Mismatch repair proteins and mitotic genome stability

Comprehensive Identification of Cell Cycle–regulated Genes of the YeastSaccharomyces cerevisiaeby Microarray Hybridization

1998 • 4,811 citations

DNA Repair and Mutagenesis

2006 • 4,725 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

DNA repair and mutagenesis

1996 • 2,289 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

MISMATCH REPAIR IN REPLICATION FIDELITY, GENETIC RECOMBINATION, AND CANCER BIOLOGY

1996 • 1,485 citations

Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair

1993 • 1,076 citations

Genomic disorders: structural features of the genome can lead to DNA rearrangements and human disease traits

1998 • 907 citations

Eukaryotic DNA mismatch repair

1999 • 860 citations

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

1995 • 785 citations

A novel repeated element with Z-DNA-forming potential is widely found in evolutionarily diverse eukaryotic genomes.

1982 • 759 citations

The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants

1989 • 728 citations

Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair.

1996 • 576 citations

Requirement for PCNA in DNA Mismatch Repair at a Step Preceding DNA Resynthesis

1996 • 569 citations

A Novel Mutation Avoidance Mechanism Dependent on S. cerevisiae RAD27 Is Distinct from DNA Mismatch Repair

1997 • 434 citations

Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants

1999 • 403 citations

Microsatellite Instability in Yeast: Dependence on the Length of the Microsatellite

1997 • 399 citations

MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair.

1995 • 391 citations

Identification and characterization of Saccharomyces cerevisiae EXO1 , a gene encoding an exonuclease that interacts with MSH2

1997 • 382 citations

Microsatellite Instability in Yeast: Dependence on Repeat Unit Size and DNA Mismatch Repair Genes

1997 • 381 citations

Mutation of a meiosis-specific MutS homolog decreases crossing over but not mismatch correction

1994 • 371 citations

hMSH2–hMSH6 Forms a Hydrolysis-Independent Sliding Clamp on Mismatched DNA

1999 • 368 citations

Heteroduplex repair in extracts of human HeLa cells

1991 • 355 citations

Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions.

1992 • 353 citations

Cloning and expression in Escherichia coli of the OGG1 gene of Saccharomyces cerevisiae, which codes for a DNA glycosylase that excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine.

1996 • 352 citations

Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DMA mismatch repair

1998 • 351 citations

Reexamination of Gene Targeting Frequency as a Function of the Extent of Homology between the Targeting Vector and the Target Locus

1992 • 330 citations

Identification of mismatch repair genes and their role in the development of cancer

1995 • 319 citations

Hypermutability of Homonucleotide Runs in Mismatch Repair and DNA Polymerase Proofreading Yeast Mutants

1997 • 313 citations

The mismatch repair system contributes to meiotic sterility in an interspecific yeast hybrid.

1996 • 308 citations

DNA damage tolerance, mismatch repair and genome instability

1994 • 308 citations

Molecular keys to speciation: DNA polymorphism and the control of genetic exchange in enterobacteria

1997 • 308 citations

Gene Conversion Tracts from Double-Strand Break Repair in Mammalian Cells

1998 • 305 citations

Role of Saccharomyces cerevisiae Msh2 and Msh3 repair proteins in double-strand break-induced recombination

1997 • 305 citations

Functional specificity of MutL homologs in yeast: Evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction

1999 • 291 citations

Transcription-Coupled Repair Deficiency and Mutations in Human Mismatch Repair Genes

1996 • 289 citations

MLH1, PMS1, and MSH2 Interactions During the Initiation of DNA Mismatch Repair in Yeast

1994 • 287 citations

The Saccharomyces cerevisiae MLH 3 gene functions in MSH3-dependent suppression of frameshift mutations

1998 • 275 citations

Pathway correcting DNA replication errors in Saccharomyces cerevisiae.

1993 • 262 citations

MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1

1999 • 253 citations

Heteroduplex deoxyribonucleic acid base mismatch repair in bacteria

1986 • 252 citations

Proliferating cell nuclear antigen: More than a clamp for DNA polymerases

1997 • 248 citations

Instability of simple sequence DNA in Saccharomyces cerevisiae.

1992 • 240 citations

Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiae.

1994 • 236 citations

MSH2 and MSH6 Are Required for Removal of Adenine Misincorporated Opposite 8-Oxo-Guanine in S. cerevisiae

1999 • 230 citations

Reexamination of gene targeting frequency as a function of the extent of homology between the targeting vector and the target locus.

1992 • 230 citations

Dual roles for DNA sequence identity and the mismatch repair system in the regulation of mitotic crossing-over in yeast

1997 • 230 citations

Dependence of intrachromosomal recombination in mammalian cells on uninterrupted homology.

1988 • 226 citations

Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction

1993 • 224 citations

Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene.

1994 • 222 citations

Isolation and characterization of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins.

1992 • 221 citations

ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair

1998 • 218 citations

RAD1 and RAD10, but Not Other Excision Repair Genes, Are Required for Double-Strand Break-Induced Recombination in Saccharomyces cerevisiae

1995 • 217 citations

Mitotic Crossovers between Diverged Sequences Are Regulated by Mismatch Repair Proteins in Saccharomyces cerevisiae

1996 • 212 citations

Replication errors: cha(lle)nging the genome

1998 • 209 citations

The 3′→5′ Exonucleases of DNA Polymerases δ and ɛ and the 5′→3′ Exonuclease Exo1 Have Major Roles in Postreplication Mutation Avoidance in Saccharomyces cerevisiae

1999 • 205 citations

A Role for Exonuclease I from S. pombe in Mutation Avoidance and Mismatch Correction

1995 • 202 citations

Mismatch correction acts as a barrier to homeologous recombination in Saccharomyces cerevisiae.

1995 • 201 citations

Evidence for Involvement of Yeast Proliferating Cell Nuclear Antigen in DNA Mismatch Repair

1996 • 200 citations

Requirement of the Yeast RTH1 5′ to 3′ Exonuclease for the Stability of Simple Repetitive DNA

1995 • 195 citations

Cloning and nucleotide sequence of DNA mismatch repair gene PMS1 from Saccharomyces cerevisiae: homology of PMS1 to procaryotic MutL and HexB

1989 • 193 citations

Exonuclease I of Saccharomyces cerevisiae Functions in Mitotic Recombination In Vivo and In Vitro

1997 • 190 citations

Requirement of the Yeast MSH3 and MSH6 Genes for MSH2-dependent Genomic Stability

1996 • 187 citations

Mutator Phenotypes Conferred by MLH1Overexpression and by Heterozygosity for mlh1Mutations

1999 • 186 citations

The Mismatch Repair System Reduces Meiotic Homeologous Recombination and Stimulates Recombination-Dependent Chromosome Loss

1996 • 178 citations

Products of DNA mismatch repair genes mutS and mutL are required for transcription-coupled nucleotide-excision repair of the lactose operon in Escherichia coli.

1996 • 174 citations

The Drosophila meiotic recombination gene mei-9 encodes a homologue of the yeast excision repair protein Rad1.

1995 • 170 citations

The Role of the Mismatch Repair Machinery in Regulating Mitotic and Meiotic Recombination Between Diverged Sequences in Yeast

1999 • 168 citations

Heteroduplex DNA correction in Saccharomyces cerevisiae is mismatch specific and requires functional PMS genes.

1989 • 164 citations

Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombination.

1998 • 160 citations

Functional Overlap in Mismatch Repair by Human MSH3 and MSH6

1998 • 152 citations

Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae.

1995 • 147 citations

Repair of DNA loops involves DNA-mismatch and nucleotide-excision repair proteins

1997 • 146 citations

Differential effects of base-pair mismatch on intrachromosomal versus extrachromosomal recombination in mouse cells.

1987 • 145 citations

Single-Strand DNA-Specific Exonucleases in Escherichia coli: Roles in Repair and Mutation Avoidance

1998 • 138 citations

Different mutator phenotypes in Mlh1 - versus Pms2 -deficient mice

1999 • 138 citations

Genetic and Biochemical Analysis of Msh2p-Msh6p: Role of ATP Hydrolysis and Msh2p-Msh6p Subunit Interactions in Mismatch Base Pair Recognition

1997 • 129 citations

Recombination between similar but not identical DNA sequences during yeast transformation occurs within short stretches of identity

1992 • 127 citations

Physical interaction between components of DNA mismatch repair and nucleotide excision repair

1998 • 121 citations

A defect in mismatch repair in Saccharomyces cerevisiae stimulates ectopic recombination between homeologous genes by an excision repair dependent process.

1990 • 117 citations

Regulation of Mitotic Homeologous Recombination in Yeast: Functions of Mismatch Repair and Nucleotide Excision Repair Genes

2000 • 115 citations

Replication Slippage between Distant Short Repeats in Saccharomyces cerevisiae Depends on the Direction of Replication and the RAD50 and RAD52 Genes

1995 • 114 citations

Mismatch Repair Proteins Regulate Heteroduplex Formation during Mitotic Recombination in Yeast

1998 • 110 citations

Frameshift Intermediates in Homopolymer Runs Are Removed Efficiently by Yeast Mismatch Repair Proteins

1997 • 108 citations

The Effect of Mismatch Repair and Heteroduplex Formation on Sexual Isolation in Bacillus

1998 • 106 citations

Mutator phenotypes of yeast strains heterozygous for mutations in the MSH 2 gene

1999 • 97 citations

Saccharomyces cerevisiae MSH2, a mispaired base recognition protein, also recognizes Holliday junctions in DNA

1997 • 94 citations

Homology Search and Choice of Homologous Partner during Mitotic Recombination

1999 • 93 citations

Barriers to recombination between closely related bacteria: MutS and RecBCD inhibit recombination between Salmonella typhimurium and Salmonella typhi

1997 • 91 citations

Effect of base pair mismatches on recombination via the RecBCD pathway

1989 • 91 citations

The role of mismatch repair in the prevention of base pair mutations in Saccharomyces cerevisiae

1998 • 88 citations

Differential involvement of the human mismatch repair proteins, hMLH1 and hMSH2, in transcription-coupled repair.

1997 • 80 citations

Mechanism and Control of Interspecies Recombination in Escherichia coli. I. Mismatch Repair, Methylation, Recombination and Replication Functions

1998 • 78 citations

Involvement of nucleotide-excision repair in msh2 pms1-independent mismatch repair

1999 • 75 citations

DNA Sequence Analysis of Spontaneous Mutagenesis in Saccharomyces cerevisiae

1998 • 75 citations

Homologous, homeologous, and illegitimate repair of double-strand breaks during transformation of a wild-type strain and a rad52 mutant strain of Saccharomyces cerevisiae.

1994 • 74 citations

Suppression of Intrachromosomal Gene Conversion in Mammalian Cells by Small Degrees of Sequence Divergence

1999 • 70 citations

Inactivation of mismatch repair overcomes the barrier to transduction between Salmonella typhimurium and Salmonella typhi

1994 • 65 citations

Gene conversions and crossing over during homologous and homeologous ectopic recombination in Saccharomyces cerevisiae.

1993 • 64 citations

'Saccharomyces cerevisiae MSH2/6 Complex Interacts with Holliday Junctions and Facilitates Their Cleavage by Phage Resolution Enzymes

1999 • 64 citations

Repair of hEteroduplex Plasmid DNA after Transformation into Saccharomyces cerevisiae

1986 • 58 citations

Influence of DNA Sequence Identity on Efficiency of Targeted Gene Replacement

1997 • 57 citations

DNA repair in prokaryotes and lower eukaryotes

1998 • 56 citations

Removal of Frameshift Intermediates by Mismatch Repair Proteins in Saccharomyces cerevisiae

1999 • 54 citations

Role of MutS ATPase Activity in MutS,L-dependent Block of in Vitro Strand Transfer

1998 • 53 citations

Induction of recombination between homologous and diverged DNAs by double-strand gaps and breaks and role of mismatch repair

1994 • 51 citations

Lack of DNA homology in a pair of divergent chromosomes greatly sensitizes them to loss by DNA damage.

1989 • 49 citations

Transformation‐associated recombination between diverged and homologous DNA repeats is induced by strand breaks

1994 • 49 citations

Mismatch Repair Mutants in Yeast Are Not Defective in Transcription-Coupled DNA Repair of UV-Induced DNA Damage

1996 • 45 citations

Mismatch Repair Systems in Saccharomyces cerevisiae

2003 • 45 citations

RETRACTED: Requirement for DNA mismatch repair proteins in the transcription-coupled repair of thymine glycols in Saccharomyces cerevisiae

1998 • 44 citations

Tosca:ADrosophilaGene Encoding a Nuclease Specifically Expressed in the Female Germline

1996 • 43 citations

Homologous and Homeologous Intermolecular Gene Conversion Are Not Differentially Affected by Mutations in the DNA Damage or the Mismatch Repair Genes RAD1, RAD50, RAD51, RAD52, RAD54, PMS1 and MSH2

1996 • 40 citations

Increased somatic recombination in methylation tolerant human cells with defective DNA mismatch repair

1998 • 40 citations

Recombinational repair of diverged DNAs : a study of homoeologous chromosomes and mammalian YACs in yeast

1992 • 36 citations

Mismatch Repair in Escherichia coli Cells Lacking Single-Strand Exonucleases ExoI, ExoVII, and RecJ

1998 • 34 citations

Altered Replication and Inverted Repeats Induce Mismatch Repair-Independent Recombination between Highly Diverged DNAs in Yeast

1997 • 34 citations

Differential effects of the mismatch repair genes MSH2 and MSH3 on homeologous recombination in Saccharomyces cerevisiae

1997 • 32 citations

Genetic alterations of p53 and ras genes in 1,3-butadiene- and 2',3'-dideoxycytidine-induced lymphomas.

1997 • 32 citations

The Yeast HSM3 Gene Acts in One of the Mismatch Repair Pathways

1998 • 32 citations

A tester system for detecting each of the six base-pair substitutions in Saccharomyces cerevisiae by selecting for an essential cysteine in iso-1-cytochrome c.

1991 • 32 citations

Repair of heteroduplex plasmid DNA after transformation into Saccharomyces cerevisiae.

1986 • 30 citations

A Uve1p-Mediated Mismatch Repair Pathway in Schizosaccharomyces pombe

1999 • 28 citations

Transcription ofmutS andmutL-homologous genes inSaccharomyces cerevisiae during the cell cycle

1996 • 27 citations

A mutation in the MSH5 gene results in alkylation tolerance.

1997 • 27 citations

Analysis of in vivo correction of defined mismatches in the DNA mismatch repair mutants msh2, msh3 and msh6 of Saccharomyces cerevisiae

1998 • 26 citations

DNA mismatch repair mutants do not increase N-methyl-N'-nitro- N-nitrosoguanidine tolerance in O⁶-methylguanine DNA methyltransferase-deficient yeast cells

1995 • 24 citations

Nucleotide excision repair in yeast

1994 • 24 citations

Analysis of yeast pms1, msh2, and mlh1 mutators points to differences in mismatch correction efficiencies between prokaryotic and eukaryotic cells

1999 • 21 citations

Recognition of DNA Insertion/Deletion Mismatches by an Activity in Saccharomyces Cerevisiae

1996 • 21 citations

Induction of recombination between homologous and diverged DNAs by double-strand gaps and breaks and role of mismatch repair.

1994 • 19 citations

In-Frame Recombination between the Yeast H⁺-ATPase Isogenes PMA1 and PMA2: Insights into the Mechanism of Recombination Initiated by a Double-Strand Break

1995 • 15 citations

Strand interruptions confer strand preference during intracellular correction of a plasmid-borne mismatch in Saccharomyces cerevisiae

1999 • 6 citations