Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

The multistep nature of cancer

1993 • 1,872 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer

1994 • 1,544 citations

HPRT-deficient (Lesch–Nyhan) mouse embryos derived from germline colonization by cultured cells

1987 • 1,231 citations

Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposis colorectal cancer: An updated review

1993 • 1,076 citations

Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair

1993 • 1,076 citations

Hypermutability and mismatch repair deficiency in RER+ tumor cells

1993 • 1,042 citations

MECHANISMS AND BIOLOGICAL EFFECTS OF MISMATCH REPAIR

1991 • 876 citations

Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability

1995 • 824 citations

Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells

1992 • 784 citations

The barrier to recombination between Escherichia coli and Salmonella typhimurium is disrupted in mismatch-repair mutants

1989 • 728 citations

Replication errors in benign and malignant tumors from hereditary nonpolyposis colorectal cancer patients.

1994 • 622 citations

Microsatellite instability: marker of a mutator phenotype in cancer.

1994 • 552 citations

A genetic map of the mouse with 4,006 simple sequence length polymorphisms

1994 • 543 citations

Genetic instability of microsatellites in endometrial carcinoma.

1993 • 523 citations

Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation.

1994 • 506 citations

Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation

1994 • 496 citations

Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents.

1990 • 460 citations

Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs.

1992 • 450 citations

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

1993 • 445 citations

Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer.

1993 • 443 citations

Mismatch Repair, Genetic Stability, and Cancer

1994 • 429 citations

Mutator phenotypes in human colorectal carcinoma cell lines.

1994 • 428 citations

Production of homozygous mutant ES cells with a single targeting construct.

1992 • 418 citations

Instability of short tandem repeats (microsatellites) in human cancers

1994 • 413 citations

Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines.

1990 • 408 citations

Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.

1995 • 403 citations

DNA adducts : identification and biological significance

1994 • 401 citations

hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds.

1994 • 366 citations

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

1993 • 361 citations

Heteroduplex repair in extracts of human HeLa cells

1991 • 355 citations

Characterization of insertion mutations in the Saccharomyces cerevisiae MSH1 and MSH2 genes: evidence for separate mitochondrial and nuclear functions.

1992 • 353 citations

Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability.

1994 • 332 citations

Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer

1994 • 329 citations

Mismatch Repair Deficiency in Phenotypically Normal Human Cells

1995 • 314 citations

On "genomenclature": a comprehensive (and respectful) taxonomy for pseudogenes and other "junk DNA".

1992 • 314 citations

DNA damage tolerance, mismatch repair and genome instability

1994 • 308 citations

MLH1, PMS1, and MSH2 Interactions During the Initiation of DNA Mismatch Repair in Yeast

1994 • 287 citations

Structure of the Human MSH2 Locus and Analysis of Two Muir-Torre Kindreds for msh2 Mutations

1994 • 287 citations

Association of sebaceous gland tumors and internal malignancy: The muir-torre syndrome

1991 • 261 citations

Regulation of the retinoblastoma protein-related p107 by G1 cyclin complexes.

1995 • 254 citations

Mismatch repair proteins MutS and MutL inhibit RecA-catalyzed strand transfer between diverged DNAs.

1994 • 251 citations

Consecutive inactivation of both alleles of the pim-1 proto-oncogene by homologous recombination in embryonic stem cells

1990 • 248 citations

Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer.

1995 • 239 citations

Interaction between mismatch repair and genetic recombination in Saccharomyces cerevisiae.

1994 • 236 citations

Dependence of intrachromosomal recombination in mammalian cells on uninterrupted homology.

1988 • 226 citations

Human strand-specific mismatch repair occurs by a bidirectional mechanism similar to that of the bacterial reaction

1993 • 224 citations

Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene.

1994 • 222 citations

Isolation and characterization of two Saccharomyces cerevisiae genes encoding homologs of the bacterial HexA and MutS mismatch repair proteins.

1992 • 221 citations

Structure of the human MLH1 locus and analysis of a large hereditary nonpolyposis colorectal carcinoma kindred for mlh1 mutations.

1995 • 219 citations

Microsatellite instability in the progression of gastric carcinoma.

1994 • 205 citations

Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine.

1986 • 203 citations

Mismatch correction acts as a barrier to homeologous recombination in Saccharomyces cerevisiae.

1995 • 201 citations

Cloning and nucleotide sequence of DNA mismatch repair gene PMS1 from Saccharomyces cerevisiae: homology of PMS1 to procaryotic MutL and HexB

1989 • 193 citations

Association of sebaceous gland tumors and internal malignancy: The muir-torre syndrome

1991 • 189 citations

Self-destruction and tolerance in resistance of mammalian cells to alkylation damage

1992 • 173 citations

Binding of Mismatched Microsatellite DNA Sequences by the Human MSH2 Protein

1994 • 166 citations

Heteroduplex DNA correction in Saccharomyces cerevisiae is mismatch specific and requires functional PMS genes.

1989 • 164 citations

Mining Treasures from 'Junk DNA'

1994 • 159 citations

Alterations of (CA)n DNA repeats and tumor suppressor genes in human gastric cancer.

1994 • 147 citations

Hereditary non-polyposis colorectal cancer — morphologies, genes and mutations

1994 • 147 citations

Microsatellite instability in ulcerative colitis-associated colorectal dysplasias and cancers.

1994 • 146 citations

Beta 2-microglobulin gene mutations: a study of established colorectal cell lines and fresh tumors.

1994 • 143 citations

Control of large chromosomal duplications in Escherichia coli by the mismatch repair system.

1991 • 140 citations

Genomic instability of microsatellite repeats and its association with the evolution of chronic myelogenous leukemia [see comments]

1994 • 137 citations

Genomic instability occurs in colorectal carcinomas but not in adenomas

1993 • 135 citations

Genetic instability in human ovarian cancer cell lines.

1994 • 134 citations

A human 200-kDa protein binds selectively to DNA fragments containing G.T mismatches.

1988 • 126 citations

DNA Loop Repair by Human Cell Extracts

1994 • 125 citations

DNA Mismatch Binding and Incision at Modified Guanine Bases by Extracts of Mammalian Cells: Implications for Tolerance to DNA Methylation Damage

1994 • 108 citations

The Saccharomyces cerevisiae Msh2 protein specifically binds to duplex oligonucleotides containing mismatched DNA base pairs and insertions.

1995 • 106 citations

Accumulation of multiple mutations in tumour suppressor genes during colorectal tumorigenesis in HNPCC patients

1994 • 96 citations

Colon cancer and DNA repair: have mismatches met their match?

1994 • 90 citations

Purified human MSH2 protein binds to DNA containing mismatched nucleotides.

1994 • 90 citations

The purification of a human mismatch-binding protein and identification of its associated ATPase and helicase activities.

1992 • 89 citations

DNA homology requirements for mitotic gap repair in Drosophila.

1993 • 84 citations

A mismatch recognition defect in colon carcinoma confers DNA microsatellite instability and a mutator phenotype.

1994 • 79 citations

DNA mismatch repair in Xenopus egg extracts: repair efficiency and DNA repair synthesis for all single base-pair mismatches.

1990 • 65 citations

Selective binding to DNA base pair mismatches by proteins from human cells

1989 • 49 citations

Characterization of a DNA mismatch-binding activity in yeast extracts.

1993 • 34 citations

The role of DNA repeats and associated secondary structures in genomic instability and neoplasia

1993 • 31 citations

Incision at DNA G.cntdot.T mispairs by extracts of mammalian cells occurs preferentially at cytosine methylation sites and is not targeted by a separate G.cntdot.T binding reaction

1993 • 30 citations

Cloning and expression of the Xenopus and mouse Msh2 DNA mismatch repair genes

1994 • 25 citations

Genetic consequences of tolerance to methylation DNA damage in mammalian cells

1993 • 25 citations

DNA alkylation by triazenes and related compounds.

1994 • 6 citations