Interpreting the molecular biology and clinical behavior of multiple myeloma in the context of global gene expression profiling

Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring

1999 • 11,586 citations

In silico prediction of protein-protein interactions in human macrophages

2014 • 11,120 citations

Significance analysis of microarrays applied to the ionizing radiation response

2001 • 10,393 citations

Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

2000 • 9,712 citations

Quantitative Monitoring of Gene Expression Patterns with a Complementary DNA Microarray

1995 • 9,575 citations

Stochastic Gene Expression in a Single Cell

2002 • 5,397 citations

Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia

2002 • 4,860 citations

Diagnosis of multiple cancer types by shrunken centroids of gene expression

2002 • 2,932 citations

Light-Directed, Spatially Addressable Parallel Chemical Synthesis

1991 • 2,692 citations

Gene expression correlates of clinical prostate cancer behavior

2002 • 2,504 citations

A molecular signature of metastasis in primary solid tumors

2002 • 2,424 citations

Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning

2002 • 2,400 citations

High density synthetic oligonucleotide arrays

1999 • 2,256 citations

LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development

2001 • 2,203 citations

Use of a cDNA microarray to analyse gene expression patterns in human cancer

1996 • 2,002 citations

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

2002 • 1,959 citations

AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

1996 • 1,885 citations

TRF2 Protects Human Telomeres from End-to-End Fusions

1998 • 1,679 citations

Parallel human genome analysis: microarray-based expression monitoring of 1000 genes.

1996 • 1,629 citations

Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction

1998 • 1,587 citations

High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5

2002 • 1,577 citations

Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic Lineages

1994 • 1,506 citations

A gene expression database for the molecular pharmacology of cancer

2000 • 1,447 citations

An early haematopoietic defect in mice lacking the transcription factor GATA-2

1994 • 1,412 citations

A Mutation in the LDL Receptor–Related Protein 5 Gene Results in the Autosomal Dominant High–Bone-Mass Trait

2002 • 1,279 citations

Plasma cell differentiation requires the transcription factor XBP-1

2001 • 1,256 citations

Oncogenic Transcription Factors in the Human Acute Leukemias

1997 • 1,227 citations

Humoral Immunity Due to Long-Lived Plasma Cells

1998 • 1,223 citations

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

1999 • 1,139 citations

A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis

1991 • 1,074 citations

Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF

1999 • 1,068 citations

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

2001 • 1,028 citations

Pitfalls in the Use of DNA Microarray Data for Diagnostic and Prognostic Classification

2002 • 1,013 citations

Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

1995 • 961 citations

Human telomeres contain two distinct Myb–related proteins, TRF1 and TRF2

1997 • 913 citations

Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines

1999 • 850 citations

Multiple myeloma: evolving genetic events and host interactions

2002 • 815 citations

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

1994 • 807 citations

Identification of cooperating oncogenes in Eμ-myc transgenic mice by provirus tagging

1991 • 765 citations

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

2001 • 763 citations

Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells

1994 • 752 citations

Frzb-1 Is a Secreted Antagonist of Wnt Signaling Expressed in the Spemann Organizer

1997 • 725 citations

Regulation of B Lymphocyte and Macrophage Development by Graded Expression of PU.1

2000 • 712 citations

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

2001 • 696 citations

Cancer: Principles and Practice of Oncology

2006 • 676 citations

Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells

2002 • 655 citations

Dickkopf1 Is Required for Embryonic Head Induction and Limb Morphogenesis in the Mouse

2001 • 627 citations

The Oncogenic Cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development

1994 • 616 citations

Transcription factor GATA-3 is required for development of the T-cell lineage

1996 • 614 citations

Bone Marrow Neovascularization, Plasma Cell Angiogenic Potential, and Matrix Metalloproteinase-2 Secretion Parallel Progression of Human Multiple Myeloma

1999 • 590 citations

Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341

2003 • 572 citations

Adherence of multiple myeloma cells to bone marrow stromal cells upregulates vascular endothelial growth factor secretion: therapeutic applications

2001 • 562 citations

Wnt/Wingless Signaling Requires BCL9/Legless-Mediated Recruitment of Pygopus to the Nuclear β-Catenin-TCF Complex

2002 • 548 citations

The TAK1-NLK Mitogen-Activated Protein Kinase Cascade Functions in the Wnt-5a/Ca²⁺ Pathway To Antagonize Wnt/β-Catenin Signaling

2002 • 540 citations

The Wnt signalling pathway

2002 • 534 citations

Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression

2001 • 525 citations

The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH

1995 • 485 citations

Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

1995 • 451 citations

JNK functions in the non‐canonical Wnt pathway to regulate convergent extension movements in vertebrates

2002 • 444 citations

Wnt Signaling Regulates B Lymphocyte Proliferation through a LEF-1 Dependent Mechanism

2000 • 444 citations

The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response

1997 • 437 citations

Molecular mechanisms of novel therapeutic approaches for multiple myeloma

2002 • 431 citations

Reversal of Bone Loss in Mice by Nongenotropic Signaling of Sex Steroids

2002 • 421 citations

Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-xL is an essential survival protein of human myeloma cells

2002 • 420 citations

The clinical significance of cytogenetic studies in 100 patients with multiple myeloma, plasma cell leukemia, or amyloidosis

1985 • 419 citations

Poor prognosis in multiple myeloma is associated only with partial or complete deletions of chromosome 13 or abnormalities involving 11q and not with other karyotype abnormalities

1995 • 418 citations

The Polyadenylation Factor CstF-64 Regulates Alternative Processing of IgM Heavy Chain Pre-mRNA during B Cell Differentiation

1996 • 416 citations

Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development.

1996 • 405 citations

Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma

2000 • 397 citations

In multiple myeloma, t(4;14)(p16;q32) is an adverse prognostic factor irrespective of FGFR3 expression

2003 • 388 citations

Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma

2001 • 385 citations

Bone marrow is a major site of long-term antibody production after acute viral infection

1995 • 384 citations

Cytogenetic findings in 200 patients with multiple myeloma

1995 • 378 citations

Syndecan-1 is required for Wnt-1-induced mammary tumorigenesis in mice

2000 • 366 citations

Myeloid cell factor–1 is a critical survival factor for multiple myeloma

2002 • 365 citations

The bone marrow: the major source of serum immunoglobulins, but still a neglected site of antibody formation.

1981 • 359 citations

A Role for the Wnt Gene Family in Hematopoiesis: Expansion of Multilineage Progenitor Cells

1997 • 355 citations

Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation

2002 • 353 citations

The Ets-1 Transcription Factor Is Required for the Development of Natural Killer Cells in Mice

1998 • 351 citations

In Situ Studies of the Primary Immune Response to (4-Hydroxy-3-Nitrophenyl)Acetyl. V. Affinity Maturation Develops in Two Stages of Clonal Selection

1998 • 349 citations

The ins and outs of the transmembrane 4 superfamily

1994 • 339 citations

Adhesion to fibronectin via β1 integrins regulates p27kip1 levels and contributes to cell adhesion mediated drug resistance (CAM-DR)

2000 • 338 citations

Commitment of B Lymphocytes to a Plasma Cell Fate Is Associated with Blimp-1 Expression In Vivo

2000 • 337 citations

Role of Members of the Wnt Gene Family in Human Hematopoiesis

1998 • 333 citations

Results of high-dose therapy for 1000 patients with multiple myeloma: durable complete remissions and superior survival in the absence of chromosome 13 abnormalities

2000 • 333 citations

Myeloma and the t(11;14)(q13;q32); evidence for a biologically defined unique subset of patients

2002 • 331 citations

Macrophage inflammatory protein-1α is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor κB ligand

2001 • 330 citations

Defective activation and survival of T cells lacking the Ets-1 transcription factor

1995 • 329 citations

Deletion of 13q14 remains an independent adverse prognostic variable in multiple myeloma despite its frequent detection by interphase fluorescence in situ hybridization

2000 • 328 citations

Transcriptional Repression by Blimp-1 (PRDI-BF1) Involves Recruitment of Histone Deacetylase

2000 • 328 citations

Recurrent 14q32 translocations determine the prognosis of multiple myeloma, especially in patients receiving intensive chemotherapy

2002 • 324 citations

Chromosome 13 abnormalities identified by FISH analysis and serum β2-microglobulin produce a powerful myeloma staging system for patients receiving high-dose therapy

2001 • 314 citations

Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene

1995 • 313 citations

Intrinsic Constraint on Plasmablast Growth and Extrinsic Limits of Plasma Cell Survival

2000 • 311 citations

Myeloma interacts with the bone marrow microenvironment to induce osteoclastogenesis and is dependent on osteoclast activity

2002 • 309 citations

Plasma cells: finding new light at the end of B cell development

2001 • 305 citations

Activated fibroblast growth factor receptor 3 is an oncogene that contributes to tumor progression in multiple myeloma

2001 • 296 citations

The heterogeneity shown by human plasma cells from tonsil, blood, and bone marrow reveals graded stages of increasing maturity, but local profiles of adhesion molecule expression

2002 • 281 citations

DNA methyltransferase inhibitors—state of the art

2002 • 276 citations

Distinct short‐lived and long‐lived antibody‐producing cell populations

1986 • 276 citations

Isolation and Biochemical Characterization of the Human Dkk-1 Homologue, a Novel Inhibitor of Mammalian Wnt Signaling

1999 • 265 citations

A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation.

1990 • 244 citations

Stages of B cell differentiation in human lymphoid tissue.

1981 • 241 citations

CD34 cell dose in granulocyte colony-stimulating factor–mobilized peripheral blood mononuclear cell grafts affects engraftment kinetics and development of extensive chronic graft-versus-host disease after human leukocyte antigen–identical sibling transplantation

2001 • 234 citations

Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial

1996 • 229 citations

Cyclin D3 at 6p21 is dysregulated by recurrent chromosomal translocations to immunoglobulin loci in multiple myeloma

2001 • 224 citations

Bone Marrow Neovascularization, Plasma Cell Angiogenic Potential, and Matrix Metalloproteinase-2 Secretion Parallel Progression of Human Multiple Myeloma

1999 • 221 citations

Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase

1997 • 220 citations

Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation

2003 • 215 citations

p53 gene mutations in multiple myeloma are associated with advanced forms of malignancy

1993 • 206 citations

Enhanced Tumor Formation in Mice Heterozygous for Blm Mutation

2002 • 205 citations

Characterization of a Circulating Subpopulation of Spontaneous Antitetanus Toxoid Antibody Producing B Cells Following in Vivo Booster Immunization

1979 • 201 citations

Monosomy 13 Is Associated With the Transition of Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma

1999 • 200 citations

Novel therapies targeting the myeloma cell and its bone marrow microenvironment

2001 • 200 citations

Nucleotide sequence, transcription map, and mutation analysis of the 13q14 chromosomal region deleted in B-cell chronic lymphocytic leukemia

2001 • 199 citations

The Wnt antagonist Dickkopf-1 is regulated by Bmp signaling and c-Jun and modulates programmed cell death

2002 • 198 citations

A subset of multiple myeloma harboring the t(4;14)(p16;q32) translocation lacks FGFR3 expression but maintains anIGH/MMSET fusion transcript

2003 • 194 citations

BLM Heterozygosity and the Risk of Colorectal Cancer

2002 • 194 citations

Insulin-like growth factor I is a growth and survival factor in human multiple myeloma cell lines

1996 • 190 citations

High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis

2001 • 190 citations

The Wnt Antagonist Frzb-1 Regulates Chondrocyte Maturation and Long Bone Development during Limb Skeletogenesis

2002 • 186 citations

A molecular compendium of genes expressed in multiple myeloma

2002 • 186 citations

Metalloproteinases in Multiple Myeloma: Production of Matrix Metalloproteinase-9 (MMP-9), Activation of proMMP-2, and Induction of MMP-1 by Myeloma Cells

1997 • 186 citations

Biological and prognostic significance of interphase fluorescence in situ hybridization detection of chromosome 13 abnormalities (delta13) in multiple myeloma: an eastern cooperative oncology group study.

2002 • 185 citations

Prognostic Value of Numerical Chromosome Aberrations in Multiple Myeloma: A FISH Analysis of 15 Different Chromosomes

1998 • 180 citations

High incidence of chromosome 13 deletion in multiple myeloma detected by multiprobe interphase FISH

2000 • 179 citations

Signaling of Rat Frizzled-2 Through Phosphodiesterase and Cyclic GMP

2002 • 179 citations

Identification of New Nonrandom Translocations in Multiple Myeloma With Multicolor Spectral Karyotyping

1998 • 172 citations

Insulin-like growth factor I is a dual effector of multiple myeloma cell growth

2000 • 171 citations

Gene expression profiling of human plasma cell differentiation and classification of multiple myeloma based on similarities to distinct stages of late-stage B-cell development

2003 • 170 citations

Identifying intercellular signaling genes expressed in malignant plasma cells by using complementary DNA arrays

2001 • 164 citations

Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53

2000 • 162 citations

Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA

2002 • 161 citations

Prognostic impact of cytogenetic and interphase fluorescence in situ hybridization‐defined chromosome 13 deletion in multiple myeloma: early results of total therapy II

2002 • 159 citations

Reactive Plasmacytoses Are Expansions of Plasmablasts Retaining the Capacity to Differentiate Into Plasma Cells

1999 • 157 citations

Generation of polyclonal plasmablasts from peripheral blood B cells: a normal counterpart of malignant plasmablasts

2002 • 156 citations

Developmental extinction of major histocompatibility complex class II gene expression in plasmocytes is mediated by silencing of the transactivator gene CIITA.

1994 • 155 citations

Characterization of Nonrandom Chromosomal Gains and Losses in Multiple Myeloma by Comparative Genomic Hybridization

1998 • 153 citations

Insulinlike growth factor–I signaling in multiple myeloma: downstream elements, functional correlates, and pathway cross-talk

2002 • 152 citations

Linkage of a QTL Contributing to Normal Variation in Bone Mineral Density to Chromosome 11q12–13

1998 • 152 citations

CD63 is a component of Weibel-Palade bodies of human endothelial cells

1993 • 150 citations

Prognostic value of cytogenetics in multiple myeloma

1998 • 145 citations

Expression and induction of collagenases (MMP-8 and -13) in plasma cells associated with bone-destructive lesions

2001 • 144 citations

Developmental Therapeutics Program at the NCI: molecular target and drug discovery process

2002 • 143 citations

Bcl-2+ tonsillar plasma cells are rescued from apoptosis by bone marrow fibroblasts.

1996 • 142 citations

VLA-4-fibronectin interaction is required for the terminal differentiation of human bone marrow cells capable of spontaneous and high rate immunoglobulin secretion.

1992 • 135 citations

Continuous absence of metaphase-defined cytogenetic abnormalities, especially of chromosome 13 and hypodiploidy, ensures long-term survival in multiple myeloma treated with Total Therapy I: interpretation in the context of global gene expression

2003 • 134 citations

Germinal center B cells and antibody production in the bone marrow.

1991 • 130 citations

Mechanisms of osteolytic bone destruction

1991 • 130 citations

COMPARE: a web accessible tool for investigating mechanisms of cell growth inhibition

2002 • 128 citations

PECAM-1 functions as a specific and potent inhibitor of mitochondrial-dependent apoptosis

2003 • 128 citations

Immunoglobulin Synthesis by Human Lymphoid Tissues: Normal Bone Marrow as a Major Site of IgG Production

1972 • 125 citations

Pax5 Determines the Identity of B Cells from the Beginning to the End of B-lymphopoiesis

2001 • 123 citations

Reactive Plasmacytoses Are Expansions of Plasmablasts Retaining the Capacity to Differentiate Into Plasma Cells

1999 • 122 citations

Bone morphogenetic protein-4 inhibits proliferation and induces apoptosis of multiple myeloma cells

2001 • 122 citations

Cellular DNA content as a marker of human multiple myeloma

1980 • 113 citations

Inactivation of tumor suppressor genes, p53 and Rb1, in plasma cell dyscrasias.

1994 • 110 citations

Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate genes for leukemogenesis at chromosome 13q14, a region commonly deleted in B-cell chronic lymphocytic leukemia.

2001 • 102 citations

WNT signaling modulates the diversification of hematopoietic cells

2000 • 102 citations

Mutations of the p53 gene in human myeloma cell lines.

1992 • 101 citations

The tumor microenvironment as a determinant of cancer cell survival: a possible mechanism for de novo drug resistance

2000 • 97 citations

Gene expression profiling reveals a highly specialized genetic program of plasma cells

2003 • 95 citations

Wnt Signaling Regulates Hemopoiesis Through Stromal Cells

2001 • 95 citations

Regulation of tumor cell motility and migration by CD63 in a human melanoma cell line.

1997 • 95 citations

Predicting long‐term (≥ 5 years) event‐free survival in multiple myeloma patients following planned tandem autotransplants

2002 • 93 citations

Down-regulation of candidate tumor suppressor genes within chromosome band 13q14.3 is independent of the DNA methylation pattern in B-cell chronic lymphocytic leukemia

2002 • 92 citations

Multicolour spectral karyotyping identifies new translocations and a recurring pathway for chromosome loss in multiple myeloma

2001 • 90 citations

Interphase fluorescence in situ hybridization (FISH) as a powerful tool for the detection of aneuploidy in multiple myeloma.

1995 • 85 citations

The mechanism of thymus-dependent antibody formation in bone marrow.

1981 • 81 citations

Serum insulinlike growth factor is not elevated in patients with multiple myeloma but is still a prognostic factor

2002 • 81 citations

Loss- and gain-of-function mutations reveal an important role of BSAP (Pax-5) at the start and end of B cell differentiation

1998 • 73 citations

Deletions of chromosome 13q in monoclonal gammopathy of undetermined significance

2000 • 73 citations

3Immunophenotype and DNA cell content in multiple myeloma

1995 • 69 citations

Frizzled Receptors Activate a Novel JNK-Dependent Pathway that May Lead to Apoptosis

2002 • 66 citations

P53 deletion is not a frequent event in multiple myeloma

1999 • 65 citations

Antimyeloma efficacy of thalidomide in the SCID-hu model

2002 • 62 citations

Matrix Metalloproteinases in Multiple Myeloma

2000 • 57 citations

PU.1 exhibits partial functional redundancy with Spi-B, but not with Ets-1 or Elf-1

2001 • 52 citations

Recurrent immunoglobulin gene translocations identify distinct molecular subtypes of myeloma

2000 • 52 citations

Human tonsil, blood and bone marrow in vivo‐induced B cells capable of spontaneous and high‐rate immunoglobulin secretion in vitro: Differences in the requirements for factors and for adherent and bone marrow stromal cells, as well as distinctive adhesion molecule expression

1994 • 47 citations

Evolving approaches to cancer drug discovery and development at the National Cancer Institute, USA

1999 • 43 citations

Regulatory role of CD95 ligation on human B cells induced in vivo capable of spontaneous and highrate Ig secretion

1997 • 36 citations

Mitotic arrest induced by XK469, a novel antitumor agent, is correlated with the inhibition of cyclin B1 ubiquitination

2001 • 36 citations

SOLUBLE IL-6Rα UPREGULATES IL-6, MMP-1 AND MMP-2 SECRETION IN BONE MARROW STROMAL CELLS

2000 • 34 citations

Tumor-specific aneuploidy not detected in CD19+ B-lymphoid cells from myeloma patients in a multidimensional flow cytometric analysis

1996 • 28 citations

p53gene mutations are rare in patients but common in patient-originating cell lines in multiple myeloma

1997 • 12 citations

Gene Expression Profiling after Short Term In-vivo Treatment Identifies Potential Mechanisms of Action of Current Drugs Used To Treat Multiple Myeloma

2002 • 8 citations

Thymidylate synthase as a molecular target for drug discovery using the National Cancer Instituteʼs Anticancer Drug Screen

2001 • 6 citations