Vav1 Transduces T Cell Receptor Signals to the Activation of Phospholipase C-γ1 via Phosphoinositide 3-Kinase-dependent and -independent Pathways

Regulation of Phosphoinositide-Specific Phospholipase C

2001 • 1,604 citations

The Regulation and Activities of the Multifunctional Serine/Threonine Kinase Akt/PKB

1999 • 882 citations

Phosphatidylinositol 4-Phosphate 5-Kinase α Is a Downstream Effector of the Small G Protein ARF6 in Membrane Ruffle Formation

1999 • 800 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254

1991 • 583 citations

Activation of phospholipase Cgamma by PI 3-kinase-induced PH domain-mediated membrane targeting

1998 • 561 citations

vav, a novel human oncogene derived from a locus ubiquitously expressed in hematopoietic cells.

1989 • 514 citations

Regulatory and Signaling Properties of the Vav Family

2000 • 513 citations

Signal transduction by the TCR for antigen

2000 • 505 citations

Phospholipase Cγ2 Is Essential in the Functions of B Cell and Several Fc Receptors

2000 • 473 citations

Rho Family GTPases Bind to Phosphoinositide Kinases

1995 • 469 citations

Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor

1998 • 420 citations

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav

1995 • 411 citations

Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction

1998 • 403 citations

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

1995 • 401 citations

Requirement for Tec Kinases Rlk and Itk in T Cell Receptor Signaling and Immunity

1999 • 399 citations

Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85.

1994 • 392 citations

Association of Grb2, Gads, and Phospholipase C-γ1 with Phosphorylated LAT Tyrosine Residues

2000 • 384 citations

Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs

1992 • 361 citations

Vav and SLP-76 Interact and Functionally Cooperate in IL-2 Gene Activation

1996 • 335 citations

The hematopoietic-specific adaptor protein Gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors

1999 • 325 citations

Product of vav proto-oncogene defines a new class of tyrosine protein kinase substrates

1992 • 306 citations

Lck Regulates Vav Activation of Members of the Rho Family of GTPases

1997 • 305 citations

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+CDS+thymocytes

1995 • 300 citations

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1997 • 285 citations

Biochemical Interactions Integrating Itk with the T Cell Receptor-initiated Signaling Cascade

2000 • 278 citations

Regulatory intramolecular association in a tyrosine kinase of the Tec family

1997 • 274 citations

Proteolysis-independent regulation of PI3K by Cbl-b–mediated ubiquitination in T cells

2001 • 274 citations

Biological and Regulatory Properties of Vav-3, a New Member of the Vav Family of Oncoproteins

1999 • 268 citations

Phosphorylation-dependent and constitutive activation of Rho proteins by wild-type and oncogenic Vav-2

1998 • 265 citations

The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-κB pathways

1999 • 239 citations

Tyrosine Phosphorylation of the vav Proto-Oncogene Product in Activated B Cells

1992 • 195 citations

Identification of a Phospholipase C-γ1 (PLC-γ1) SH3 Domain-Binding Site in SLP-76 Required for T-Cell Receptor-Mediated Activation of PLC-γ1 and NFAT

2001 • 194 citations

p95vav associates with tyrosine-phosphorylated SLP-76 in antigen-stimulated T cells.

1996 • 194 citations

Rac GTPase interacts specifically with phosphatidylinositol 3-kinase

1996 • 186 citations

CD19 as a Membrane-Anchored Adaptor Protein of B Lymphocytes: Costimulation of Lipid and Protein Kinases by Recruitment of Vav

1998 • 179 citations

A Functional T-Cell Receptor Signaling Pathway Is Required for p95^vav Activity

1995 • 173 citations

Sensory Adaptation in Naive Peripheral CD4 T Cells

2001 • 163 citations

Vav1 Regulates Phospholipase Cγ Activation and Calcium Responses in Mast Cells

2001 • 156 citations

Cutting Edge: Essential Role of Phospholipase C-γ2 in B Cell Development and Function

2000 • 153 citations

Grf40, A Novel Grb2 Family Member, Is Involved in T Cell Signaling through Interaction with SLP-76 and LAT

1999 • 147 citations

Isolation and characterization of murine vav2, a member of the vav family of proto-oncogenes.

1996 • 143 citations

Vav3 Modulates B Cell Receptor Responses by Regulating Phosphoinositide 3-Kinase Activation

2002 • 143 citations

The T-Cell Receptor Regulates Akt (Protein Kinase B) via a Pathway Involving Rac1 and Phosphatidylinositide 3-Kinase

2000 • 119 citations

The vav exchange factor is an essential regulator in actin-dependent receptor translocation to the lymphocyte–antigen-presenting cell interface

2000 • 117 citations

Dynamic Tuning of T Cell Reactivity by Self-Peptide–Major Histocompatibility Complex Ligands

2001 • 114 citations

Vav Regulates Peptide-specific Apoptosis in Thymocytes

1998 • 104 citations

Tec kinases: modulators of lymphocyte signaling and development

2001 • 100 citations

Differential Regulation of Activation-induced Tyrosine Phosphorylation and Recruitment of SLP-76 to Vav by Distinct Isoforms of the CD45 Protein-tyrosine Phosphatase

1996 • 95 citations

Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain.

1995 • 90 citations

Adapters in lymphocyte signalling

2001 • 82 citations

Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1

1995 • 80 citations

Tec Kinase Signaling in T Cells Is Regulated by Phosphatidylinositol 3-Kinase and the Tec Pleckstrin Homology Domain

2001 • 78 citations

Altered peptide ligands induce quantitatively but not qualitatively different intracellular signals in primary thymocytes

1998 • 71 citations

Emt/Itk Associates with Activated TCR Complexes: Role of the Pleckstrin Homology Domain

1999 • 66 citations

Vav binds to several SH2/SH3 containing proteins in activated lymphocytes.

1994 • 65 citations

The amino-terminal Src homology 2 domain of phospholipase C gamma 1 is essential for TCR-induced tyrosine phosphorylation of phospholipase C gamma 1.

1998 • 58 citations

Role of the vav Proto-oncogene Product (Vav) in Erythropoietin-mediated Cell Proliferation and Phosphatidylinositol 3-Kinase Activity

1997 • 55 citations

The Amino-Terminal Src Homology 2 Domain of Phospholipase Cγ1 Is Essential for TCR-Induced Tyrosine Phosphorylation of Phospholipase Cγ1

1998 • 51 citations

Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk.

2001 • 47 citations