Rac2 Stimulates Akt Activation Affecting BAD/Bcl-XL Expression while Mediating Survival and Actin Function in Primary Mast Cells

Rho GTPases and the Actin Cytoskeleton

1998 • 6,129 citations

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

The small GTP-binding protein rac regulates growth factor-induced membrane ruffling

1992 • 3,628 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

1998 • 2,496 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G ₁

1995 • 1,142 citations

Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

1996 • 1,121 citations

A safe packaging line for gene transfer: separating viral genes on two different plasmids

1988 • 1,118 citations

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1997 • 1,075 citations

Antiapoptotic Signalling by the Insulin-Like Growth Factor I Receptor, Phosphatidylinositol 3-Kinase, and Akt

1997 • 1,051 citations

Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1

1991 • 961 citations

An essential role for Rac in Ras transformation

1995 • 895 citations

Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

1985 • 813 citations

Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases

1999 • 765 citations

Multiple ras functions can contribute to mammalian cell transformation

1995 • 658 citations

Inhibition of Myosin Light Chain Kinase by p21-Activated Kinase

1999 • 592 citations

rac, a novel ras-related family of proteins that are botulinum toxin substrates

1989 • 585 citations

Increasing Complexity of the Ras Signaling Pathway

1998 • 585 citations

Rac and Cdc42 Induce Actin Polymerization and G1 Cell Cycle Progression Independently of p65PAK and the JNK/SAPK MAP Kinase Cascade

1996 • 571 citations

Deficiency of the Hematopoietic Cell-Specific Rho Family GTPase Rac2 Is Characterized by Abnormalities in Neutrophil Function and Host Defense

1999 • 568 citations

Rho GTPases

1998 • 534 citations

Transduction of interleukin-2 antiapoptotic and proliferative signals via Akt protein kinase

1997 • 534 citations

Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation

2000 • 476 citations

Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes

1997 • 445 citations

Membrane Localization of Phosphatidylinositol 3-Kinase Is Sufficient To Activate Multiple Signal-Transducing Kinase Pathways

1996 • 443 citations

Activation of the small GTP-binding proteins rho and rac by growth factor receptors

1995 • 437 citations

Rac Regulation of Transformation, Gene Expression, and Actin Organization by Multiple, PAK-Independent Pathways

1997 • 433 citations

GATA-1 and Erythropoietin Cooperate to Promote Erythroid Cell Survival by Regulating bcl-xL Expression

1999 • 364 citations

Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency.

2000 • 335 citations

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1997 • 285 citations

The c-kit receptor ligand functions as a mast cell chemoattractant

1992 • 281 citations

Gelsolin is a downstream effector of rac for fibroblast motility

1998 • 267 citations

Rho family members: Activators of MAP kinase cascades

1995 • 253 citations

Characterization of RAC3, a Novel Member of the Rho Family

1997 • 240 citations

Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells.

1995 • 237 citations

Pheromone signalling and polarized morphogenesis in yeast

1997 • 221 citations

The c-kit receptor ligand functions as a mast cell chemoattractant

1992 • 217 citations

Stem cell factor induces mast cell adhesion to fibronectin.

1994 • 205 citations

Coupling of Jun amino-terminal kinase and Decapentaplegic signaling pathways in Drosophila morphogenesis.

1997 • 200 citations

Signaling Functions of L-selectin

1995 • 190 citations

A Rac1 Effector Site Controlling Mitogenesis through Superoxide Production

1998 • 187 citations

Bcl-Xl– and Bax-–Mediated Regulation of Apoptosis of Human Neutrophils Via Caspase-3

1999 • 174 citations

Phosphoinositide 3-Kinase-dependent and -independent Activation of the Small GTPase Rac2 in Human Neutrophils

1999 • 172 citations

VLA-5 is expressed by mouse and human long-term repopulating hematopoietic cells and mediates adhesion to extracellular matrix protein fibronectin.

1998 • 170 citations

Role of the Guanosine Triphosphatase Rac2 in T Helper 1 Cell Differentiation

2000 • 170 citations

Regulation of mouse peritoneal mast cell secretory function by stem cell factor, IL-3 or IL-4.

1993 • 154 citations

Role for Bcl-xL in Delayed Eosinophil Apoptosis Mediated by Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-5

1998 • 142 citations

Clonal origin of murine hemopoietic colonies with apparent restriction to granuclocyte‐macrophage‐megakaryocyte (GMM) differentiation

1982 • 128 citations

Rac GTPase interacts with GAPs and target proteins through multiple effector sites.

1995 • 126 citations

High-Efficiency Gene Transfer into Normal and Adenosine Deaminase-Deficient T Lymphocytes Is Mediated by Transduction on Recombinant Fibronectin Fragments

1998 • 124 citations

IgE antibody up-regulates high affinity IgE binding on murine bone marrow-derived mast cells

1996 • 119 citations

Membrane Association of Rac Is Required for High Activity of the Respiratory Burst Oxidase

1996 • 116 citations

c-kit receptor signaling through its phosphatidylinositide-3'-kinase-binding site and protein kinase C: role in mast cell enhancement of degranulation, adhesion, and membrane ruffling.

1997 • 114 citations

A member of the ras gene superfamily is expressed specifically in T, B and myeloid hemopoietic cells.

1990 • 108 citations

Bad Can Act as a Key Regulator of T Cell Apoptosis and T Cell Development

1999 • 107 citations

The Ets2 Transcription Factor Inhibits Apoptosis Induced by Colony-Stimulating Factor 1 Deprivation of Macrophages through a Bcl-x_L-Dependent Mechanism

1999 • 100 citations

Anti-apoptotic function of Rac in hematopoietic cells

1999 • 88 citations

The murine rac1 gene: cDNA cloning, tissue distribution and regulated expression of rac1 mRNA by disassembly of actin microfilaments.

1991 • 87 citations

Bcl-Xl– and Bax-–Mediated Regulation of Apoptosis of Human Neutrophils Via Caspase-3

1999 • 84 citations

PTPROt: An Alternatively Spliced and Developmentally Regulated B-Lymphoid Phosphatase That Promotes G0/G1 Arrest

1999 • 81 citations

Two Distinct Interleukin-3-Mediated Signal Pathways, Ras-NFIL3 (E4BP4) and Bcl-x_L, Regulate the Survival of Murine Pro-B Lymphocytes

1999 • 79 citations

Mast cell adhesion to fibronectin.

1991 • 77 citations

Enhanced apoptosis in the thymus of transgenic mice expressing constitutively activated forms of human Rac2GTPase

1997 • 71 citations

Purification and identification of FOAD-II, a cytosolic protein that regulates secretion in streptolysin-O permeabilized mast cells, as a rac/rhoGDI complex.

1996 • 58 citations

A hemopoietic specific gene encoding a small GTP binding protein is overexpressed during T cell activation

1991 • 50 citations

Interferon‐γ inhibits serotonin release from mouse peritoneal mast cells

1991 • 48 citations

Both Stat3-Activation and Stat3-Independent BCL2 Downregulation Are Important for Interleukin-6–Induced Apoptosis of 1A9-M Cells

1999 • 42 citations

Both Stat3-Activation and Stat3-Independent BCL2 Downregulation Are Important for Interleukin-6–Induced Apoptosis of 1A9-M Cells

1999 • 36 citations

Interleukin-11 mRNA Stabilization in Phorbol Ester-Stimulated Primate Bone Marrow Stromal Cells

1996 • 23 citations