Cutting Edge: Distinct Motifs Within CD28 Regulate T Cell Proliferation and Induction of Bcl-XL

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

Induction by Antigen of Intrathymic Apoptosis of CD4 ⁺ CD8 ⁺ TCR ^lo Thymocytes in Vivo

1990 • 1,781 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

Regulation of Lymphokine Messenger RNA Stability by a Surface-Mediated T Cell Activation Pathway

1989 • 910 citations

PKB/Akt: connecting phosphoinositide 3-kinase to cell survival and beyond

1997 • 699 citations

Regulation of Interleukin-2 Gene Enhancer Activity by the T Cell Accessory Molecule CD28

1991 • 660 citations

Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling

1994 • 378 citations

The Roles of Costimulation and Fas in T Cell Apoptosis and Peripheral Tolerance

1996 • 367 citations

Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo

2000 • 339 citations

Upstream-Downstream: CD28 Cosignaling Pathways and T Cell Function

1996 • 229 citations

CD28/B7 interactions deliver a unique signal to naive T cells that regulates cell survival but not early proliferation.

1996 • 220 citations

GATA-3-dependent enhancer activity in IL-4 gene regulation.

1998 • 205 citations

Proline Residues in Cd28 and the Src Homology (Sh)3 Domain of Lck Are Required for T Cell Costimulation

1999 • 180 citations

Cutting Edge: GATA-3-Dependent Enhancer Activity in IL-4 Gene Regulation

1998 • 158 citations

The cytoplasmic domain of CD28 is both necessary and sufficient for costimulation of interleukin-2 secretion and association with phosphatidylinositol 3'-kinase.

1994 • 145 citations

Ligation of the T cell co‐stimulatory receptor CD28 activates the serine‐threonine protein kinase protein kinase B

1997 • 124 citations

Phosphoinositide 3-Kinase Regulation of T Cell Receptor-mediated Interleukin-2 Gene Expression in Normal T Cells

1998 • 70 citations

Two Distinct Intracytoplasmic Regions of the T-cell Adhesion Molecule CD28 Participate in Phosphatidylinositol 3-Kinase Association

1996 • 63 citations

CD28-Mediated Costimulation in the Absence of Phosphatidylinositol 3-Kinase Association and Activation

1995 • 61 citations

Signaling through CD28/CTLA-4 family receptors: puzzling participation of phosphatidylinositol-3 kinase.

1996 • 59 citations

Expression of Bcl-XL Restores Cell Survival, but Not Proliferation and Effector Differentiation, in Cd28-Deficient T Lymphocytes

2000 • 59 citations

The Cytoplasmic Domain of CD28 Is both Necessary and Sufficient for Costimulation of Interleukin-2 Secretion and Association with Phosphatidylinositol 3′-Kinase

1994 • 55 citations

Wortmannin, a phosphatidylinositol 3-kinase inhibitor, blocks antigen-mediated, but not CD3 monoclonal antibody-induced, activation of murine CD4+ T cells.

1997 • 53 citations

Phosphatidylinositol 3‐kinase activity is not essential for CD28 costimulatory activity in Jurkat T cells: studies with a selective inhibitor, wortmannin

1995 • 48 citations

CD28 can promote T cell survival through a phosphatidylinositol 3‐kinase‐independent mechanism

1997 • 43 citations

Structural Requirements for CD43 Function

1999 • 29 citations

Structural requirements for CD28-mediated costimulation of IL-2 production in Jurkat T cells.

1996 • 26 citations