Vav1 Regulates Phospholipase Cγ Activation and Calcium Responses in Mast Cells

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

THE HIGH-AFFINITY I<scp>g</scp>E RECEPTOR (FcεRI): From Physiology to Pathology

1999 • 949 citations

Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

1997 • 769 citations

Mitogen-activated protein kinase cascades and regulation of gene expression

1996 • 759 citations

Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K

1997 • 746 citations

Monoclonal dinitrophenyl-specific murine IgE antibody: preparation, isolation, and characterization.

1980 • 653 citations

Essential Role of LAT in T Cell Development

1999 • 537 citations

Regulatory and Signaling Properties of the Vav Family

2000 • 513 citations

Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases

1992 • 503 citations

Phospholipase Cγ2 Is Essential in the Functions of B Cell and Several Fc Receptors

2000 • 473 citations

Coupling of Ras and Rac Guanosine Triphosphatases Through the Ras Exchanger Sos

1998 • 452 citations

Defective antigen receptor-mediated proliferation of B and T cells in the absence of Vav

1995 • 411 citations

Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development

1998 • 405 citations

Defective signalling through the T- and B-cell antigen receptors in lymphoid cells lacking the vav proto-oncogene

1995 • 401 citations

Association of Grb2, Gads, and Phospholipase C-γ1 with Phosphorylated LAT Tyrosine Residues

2000 • 384 citations

Calcium mobilization via sphingosine kinase in signalling by the FcɛRI antigen receptor

1996 • 374 citations

Stabilization of Interleukin-2 mRNA by the c-Jun NH ₂ -Terminal Kinase Pathway

1998 • 353 citations

Cytokine production by mast cells and basophils

1991 • 344 citations

Vav and SLP-76 Interact and Functionally Cooperate in IL-2 Gene Activation

1996 • 335 citations

LAT Is Essential for FcεRI-Mediated Mast Cell Activation

2000 • 332 citations

Defective T-cell receptor signalling and positive selection of Vav-deficient CD4+CDS+thymocytes

1995 • 300 citations

A Requirement for the Rho-Family GTP Exchange Factor Vav in Positive and Negative Selection of Thymocytes

1997 • 285 citations

Functional and Physical Interactions of Syk Family Kinases with the Vav Proto-Oncogene Product

1996 • 281 citations

Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes

1998 • 270 citations

Essential role of the tyrosine kinase substrate phospholipase C-γ1 in mammalian growth and development

1997 • 251 citations

The Rho-family GTP exchange factor Vav is a critical transducer of T cell receptor signals to the calcium, ERK, and NF-κB pathways

1999 • 239 citations

Protein-tyrosine kinase p72syk in high affinity IgE receptor signaling. Identification as a component of pp72 and association with the receptor gamma chain after receptor aggregation.

1993 • 232 citations

Phosphoinositide 3-Kinase Regulates Phospholipase Cγ-mediated Calcium Signaling

1998 • 218 citations

Multichain immune recognition receptors: similarities in structure and signaling pathways

1992 • 210 citations

Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases

1996 • 209 citations

IgE-mediated release of leukotriene C4, chondroitin sulfate E proteoglycan, beta-hexosaminidase, and histamine from cultured bone marrow-derived mouse mast cells.

1983 • 201 citations

Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor.

1994 • 200 citations

Involvement of Guanosine Triphosphatases and Phospholipase C-γ2 in Extracellular Signal–regulated Kinase, c-Jun NH2-terminal Kinase, and p38 Mitogen-activated Protein Kinase Activation by the B Cell Antigen Receptor

1998 • 195 citations

Transphosphorylation as the mechanism by which the high-affinity receptor for IgE is phosphorylated upon aggregation.

1994 • 194 citations

Pillars article: antigen receptor tail clue. Nature. 1989. 338: 383-384.

2014 • 190 citations

IgE-induced tyrosine phosphorylation of phospholipase C-gamma 1 in rat basophilic leukemia cells.

1991 • 184 citations

A Functional T-Cell Receptor Signaling Pathway Is Required for p95^vav Activity

1995 • 173 citations

SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells.

1999 • 154 citations

Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.

1996 • 152 citations

Cdc42 and Rac Stimulate Exocytosis of Secretory Granules by Activating the Ip3/Calcium Pathway in Rbl-2h3 Mast Cells

2000 • 145 citations

Wortmannin blocks lipid and protein kinase activities associated with PI 3-kinase and inhibits a subset of responses induced by Fc epsilon R1 cross-linking.

1995 • 137 citations

A Tyrosine Kinase Signaling Pathway Accounts for the Majority of Phosphatidylinositol 3,4,5-Trisphosphate Formation in Chemoattractant-stimulated Human Neutrophils

1996 • 115 citations

Tyrosine Phosphorylation of the vav Proto-oncogene Product Links FcεRI to the Rac1-JNK Pathway

1997 • 113 citations

The vav proto-oncogene is required early in embryogenesis but not for hematopoietic development in vitro.

1995 • 111 citations

Functional effects of overexpression of protein kinase C-alpha, -beta, -delta, -epsilon, and -eta in the mast cell line RBL-2H3.

1997 • 105 citations

A Guanine Nucleotide Exchange Factor-independent Function of Vav1 in Transcriptional Activation

2000 • 103 citations

Fyn and ZAP-70 Are Required for Vav Phosphorylation in T Cells Stimulated by Antigen-presenting Cells

1998 • 101 citations

Role of phospholipase Cγ at fertilization and during mitosis in sea urchin eggs and embryos

1999 • 98 citations

Studies with a monoclonal antibody to the β subunit of the receptor with high affinity for immunoglobulin E

1988 • 96 citations

Induction of Exocytosis from Permeabilized Mast Cells by the Guanosine Triphosphatases Rac and Cdc42

1998 • 89 citations

The Src Homology 2 Domain of Vav Is Required for Its Compartmentation to the Plasma Membrane and Activation of C-Jun Nh2-Terminal Kinase 1

2000 • 73 citations

ER-27319, an acridone-related compound, inhibits release of antigen-induced allergic mediators from mast cells by selective inhibition of Fcɛ receptor I-mediated activation of Syk

1997 • 71 citations

Epidermal Growth Factor Signaling and Mitogenesis inPlcg1Null Mouse Embryonic Fibroblasts

1998 • 69 citations

Tyrosine Phosphorylation of Vav Stimulates IL-6 Production in Mast Cells by a Rac/c-Jun N-Terminal Kinase-Dependent Pathway

1999 • 65 citations

IDENTIFICATION OF A CALCIUM-INDUCIBLE, CYCLOSPORINE-SENSITIVE ELEMENT IN THE IFN-?? PROMOTER THAT IS A POTENTIAL NFAT BINDING SITE1

1996 • 61 citations

Thapsigargin-Induced Degranulation of Mast Cells Is Dependent on Transient Activation of Phosphatidylinositol-3 Kinase

2000 • 61 citations

Association of a p95 Vav-containing Signaling Complex with the FcϵRI γ Chain in the RBL-2H3 Mast Cell Line

1996 • 56 citations

Activated Cdc42/Rac reconstitutes FcɛRI-mediated Ca²⁺mobilization and degranulation in mutant RBL mast cells

2001 • 56 citations

Role of the vav Proto-oncogene Product (Vav) in Erythropoietin-mediated Cell Proliferation and Phosphatidylinositol 3-Kinase Activity

1997 • 55 citations

Structure and function of vav

1996 • 54 citations

Thapsigargin-induced secretion is dependent on activation of a cholera toxin-sensitive and phosphatidylinositol-3-kinase-regulated phospholipase D in a mast cell line.

1998 • 37 citations

Role of basal calcium in the EGF activation of MAP kinases

2000 • 19 citations

Polyethylene glycol-mediated infection of non-permissive mammalian cells with semliki forest virus: application to signal transduction studies

1999 • 18 citations

Requirement for a Negative Charge at Threonine 60 of the FcRγ for Complete Activation of Syk

1999 • 17 citations

Role of the cyclosporin-sensitive transcription factor NFAT1 in the allergic response

1997 • 14 citations