PI3K in lymphocyte development, differentiation and activation

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

1994 • 3,249 citations

Three-dimensional segregation of supramolecular activation clusters in T cells

1998 • 2,316 citations

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1999 • 1,972 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

The lineage decisions of helper T cells

2002 • 1,678 citations

The B7–CD28 superfamily

2002 • 1,646 citations

The PI3K–PDK1 connection: more than just a road to PKB

2000 • 1,563 citations

Synthesis and Function of 3-Phosphorylated Inositol Lipids

2001 • 1,527 citations

The CD28 Signaling Pathway Regulates Glucose Metabolism

2002 • 1,331 citations

LAT

1998 • 1,251 citations

CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

1995 • 1,212 citations

Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation

2000 • 1,209 citations

Regulatory T cells in the control of immune pathology

2001 • 1,197 citations

B Cell Development Pathways

2001 • 1,185 citations

Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses

1993 • 1,148 citations

Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

2000 • 1,031 citations

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1988 • 1,027 citations

T Lymphocyte Costimulation Mediated by Reorganization of Membrane Microdomains

1999 • 964 citations

Phosphoinositide 3-kinases: A conserved family of signal transducers

1997 • 944 citations

Membrane Compartmentation Is Required for Efficient T Cell Activation

1998 • 925 citations

Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice

2002 • 910 citations

Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

2000 • 825 citations

Role of Substrates and Products of PI 3-kinase in Regulating Activation of Rac-Related Guanosine Triphosphatases by Vav

1998 • 798 citations

Signal-dependent membrane targeting by pleckstrin homology (PH) domains

2000 • 692 citations

CD19: Lowering the Threshold for Antigen Receptor Stimulation of B Lymphocytes

1992 • 673 citations

Toll-like receptor 2–mediated NF-κB activation requires a Rac1-dependent pathway

2000 • 663 citations

Impairment of T-cell-dependent B-cell responses and B-l cell development in CD19-deficient mice

1995 • 663 citations

Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α

1999 • 642 citations

Activation of the Sire-family tyrosine kinase Hck by SH3 domain displacement

1997 • 601 citations

PTEN: a tumour suppressor that functions as a phospholipid phosphatase

1999 • 592 citations

Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways

2002 • 584 citations

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

2001 • 575 citations

TOR signalling in bugs, brain and brawn

2003 • 568 citations

Targeted disruption ofSHIPleads to hemopoietic perturbations, lung pathology, and a shortened life span

1998 • 566 citations

The Gβγ Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor, p101

1997 • 549 citations

T Cell Memory

2002 • 529 citations

Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities

2000 • 515 citations

Impaired Fas Response and Autoimmunity in Pten ^+/− Mice

1999 • 512 citations

Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit

1998 • 508 citations

The role of phosphoinositides in membrane transport

2001 • 482 citations

Rho Family GTPases Bind to Phosphoinositide Kinases

1995 • 469 citations

Xid -Like Immunodeficiency in Mice with Disruption of the p85α Subunit of Phosphoinositide 3-Kinase

1999 • 465 citations

Activation of BTK by a Phosphorylation Mechanism Initiated by SRC Family Kinases

1996 • 445 citations

Proliferative Defect and Embryonic Lethality in Mice Homozygous for a Deletion in the p110α Subunit of Phosphoinositide 3-Kinase

1999 • 442 citations

A Crucial Role for the p110δ Subunit of Phosphatidylinositol 3-Kinase in B Cell Development and Activation

2002 • 440 citations

Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals

1998 • 436 citations

Requirement for Tec Kinases Rlk and Itk in T Cell Receptor Signaling and Immunity

1999 • 399 citations

Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities

2000 • 398 citations

SHIP Modulates Immune Receptor Responses by Regulating Membrane Association of Btk

1998 • 397 citations

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase

1999 • 396 citations

Activation of phosphoinositide 3-kinase activity by Cdc42Hs binding to p85.

1994 • 392 citations

Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

2002 • 390 citations

Binding of phosphatidyl-inositol-3-OH kinase to CD28 is required for T-cell signalling

1994 • 378 citations

Essential Role of Phosphoinositide 3-Kinase δ in Neutrophil Directional Movement

2003 • 364 citations

Essential, Nonredundant Role for the Phosphoinositide 3-Kinase p110δ in Signaling by the B-Cell Receptor Complex

2002 • 355 citations

Positive Selection from Newly Formed to Marginal Zone B Cells Depends on the Rate of Clonal Production, CD19, and btk

2000 • 349 citations

Protein Kinase B Regulates T Lymphocyte Survival, Nuclear Factor κb Activation, and Bcl-XL Levels in Vivo

2000 • 339 citations

T Cell Receptor–initiated Calcium Release Is Uncoupled from Capacitative Calcium Entry in Itk-deficient T Cells

1998 • 336 citations

The Follicular versus Marginal Zone B Lymphocyte Cell Fate Decision Is Regulated by Aiolos, Btk, and CD21

2001 • 335 citations

Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast

1998 • 328 citations

Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-γ but not TH2 cytokines

2001 • 322 citations

VAV proteins as signal integrators for multi-subunit immune-recognition receptors

2002 • 321 citations

Regulation of Btk Function by a Major Autophosphorylation Site Within the SH3 Domain

1996 • 321 citations

CD19 of B Cells as a Surrogate Kinase Insert Region to Bind Phosphatidylinositol 3-Kinase

1993 • 320 citations

Early embryonic lethality in mice deficient in the p110β catalytic subunit of PI 3-kinase

2002 • 316 citations

Impaired NFATc Translocation and Failure of Th2 Development in Itk-Deficient CD4+ T Cells

1999 • 307 citations

Phosphoinositide 3-Kinase γ Is an Essential Amplifier of Mast Cell Function

2002 • 293 citations

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α

2000 • 291 citations

T-cell antigen CD28 interacts with the lipid kinase phosphatidylinositol 3-kinase by a cytoplasmic Tyr(P)-Met-Xaa-Met motif.

1994 • 291 citations

Molecular Balance between the Regulatory and Catalytic Subunits of Phosphoinositide 3-Kinase Regulates Cell Signaling and Survival

2002 • 284 citations

Regulatory intramolecular association in a tyrosine kinase of the Tec family

1997 • 274 citations

BCAP

2000 • 271 citations

Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation.

1994 • 257 citations

Role of the Pi3k Regulatory Subunit in the Control of Actin Organization and Cell Migration

2000 • 245 citations

Critical Roles of Pten in B Cell Homeostasis and Immunoglobulin Class Switch Recombination

2003 • 234 citations

Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase

2001 • 229 citations

Regulation of Lck activity by CD4 and CD28 in the immunological synapse

2002 • 225 citations

PtdIns-3,4,5-P3

1998 • 220 citations

Vav1 Transduces T Cell Receptor Signals to the Activation of Phospholipase C-γ1 via Phosphoinositide 3-Kinase-dependent and -independent Pathways

2002 • 214 citations

Sustained and dynamic inositol lipid metabolism inside and outside the immunological synapse

2002 • 212 citations

The Inositol Polyphosphate 5-Phosphatase Ship Is a Crucial Negative Regulator of B Cell Antigen Receptor Signaling

1998 • 212 citations

A point mutation in CD28 distinguishes proliferative signals from survival signals

2001 • 210 citations

Regulation of B-cell signal transduction by adaptor proteins

2002 • 208 citations

Living with Lethal PIP3 Levels: Viability of Flies Lacking PTEN Restored by a PH Domain Mutation in Akt/PKB

2002 • 202 citations

Resistance to thromboembolism in PI3Kγ‐deficient mice

2001 • 202 citations

Xid-like Phenotypes

2000 • 195 citations

Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function

2003 • 194 citations

PI3-kinase inhibition: a target for drug development?

2000 • 194 citations

PI 3-kinase: a pivotal pathway in T-cell activation?

1996 • 188 citations

It's all Rel-ative: NF-κB and CD28 costimulation of T-cell activation

2002 • 183 citations

Stimulation of CD28 triggers an association between CD28 and phosphatidylinositol 3-kinase in Jurkat T cells.

1994 • 183 citations

Btk function in B cell development and response

1998 • 181 citations

Proline Residues in Cd28 and the Src Homology (Sh)3 Domain of Lck Are Required for T Cell Costimulation

1999 • 180 citations

Increased phosphoinositide 3‐kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo

2000 • 178 citations

Mutation of Tec family kinases alters T helper cell differentiation

2001 • 174 citations

Imaging antigen-induced PI3K activation in T cells

2002 • 159 citations

Cutting Edge: Distinct Motifs Within CD28 Regulate T Cell Proliferation and Induction of Bcl-XL

2001 • 153 citations

Nonradioactive methods for the assay of phosphoinositide 3-kinases and phosphoinositide phosphatases and selective detection of signaling lipids in cell and tissue extracts

2003 • 150 citations

Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta.

2003 • 145 citations

Vav3 Modulates B Cell Receptor Responses by Regulating Phosphoinositide 3-Kinase Activation

2002 • 143 citations

PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction

2003 • 135 citations

Regulation of B‐cell activation and differentiation by the phosphatidylinositol 3‐kinase and phospholipase Cγ pathways

2000 • 134 citations

The Physiologic Role of CD19 Cytoplasmic Tyrosines

2002 • 131 citations

PI 3-K and T-cell activation: limitations of T-leukemic cell lines as signaling models

2001 • 129 citations

T Cell Receptor (TCR) Interacting Molecule (TRIM), A Novel Disulfide-linked Dimer Associated with the TCR–CD3–ζ Complex, Recruits Intracellular Signaling Proteins to the Plasma Membrane

1998 • 129 citations

Growth Factor Receptor-bound Protein 2 SH2/SH3 Domain Binding to CD28 and Its Role in Co-signaling

1998 • 127 citations

Differential Regulation of B Cell Development, Activation, and Death by the Src Homology 2 Domain–Containing 5′ Inositol Phosphatase (Ship)

2000 • 126 citations

CD19 Function in Early and Late B Cell Development: I. Maintenance of Follicular and Marginal Zone B Cells Requires CD19-Dependent Survival Signals

2003 • 126 citations

A requirement for lipid rafts in B cell receptor induced Ca 2+ flux

2000 • 125 citations

Selective CD28pYMNM mutations implicate phosphatidylinositol 3-kinase in CD86-CD28-mediated costimulation

1995 • 124 citations

The Dynamics of Protein Kinase B Regulation during B Cell Antigen Receptor Engagement

1999 • 124 citations

Essential Immunoregulatory Role for BCAP in B Cell Development and Function

2002 • 123 citations

A Positive Regulatory Role for Cbl Family Proteins in Tumor Necrosis Factor-related Activation-induced Cytokine (TRANCE) and CD40L-mediated Akt Activation

2001 • 123 citations

Ligation of CD28 receptor by B7 induces formation of D‐3 phosphoinositides in T lymphocytes independently of T cell receptor/CD3 activation

1993 • 121 citations

The T-Cell Receptor Regulates Akt (Protein Kinase B) via a Pathway Involving Rac1 and Phosphatidylinositide 3-Kinase

2000 • 119 citations

Evidence That SHIP-1 Contributes to Phosphatidylinositol 3,4,5-Trisphosphate Metabolism in T Lymphocytes and Can Regulate Novel Phosphoinositide 3-Kinase Effectors

2002 • 118 citations

CD19-dependent Activation of Akt Kinase in B-lymphocytes

2001 • 116 citations

TAPP1 and TAPP2 Are Targets of Phosphatidylinositol 3-Kinase Signaling in B Cells: Sustained Plasma Membrane Recruitment Triggered by the B-Cell Antigen Receptor

2002 • 115 citations

Phosphoinositide 3-kinases in T lymphocyte activation

2001 • 111 citations

Tec family kinases in lymphocyte signaling and function

2000 • 103 citations

Critical Requirement for the Membrane-Proximal Cytosolic Tyrosine Residue for CD28-Mediated Costimulation In Vivo

2001 • 97 citations

A Novel B Lymphocyte–Associated Adaptor Protein, Bam32, Regulates Antigen Receptor Signaling Downstream of Phosphatidylinositol 3-Kinase

2000 • 94 citations

The SH3 domain of Itk/Emt binds to proline-rich sequences in the cytoplasmic domain of the T cell costimulatory receptor CD28.

1997 • 88 citations

Impaired Kit- but Not FcεRI-initiated Mast Cell Activation in the Absence of Phosphoinositide 3-Kinase p85α Gene Products

2000 • 87 citations

A PI3-Kinase Signaling Code for Insulin-Triggered Insertion of Glucose Transporters into the Plasma Membrane

2002 • 86 citations

Both phosphatidylinositol 3-kinase and phosphatidylinositol 4-kinase products are increased by antigen receptor signaling in B cells.

1994 • 84 citations

Phosphatidylinositol 3-Kinase and NF-κB/Rel Are at the Divergence of CD40-Mediated Proliferation and Survival Pathways

2000 • 83 citations

Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes

2001 • 79 citations

Phosphoinositide 3-Kinase Regulation of T Cell Receptor-mediated Interleukin-2 Gene Expression in Normal T Cells

1998 • 70 citations

Grb2 Forms an Inducible Protein Complex with CD28 through a Src Homology 3 Domain-Proline Interaction

1998 • 69 citations

PI3K-signalling in B- and T-cells: insights from gene-targeted mice

2003 • 66 citations

Loss of Phosphatidylinositol 3-Phosphate Binding by the C-terminal Tiam-1 Pleckstrin Homology Domain Prevents in Vivo Rac1 Activation without Affecting Membrane Targeting

2003 • 65 citations

FcγRIIb Modulation of Surface Immunoglobulin-induced Akt Activation in Murine B Cells

1999 • 64 citations

Two Distinct Intracytoplasmic Regions of the T-cell Adhesion Molecule CD28 Participate in Phosphatidylinositol 3-Kinase Association

1996 • 63 citations

Targets of B‐cell antigen receptor signaling: the phosphatidylinositol 3‐kinase/Akt/glycogen synthase kinase‐3 signaling pathway and the Rap1 GTPase

2000 • 59 citations

Expression of Bcl-XL Restores Cell Survival, but Not Proliferation and Effector Differentiation, in Cd28-Deficient T Lymphocytes

2000 • 59 citations

Tyrosine phosphorylation of B-cell adaptor for phosphoinositide 3-kinase is required for Akt activation in response to CD19 engagement

2002 • 59 citations

The B Lymphocyte Adaptor Molecule of 32 kD (Bam32) Regulates B Cell Antigen Receptor Signaling and Cell Survival

2002 • 59 citations

Wortmannin, a phosphatidylinositol 3-kinase inhibitor, blocks antigen-mediated, but not CD3 monoclonal antibody-induced, activation of murine CD4+ T cells.

1997 • 53 citations

Phosphoinositide 3-Kinases in Inunimity: Lessons from Knockout Mice

2002 • 52 citations

Itk Negatively Regulates Induction of T Cell Proliferation by CD28 Costimulation

1997 • 52 citations

In situdetection of activated Bruton’s tyrosine kinase in the Ig signaling complex by phosphopeptide-specific monoclonal antibodies

1999 • 48 citations

Complementary Roles for CD19 and Bruton’s Tyrosine Kinase in B Lymphocyte Signal Transduction

2002 • 47 citations

Requirements for activation and RAFT localization of the T-lymphocyte kinase Rlk/Txk.

2001 • 47 citations

Phosphatidylinositol 3-Kinase p85 Adaptor Function in T-cells

2002 • 40 citations

Antigen-receptor cross-linking and lipopolysaccharide trigger distinct phosphoinositide 3-kinase-dependent pathways to NF-κB activation in primary B cells

2001 • 40 citations

Acute pathological effects on rats of orally administered wortmannin-containing preparations and purified wortmannin from Fusarium oxysporum

1989 • 33 citations

Critical Role of the Pleckstrin Homology and Cysteine-rich Domains in Vav Signaling and Transforming Activity

2002 • 28 citations

Immunosuppressive Effects of Dietary Wortmannin on Rats and Mice

1989 • 21 citations

Requirement for CD28 co-stimulation is lower in SHP-1-deficient T cells

2001 • 21 citations

FcγRIIB-mediated inhibition of T-cell receptor signal transduction involves the phosphorylation of SH2-containing inositol 5-phosphatase (SHIP), dephosphorylation of the linker of activated T-cells (LAT) and inhibition of calcium mobilization

2001 • 19 citations

Evidence for phosphatidylinositol 3-kinase-dependent T cell antigen receptor (TCR) signal transduction

1997 • 14 citations