Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b

CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones

1992 • 1,573 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

1988 • 671 citations

Cbl-b regulates the CD28 dependence of T-cell activation

2000 • 607 citations

B lymphocytes express and lose syndecan at specific stages of differentiation.

1989 • 422 citations

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

1998 • 420 citations

Chronic inflammation caused by lymphotoxin is lymphoid neogenesis.

1996 • 405 citations

Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice

1998 • 371 citations

Altered thymic positive selection and intracellular signals in Cbl-deficient mice

1998 • 343 citations

POSITIVE VERSUS NEGATIVE SIGNALING BY LYMPHOCYTE ANTIGEN RECEPTORS

1998 • 320 citations

Dendritic Cells Induce Autoimmune Diabetes and Maintain Disease via De Novo Formation of Local Lymphoid Tissue

1998 • 315 citations

Adaptors and Molecular Scaffolds in Immune Cell Signaling

1999 • 222 citations

Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene.

1995 • 185 citations

T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice.

1989 • 182 citations

Religation of the T cell receptor after primary activation of mature T cells inhibits proliferation and induces apoptotic cell death.

1993 • 152 citations

Blockade of the CD28 co-stimulatory pathway: a means to induce tolerance

1994 • 139 citations

The protein product of the c-cbl protooncogene is phosphorylated after B cell receptor stimulation and binds the SH3 domain of Bruton's tyrosine kinase.

1995 • 131 citations

Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation

1997 • 89 citations

Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation

1999 • 75 citations

Functional management of an antiviral cytotoxic T-cell response

1997 • 64 citations

Tyrosine-phosphorylated Cbl binds to Crk after T cell activation.

1996 • 60 citations

A direct interaction between the adaptor protein Cbl-b and the kinase Zap-70 induces a positive signal in T cells

1999 • 44 citations

Binding of T cell receptor to major histocompatibility complex class II‐peptide complexes at the single‐cell level results in the induction of antigen unresponsiveness (anergy)

1992 • 28 citations