Mismatch Repair Co-opted by Hypermutation

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

MISMATCH REPAIR IN REPLICATION FIDELITY, GENETIC RECOMBINATION, AND CANCER BIOLOGY

1996 • 1,485 citations

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

1995 • 785 citations

Variability in the Lambda Light Chain Sequences of Mouse Antibody

1970 • 554 citations

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

1984 • 545 citations

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

1995 • 536 citations

Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines.

1990 • 408 citations

Immunoglobulin gene rearrangement in B cell deficient mice generated by targeted deletion of the J_H locus

1993 • 404 citations

Heteroduplex repair in extracts of human HeLa cells

1991 • 355 citations

Methyl-directed repair of DNA base-pair mismatches in vitro.

1983 • 344 citations

Origin of Antibody Variation

1966 • 314 citations

EFFECTS OF HIGH LEVELS OF DNA ADENINE METHYLATION ON METHYL-DIRECTED MISMATCH REPAIR IN ESCHERICHIA COLI

1983 • 294 citations

A Quasi-Monoclonal Mouse

1996 • 204 citations

B cell development in mice that lack one or both immunoglobulin kappa light chain genes.

1993 • 185 citations

Escherichia coli mutants uvr D and uvr E deficient in gene conversion of λ-heteroduplexes

1975 • 154 citations

Elevated levels of mutation in multiple tissues of mice deficient in the DNA mismatch repair gene Pms2

1997 • 153 citations

VH gene replacement in hyperselected B cells of the quasimonoclonal mouse.

1997 • 77 citations

Affinity maturation and class switching

1996 • 61 citations

Methyl-Directed Repair of DNA Mismatches

1988 • 47 citations

B Lymphocytes of Xeroderma Pigmentosum or Cockayne Syndrome Patients with Inherited Defects in Nucleotide Excision Repair Are Fully Capable of Somatic Hypermutation of Immunoglobulin Genes

1997 • 45 citations

Measurements of Mutation Rates in B Lymphocytes

1987 • 44 citations

Introduction: What mechanism(s) drive hypermutation?

1996 • 20 citations