P<scp>hosphoinositide</scp>3-K<scp>inase</scp>: Diverse Roles in Immune Cell Activation

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

2002 • 5,914 citations

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1999 • 1,972 citations

Activating Receptors and Coreceptors Involved in Human Natural Killer Cell-Mediated Cytolysis

2001 • 1,728 citations

IgG Fc Receptors

2001 • 1,667 citations

Synthesis and Function of 3-Phosphorylated Inositol Lipids

2001 • 1,527 citations

Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

2002 • 1,518 citations

The CD28 Signaling Pathway Regulates Glucose Metabolism

2002 • 1,331 citations

PHOSPHOINOSITIDE KINASES

1998 • 1,321 citations

Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation

2000 • 1,209 citations

Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

2000 • 1,031 citations

The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function

1999 • 1,007 citations

REGULATION OF IMMUNE RESPONSES THROUGH INHIBITORY RECEPTORS

1999 • 947 citations

A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages.

1996 • 946 citations

Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice

2002 • 910 citations

Polarization of Chemoattractant Receptor Signaling During Neutrophil Chemotaxis

2000 • 892 citations

Magnetic relaxation switches capable of sensing molecular interactions

2002 • 882 citations

Phosphorylation and Activation of p70 ^s6k by PDK1

1998 • 835 citations

Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

2000 • 825 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

PI3K in lymphocyte development, differentiation and activation

2003 • 739 citations

Signalling through the high-affinity IgE receptor FcεRI

1999 • 730 citations

Defective B cell development and function in Btk-deficient mice

1995 • 729 citations

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

2000 • 692 citations

Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

2000 • 656 citations

Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α

1999 • 642 citations

Cbl-b regulates the CD28 dependence of T-cell activation

2000 • 607 citations

PI3K and negative regulation of TLR signaling

2003 • 601 citations

The Forkhead Transcription Factor FoxO Regulates Transcription of p27Kip1 and Bim in Response to IL-2

2002 • 580 citations

Immune functions encoded by the natural killer gene complex

2003 • 564 citations

Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrest

2001 • 532 citations

Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation

2001 • 531 citations

A PtdInsP3- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity

2002 • 522 citations

Signal transduction by the TCR for antigen

2000 • 505 citations

Lipid products of PI(3)Ks maintain persistent cell polarity and directed motility in neutrophils

2002 • 477 citations

Xid -Like Immunodeficiency in Mice with Disruption of the p85α Subunit of Phosphoinositide 3-Kinase

1999 • 465 citations

P-Rex1, a PtdIns(3,4,5)P3- and Gβγ-Regulated Guanine-Nucleotide Exchange Factor for Rac

2002 • 460 citations

The role of PI3K in immune cells

2003 • 460 citations

Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation

2002 • 449 citations

Immunodeficiency in Protein Kinase Cβ-Deficient Mice

1996 • 444 citations

A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation

2002 • 440 citations

Role of the Sphingosine-1-Phosphate Receptor EDG-1 in PDGF-Induced Cell Motility

2001 • 421 citations

A Requirement for Phosphatidylinositol 3-Kinase in Pseudopod Extension

1999 • 414 citations

Phosphoinositide 3-kinase signalling – which way to target?

2003 • 412 citations

Continuous T cell receptor signaling required for synapse maintenance and full effector potential

2003 • 405 citations

Requirement for Tec Kinases Rlk and Itk in T Cell Receptor Signaling and Immunity

1999 • 399 citations

NKG2D-DAP10 triggers human NK cell–mediated killing via a Syk-independent regulatory pathway

2003 • 365 citations

Essential Role of Phosphoinositide 3-Kinase δ in Neutrophil Directional Movement

2003 • 364 citations

Essential, Nonredundant Role for the Phosphoinositide 3-Kinase p110δ in Signaling by the B-Cell Receptor Complex

2002 • 355 citations

T Cell Receptor–initiated Calcium Release Is Uncoupled from Capacitative Calcium Entry in Itk-deficient T Cells

1998 • 336 citations

Temporal and Spatial Regulation of Chemotaxis

2002 • 335 citations

Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines

2001 • 322 citations

PKC-β controls IκB kinase lipid raft recruitment and activation in response to BCR signaling

2002 • 319 citations

Phosphoinositide 3‐kinase‐dependent activation of Rac

2003 • 318 citations

Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk

1995 • 313 citations

Impaired NFATc Translocation and Failure of Th2 Development in Itk-Deficient CD4+ T Cells

1999 • 307 citations

Essential role for Gab2 in the allergic response

2001 • 306 citations

Bruton's Tyrosine Kinase Is Required for Activation of Iκb Kinase and Nuclear Factor κb in Response to B Cell Receptor Engagement

2000 • 299 citations

Structure, function, and biology of SHIP proteins

2000 • 298 citations

Phosphoinositide 3-Kinase γ Is an Essential Amplifier of Mast Cell Function

2002 • 293 citations

Restricted Accumulation of Phosphatidylinositol 3-Kinase Products in a Plasmalemmal Subdomain during Fcγ Receptor-Mediated Phagocytosis

2001 • 286 citations

Simultaneous measurement of multiple active kinase states using polychromatic flow cytometry

2002 • 282 citations

A contractile activity that closes phagosomes in macrophages

1999 • 279 citations

Biochemical Interactions Integrating Itk with the T Cell Receptor-initiated Signaling Cascade

2000 • 278 citations

Proteolysis-independent regulation of PI3K by Cbl-b–mediated ubiquitination in T cells

2001 • 274 citations

BCAP

2000 • 271 citations

The PI‐3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP₃

2003 • 264 citations

Critical Roles for Rac1 and Rac2 GTPases in B Cell Development and Signaling

2003 • 262 citations

Roles of PI3Ks in leukocyte chemotaxis and phagocytosis

2002 • 252 citations

Involvement of Bruton's Tyrosine Kinase in FcεRI-dependent Mast Cell Degranulation and Cytokine Production

1998 • 249 citations

Protein Kinase C β Controls Nuclear Factor κB Activation in B Cells Through Selective Regulation of the IκB Kinase α

2002 • 239 citations

Location, Location, Location: Membrane Targeting Directed by PX Domains

2001 • 237 citations

Distinct PI(3)Ks mediate mitogenic signalling and cell migration in macrophages

1999 • 237 citations

Neutrophils lacking phosphoinositide 3-kinase γ show loss of directionality duringN-formyl-Met-Leu-Phe-induced chemotaxis

2002 • 235 citations

Critical Roles of Pten in B Cell Homeostasis and Immunoglobulin Class Switch Recombination

2003 • 234 citations

Dap10 and Dap12 Form Distinct, but Functionally Cooperative, Receptor Complexes in Natural Killer Cells

2000 • 232 citations

Floating the Raft Hypothesis

2001 • 226 citations

Myosin X is a downstream effector of PI(3)K during phagocytosis

2002 • 220 citations

Phosphoinositide 3-Kinase Regulates Phospholipase Cγ-mediated Calcium Signaling

1998 • 218 citations

Bruton's Tyrosine Kinase Links the B Cell Receptor to Nuclear Factor κb Activation

2000 • 215 citations

Vav1 Transduces T Cell Receptor Signals to the Activation of Phospholipase C-γ1 via Phosphoinositide 3-Kinase-dependent and -independent Pathways

2002 • 214 citations

BTK Regulates PtdIns-4,5-P2 Synthesis

2003 • 214 citations

Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse

2002 • 212 citations

The Inositol Polyphosphate 5-Phosphatase Ship Is a Crucial Negative Regulator of B Cell Antigen Receptor Signaling

1998 • 212 citations

A point mutation in CD28 distinguishes proliferative signals from survival signals

2001 • 210 citations

Regulation of quiescence in lymphocytes

2003 • 210 citations

Phosphoinositide 3-kinase in immunological systems

2002 • 206 citations

Cbl-b, a RING-type E3 Ubiquitin Ligase, Targets Phosphatidylinositol 3-Kinase for Ubiquitination in T Cells

2001 • 201 citations

The gift of Gab

2002 • 201 citations

Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice

2002 • 196 citations

Xid-like Phenotypes

2000 • 195 citations

Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function

2003 • 194 citations

NKG2D triggers cytotoxicity in mouse NK cells lacking DAP12 or Syk family kinases

2003 • 190 citations

Influence of SHIP on the NK Repertoire and Allogeneic Bone Marrow Transplantation

2002 • 186 citations

Iκb Kinase α Is Essential for Mature B Cell Development and Function

2001 • 186 citations

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

2000 • 185 citations

Signal transduction through Vav-2 participates in humoral immune responses and B cell maturation

2001 • 180 citations

High resolution mapping of mast cell membranes reveals primary and secondary domains of FcϵRI and LAT

2001 • 177 citations

SYK Is Upstream of Phosphoinositide 3-Kinase in B Cell Receptor Signaling

1999 • 175 citations

Qualitative Regulation of B Cell Antigen Receptor Signaling by CD19: Selective Requirement for PI3-Kinase Activation, Inositol-1,4,5-Trisphosphate Production and Ca2+ Mobilization

1997 • 172 citations

Compensation between Vav-1 and Vav-2 in B cell development and antigen receptor signaling

2001 • 171 citations

Rac2 Stimulates Akt Activation Affecting BAD/Bcl-XL Expression while Mediating Survival and Actin Function in Primary Mast Cells

2000 • 168 citations

Molecular adapters in FcεRI signaling and the allergic response

2002 • 166 citations

CD28 and Inducible Costimulatory Protein Src Homology 2 Binding Domains Show Distinct Regulation of Phosphatidylinositol 3-Kinase, Bcl-xL, and IL-2 Expression in Primary Human CD4 T Lymphocytes

2003 • 164 citations

Negative Regulation of T Cell Proliferation and Interleukin 2 Production by the Serine Threonine Kinase Gsk-3

2000 • 162 citations

Imaging antigen-induced PI3K activation in T cells

2002 • 159 citations

A Regulatory Role for Src Homology 2 Domain–Containing Inositol 5′-Phosphatase (Ship) in Phagocytosis Mediated by Fcγ Receptors and Complement Receptor 3 (αMβ2; Cd11b/Cd18)

2000 • 157 citations

Vav1 Regulates Phospholipase Cγ Activation and Calcium Responses in Mast Cells

2001 • 156 citations

Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1 alpha-induced lymphocyte polarization and chemotaxis.

1999 • 155 citations

Cutting Edge: Distinct Motifs Within CD28 Regulate T Cell Proliferation and Induction of Bcl-XL

2001 • 153 citations

Akt-Dependent Phosphorylation Specifically Regulates Cot Induction of NF-κB-Dependent Transcription

2002 • 151 citations

T-cell signalling and autoimmunity: molecular mechanisms of disease

2002 • 144 citations

Vav3 Modulates B Cell Receptor Responses by Regulating Phosphoinositide 3-Kinase Activation

2002 • 143 citations

B Cell Growth Is Controlled by Phosphatidylinosotol 3-Kinase-Dependent Induction of Rel/NF-κB Regulated c-myc Transcription

2002 • 143 citations

CD28-dependent Activation of Protein Kinase B/Akt Blocks Fas-mediated Apoptosis by Preventing Death-inducing Signaling Complex Assembly

2002 • 140 citations

The p85 Subunit of Phosphatidylinositol 3-Kinase Associates with the Fc Receptor γ-Chain and Linker for Activitor of T Cells (LAT) in Platelets Stimulated by Collagen and Convulxin

1998 • 138 citations

The p85 Regulatory Subunit Controls Sequential Activation of Phosphoinositide 3-Kinase by Tyr Kinases and Ras

2002 • 137 citations

Regulation of neutrophil function by Rac GTPases

2003 • 136 citations

PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction

2003 • 135 citations

PI 3-Kinases and PTEN

2002 • 134 citations

Role of zetaPKC in B-cell signaling and function

2002 • 132 citations

The Physiologic Role of CD19 Cytoplasmic Tyrosines

2002 • 131 citations

Phosphoinositide Binding Domains

1999 • 130 citations

PI 3-K and T-cell activation: limitations of T-leukemic cell lines as signaling models

2001 • 129 citations

The Rac2 Guanosine Triphosphatase Regulates B Lymphocyte Antigen Receptor Responses and Chemotaxis and Is Required for Establishment of B-1a and Marginal Zone B Lymphocytes

2002 • 126 citations

Differential Regulation of B Cell Development, Activation, and Death by the Src Homology 2 Domain–Containing 5′ Inositol Phosphatase (Ship)

2000 • 126 citations

Protein kinase B (Akt) regulation and function in T lymphocytes

2002 • 125 citations

Vav Regulates Activation of Rac but Not Cdc42 during FcγR-mediated Phagocytosis

2002 • 124 citations

Essential Immunoregulatory Role for BCAP in B Cell Development and Function

2002 • 123 citations

A Positive Regulatory Role for Cbl Family Proteins in Tumor Necrosis Factor-related Activation-induced Cytokine (TRANCE) and CD40L-mediated Akt Activation

2001 • 123 citations

Involvement of Phosphatidylinositol 3-Kinase in Stromal Cell-Derived Factor-1α-Induced Lymphocyte Polarization and Chemotaxis

1999 • 122 citations

Imaging antigen recognition by naive CD4+ T cells: compulsory cytoskeletal alterations for the triggering of an intracellular calcium response

1998 • 121 citations

Functional dissection of BCR signaling pathways

2000 • 120 citations

Activation of the PKB/AKT Pathway by ICAM-2

2002 • 119 citations

Critical role for scaffolding adapter Gab2 in FcγR-mediated phagocytosis

2003 • 117 citations

CD19-dependent Activation of Akt Kinase in B-lymphocytes

2001 • 116 citations

Physiological Functions of Pten in Mouse Tissues.

2003 • 114 citations

Tec family kinases in lymphocyte signaling and function

2000 • 103 citations

CD19 regulates B lymphocyte responses to transmembrane signals

1998 • 100 citations

Perturbed Regulation of ZAP-70 and Sustained Tyrosine Phosphorylation of LAT and SLP-76 in c-Cbl-Deficient Thymocytes

1999 • 98 citations

Critical Requirement for the Membrane-Proximal Cytosolic Tyrosine Residue for CD28-Mediated Costimulation In Vivo

2001 • 97 citations

Proliferation and Survival of Activated B Cells Requires Sustained Antigen Receptor Engagement and Phosphoinositide 3-Kinase Activation

2003 • 96 citations

Phagocytic signaling strategies: Fcγreceptor-mediated phagocytosis as a model system

2001 • 95 citations

Convergence of Signaling Pathways on the Activation of ERK in B Cells

2002 • 89 citations

Class I Phosphoinositide 3-Kinase p110β Is Required for Apoptotic Cell and Fcγ Receptor-mediated Phagocytosis by Macrophages

2003 • 89 citations

PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2

2002 • 87 citations

Impaired Kit- but Not FcεRI-initiated Mast Cell Activation in the Absence of Phosphoinositide 3-Kinase p85α Gene Products

2000 • 87 citations

Cbl and Cbl-b in T-cell regulation

2002 • 85 citations

Phosphatidylinositol 3-Kinase Regulates the CD4/CD8 T Cell Differentiation Ratio

2003 • 82 citations

Bam32 Links the B Cell Receptor to ERK and JNK and Mediates B Cell Proliferation but Not Survival

2003 • 81 citations

Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes

2001 • 79 citations

Transgene Expression of bcl-xL Permits Anti-immunoglobulin (Ig)–induced Proliferation in xid B Cells

1998 • 74 citations

The Adapter Protein LAT Enhances Fcγ Receptor-mediated Signal Transduction in Myeloid Cells

2000 • 73 citations

Phosphoinositide 3-Kinase Regulation of T Cell Receptor-mediated Interleukin-2 Gene Expression in Normal T Cells

1998 • 70 citations

Activating and inhibitory signaling in mast cells: New opportunities for therapeutic intervention?

2000 • 67 citations

CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase.

1995 • 66 citations

Regulation of Phosphatidylinositol 3-Kinase Activity and Phosphatidylinositol 3,4,5-Trisphosphate Accumulation by Neutrophil Priming Agents

2002 • 65 citations

The Gab1 Docking Protein Links the B Cell Antigen Receptor to the Phosphatidylinositol 3-Kinase/Akt Signaling Pathway and to the SHP2 Tyrosine Phosphatase

2001 • 65 citations

xid affects events leading to B cell cycle entry.

1997 • 61 citations

Rac2‐deficient mice display perturbed T‐cell distribution and chemotaxis, but only minor abnormalities in T_H1 responses

2002 • 60 citations

Contribution of BCAP to maintenance of mature B cells through c-Rel

2003 • 58 citations

Novel Function of Phosphoinositide 3-Kinase in T Cell Ca2+ Signaling

2000 • 58 citations

FcγRIIB1/SHIP-mediated Inhibitory Signaling in B Cells Involves Lipid Rafts

2001 • 54 citations

BCR targets cyclin D2 via Btk and the p85α subunit of PI3-K to induce cell cycle progression in primary mouse B cells

2003 • 54 citations

Wortmannin, a phosphatidylinositol 3-kinase inhibitor, blocks antigen-mediated, but not CD3 monoclonal antibody-induced, activation of murine CD4+ T cells.

1997 • 53 citations

Ordered Just So: Lipid Rafts and Lymphocyte Function

2002 • 52 citations

Cbl-b Positively Regulates Btk-mediated Activation of Phospholipase C-γ2 in B Cells

2002 • 50 citations

p110β and p110δ Phosphatidylinositol 3-Kinases Up-regulate FcεRI-activated Ca2+ Influx by Enhancing Inositol 1,4,5-Trisphosphate Production

2001 • 47 citations

Disruption of a SinglePtenAllele Augments the Chemotactic Response of B Lymphocytes to Stromal Cell-Derived Factor-1

2002 • 46 citations

Rac Activation: P-Rex1 — A Convergence Point for PIP3 and Gβγ?

2002 • 42 citations

Distinct Phosphoinositide 3-Kinases Mediate Mast Cell Degranulation in Response to G-protein-coupled VersusFcεRI Receptors

2003 • 41 citations

Vav Is Required for Cyclin D2 Induction and Proliferation of Mouse B Lymphocytes Activated via the Antigen Receptor

2001 • 33 citations

Adapter Molecule Grb2-Associated Binder 1 Is Specifically Expressed in Marginal Zone B Cells and Negatively Regulates Thymus-Independent Antigen-2 Responses

2002 • 27 citations

Aggregation of the human high affinity immunoglobulin G receptor (FcγRI) activates both tyrosine kinase and G protein-coupled phosphoinositide 3-kinase isoforms

1998 • 26 citations

Bruton's Tyrosine‐Kinase‐Deficient Murine B Lymphocytes Fail to Enter S Phase when Stimulated with Anti‐Immunoglobulin Plus Interleukin‐4

1999 • 20 citations

Imaging antigen recognition by naive CD4+ T cells: compulsory cytoskeletal alterations for the triggering of an intracellular calcium response

1998 • 5 citations