Novel Function of Phosphoinositide 3-Kinase in T Cell Ca2+ Signaling

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 3,053 citations

A model for receptor-regulated calcium entry

1986 • 2,535 citations

LAT

1998 • 1,251 citations

The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function

1999 • 1,007 citations

Isolation of an organ specific protein antigen from cell-surface membrane rat liver

1968 • 883 citations

Micro-injection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+

1986 • 775 citations

Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores.

1993 • 752 citations

Ion channels activated by inositol 1,4,5-trisphosphate in plasma membrane of human T-lymphocytes

1987 • 676 citations

The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase.

1996 • 636 citations

Activation of Phospholipase C-γ by Phosphatidylinositol 3,4,5-Trisphosphate

1998 • 330 citations

PI 3-kinase: structural and functional analysis of intersubunit interactions.

1994 • 329 citations

Identification of a specific lns(l,3,4,5)P4-binding protein as a member of the GAP1 family

1995 • 294 citations

Polyphosphoinositides Produced by Phosphatidylinositol 3-Kinase Are Poor Substrates for Phospholipases C from Rat Liver and Bovine Brain

1989 • 238 citations

IP ₃ Receptor: Localization to Plasma Membrane of T Cells and Cocapping with the T Cell Receptor

1992 • 213 citations

The Lipid Products of Phosphoinositide 3-Kinase Increase Cell Motility through Protein Kinase C

1997 • 133 citations

T Cell Receptor (TCR) Interacting Molecule (TRIM), A Novel Disulfide-linked Dimer Associated with the TCR–CD3–ζ Complex, Recruits Intracellular Signaling Proteins to the Plasma Membrane

1998 • 129 citations

Activation of Ca2+ current in Jurkat T cells following the depletion of Ca2+ stores by microsomal Ca(2+)-ATPase inhibitors.

1994 • 123 citations

Plasma membrane inositol 1,4,5-trisphosphate receptor of lymphocytes: selective enrichment in sialic acid and unique binding specificity.

1992 • 120 citations

Inhibition by SK&F 96365 of Ca²⁺ current, IL‐2 production and activation in T lymphocytes

1994 • 111 citations

Regulation of D‐3 phosphoinositides during T cell activation via the T cell antigen receptor/CD3 complex and CD2 antigens

1992 • 103 citations

Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1 IP4BP and GAP1 m result from the GAP1 IP4BP PH domain directing plasma membrane targeting

1997 • 88 citations

Multiple roles for PI 3-kinase in the regulation of PLCγ activity and Ca2+ mobilization in antigen-stimulated mast cells

1999 • 78 citations

Failure of phosphatidic acid to translocate Ca2+ across phosphatidylcholine membranes

1983 • 75 citations

Phosphatidylinositol 3,4,5-trisphosphate is a substrate for the 75 kDa inositol polyphosphate 5-phosphatase and a novel 5-phosphatase which forms a complex with the p85/p110 form of phosphoinositide 3-kinase.

1995 • 73 citations

Inhibition of Phosphatidylinositol 3‐Kinase Blocks T Cell Antigen Receptor/CD3‐Induced Activation of the Mitogen‐Activated Kinase Erk2

1996 • 72 citations

Phosphoinositide 3-Kinase Regulation of T Cell Receptor-mediated Interleukin-2 Gene Expression in Normal T Cells

1998 • 70 citations

Fibroblasts Transformed with v- src Show Enhanced Formation of an Inositol Tetrakisphosphate

1989 • 67 citations

Ca2+ Signaling in T-Lymphocytes

1998 • 65 citations

Activation of protein kinase B and induction of adipogenesis by insulin in 3T3-L1 preadipocytes: contribution of phosphoinositide-3,4,5-trisphosphate versus phosphoinositide-3,4-bisphosphate.

1999 • 61 citations

Involvement of Phosphatidylinositol 3-Kinase in NFAT Activation in T Cells

1997 • 59 citations

Effect of Inositol 1,3,4,5-Tetrakisphosphate on Inositol Trisphosphate-activated Ca2⁺ Signaling in Mouse Lacrimal Acinar Cells

1996 • 56 citations

Tyrosine Phosphorylation of the CD3-ε Subunit of the T Cell Antigen Receptor Mediates Enhanced Association with Phosphatidylinositol 3-Kinase in Jurkat T Cells

1997 • 54 citations

Defective degranulation and calcium mobilization of bone-marrow derived mast cells from Xid and Btk-deficient mice

1998 • 43 citations

Synthesis of the D-3 Series of Phosphatidylinositol Phosphates

1996 • 43 citations

Purification and Biochemical Characterization of a Mammalian Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase

1995 • 41 citations

Molecular interactions of endogenous D-myo-inositol phosphates with the intracellular D-myo-inositol 1,4,5-trisphosphate recognition site

1994 • 40 citations

Phosphatidylinositol 3,4,5-Trisphosphate Triggers Platelet Aggregation by Activating Ca²⁺ Influx

1998 • 34 citations

Differential regulation of surface Ig- and Lyb2-mediated B cell activation by cyclic AMP. I. Evidence for alternative regulation of signaling through two different receptors linked to phosphatidylinositol hydrolysis in murine B cells.

1991 • 31 citations

9 Role of calcium in T-lymphocyte activation

1995 • 30 citations

Isolation of InsP4 and InsP6 binding proteins from human platelets: InsP4 promotes Ca2+ efflux from inside-out plasma membrane vesicles containing 104 kDa GAP1IP4BP protein

1996 • 30 citations

Inositol 1,3,4,5-tetrakisphosphate and Ca2+ homoeostasis: the role of GAPIIP4BP

1997 • 27 citations

Adriamycin inhibits inositol 1,4,5-trisphosphate 3-kinase activity in vitro and blocks formation of inositol 1,3,4,5-tetrakisphosphate in stimulated Jurkat T-lymphocytes. Does inositol 1,3,4,5-tetrakisphosphate play a role in Ca(2+)-entry?

1994 • 24 citations

Identification of Multiple Phosphoinositide-specific Phospholipases D as New Regulatory Enzymes for Phosphatidylinositol 3,4,5-Trisphosphate

1999 • 24 citations

Distinct Mechanisms for Ca2+ Entry Induced by OKT3 and Ca2+ Depletion in Jurkat T Cells

1995 • 16 citations

Inositol tetrakisphosphates as second messengers induce Ca++-dependent chloride currents in Xenopus laevis oocytes

1991 • 7 citations