Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

de la Chapelle, A.

1997 • 3,184 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis

1993 • 2,711 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer

1994 • 1,544 citations

Frameshift Mutations and the Genetic Code

1966 • 1,400 citations

Mutator phenotype may be required for multistage carcinogenesis.

1991 • 1,327 citations

Hypermutability and mismatch repair deficiency in RER+ tumor cells

1993 • 1,042 citations

Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability

1995 • 824 citations

Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences.

1994 • 807 citations

Hereditary Nonpolyposis Colorectal Cancer: the Syndrome, the Genes, and Historical Perspectives

1995 • 521 citations

Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation

1994 • 496 citations

Mutations of GTBP in Genetically Unstable Cells

1995 • 471 citations

Mutator phenotypes in human colorectal carcinoma cell lines.

1994 • 428 citations

Human colonic adenocarcinoma cells

1976 • 375 citations

Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability.

1994 • 332 citations

Hereditary Nonpolyposis Colorectal Cancer—Lynch Syndromes I and II

1988 • 255 citations

Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer.

1995 • 239 citations

DNA Loop Repair by Human Cell Extracts

1994 • 125 citations

Defects in Replication Fidelity of Simple Repeated Sequences Reveal a New Mutator Mechanism for Oncogenesis

1994 • 72 citations

Molecular analysis of mutations in the hprt gene in circulating lymphocytes from normal and DNA-repair-deficient donors

1993 • 49 citations

The microsatellite mutator phenotype of colon cancer cells is often recessive.

1995 • 34 citations

Spectrum of spontaneous HPRT mutations in TK6 human lymphoblasts

1993 • 27 citations

Characterization of in vivo somatic mutations at the hypoxanthine phosphoribosyltransferase gene of a human control population.

1993 • 22 citations

Design of a selectable reporter for the detection of mutations in mammalian simple repeat sequences

1995 • 18 citations

Mutagenicity and mutational spectrum of N-methyl-N'-nitro-N-nitrosoguanidine in the hprt gene in G1-S and late S phase of diploid human fibroblasts.

1993 • 16 citations