Phagocytic signaling strategies: Fcγreceptor-mediated phagocytosis as a model system

Actin Depolymerizing Factor (ADF/Cofilin) Enhances the Rate of Filament Turnover: Implication in Actin-based Motility

1997 • 1,028 citations

Identification of Two Distinct Mechanisms of Phagocytosis Controlled by Different Rho GTPases

1998 • 993 citations

A role for phosphoinositide 3-kinase in the completion of macropinocytosis and phagocytosis by macrophages.

1996 • 946 citations

Phosphatidylinositol 4-Phosphate 5-Kinase α Is a Downstream Effector of the Small G Protein ARF6 in Membrane Ruffle Formation

1999 • 800 citations

Mechanism of N-Wasp Activation by Cdc42 and Phosphatidylinositol 4,5-Bisphosphate

2000 • 615 citations

WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell mov

2001 • 594 citations

IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

2000 • 550 citations

Localized Biphasic Changes in Phosphatidylinositol-4,5-Bisphosphate at Sites of Phagocytosis

2000 • 537 citations

Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3

2000 • 501 citations

Activation by Cdc42 and Pip2 of Wiskott-Aldrich Syndrome Protein (Wasp) Stimulates Actin Nucleation by Arp2/3 Complex

2000 • 498 citations

A Critical Role for Syk in Signal Transduction and Phagocytosis Mediated by Fcγ Receptors on Macrophages

1997 • 495 citations

Cofilin promotes rapid actin filament turnover in vivo

1997 • 466 citations

Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes

1997 • 445 citations

A Requirement for Phosphatidylinositol 3-Kinase in Pseudopod Extension

1999 • 414 citations

Type I phosphatidylinositol 4-phosphate 5-kinase isoforms are specifically stimulated by phosphatidic acid

1994 • 410 citations

SHIP Modulates Immune Receptor Responses by Regulating Membrane Association of Btk

1998 • 397 citations

Modulation of Immune Complex–induced Inflammation In Vivo by the Coordinate Expression of Activation and Inhibitory Fc Receptors

1999 • 394 citations

The Syk Protein Tyrosine Kinase Is Essential for Fcγ Receptor Signaling in Macrophages and Neutrophils

1998 • 378 citations

Phosphatidic acid is a specific activator of phosphatidylinositol-4-phosphate kinase.

1992 • 368 citations

Focal Exocytosis of Vamp3-Containing Vesicles at Sites of Phagosome Formation

2000 • 322 citations

ARF6 requirement for Rac ruffling suggests a role for membrane trafficking in cortical actin rearrangements

1999 • 315 citations

Mammalian phospholipase D structure and regulation

1999 • 311 citations

The molecular dissection of Fc gamma receptor mediated phagocytosis

1995 • 309 citations

A role for MARCKS, the alpha isozyme of protein kinase C and myosin I in zymosan phagocytosis by macrophages.

1995 • 303 citations

Dynamin 2 Is Required for Phagocytosis in Macrophages

1999 • 283 citations

A contractile activity that closes phagosomes in macrophages

1999 • 279 citations

The actin cytoskeleton and plasma membrane connection: PtdIns(4,5)P2 influences cytoskeletal protein activity at the plasma membrane

2000 • 271 citations

Fc receptor-mediated phagocytosis requires CDC42 and Rac1

1998 • 254 citations

The structural basis of Arfaptin-mediated cross-talk between Rac and Arf signalling pathways

2001 • 251 citations

Fcγ Receptor–Mediated Phagocytosis in Macrophages Lacking the Src Family Tyrosine Kinases Hck, Fgr, and Lyn

2000 • 246 citations

Tyrosine Phosphorylation of the Fc Receptor γ-Chain in Collagen-stimulated Platelets

1996 • 233 citations

A Rab11-containing rapidly recycling compartment in macrophages that promotes phagocytosis

2000 • 233 citations

Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases.

1995 • 222 citations

A Requirement for ARF6 in Fcγ Receptor-mediated Phagocytosis in Macrophages

1998 • 211 citations

Phosphorylation of Adf/Cofilin Abolishes Egf-Induced Actin Nucleation at the Leading Edge and Subsequent Lamellipod Extension

2000 • 206 citations

Wiskott-Aldrich syndrome protein is necessary for efficient IgG-mediated phagocytosis

2000 • 197 citations

Rho is Required for the Initiation of Calcium Signaling and Phagocytosis by Fcγ Receptors in Macrophages

1997 • 170 citations

A Subset of Human Dendritic Cells Expresses IgA Fc Receptor (CD89), Which Mediates Internalization and Activation Upon Cross-Linking by IgA Complexes

2001 • 157 citations

A Regulatory Role for Src Homology 2 Domain–Containing Inositol 5′-Phosphatase (Ship) in Phagocytosis Mediated by Fcγ Receptors and Complement Receptor 3 (αMβ2; Cd11b/Cd18)

2000 • 157 citations

v-SNARE-dependent secretion is required for phagocytosis

1998 • 149 citations

Membrane recruitment of Rac1 triggers phagocytosis

2000 • 147 citations

Clustered syk tyrosine kinase domains trigger phagocytosis.

1996 • 140 citations

Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils.

1993 • 139 citations

Human receptors for immunoglobulin G: Key elements in the pathogenesis of rheumatic disease

2001 • 139 citations

Immunoglobulin-mediated phagocytosis by human monocytes requires protein kinase C activation. Evidence for protein kinase C translocation to phagosomes.

1992 • 123 citations

Conformational Changes Induced in the Protein Tyrosine Kinase p72^syk by Tyrosine Phosphorylation or by Binding of Phosphorylated Immunoreceptor Tyrosine-Based Activation Motif Peptides

1996 • 121 citations

Regulation of polymorphonuclear leukocyte phagocytosis by myosin light chain kinase after activation of mitogen-activated protein kinase

2000 • 118 citations

Two Pathways through Cdc42 Couple the N-Formyl Receptor to Actin Nucleation in Permeabilized Human Neutrophils

2000 • 116 citations

Abrogation of the Fc gamma receptor IIA-mediated phagocytic signal by stem-loop Syk antisense oligonucleotides.

1996 • 108 citations

ARF6 Is Required for Growth Factor- and Rac-Mediated Membrane Ruffling in Macrophages at a Stage Distal to Rac Membrane Targeting

1999 • 106 citations

Syk Tyrosine Kinase Is Required for Immunoreceptor Tyrosine Activation Motif-dependent Actin Assembly

1996 • 100 citations

Differential Involvement of Src Family Kinases in Fcγ Receptor-Mediated Phagocytosis

2000 • 100 citations

Negative Regulation of Phagocytosis in Murine Macrophages by the Src Kinase Family Member, Fgr

2000 • 98 citations

Fc gamma receptor-mediated activation of phospholipase D regulates macrophage phagocytosis of IgG-opsonized particles.

1999 • 86 citations

Amphiphysin IIm, a Novel Amphiphysin II Isoform, Is Required for Macrophage Phagocytosis

2000 • 77 citations

Fcγ Receptor-Mediated Activation of Phospholipase D Regulates Macrophage Phagocytosis of IgG-Opsonized Particles

1999 • 74 citations

Tyrosine phosphorylation and association of Syk with FcγRII in monocytic THP-1 cells

1995 • 74 citations

The Adapter Protein LAT Enhances Fcγ Receptor-mediated Signal Transduction in Myeloid Cells

2000 • 73 citations

Ceramide Inhibits IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes

1997 • 59 citations

Phospholipase A2 inhibition results in sequestration of plasma membrane into electronlucent vesicles during IgG-mediated phagocytosis

1997 • 52 citations

Herbimycin A inhibits both dephosphorylation and translocation of cofilin induced by opsonized zymosan in macrophagelike U937 cells

1999 • 42 citations

Mitogen-activated protein kinase is activated during IgG-mediated phagocytosis, but is not required for target ingestion.

1998 • 38 citations

Sphingosine Blocks Human Polymorphonuclear Leukocyte Phagocytosis Through Inhibition of Mitogen-Activated Protein Kinase Activation

1999 • 29 citations

Aggregation of the human high affinity immunoglobulin G receptor (FcγRI) activates both tyrosine kinase and G protein-coupled phosphoinositide 3-kinase isoforms

1998 • 26 citations

Phagocytosis : the host

1999 • 25 citations

Fc receptor-mediated phagocytosis

1999 • 8 citations