A Novel Mutation Avoidance Mechanism Dependent on S. cerevisiae RAD27 Is Distinct from DNA Mismatch Repair

de la Chapelle, A.

1997 • 3,184 citations

The double-strand-break repair model for recombination

1983 • 2,468 citations

APC mutations occur early during colorectal tumorigenesis

1992 • 1,901 citations

MISMATCH REPAIR IN REPLICATION FIDELITY, GENETIC RECOMBINATION, AND CANCER BIOLOGY

1996 • 1,485 citations

The distribution of the numbers of mutants in bacterial populations

1949 • 1,471 citations

Frameshift Mutations and the Genetic Code

1966 • 1,400 citations

Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair

1993 • 1,076 citations

Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patients

1996 • 957 citations

Construction of a set of convenient saccharomyces cerevisiae strains that are isogenic to S288C

1995 • 945 citations

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

1992 • 929 citations

Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability

1995 • 824 citations

Biochemistry and genetics of eukaryotic mismatch repair.

1996 • 598 citations

Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair.

1996 • 576 citations

Mutations in the cardiac myosin binding protein–C gene on chromosome 11 cause familial hypertrophic cardiomyopathy

1995 • 574 citations

Hereditary Nonpolyposis Colorectal Cancer: the Syndrome, the Genes, and Historical Perspectives

1995 • 521 citations

Applications of high efficiency lithium acetate transformation of intact yeast cells using single‐stranded nucleic acids as carrier

1991 • 433 citations

Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.

1994 • 407 citations

The characterization of a mammalian DNA structure-specific endonuclease.

1994 • 406 citations

RECOMBINATION IN YEAST

1971 • 405 citations

Reconstitution of complete SV40 DNA replication with purified replication factors.

1994 • 403 citations

Hereditary nonpolyposis colorectal cancer (lynch syndromes I and II). I. Clinical description of resource

1985 • 402 citations

Mutations of theAPC adenomatous polyposis coli) gene

1993 • 392 citations

Genetic Requirements for the Single-Strand Annealing Pathway of Double-Strand Break Repair in Saccharomyces cerevisiae

1996 • 379 citations

Characterization of Double-Strand Break-Induced Recombination: Homology Requirements and Single-Stranded DNA Formation

1992 • 377 citations

Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions.

1992 • 353 citations

Mismatch repair: mechanisms and relationship to cancer susceptibility

1995 • 307 citations

Complete enzymatic synthesis of DNA containing the SV40 origin of replication.

1988 • 297 citations

Functional domains within FEN-1 and RAD2 define a family of structure-specific endonucleases: implications for nucleotide excision repair.

1994 • 275 citations

Characterization of a mutant strain of Saccharomyces cerevisiae with a deletion of the RAD27 gene, a structural homolog of the RAD2 nucleotide excision repair gene

1995 • 264 citations

Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas

1992 • 257 citations

Microsatellite instability in inherited and sporadic neoplasms

1995 • 257 citations

Microsatellite instability and mutation analysis of hMSH2 and hMLH1 in patients with sporadic, familial and hereditary colorectal cancer

1996 • 239 citations

Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiae.

1994 • 236 citations

Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction

1993 • 224 citations

Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene.

1994 • 222 citations

MEIOTIC GENE CONVERSION MUTANTS IN SACCHAROMYCES CEREVISIAE. I. ISOLATION AND CHARACTERIZATION OF pms1-1 AND pms1-2

1985 • 220 citations

A Role for Exonuclease I from S. pombe in Mutation Avoidance and Mismatch Correction

1995 • 202 citations

Processing of branched DNA intermediates by a complex of human FEN-1 and PCNA

1996 • 200 citations

Requirement of the Yeast RTH1 5′ to 3′ Exonuclease for the Stability of Simple Repetitive DNA

1995 • 195 citations

Characterization of double-strand break-induced recombination: homology requirements and single-stranded DNA formation.

1992 • 188 citations

Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair

1996 • 181 citations

Aberrations of the p53 tumor suppressor gene in human non-small cell carcinomas of the lung

1993 • 180 citations

Enzymatic completion of mammalian lagging-strand DNA replication.

1994 • 177 citations

Micro-homology mediated PCR targeting inSaccharomyces cerevisiae

1995 • 175 citations

TP53 gene mutations and p53 protein immunoreactivity in malignant and premalignant Barrett's esophagus

1994 • 172 citations

Conditional Lethality of Null Mutations in RTH1 That Encodes the Yeast Counterpart of a Mammalian 5′- to 3′-Exonuclease Required for Lagging Strand DNA Synthesis in Reconstituted Systems

1995 • 168 citations

Substrate Length Requirements for Efficient Mitotic Recombination in Saccharomyces cerevisiae

1993 • 163 citations

Mutations in DNA mismatch repair genes are not responsible for microsatellite instability in most sporadic endometrial carcinomas.

1995 • 160 citations

Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage.

1994 • 154 citations

Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I.

1994 • 139 citations

Discontinuous DNA synthesis by purified mammalian proteins.

1990 • 135 citations

Fidelity of mammalian DNA replication and replicative DNA polymerases

1991 • 119 citations

Deletions and insertions in the p53 tumor suppressor gene in human cancers: confirmation of the DNA polymerase slippage/misalignment model.

1996 • 117 citations

An examination of adaptive reversion in Saccharomyces cerevisiae.

1992 • 107 citations

Substrate length requirements for efficient mitotic recombination in Saccharomyces cerevisiae.

1993 • 106 citations

Mutations in RAD27 Define a Potential Link between G₁ Cyclins and DNA Replication

1995 • 104 citations

Molecular and genetic analysis of the gene encoding the Saccharomyces cerevisiae strand exchange protein Sep1.

1991 • 104 citations

Completion of mammalian lagging strand DNA replication using purified proteins

1993 • 90 citations

Short direct repeats flanking deletions, and duplicating insertions in p53 gene in human cancers.

1993 • 85 citations

Instability of inhibited replication forks in E. coli

1995 • 78 citations

Stabilization of diverged tandem repeats by mismatch repair: evidence for deletion formation via a misaligned replication intermediate.

1996 • 71 citations

Homozygous tandem duplication within the gene encoding the β-subunit of rod phosphodiesterase as a cause for autosomal recessive retinitis pigmentosa

1995 • 70 citations

Novel pattern of p53 gene mutations in an American black cohort with high mortality from breast cancer

1994 • 66 citations

The Prevention of Repeat-Associated Deletions in Saccharomyces cerevisiae by Mismatch Repair Depends on Size and Origin of Deletions

1996 • 59 citations

The sep1 mutant of Saccharomyces cerevisiae arrests in pachytene and is deficient in meiotic recombination.

1995 • 51 citations

Initiation of adenovirus DNA replication. I. Mechanism of action of a host protein required for replication of adenovirus DNA templates devoid of the terminal protein.

1988 • 43 citations

Genetic basis of lethal junctional epidermolysis bullosa in an affected fetus: Implications for prenatal diagnosis in one family

1995 • 35 citations

Initiation of adenovirus DNA replication

1980 • 33 citations

Conditional hyporecombination mutants of three REC genes of Saccharomyces cerevisiae

1990 • 16 citations