MLH1 Promoter Methylation and Gene Silencing is the Primary Cause of Microsatellite Instability in Sporadic Endometrial Cancers

de la Chapelle, A.

1997 • 3,184 citations

The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)

1991 • 2,142 citations

Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma

1998 • 1,852 citations

Cancer statistics, 1996

1996 • 1,807 citations

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines.

1997 • 1,465 citations

Clinical Cancer Research

1941 • 1,358 citations

Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability.

1998 • 855 citations

Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis

1996 • 814 citations

Mutations predisposing to hereditary nonpolyposis colorectal cancer: Database and results of a collaborative study. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer

1997 • 756 citations

Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression.

1997 • 751 citations

Extracolonic cancer in hereditary nonpolyposis colorectal cancer

1993 • 690 citations

Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies.

1997 • 689 citations

Biallelic inactivation of hMLH 1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers

1998 • 629 citations

Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients.

1994 • 622 citations

Extracolonic cancer in hereditary nonpolyposis colorectal cancer

1993 • 589 citations

Genetic instability of microsatellites in endometrial carcinoma.

1993 • 523 citations

PTEN/MMAC1 mutations in endometrial cancers.

1997 • 517 citations

MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas

1998 • 498 citations

Altered expression of hMSH2 and hMLH1 in tumors with microsatellite instability and genetic alterations in mismatch repair genes.

1996 • 465 citations

Microsatellite instability in endometrial carcinoma.

1994 • 228 citations

Allelic loss of sequences from the long arm of chromosome 10 and replication errors in endometrial cancers.

1995 • 181 citations

Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas.

1995 • 160 citations

Alterations of the p53 tumor suppressor gene and its association with activation of the c-K-ras-2 protooncogene in premalignant and malignant lesions of the human uterine endometrium.

1993 • 131 citations

Mutational analysis ofMLH1 andMSH2 in 25 prospectively-acquired RER+ endometrial cancers

1997 • 106 citations

Mismatch Repair Gene Defects Contribute to the Genetic Basis of Double Primary Cancers of the Colorectum and Endometrium

1999 • 91 citations

Mutational Analysis of Mismatch Repair Genes, hMLH1 and hMSH2, in Sporadic Endometrial Carcinomas with Microsatellite Instability

1996 • 72 citations

Mutations of the Ki-ras oncogene in endometrial carcinoma

1992 • 68 citations

Studies on Ras Oncogene Activation in Endometrial Carcinoma

1993 • 48 citations

Differences in patterns ofTP53 andKRAS2 mutations in a large series of endometrial carcinomas with or without microsatellite instability

1999 • 48 citations

Involvement of p53 gene mutations in human endometrial carcinomas

1993 • 45 citations

Absence of mutations in DNA mismatch repair genes in sporadic endometrial tumors with microsatellite instability.

1996 • 40 citations

Oligomerization of p53 is necessary to inhibit its transcriptional transactivation property at high protein concentration

1998 • 38 citations