Severe Attenuation of the B Cell Immune Response in Msh2-deficient Mice

Germinal Centers

1994 • 1,680 citations

MECHANISMS AND BIOLOGICAL EFFECTS OF MISMATCH REPAIR

1991 • 876 citations

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

1995 • 785 citations

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.

1982 • 755 citations

The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants

1989 • 728 citations

The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine)

1992 • 688 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations.

1991 • 683 citations

Mutation Drift and Repertoire Shift in the Maturation of the Immune Response

1987 • 635 citations

Biochemistry and genetics of eukaryotic mismatch repair.

1996 • 598 citations

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

1984 • 545 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers.

1992 • 456 citations

Mutator phenotypes in human colorectal carcinoma cell lines.

1994 • 428 citations

The SCID but Not the RAG-2 Gene Product Is Required for Sμ–Sε Heavy Chain Class Switching

1996 • 411 citations

Evolutionary and Somatic Selection of the Antibody Repertoire in the Mouse

1987 • 388 citations

MSH2 deficient mice are viable and susceptible to lymphoid tumours

1995 • 378 citations

Antigen-induced B-cell death and elimination during germinal-centre immune responses

1995 • 377 citations

Early Murine Cytomegalovirus (MCMV) Infection Induces Liver Natural Killer (NK) Cell Inflammation and Protection Through Macrophage Inflammatory Protein 1α (MIP-1α)–dependent Pathways

1998 • 375 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells.

1993 • 367 citations

Hot Spot Focusing of Somatic Hypermutation in MSH2-Deficient Mice Suggests Two Stages of Mutational Targeting

1998 • 352 citations

The phenotype and fate of the antibody‐forming cells of the splenic foci

1996 • 340 citations

Identification of mismatch repair genes and their role in the development of cancer

1995 • 319 citations

Soluble antigen can cause enhanced apoptosis of germinal-centre B cells

1995 • 301 citations

Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiae.

1994 • 236 citations

In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. IV. Affinity-dependent, antigen-driven B cell apoptosis in germinal centers as a mechanism for maintaining self-tolerance.

1995 • 224 citations

The Immunoglobulin Class Switch: Beyond “Accessibility”

1997 • 217 citations

Germinal centers develop oligoclonally

1987 • 201 citations

Increased Hypermutation at G and C Nucleotides in Immunoglobulin Variable Genes from Mice Deficient in the MSH2 Mismatch Repair Protein

1998 • 183 citations

Mismatch repair, molecular switches, and signal transduction

1998 • 176 citations

Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice.

1996 • 165 citations

MutS homologs in mammalian cells

1997 • 163 citations

Mismatch Repair Co-opted by Hypermutation

1998 • 159 citations

Evolution of Antibody Variable Region Structure during the Immune Response

1987 • 149 citations

Mismatch Repair Deficiency Interferes with the Accumulation of Mutations in Chronically Stimulated B Cells and Not with the Hypermutation Process

1998 • 139 citations

Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells.

1996 • 123 citations

Biology of germinal centers in lymphoid tissue

1994 • 122 citations

The T-cell-independent immune response to the hapten NP uses a large repertoire of heavy chain genes

1985 • 120 citations

Hypermutation of Immunoglobulin Genes in Memory B Cells of DNA Repair–deficient Mice

1998 • 116 citations

Altered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2

1998 • 105 citations

Bcl-2 Obstructs Negative Selection of Autoreactive, Hypermutated Antibody V Regions during Memory B Cell Development

1998 • 98 citations

Bcmd governs recruitment of new B cells into the stable peripheral B cell pool in the A/WySnJ mouse.

1996 • 98 citations

Development of antibody diversity in single germinal centers: selective expansion of high‐affinity variants

1994 • 85 citations

Amplified follicular immune complex deposition in mice lacking the Fc receptor gamma-chain does not alter maturation of the B cell response.

1997 • 83 citations

A limited number of B cell lineages generates the heterogeneity of a secondary immune response.

1987 • 83 citations

Antigen-Primed T Cells from B Cell-Deficient JHD Mice Fail to Provide B Cell Help

1998 • 83 citations

Female embryonic lethality in mice nullizygous for both Msh2 and p53

1997 • 71 citations

Molecular analysis of original antigenic sin. I. Clonal selection, somatic mutation, and isotype switching during a memory B cell response.

1989 • 69 citations

Differentiation of the Secondary B‐Lymphocyte Repertoire: The Germinal Center Reaction

1994 • 68 citations

Augmented Expression of a Human Gene for 8-oxoguanine DNA Glycosylase (MutM) in B Lymphocytes of the Dark Zone in Lymph Node Germinal Centers

1997 • 49 citations

Distinct pathways of B cell differentiation. I. Residual T cells in athymic mice support the development of splenic germinal centers and B cell memory without an induction of antibody.

1994 • 45 citations

The Role of DNA Repair in Somatic Hypermutation of Immunoglobulin Genes

1998 • 45 citations

The Adaptive Potential of the Memory Response: Clonal Recruitment and Epitope Recognition

1988 • 39 citations

Altering the antibody repertoire via transgene homologous recombination: evidence for global and clone-autonomous regulation of antigen-driven B cell differentiation.

1995 • 32 citations

A Periarteriolar Lymphoid Sheath-Associated B Cell Focus Response Is Not Observed During the Development of the Anti-Arsonate Germinal Center Reaction

1998 • 31 citations

The cellular origins of memory B cells

1997 • 21 citations

V(D)J hypermutation and DNA mismatch repair: Vexed by fixation

1998 • 19 citations

Lymphoid development

1997 • 2 citations

Deleted Work

1955 • 0 citations