Molecular adapters in FcεRI signaling and the allergic response

LAT

1998 • 1,251 citations

Protein Kinase C Isotypes Controlled by Phosphoinositide 3-Kinase Through the Protein Kinase PDK1

1998 • 1,118 citations

Regulatory and Signaling Properties of the Vav Family

2000 • 513 citations

Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases

1992 • 503 citations

Fyn kinase initiates complementary signals required for IgE-dependent mast cell degranulation

2002 • 449 citations

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

1998 • 436 citations

Association of Grb2, Gads, and Phospholipase C-γ1 with Phosphorylated LAT Tyrosine Residues

2000 • 384 citations

Ca(2+)-dependent and Ca(2+)-independent isozymes of protein kinase C mediate exocytosis in antigen-stimulated rat basophilic RBL-2H3 cells. Reconstitution of secretory responses with Ca2+ and purified isozymes in washed permeabilized cells.

1993 • 369 citations

Roles of mast cells and basophils in innate and acquired immunity

2000 • 350 citations

LAT Is Essential for FcεRI-Mediated Mast Cell Activation

2000 • 332 citations

VAV proteins as signal integrators for multi-subunit immune-recognition receptors

2002 • 321 citations

Coupling of the TCR to Integrin Activation by SLAP-130/Fyb

2001 • 314 citations

Essential role for Gab2 in the allergic response

2001 • 306 citations

Positive Regulation of T Cell Activation and Integrin Adhesion by the Adapter Fyb/Slap

2001 • 282 citations

Biochemical Interactions Integrating Itk with the T Cell Receptor-initiated Signaling Cascade

2000 • 278 citations

Membrane rafts and signaling by the multichain immune recognition receptors

2000 • 226 citations

The Diverse Roles of Mast Cells

2001 • 215 citations

Vav1 Transduces T Cell Receptor Signals to the Activation of Phospholipase C-γ1 via Phosphoinositide 3-Kinase-dependent and -independent Pathways

2002 • 214 citations

Signal Transduction by the High-Affinity Immunoglobulin E Receptor FcεRI: Coupling Form to Function

2001 • 206 citations

The gift of Gab

2002 • 201 citations

LAT Is Required for Tyrosine Phosphorylation of Phospholipase Cγ2 and Platelet Activation by the Collagen Receptor GPVI

1999 • 180 citations

High resolution mapping of mast cell membranes reveals primary and secondary domains of FcϵRI and LAT

2001 • 177 citations

Redundant and Opposing Functions of Two Tyrosine Kinases, Btk and Lyn, in Mast Cell Activation

2000 • 164 citations

Impaired tyrosine phosphorylation and Ca2+ mobilization, but not degranulation, in lyn-deficient bone marrow-derived mast cells.

1997 • 163 citations

An Unusual Mechanism for Ligand Antagonism

1998 • 157 citations

Vav1 Regulates Phospholipase Cγ Activation and Calcium Responses in Mast Cells

2001 • 156 citations

SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells.

1999 • 154 citations

The Unique Domain as the Site on Lyn Kinase for Its Constitutive Association with the High Affinity Receptor for IgE

1997 • 124 citations

Recruitment of Slp-76 to the Membrane and Glycolipid-Enriched Membrane Microdomains Replaces the Requirement for Linker for Activation of T Cells in T Cell Receptor Signaling

2000 • 114 citations

Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc

1998 • 114 citations

FYN-T-FYB-SLP-76 Interactions Define a T-cell Receptor ζ/CD3-mediated Tyrosine Phosphorylation Pathway That Up-regulates Interleukin 2 Transcription in T-cells

1999 • 98 citations

Characterization of Cbl tyrosine phosphorylation and a Cbl-Syk complex in RBL-2H3 cells.

1996 • 92 citations

Downstream of Kinase, p62dok, Is a Mediator of FcγRIIB Inhibition of FcεRI Signaling

2002 • 87 citations

Fibronectin receptor integrins are involved in mast cell activation

1994 • 78 citations

Multiple roles for PI 3-kinase in the regulation of PLCγ activity and Ca2+ mobilization in antigen-stimulated mast cells

1999 • 78 citations

Vav1 Is a Component of Transcriptionally Active Complexes

2002 • 76 citations

The Src Homology 2 Domain of Vav Is Required for Its Compartmentation to the Plasma Membrane and Activation of C-Jun Nh2-Terminal Kinase 1

2000 • 73 citations

Activating and inhibitory signaling in mast cells: New opportunities for therapeutic intervention?

2000 • 67 citations

Adaptor FYB (Fyn-binding protein) regulates integrin-mediated adhesion and mediator release: Differential involvement of the FYB SH3 domain

2001 • 66 citations

SLP-76 Is a Substrate of the High Affinity IgE Receptor-stimulated Protein Tyrosine Kinases in Rat Basophilic Leukemia Cells

1997 • 66 citations

Clnk, a Novel Slp-76–Related Adaptor Molecule Expressed in Cytokine-Stimulated Hemopoietic Cells

1999 • 61 citations

Regulation of FcεRI-mediated degranulation by an adaptor protein 3BP2 in rat basophilic leukemia RBL-2H3 cells

2002 • 56 citations

Regulation of the Adapter Molecule Grb2 by the FcεR1 in the Mast Cell Line RBL2H3

1995 • 55 citations

A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation

2000 • 50 citations

Unexpected signals in a system subject to kinetic proofreading

2001 • 50 citations

Scaffolds, adaptors and linkers of TCR signaling: theory and practice

2002 • 47 citations

Elevated Levels of Cyclooxygenase-2 in Antigen-Stimulated Mast Cells Is Associated with Minimal Activation of p38 Mitogen-Activated Protein Kinase

2001 • 46 citations

The Adapter Molecule Gab2 Regulates FcεRI-Mediated Signal Transduction in Mast Cells

2002 • 45 citations

Molecular analysis of the fyn-complex: cloning of SKAP55 and SLAP-130, two novel adaptor proteins which associate with fyn and may participate in the regulation of T cell receptor-mediated signaling

1997 • 25 citations

Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI).

1998 • 22 citations

Differential Interaction of Crkl with Cbl or C3G, Hef-1, and γ Subunit Immunoreceptor Tyrosine-Based Activation Motif in Signaling of Myeloid High Affinity Fc Receptor for IgG (FcγRI)

1998 • 19 citations

Integrin VLA‐5: modulator and activator of mast cells

2001 • 12 citations