Regulation of Phosphatidylinositol 3-Kinase Activity and Phosphatidylinositol 3,4,5-Trisphosphate Accumulation by Neutrophil Priming Agents

Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation

2000 • 1,209 citations

Modulation of multiple neutrophil functions by preparative methods or trace concentrations of bacterial lipopolysaccharide.

1985 • 796 citations

A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein βγ subunits

1994 • 597 citations

Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase.

1986 • 576 citations

The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101

1997 • 549 citations

Pathway of phosphatidylinositol(3,4,5)-trisphosphate synthesis in activated neutrophils

1991 • 488 citations

Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras

1997 • 451 citations

Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate

1993 • 449 citations

Neutrophil activation and acute lung injury

2001 • 427 citations

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox

2001 • 402 citations

NF-κB Activation Is a Critical Regulator of Human Granulocyte Apoptosis in Vitro

1999 • 329 citations

Identification of a specific lns(l,3,4,5)P4-binding protein as a member of the GAP1 family

1995 • 294 citations

Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human myeloid derived cells.

1993 • 208 citations

Phosphatidylinositol 3-phosphate is generated in phagosomal membranes

2001 • 178 citations

Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function

1998 • 173 citations

Two transduction sequences are necessary for neutrophil activation by receptor agonists.

1988 • 172 citations

Receptor stimulated accumulation of phosphatidylinositol (3,4,5)-trisphosphate by G-protein mediated pathways in human myeloid derived cells.

1993 • 162 citations

Phosphatidylinositol 3-kinase is activated by nerve growth factor and epidermal growth factor in PC12 cells.

1992 • 142 citations

Inhibition of the phagocytosis-induced respiratory burst by the fungal metabolite wortmannin and some analogues

1987 • 142 citations

Platelet-Derived Growth Factor-BB and Thrombin Activate Phosphoinositide 3-Kinase and Protein Kinase B: Role in Mediating Airway Smooth Muscle Proliferation

1998 • 123 citations

Phosphoinositide 3-kinase and the regulation of cell growth

1996 • 117 citations

A Tyrosine Kinase Signaling Pathway Accounts for the Majority of Phosphatidylinositol 3,4,5-Trisphosphate Formation in Chemoattractant-stimulated Human Neutrophils

1996 • 115 citations

Demonstration of reversible priming of human neutrophils using platelet- activating factor

1996 • 100 citations

Activation of SHIP by NADPH Oxidase-stimulated Lyn Leads to Enhanced Apoptosis in Neutrophils

2002 • 96 citations

Recruitment of hepatocyte nuclear factor 4 into specific intranuclear compartments depends on tyrosine phosphorylation that affects its DNA-binding and transactivation potential.

1995 • 88 citations

Stimulation of Human Neutrophils by Chemotactic Factors Is Associated with the Activation of Phosphatidylinositol 3-Kinase γ

2000 • 76 citations

Synthesis of phosphatidylinositol 3,4,5-trisphosphate in permeabilized neutrophils regulated by receptors and G-proteins

1993 • 73 citations

Signal transduction in neutrophil activation Phosphatidylinositol 3‐kinase is stimulated without tyrosine phosphorylation

1992 • 58 citations

Lung vascular injury induced by chemotactic factors: enhancement by bacterial endotoxins.

1986 • 55 citations

Enhancement of chemotactic peptide-induced activation of phosphoinositide 3-kinase by granulocyte–macrophage colony-stimulating factor and its relation to the cytokine-mediated priming of neutrophil superoxide-anion production

1999 • 51 citations

A Novel, Rapid, and Highly Sensitive Mass Assay for Phosphatidylinositol 3,4,5-Trisphosphate (PtdIns(3,4,5)P3) and Its Application to Measure Insulin-stimulated PtdIns(3,4,5)P3 Production in Rat Skeletal Muscle in Vivo

1997 • 48 citations

Priming of human neutrophil superoxide generation by tumour necrosis factor‐α is signalled by enhanced phosphatidylinositol 3,4,5‐trisphosphate but not inositol 1,4,5‐trisphosphate accumulation

1998 • 43 citations

Neutrophil Rheology and Transit through Capillaries and Sinusoids

1999 • 33 citations

Priming of Phosphatidic Acid Production by Staurosporine in f-Met-Leu-Phe-Stimulated Human Neutrophils—Correlation with Respiratory Burst

1998 • 22 citations

Moving in mysterious ways

2000 • 22 citations

Enhancement of chemotactic peptide-induced activation of phosphoinositide 3-kinase by granulocyte‒macrophage colony-stimulating factor and its relation to the cytokine-mediated priming of neutrophil superoxide-anion production

1999 • 18 citations

TNFα Elicits Association of PI 3-Kinase with the p60TNFR and Activation of PI 3-Kinase in Adherent Neutrophils

2001 • 15 citations

Up-regulation of the amount of Giα2 associated with the plasma membrane in human neutrophils stimulated by granulocyte-macrophage colony-stimulating factor

1993 • 13 citations

Phosphatidylinositol(3,4,5)Trisphosphate (Ptdins(3,4,5)P3) Mass Measurement Using a Radioligand Displacement Assay

1998 • 12 citations