essential cysteine in iso-1-cytochrome c.

1991 • 32 citations

Mismatch Repair in Schizosacchromyces pombe Requires the mutL Homologous Gene pms1: Molecular Cloning and Functional Analysis

1997 • 31 citations

Frameshift mismatch recognition by the human MutSα complex

1998 • 30 citations

A Uve1p-Mediated Mismatch Repair Pathway in Schizosaccharomyces pombe

1999 • 28 citations

A mutation in the MSH5 gene results in alkylation tolerance.

1997 • 27 citations

Transcription ofmutS andmutL-homologous genes inSaccharomyces cerevisiae during the cell cycle

1996 • 27 citations

Analysis of in vivo correction of defined mismatches in the DNA mismatch repair mutants msh2, msh3 and msh6 of Saccharomyces cerevisiae

1998 • 26 citations

Identification and characterization of the mouse MutS homolog 5: Msh5

1999 • 25 citations

Analysis of yeast pms1, msh2, and mlh1 mutators points to differences in mismatch correction efficiencies between prokaryotic and eukaryotic cells

1999 • 21 citations

Four mismatch repair paralogues coexist in

1999 • 19 citations

The mutator gene swi8 effects specific mutations in the mating-type region of Schizosaccharomyces pombe.

1994 • 18 citations

Identification of two mismatch-binding activities in protein extracts of Schizosaccharomyces pombe

1994 • 15 citations

In-Frame Recombination between the Yeast H⁺-ATPase Isogenes PMA1 and PMA2: Insights into the Mechanism of Recombination Initiated by a Double-Strand Break

1995 • 15 citations

Repair of DNA Double-Strand Breaks and Mismatches in Drosophila

2001 • 4 citations

Transcription of

1996 • 1 citations