PI3K and negative regulation of TLR signaling

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

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1998 • 1,253 citations

IRAK-M Is a Negative Regulator of Toll-like Receptor Signaling

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Central Role for G Protein-Coupled Phosphoinositide 3-Kinase γ in Inflammation

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Dendritic cell regulation of TH1-TH2 development

2000 • 1,136 citations

Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration

2000 • 1,031 citations

Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice

2002 • 910 citations

Roles of PLC-β2 and -β3 and PI3Kγ in Chemoattractant-Mediated Signal Transduction

2000 • 825 citations

The Phosphatidylinositol 3-Kinase-Akt Pathway Limits Lipopolysaccharide Activation of Signaling Pathways and Expression of Inflammatory Mediators in Human Monocytic Cells

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Cutting Edge: Endotoxin Tolerance in Mouse Peritoneal Macrophages Correlates with Down-Regulation of Surface Toll-Like Receptor 4 Expression

2000 • 772 citations

Akt Phosphorylates and Negatively Regulates Apoptosis Signal-Regulating Kinase 1

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Dendritic Cells in Cancer Immunotherapy

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Toll-like Receptor 2 (TLR2) and TLR4 Differentially Activate Human Dendritic Cells

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Toll-like receptor 2–mediated NF-κB activation requires a Rac1-dependent pathway

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Activation of Phosphatidylinositol 3-Kinase in Response to Interleukin-1 Leads to Phosphorylation and Activation of the NF-κB p65/RelA Subunit

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SOCS-1 Participates in Negative Regulation of LPS Responses

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SOCS1/JAB Is a Negative Regulator of LPS-Induced Macrophage Activation

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TRANCE, a TNF Family Member, Activates Akt/PKB through a Signaling Complex Involving TRAF6 and c-Src

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CD4+ T-cell subsets in autoimmunity

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Signal transduction via CD40 involves activation of lyn kinase and phosphatidylinositol-3-kinase, and phosphorylation of phospholipase C gamma 2.

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Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice

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PI3-kinase inhibition: a target for drug development?

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TAK1 regulates multiple protein kinase cascades activated by bacterial lipopolysaccharide

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Differential roles of Toll-like receptors in the elicitation of proinflammatory responses by macrophages

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Phosphatidylinositol 3-Kinase-dependent Activation of Protein Kinase C-ζ in Bacterial Lipopolysaccharide-treated Human Monocytes

1997 • 139 citations

Potential Role of Phosphatidylinositol 3 Kinase, rather than DNA-dependent Protein Kinase, in CpG DNA–induced Immune Activation

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Negative regulation by phosphatidylinositol 3-kinase of inducible nitric oxide synthase expression in macrophages.

1999 • 123 citations

Wortmannin, a Specific Inhibitor of Phosphatidylinositol-3-kinase, Enhances LPS-Induced NO Production from Murine Peritoneal Macrophages

1997 • 108 citations

Negative Regulation by Phosphatidylinositol 3-Kinase of Inducible Nitric Oxide Synthase Expression in Macrophages

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Cutting Edge: CpG DNA Inhibits Dendritic Cell Apoptosis by Up-Regulating Cellular Inhibitor of Apoptosis Proteins Through the Phosphatidylinositide-3′-OH Kinase Pathway

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Phosphatidylinositol 3-Kinase Activity Negatively Regulates Stability of Cyclooxygenase 2 mRNA

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Tolerance to Pyrogens

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Endotoxin Tolerance in Mouse Peritoneal Macrophages Correlates with Down-Regulation of Surface Toll-Like Receptor 4 Expression

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A Novel Function of Phosphorothioate Oligodeoxynucleotides as Chemoattractants for Primary Macrophages

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Inhibition of Phosphatidylinositol-3′-kinase Prevents Induction of Endotoxin Tolerancein Vitro

1996 • 19 citations