Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice

Cellular survival: a play in three Akts

1999 • 4,229 citations

Mast cells

1997 • 1,636 citations

Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

1996 • 1,121 citations

THE HIGH-AFFINITY I<scp>g</scp>E RECEPTOR (FcεRI): From Physiology to Pathology

1999 • 949 citations

Critical protective role of mast cells in a model of acute septic peritonitis

1996 • 942 citations

Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation

1978 • 846 citations

Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase

1991 • 785 citations

The kit Ligand, Stem Cell Factor

1993 • 653 citations

CYTOKINE REGULATION OF HOST DEFENSE AGAINST PARASITIC GASTROINTESTINAL NEMATODES:Lessons from Studies with Rodent Models^*

1997 • 648 citations

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

1991 • 641 citations

Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation

1978 • 634 citations

cDNA cloning of a Novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF β-receptor

1991 • 585 citations

IL-13, IL-4Rα, and Stat6 Are Required for the Expulsion of the Gastrointestinal Nematode Parasite Nippostrongylus brasiliensis

1998 • 582 citations

Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites

1998 • 568 citations

Phosphoinositide kinases

1996 • 529 citations

Mast cells and basophils

2000 • 527 citations

Interleukin 10: a novel stimulatory factor for mast cells and their progenitors.

1991 • 514 citations

Fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell-deficient W/Wv mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells.

1985 • 503 citations

Abnormal mast cells in mice deficient in a heparin-synthesizing enzyme

1999 • 478 citations

Xid -Like Immunodeficiency in Mice with Disruption of the p85α Subunit of Phosphoinositide 3-Kinase

1999 • 465 citations

IgE Enhances Mouse Mast Cell FcεRI Expression In Vitro and In Vivo: Evidence for a Novel Amplification Mechanism in IgE-dependent Reactions

1997 • 448 citations

Cytokine-mediated regulation of chronic intestinal helminth infection.

1994 • 425 citations

Induction of mast cell proliferation, maturation, and heparin synthesis by the rat c-kit ligand, stem cell factor.

1991 • 424 citations

Heparin is essential for the storage of specific granule proteases in mast cells

1999 • 422 citations

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase

1999 • 396 citations

Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor α chain gene

1993 • 395 citations

Identification of a Committed Precursor for the Mast Cell Lineage

1996 • 379 citations

Point mutation in Kit receptor tyrosine kinase reveals essential roles for Kit signaling in spermatogenesis and oogenesis without affecting other Kit responses

2000 • 341 citations

Anaphylaxis

1991 • 320 citations

Delayed Expulsion of the Nematode Trichinella spiralisIn Mice Lacking the Mucosal Mast Cell–Specific Granule Chymase, Mouse Mast Cell Protease-1

2000 • 304 citations

Effects of interleukin 12 on immune responses and host protection in mice infected with intestinal nematode parasites.

1994 • 281 citations

Kit signaling through PI 3-kinase and Src kinase pathways: an essential role for Rac1 and JNK activation in mast cell proliferation

1998 • 271 citations

Mast cells that reside at different locations in the jejunum of mice infected with Trichinella spiralis exhibit sequential changes in their granule ultrastructure and chymase phenotype.

1996 • 230 citations

The Diverse Roles of Mast Cells

2001 • 215 citations

Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase

1992 • 210 citations

Different mouse mast cell populations express various combinations of at least six distinct mast cell serine proteases.

1990 • 210 citations

Genetically mast-cell-deficient W/Wv and Sl/Sld mice. Their value for the analysis of the roles of mast cells in biologic responses in vivo.

1987 • 206 citations

IL-3-dependent murine mast cells undergo apoptosis on removal of IL-3. Prevention of apoptosis by c-kit ligand.

1993 • 195 citations

Inducible Expression of Stat4 in Dendritic Cells and Macrophages and Its Critical Role in Innate and Adaptive Immune Responses

2001 • 187 citations

Granulocyte-macrophage colony-stimulating factor, interleukin-3, and steel factor induce rapid tyrosine phosphorylation of p42 and p44 MAP kinase

1992 • 176 citations

Hemopoietic Growth Factors with the Exception of Interleukin-4 Activate the p38 Mitogen-activated Protein Kinase Pathway

1997 • 172 citations

Selective effector mechanisms for the expulsion of intestinal helminths

1994 • 155 citations

Intraepithelial Infiltration by Mast Cells with Both Connective Tissue-Type and Mucosal-Type Characteristics in Gut, Trachea, and Kidneys of IL-9 Transgenic Mice

1998 • 137 citations

IL-10 induces transcription of the gene for mouse mast cell protease-1, a serine protease preferentially expressed in mucosal mast cells of Trichinella spiralis-infected mice.

1992 • 114 citations

Role of common cytokine receptor γ chain (γc)– and Jak3-dependent signaling in the proliferation and survival of murine mast cells

2000 • 108 citations

MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells

2000 • 105 citations

Role of mast cells in anaphylaxis. Evidence for the importance of mast cells in the cardiopulmonary alterations and death induced by anti-IgE in mice.

1989 • 98 citations

Transcriptional regulation of the mucosal mast cell-specific protease gene, MMCP-2, by interleukin 10 and interleukin 3.

1992 • 97 citations

Impaired Kit- but Not FcεRI-initiated Mast Cell Activation in the Absence of Phosphoinositide 3-Kinase p85α Gene Products

2000 • 87 citations

24. Animal Models for Human Disease

2019 • 86 citations

Mucosal mast cells and the expulsive mechanisms of mice against Strongyloides venezuelensis

1993 • 84 citations

Critical Role for Signal Transducer and Activator of Transcription Factor 6 in Mediating Intestinal Muscle Hypercontractility and Worm Expulsion inTrichinella spiralis-Infected Mice

2001 • 81 citations

Reversible expression of mouse mast cell protease 2 mRNA and protein in cultured mast cells exposed to IL-10.

1993 • 80 citations

Anaphylaxis in Mast Cell-Deficient Mice

1984 • 70 citations

The role of Th2 cytokines in mast cell homeostasis

2001 • 62 citations

Mast Cell and Basophil Development

2001 • 61 citations

Differences in the expression of the cardiopulmonary alterations associated with anti-immunoglobulin E-induced or active anaphylaxis in mast cell-deficient and normal mice. Mast cells are not required for the cardiopulmonary changes associated with certain fatal anaphylactic responses.

1991 • 53 citations

Differential responsiveness of purified mouse c-kit+ mast cells and their progenitors to IL-3 and stem cell factor.

1995 • 44 citations

Reconstitution of mucosal mast cells in W/W^vmice by adoptive transfer of bone marrow-derived cultured mast cells and its effects on the protective capacity to Strongyloides ratti-infection

1987 • 35 citations

Effects of spleen cells and serum on transfer of immunity to Strongyloides venezuelensis infection in hypothymic (nude) mice

1990 • 26 citations

Intestinal mast cell response and mucosal defence against Strongyloides venezuelensis in interleukin‐3‐hyporesponsive mice

1998 • 18 citations

Kinetic study of mast-cell growth factor production by lymphocytes during the course of Strongyloides ratti infection in mice

1988 • 14 citations

Deleted Work

1955 • 0 citations