Deficiency in Msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination: parallels with somatic hypermutation

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

1995 • 785 citations

Somatic hypermutagenesis in immunoglobulin genes

1992 • 458 citations

The SCID but Not the RAG-2 Gene Product Is Required for Sμ–Sε Heavy Chain Class Switching

1996 • 411 citations

Hot Spot Focusing of Somatic Hypermutation in MSH2-Deficient Mice Suggests Two Stages of Mutational Targeting

1998 • 352 citations

Ku80 is required for immunoglobulin isotype switching

1998 • 330 citations

Antibody Class Switching

1996 • 327 citations

Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination

1997 • 305 citations

Ku70 Is Required for Late B Cell Development and Immunoglobulin Heavy Chain Class Switching

1998 • 293 citations

DNA sequences at immunoglobulin switch region recombination sites

1993 • 275 citations

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.

1993 • 271 citations

TdT-Accessible Breaks Are Scattered over the Immunoglobulin V Domain in a Constitutively Hypermutating B Cell Line

1998 • 255 citations

Targeted gene disruption reveals a role for natural secretory IgM in the maturation of the primary immune response

1998 • 225 citations

Two Pathways for Removal of Nonhomologous DNA Ends during Double-Strand Break Repair in Saccharomyces cerevisiae

1997 • 212 citations

Both DNA strands of antibody genes are hypermutation targets

1998 • 163 citations

Repair of DNA loops involves DNA-mismatch and nucleotide-excision repair proteins

1997 • 146 citations

Mismatch Repair Deficiency Interferes with the Accumulation of Mutations in Chronically Stimulated B Cells and Not with the Hypermutation Process

1998 • 139 citations

Requirement of Mismatch Repair Genes MSH2 and MSH3 in the RAD1-RAD10 Pathway of Mitotic Recombination in Saccharomyces cerevisiae

1996 • 131 citations

Mice carrying a CD20 gene disruption

1998 • 129 citations

Ig Sgamma3 DNA-specifc double strand breaks are induced in mitogen-activated B cells and are implicated in switch recombination.

1997 • 122 citations

Hypermutation of Immunoglobulin Genes in Memory B Cells of DNA Repair–deficient Mice

1998 • 116 citations

The Saccharomyces cerevisiae Msh2 protein specifically binds to duplex oligonucleotides containing mismatched DNA base pairs and insertions.

1995 • 106 citations

Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2

1998 • 105 citations

Saccharomyces cerevisiae MSH2, a mispaired base recognition protein, also recognizes Holliday junctions in DNA

1997 • 94 citations

Microsites for immunoglobulin switch recombination breakpoints from Xenopus to mammals

1997 • 86 citations

Severe Attenuation of the B Cell Immune Response in Msh2-deficient Mice

1999 • 81 citations

Target Specificity of Immunoglobulin Class Switch Recombination Is Not Determined by Nucleotide Sequences of S Regions

1998 • 78 citations

Frequent but biased class switch recombination in the Sμ flanking regions

1998 • 51 citations

Iα exon-replacement mice synthesize a spliced HPRT–Cα transcript which may explain their ability to switch to IgA. Inhibition of switching to IgG in these mice

1999 • 38 citations

The complete murine immunoglobulin class switch region of the alpha heavy chain gene-hierarchic repetitive structure and recombination breakpoints.

1993 • 31 citations

Developmental and Molecular Regulation of Immunoglobulin Class Switch Recombination

1996 • 30 citations

Analysis of immunoglobulin Sgamma3 recombination breakpoints by PCR: implications for the mechanism of isotype switching

1997 • 24 citations