Hypermutability of Homonucleotide Runs in Mismatch Repair and DNA Polymerase Proofreading Yeast Mutants

Lessons from Hereditary Colorectal Cancer

1996 • 4,900 citations

MISMATCH REPAIR IN REPLICATION FIDELITY, GENETIC RECOMBINATION, AND CANCER BIOLOGY

1996 • 1,485 citations

Frameshift Mutations and the Genetic Code

1966 • 1,400 citations

Mutator phenotype may be required for multistage carcinogenesis.

1991 • 1,327 citations

Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair

1993 • 1,076 citations

Molecular Biology of Bacteriophage T4

1994 • 881 citations

Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer.

1995 • 743 citations

Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair.

1996 • 576 citations

Requirement for PCNA in DNA Mismatch Repair at a Step Preceding DNA Resynthesis

1996 • 569 citations

Survey of human and rat microsatellites

1992 • 559 citations

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

1993 • 445 citations

Mutator phenotypes in human colorectal carcinoma cell lines.

1994 • 428 citations

Microsatellite Instability in Yeast: Dependence on Repeat Unit Size and DNA Mismatch Repair Genes

1997 • 381 citations

High frequencies of short frameshifts in poly-CA/TG tandem repeats borne by bacteriophage M13 inEscherichia coliK-12

1987 • 362 citations

Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions.

1992 • 353 citations

Demonstration That Mutation of the Type II Transforming Growth Factor β Receptor Inactivates Its Tumor Suppressor Activity in Replication Error-positive Colon Carcinoma Cells

1995 • 340 citations

APC mutations in colorectal tumors with mismatch repair deficiency.

1996 • 329 citations

MECHANISMS OF SPONTANEOUS AND INDUCED FRAMESHIFT MUTATION IN BACTERIOPHAGE T4

1985 • 292 citations

Spectra of spontaneous mutations in Escherichia coli strains defective in mismatch correction: the nature of in vivo DNA replication errors.

1987 • 291 citations

Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activity.

1991 • 277 citations

Pathway correcting DNA replication errors in Saccharomyces cerevisiae.

1993 • 262 citations

Microsatellite instability in inherited and sporadic neoplasms

1995 • 257 citations

Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer.

1995 • 239 citations

SELECTION OF lys2 MUTANTS OF THE YEAST SACCHAROMYCES CEREVISIAE BY THE UTILIZATION OF α-AMINOADIPATE

1979 • 231 citations

Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene.

1994 • 222 citations

MEIOTIC GENE CONVERSION MUTANTS IN SACCHAROMYCES CEREVISIAE. I. ISOLATION AND CHARACTERIZATION OF pms1-1 AND pms1-2

1985 • 220 citations

The 3′ → 5′ exonucleases of both DNA polymerases δ and ε participate in correcting errors of DNA replication in Saccharomyces cerevisiae

1994 • 206 citations

Spontaneous mutation in the Escherichia coli lacI gene.

1991 • 200 citations

Requirement of the Yeast RTH1 5′ to 3′ Exonuclease for the Stability of Simple Repetitive DNA

1995 • 195 citations

Parathyroid Hormone-Related Protein: Biochemistry and Molecular Biology

1991 • 188 citations

Requirement of the Yeast MSH3 and MSH6 Genes for MSH2-dependent Genomic Stability

1996 • 187 citations

Characterization of the human parathyroid hormone-like peptide gene

1989 • 180 citations

Frameshift mutagenesis by eucaryotic DNA polymerases in vitro.

1986 • 177 citations

DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines.

1995 • 168 citations

Depletion of the cellular amounts of the MutS and MutH methyl-directed mismatch repair proteins in stationary-phase Escherichia coli K-12 cells

1996 • 167 citations

rII cistrons of bacteriophage T4

1981 • 156 citations

DNA polymerase II, the probable homolog of mammalian DNA polymerase epsilon, replicates chromosomal DNA in the yeast Saccharomyces cerevisiae.

1992 • 154 citations

Mutations in the MSH3 gene preferentially lead to deletions within tracts of simple repetitive DNA in Saccharomyces cerevisiae.

1995 • 147 citations

3′ → 5′ Exonucleases of DNA Polymerases ϵ and δ Correct Base Analog Induced DNA Replication Errors on Opposite DNA Strands in Saccharomyces cerevisiae

1996 • 131 citations

Reduced Frameshift Fidelity and Processivity of HIV-1 Reverse Transcriptase Mutants Containing Alanine Substitutions in Helix H of the Thumb Subdomain

1995 • 121 citations

Replication Slippage between Distant Short Repeats in Saccharomyces cerevisiae Depends on the Direction of Replication and the RAD50 and RAD52 Genes

1995 • 114 citations

Exonucleolytic Proofreading during Replication of Repetitive DNA

1996 • 111 citations

Error-prone replication of repeated DNA sequences by T7 DNA polymerase in the absence of its processivity subunit.

1994 • 108 citations

Temperature-sensitive mutations in the yeast DNA polymerase I gene.

1987 • 108 citations

Frameshift Intermediates in Homopolymer Runs Are Removed Efficiently by Yeast Mismatch Repair Proteins

1997 • 108 citations

DNA Polymerases Required for Repair of UV-Induced Damage in Saccharomyces cerevisiae

1995 • 101 citations

Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype

1996 • 90 citations

Z-DNA-forming sequences are spontaneous deletion hot spots.

1989 • 87 citations

Molecular analysis of mutations in mutator colorectal carcinoma cell lines

1995 • 86 citations

Adaptive mutation sequences reproduced by mismatch repair deficiency.

1995 • 80 citations

The Prevention of Repeat-Associated Deletions in Saccharomyces cerevisiae by Mismatch Repair Depends on Size and Origin of Deletions

1996 • 59 citations

Cell-specific and regulator-induced promoter usage and messenger ribonucleic acid splicing for parathyroid hormone-related protein.

1996 • 58 citations

Spectrum of spontaneous frameshift mutations

1986 • 51 citations

Diverse hypermutability of multiple expressed sequence motifs present in a cancer with microsatellite instability.

1996 • 48 citations

Microsatellite instability and mismatch repair defects in cancer cells

1996 • 44 citations

PATTERNS OF GENETIC AND PHENOTYPIC SUPPRESSION OF lys2 MUTATIONS IN THE YEAST SACCHAROMYCES CEREVISIAE

1979 • 36 citations

Altered Replication and Inverted Repeats Induce Mismatch Repair-Independent Recombination between Highly Diverged DNAs in Yeast

1997 • 34 citations

DNA Polymerase II, the Epsilon Polymerase of Saccharomyces cerevisiae

1993 • 22 citations

Spontaneous mutations ataprt locus in a mammalian cell line defective in mismatch recognition

1994 • 19 citations

Mutator genes and mosaicism in colorectal cancer

1996 • 17 citations

Differential expression of RNA transcripts encoding unique carboxy-terminal sequences of human parathyroid hormone-related peptide.

1994 • 17 citations